{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:07:42Z","timestamp":1787062062952,"version":"build-2736575974"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04565-5","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:16:29Z","timestamp":1764695789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic features of blaNDM\u22121 harboring Klebsiella pneumoniae isolates from Kerman, Iran"],"prefix":"10.1186","volume":"26","author":[{"given":"Sajad","family":"Aslani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Afgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ekrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Savari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Isaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Moein","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-2888","authenticated-orcid":false,"given":"Davood","family":"Kalantar-Neyestanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"issue":"3","key":"4565_CR1","doi-asserted-by":"publisher","first-page":"e03017","DOI":"10.1128\/spectrum.03017-23","volume":"12","author":"F Ofosu-Appiah","year":"2024","unstructured":"Ofosu-Appiah F, Acquah EE, Mohammed J, Sakyi Addo C, Agbodzi B, Ofosu DAS, et al. Klebsiella pneumoniae ST147 harboring blaNDM-1, multidrug resistance and hypervirulence plasmids. Microbiol Spectr. 2024;12(3):e03017\u201323.","journal-title":"Microbiol Spectr"},{"issue":"6","key":"4565_CR2","doi-asserted-by":"publisher","first-page":"e99209","DOI":"10.1371\/journal.pone.0099209","volume":"9","author":"CM Hudson","year":"2014","unstructured":"Hudson CM, Bent ZW, Meagher RJ, Williams KP. Resistance determinants and mobile genetic elements of an NDM-1-Encoding Klebsiella pneumoniae strain. PLoS ONE. 2014;9(6):e99209.","journal-title":"PLoS ONE"},{"key":"4565_CR3","doi-asserted-by":"publisher","first-page":"104507","DOI":"10.1016\/j.micpath.2020.104507","volume":"149","author":"H Solgi","year":"2020","unstructured":"Solgi H, Shahcheraghi F, Bolourchi N, Ahmadi A. Molecular characterization of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae ST11 harbouring blaNDM-1 and blaOXA-48 carbapenemases in Iran. Microb Pathog. 2020;149:104507.","journal-title":"Microb Pathog"},{"key":"4565_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3389\/fmicb.2020.00700","volume":"11","author":"T Xiang","year":"2020","unstructured":"Xiang T, Chen C, Wen J, Liu Y, Zhang Q, Cheng N, et al. Resistance of Klebsiella pneumoniae strains carrying blaNDM\u20131 gene and the genetic environment of blaNDM\u20131. Front Microbiol. 2020;11:700.","journal-title":"Front Microbiol"},{"issue":"7","key":"4565_CR5","doi-asserted-by":"publisher","first-page":"e0231119","DOI":"10.1371\/journal.pone.0231119","volume":"16","author":"A Hirabayashi","year":"2021","unstructured":"Hirabayashi A, Yahara K, Mitsuhashi S, Nakagawa S, Imanishi T, Ha VTT, et al. Plasmid analysis of NDM metallo-\u03b2-lactamase-producing enterobacterales isolated in Vietnam. PLoS ONE. 2021;16(7):e0231119.","journal-title":"PLoS ONE"},{"key":"4565_CR6","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3389\/fmicb.2020.00936","volume":"11","author":"H Solgi","year":"2020","unstructured":"Solgi H, Nematzadeh S, Giske CG, Badmasti F, Westerlund F, Lin YL, et al. Molecular epidemiology of OXA-48 and NDM-1 producing enterobacterales species at a university hospital in Tehran, Iran, between 2015 and 2016. Front Microbiol. 2020;11:936.","journal-title":"Front Microbiol"},{"key":"4565_CR7","doi-asserted-by":"publisher","first-page":"127159","DOI":"10.1016\/j.micres.2022.127159","volume":"264","author":"J Qiu","year":"2022","unstructured":"Qiu J, Zhai Y, Wei M, Zheng C, Jiao X. Toxin-antitoxin systems: Classification, biological roles, and applications. Microbiol Res. 2022;264:127159.","journal-title":"Microbiol Res"},{"key":"4565_CR8","doi-asserted-by":"crossref","unstructured":"Aslani S, Kiaei S, Afgar A, Morones-Ram\u00edrez JR, Aratboni HA, Faridi A et al. Determination of incompatibility group plasmids and copy number of the blaNDM-1 gene in carbapenem-resistant Klebsiella pneumoniae strains recovered from different hospitals in Kerman, Iran. J Med Microbiol. 2021;70(5):001361.","DOI":"10.1099\/jmm.0.001361"},{"key":"4565_CR9","unstructured":"CLSI. Performance standards for antimicrobial susceptibility testing. 34th ed. CLSI supplement M100. Clinical and Laboratory Standards Institute; 2024."},{"issue":"5","key":"4565_CR10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.2353\/jmoldx.2009.080136","volume":"11","author":"LJ Hartman","year":"2009","unstructured":"Hartman LJ, Selby EB, Whitehouse CA, Coyne SR, Jaissle JG, Twenhafel NA, et al. Rapid real-time PCR assays for detection of Klebsiella pneumoniae with the RmpA or MagA genes associated with the hypermucoviscosity phenotype: screening of nonhuman primates. J Mol Diagn. 2009;11(5):464\u201371.","journal-title":"J Mol Diagn"},{"key":"4565_CR11","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.2147\/IDR.S214960","volume":"12","author":"X Liu","year":"2019","unstructured":"Liu X, Zhang J, Li Y, Shen Q, Jiang W, Zhao K, et al. Diversity and frequency of resistance and virulence genes in blaKPC and blaNDM co-producing Klebsiella pneumoniae strains from China. Infect Drug Resist. 2019;12:2819\u201326.","journal-title":"Infect Drug Resist"},{"key":"4565_CR12","doi-asserted-by":"publisher","first-page":"106231","DOI":"10.1016\/j.mimet.2021.106231","volume":"185","author":"NBS Silva","year":"2021","unstructured":"Silva NBS, Alves PGV, De Andrade Marques L, Silva SF, De Oliveira Faria G, De Ara\u00fajo LB, et al. Quantification of biofilm produced by clinical, environment and hands\u2019 isolates Klebsiella species using colorimetric and classical methods. J Microbiol Methods. 2021;185:106231.","journal-title":"J Microbiol Methods"},{"issue":"5","key":"4565_CR13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1099\/jmm.0.015198-0","volume":"59","author":"JF Turton","year":"2010","unstructured":"Turton JF, Perry C, Elgohari S, Hampton CV. PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol. 2010;59(5):541\u20137.","journal-title":"J Med Microbiol"},{"issue":"1","key":"4565_CR14","doi-asserted-by":"publisher","first-page":"38929","DOI":"10.1038\/srep38929","volume":"6","author":"R Wasfi","year":"2016","unstructured":"Wasfi R, Elkhatib WF, Ashour HM. Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals. Sci Rep. 2016;6(1):38929.","journal-title":"Sci Rep"},{"issue":"1","key":"4565_CR15","doi-asserted-by":"publisher","first-page":"17291","DOI":"10.1038\/s41598-017-17681-8","volume":"7","author":"W Jian-li","year":"2017","unstructured":"Jian-li W, Yuan-yuan S, Shou-yu G, Fei-fei D, Jia-yu Y, Xue-hua W, et al. Serotype and virulence genes of Klebsiella pneumoniae isolated from Mink and its pathogenesis in mice and Mink. Sci Rep. 2017;7(1):17291.","journal-title":"Sci Rep"},{"issue":"4","key":"4565_CR16","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/jam.13533","volume":"123","author":"C Vuotto","year":"2017","unstructured":"Vuotto C, Longo F, Pascolini C, Donelli G, Balice MP, Libori MF, et al. Biofilm formation and antibiotic resistance in Klebsiella pneumoniae urinary strains. J Appl Microbiol. 2017;123(4):1003\u201318.","journal-title":"J Appl Microbiol"},{"issue":"3","key":"4565_CR17","doi-asserted-by":"publisher","first-page":"e4982","DOI":"10.1371\/journal.pone.0004982","volume":"4","author":"S Brisse","year":"2009","unstructured":"Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, et al. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS ONE. 2009;4(3):e4982.","journal-title":"PLoS ONE"},{"key":"4565_CR18","doi-asserted-by":"crossref","unstructured":"Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC. qnr Prevalence in Ceftazidime-Resistant Enterobacteriaceae Isolates from the United States. Antimicrob Agents Chemother. 2006;50(8):2872\u20134.","DOI":"10.1128\/AAC.01647-05"},{"key":"4565_CR19","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.micpath.2017.01.035","volume":"104","author":"X Xu","year":"2017","unstructured":"Xu X, Li X, Luo M, Liu P, Su K, Qing Y, et al. Molecular characterisations of integrons in clinical isolates of Klebsiella pneumoniae in a Chinese tertiary hospital. Microb Pathog. 2017;104:164\u201370.","journal-title":"Microb Pathog"},{"issue":"1","key":"4565_CR20","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1128\/AAC.00783-09","volume":"54","author":"M Tato","year":"2010","unstructured":"Tato M, Coque TM, Baquero F, Cant\u00f3n R. Dispersal of carbapenemase blaVIM-1 gene associated with different Tn 402 Variants, mercury Transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54(1):320\u20137.","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"4565_CR21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12866-017-1012-8","volume":"17","author":"AU Khan","year":"2017","unstructured":"Khan AU, Maryam L, Zarrilli R, Structure. Genetics and worldwide spread of new Delhi Metallo-\u03b2-lactamase (NDM): a threat to public health. BMC Microbiol. 2017;17(1):101.","journal-title":"BMC Microbiol"},{"issue":"1","key":"4565_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13099-024-00611-1","volume":"16","author":"B Pourakbari","year":"2024","unstructured":"Pourakbari B, Mamishi S, Poormohammadi S, Hosseinpour Sadeghi R, Mahmoudi S. High prevalence of carbapenem resistance and clonal expansion of blaNDM gene in Klebsiella pneumoniae isolates in an Iranian referral pediatric hospital. Gut Pathog. 2024;16(1):17.","journal-title":"Gut Pathog"},{"issue":"3","key":"4565_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1089\/mdr.2018.0181","volume":"26","author":"S Aghamohammad","year":"2020","unstructured":"Aghamohammad S, Badmasti F, Solgi H, Aminzadeh Z, Khodabandelo Z, Shahcheraghi F. First report of Extended-Spectrum Betalactamase-Producing Klebsiella pneumoniae among fecal carriage in iran: high diversity of clonal relatedness and virulence factor profiles. Microb Drug Resist. 2020;26(3):261\u20139.","journal-title":"Microb Drug Resist"},{"key":"4565_CR24","doi-asserted-by":"publisher","first-page":"105459","DOI":"10.1016\/j.meegid.2023.105459","volume":"112","author":"MN Hajiagha","year":"2023","unstructured":"Hajiagha MN, Kafil HS. Efflux pumps and microbial biofilm formation. Infect Genet Evol. 2023;112:105459.","journal-title":"Infect Genet Evol"},{"issue":"16","key":"4565_CR25","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.1128\/AEM.05068-11","volume":"77","author":"X Wang","year":"2011","unstructured":"Wang X, Wood TK. Toxin-Antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol. 2011;77(16):5577\u201383.","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"4565_CR26","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/2049-632X.12145","volume":"70","author":"Y Wen","year":"2014","unstructured":"Wen Y, Behiels E, Devreese B. Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. Pathog Dis. 2014;70(3):240\u20139.","journal-title":"Pathog Dis"},{"key":"4565_CR27","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.2147\/IDR.S218945","volume":"12","author":"Z Kong","year":"2019","unstructured":"Kong Z, Cai R, Cheng C, Zhang C, Kang H, Ma P, et al. First reported nosocomial outbreak of NDM-5-Producing Klebsiella pneumoniae in A neonatal unit in China. Infect Drug Resist. 2019;12:3557\u201366.","journal-title":"Infect Drug Resist"},{"issue":"9","key":"4565_CR28","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1099\/mic.0.26434-0","volume":"149","author":"J Jagnow","year":"2003","unstructured":"Jagnow J, Clegg S. Klebsiella pneumoniae MrkD-mediated biofilm formation on extracellular matrix- and collagen-coated surfaces. Microbiology. 2003;149(9):2397\u2013405.","journal-title":"Microbiology"},{"issue":"8","key":"4565_CR29","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1128\/JB.187.8.2870-2880.2005","volume":"187","author":"D Balestrino","year":"2005","unstructured":"Balestrino D, Haagensen JAJ, Rich C, Forestier C. Characterization of type 2 quorum sensing in Klebsiella pneumoniae and relationship with biofilm formation. J Bacteriol. 2005;187(8):2870\u201380.","journal-title":"J Bacteriol"},{"issue":"8","key":"4565_CR30","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1128\/IAI.00129-06","volume":"74","author":"JD Boddicker","year":"2006","unstructured":"Boddicker JD, Anderson RA, Jagnow J, Clegg S. Signature-Tagged mutagenesis of Klebsiella pneumoniae to identify genes that influence biofilm formation on extracellular matrix material. Infect Immun. 2006;74(8):4590\u20137.","journal-title":"Infect Immun"},{"issue":"3","key":"4565_CR31","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1462-2920.2007.01491.x","volume":"10","author":"D Balestrino","year":"2008","unstructured":"Balestrino D, Ghigo J, Charbonnel N, Haagensen JAJ, Forestier C. The characterization of functions involved in the establishment and maturation of Klebsiella pneumoniae in vitro biofilm reveals dual roles for surface exopolysaccharides. Environ Microbiol. 2008;10(3):685\u2013701.","journal-title":"Environ Microbiol"},{"issue":"2","key":"4565_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4161\/viru.22974","volume":"4","author":"MD Alc\u00e1ntar-Curiel","year":"2013","unstructured":"Alc\u00e1ntar-Curiel MD, Blackburn D, Salda\u00f1a Z, Gayosso-V\u00e1zquez C, Iovine N, De La Cruz MA, et al. Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation. Virulence. 2013;4(2):129\u201338.","journal-title":"Virulence"},{"key":"4565_CR33","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.3389\/fmicb.2018.03198","volume":"9","author":"RL Ferreira","year":"2019","unstructured":"Ferreira RL, Da Silva BCM, Rezende GS, Nakamura-Silva R, Pitondo-Silva A, Campanini EB, et al. High prevalence of Multidrug-Resistant Klebsiella pneumoniae harboring several virulence and \u03b2-Lactamase encoding genes in a Brazilian intensive care unit. Front Microbiol. 2019;9:3198.","journal-title":"Front Microbiol"},{"issue":"9","key":"4565_CR34","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1128\/AAC.48.9.3477-3482.2004","volume":"48","author":"H Sahly","year":"2004","unstructured":"Sahly H, Aucken H, Bened\u00ed VJ, Forestier C, Fussing V, Hansen DS, et al. Increased serum resistance in Klebsiella pneumoniae strains producing Extended-Spectrum \u03b2-Lactamases. Antimicrob Agents Chemother. 2004;48(9):3477\u201382.","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"4565_CR35","doi-asserted-by":"publisher","first-page":"101209","DOI":"10.1016\/j.psj.2021.101209","volume":"100","author":"PK Roy","year":"2021","unstructured":"Roy PK, Ha AJW, Mizan MFR, Hossain MI, Md A, Toushik SH, et al. Effects of environmental conditions (temperature, pH, and glucose) on biofilm formation of Salmonella enterica serotype Kentucky and virulence gene expression. Poult Sci. 2021;100(7):101209.","journal-title":"Poult Sci"},{"issue":"7","key":"4565_CR36","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1099\/jmm.0.000965","volume":"68","author":"A Ghasemian","year":"2019","unstructured":"Ghasemian A, Mohabati Mobarez A, Najar Peerayeh S, Talebi Bezmin Abadi A, Khodaparast S, Mahmood SS. Expression of adhesin genes and biofilm formation among Klebsiella Oxytoca clinical isolates from patients with antibiotic-associated haemorrhagic colitis. J Med Microbiol. 2019;68(7):978\u201385.","journal-title":"J Med Microbiol"},{"issue":"1","key":"4565_CR37","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1038\/s41467-024-46684-z","volume":"15","author":"M Nieto-Rosado","year":"2024","unstructured":"Nieto-Rosado M, Sands K, Portal EAR, Thomson KM, Carvalho MJ, Mathias J, et al. Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum \u03b2-lactamase- and carbapenemase-producing bacteria. Nat Commun. 2024;15(1):2758.","journal-title":"Nat Commun"},{"issue":"3","key":"4565_CR38","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3390\/antibiotics14030222","volume":"14","author":"M Galgano","year":"2025","unstructured":"Galgano M, Pellegrini F, Catalano E, Capozzi L, Del Sambro L, Sposato A, et al. Acquired bacterial resistance to antibiotics and resistance genes: from past to future. Antibiotics. 2025;14(3):222.","journal-title":"Antibiotics"},{"key":"4565_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6086979","volume":"2022","author":"E Soltani","year":"2022","unstructured":"Soltani E, Hasani A, Rezaee MA, Nahandi MZ, Hasani A, Gholizadeh P. An alliance of Carbapenem-Resistant Klebsiella pneumoniae with precise capsular serotypes and clinical determinants: A disquietude in hospital setting. Can J Infect Dis Med Microbiol. 2022;2022:1\u20139.","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"4565_CR40","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/IDR.S461666","volume":"17","author":"M Jiang","year":"2024","unstructured":"Jiang M, Zhang H, Lu W, Qiu X, Lin C, Zhao R, et al. Molecular characteristics of virulence genes in Carbapenem-Resistant and Carbapenem-Sensitive Klebsiella pneumoniae in relation to different capsule serotypes in Ningbo, China. Infect Drug Resist. 2024;17:2109\u201320.","journal-title":"Infect Drug Resist"},{"issue":"8","key":"4565_CR41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1089\/mdr.2023.0296","volume":"30","author":"NM El Naggar","year":"2024","unstructured":"El Naggar NM, Shawky RM, Serry FME, Emara M. The increased prevalence of RmpA gene in Klebsiella pneumoniae isolates coharboring blaNDM and blaOXA-48-like genes. Microb Drug Resist. 2024;30(8):317\u201324.","journal-title":"Microb Drug Resist"},{"issue":"7","key":"4565_CR42","doi-asserted-by":"publisher","first-page":"e3001276","DOI":"10.1371\/journal.pbio.3001276","volume":"19","author":"M Haudiquet","year":"2021","unstructured":"Haudiquet M, Buffet A, Rendueles O, Rocha EPC. Interplay between the cell envelope and mobile genetic elements shapes gene flow in populations of the nosocomial pathogen Klebsiella pneumoniae. PLoS Biol. 2021;19(7):e3001276.","journal-title":"PLoS Biol"},{"issue":"2","key":"4565_CR43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1128\/CMR.00059-12","volume":"26","author":"A Beceiro","year":"2013","unstructured":"Beceiro A, Tom\u00e1s M, Bou G. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev. 2013;26(2):185\u2013230.","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"4565_CR44","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1128\/AAC.03560-14","volume":"59","author":"YJ Pan","year":"2015","unstructured":"Pan YJ, Lin TL, Lin YT, Su PA, Chen CT, Hsieh PF, et al. Identification of capsular types in Carbapenem-Resistant Klebsiella pneumoniae strains by Wzc sequencing and implications for capsule depolymerase treatment. Antimicrob Agents Chemother. 2015;59(2):1038\u201347.","journal-title":"Antimicrob Agents Chemother"},{"key":"4565_CR45","doi-asserted-by":"publisher","first-page":"1545678","DOI":"10.3389\/fmed.2025.1545678","volume":"12","author":"T Tian","year":"2025","unstructured":"Tian T, Han H, Guan ZH, Zhang K, Huang X, Wang W, et al. A systematic review of hypervirulent Klebsiella pneumoniae research: bibliometric and topic modeling perspectives. Front Med. 2025;12:1545678.","journal-title":"Front Med"},{"issue":"1","key":"4565_CR46","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/pr.2014.153","volume":"77","author":"H Lahlaoui","year":"2015","unstructured":"Lahlaoui H, De Luca F, Maradel S, Ben-Haj-Khalifa A, Ben Hamouda H, Kheder M, et al. Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia. Pediatr Res. 2015;77(1):107\u201310.","journal-title":"Pediatr Res"},{"issue":"12","key":"4565_CR47","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.tibs.2005.10.004","volume":"30","author":"L Buts","year":"2005","unstructured":"Buts L, Lah J, Dao-Thi MH, Wyns L, Loris R. Toxin\u2013antitoxin modules as bacterial metabolic stress managers. Trends Biochem Sci. 2005;30(12):672\u20139.","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"4565_CR48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1757-4749-5-34","volume":"5","author":"K Schaufler","year":"2013","unstructured":"Schaufler K, Wieler LH, Semmler T, Ewers C, Guenther S. ESBL-plasmids carrying toxin-antitoxin systems can be cured of wild-type Escherichia coli using a heat technique. Gut Pathog. 2013;5(1):34.","journal-title":"Gut Pathog"},{"issue":"8","key":"4565_CR49","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/jac\/dkq181","volume":"65","author":"B Mnif","year":"2010","unstructured":"Mnif B, Vimont S, Boyd A, Bourit E, Picard B, Branger C, et al. Molecular characterization of addiction systems of plasmids encoding extended-spectrum \u03b2-lactamases in Escherichia coli. J Antimicrob Chemother. 2010;65(8):1599\u2013603.","journal-title":"J Antimicrob Chemother"},{"key":"4565_CR50","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fcimb.2017.00483","volume":"7","author":"CR Lee","year":"2017","unstructured":"Lee CR, Lee JH, Park KS, Jeon JH, Kim YB, Cha CJ, et al. Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and resistance mechanisms. Front Cell Infect Microbiol. 2017;7:483.","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"4565_CR51","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/toxins8070227","volume":"8","author":"L Fern\u00e1ndez-Garc\u00eda","year":"2016","unstructured":"Fern\u00e1ndez-Garc\u00eda L, Blasco L, Lopez M, Bou G, Garc\u00eda-Contreras R, Wood T, et al. Toxin-Antitoxin systems in clinical pathogens. Toxins. 2016;8(7):227.","journal-title":"Toxins"},{"issue":"1","key":"4565_CR52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.plasmid.2009.09.005","volume":"63","author":"VS Lioy","year":"2010","unstructured":"Lioy VS, Rey O, Balsa D, Pellicer T, Alonso JC. A toxin\u2013antitoxin module as a target for antimicrobial development. Plasmid. 2010;63(1):31\u20139.","journal-title":"Plasmid"},{"key":"4565_CR53","doi-asserted-by":"publisher","first-page":"105816","DOI":"10.1016\/j.envint.2020.105816","volume":"140","author":"J Huyan","year":"2020","unstructured":"Huyan J, Tian Z, Zhang Y, Zhang H, Shi Y, Gillings MR, et al. Dynamics of class 1 integrons in aerobic biofilm reactors spiked with antibiotics. Environ Int. 2020;140:105816.","journal-title":"Environ Int"},{"key":"4565_CR54","doi-asserted-by":"publisher","first-page":"1231938","DOI":"10.3389\/fmicb.2023.1231938","volume":"14","author":"BA Bhat","year":"2023","unstructured":"Bhat BA, Mir RA, Qadri H, Dhiman R, Almilaibary A, Alkhanani M, et al. Integrons in the development of antimicrobial resistance: critical review and perspectives. Front Microbiol. 2023;14:1231938.","journal-title":"Front Microbiol"},{"issue":"1","key":"4565_CR55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13756-019-0509-3","volume":"8","author":"F Firoozeh","year":"2019","unstructured":"Firoozeh F, Mahluji Z, Khorshidi A, Zibaei M. Molecular characterization of class 1, 2 and 3 integrons in clinical multi-drug resistant Klebsiella pneumoniae isolates. Antimicrob Resist Infect Control. 2019;8(1):59.","journal-title":"Antimicrob Resist Infect Control"},{"issue":"3","key":"4565_CR56","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1179\/1973947814Y.0000000180","volume":"27","author":"H Zeighami","year":"2015","unstructured":"Zeighami H, Haghi F, Hajiahmadi F. Molecular characterization of integrons in clinical isolates of betalactamase-producing Escherichia coli and Klebsiella pneumoniae in Iran. J Chemother. 2015;27(3):145\u201351.","journal-title":"J Chemother"},{"issue":"4","key":"4565_CR57","doi-asserted-by":"publisher","first-page":"292","DOI":"10.7555\/JBR.30.20150153","volume":"30","author":"X Wenying","year":"2016","unstructured":"Wenying X, Ting X, Tingting Q, Pengpeng L, Yun L, Haiquan K, et al. Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China, 2000\u20132014. J Biomed Res. 2016;30(4):292.","journal-title":"J Biomed Res"},{"issue":"2","key":"4565_CR58","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1128\/AAC.05620-11","volume":"56","author":"L Poirel","year":"2012","unstructured":"Poirel L, Bonnin RA, Boulanger A, Schrenzel J, Kaase M, Nordmann P. Tn125 -Related acquisition of blaNDM -Like genes in acinetobacter baumannii. Antimicrob Agents Chemother. 2012;56(2):1087\u20139.","journal-title":"Antimicrob Agents Chemother"},{"key":"4565_CR59","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.3389\/fmicb.2019.02817","volume":"10","author":"RE Weber","year":"2019","unstructured":"Weber RE, Pietsch M, Fr\u00fchauf A, Pfeifer Y, Martin M, Luft D, et al. IS26-Mediated transfer of blaNDM\u20131 as the main route of resistance transmission during a Polyclonal, multispecies outbreak in a German hospital. Front Microbiol. 2019;10:2817.","journal-title":"Front Microbiol"},{"issue":"6","key":"4565_CR60","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/jac\/dkz044","volume":"74","author":"DD He","year":"2019","unstructured":"He DD, Zhao SY, Wu H, Hu GZ, Zhao JF, Zong ZY, et al. Antimicrobial resistance-encoding plasmid clusters with heterogeneous MDR regions driven by IS26 in a single Escherichia coli isolate. J Antimicrob Chemother. 2019;74(6):1511\u20136.","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"4565_CR61","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1089\/mdr.2013.0100","volume":"20","author":"X Wang","year":"2014","unstructured":"Wang X, Xu X, Li Z, Chen H, Wang Q, Yang P, et al. An outbreak of a nosocomial NDM-1-Producing Klebsiella pneumoniae ST147 at a teaching hospital in Mainland China. Microb Drug Resist. 2014;20(2):144\u20139.","journal-title":"Microb Drug Resist"},{"issue":"11","key":"4565_CR62","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1128\/AAC.01128-12","volume":"56","author":"MA Toleman","year":"2012","unstructured":"Toleman MA, Walsh TR. Reply to genetic contexts of blaNDM-1. Antimicrob Agents Chemother. 2012;56(11):6071\u20136071.","journal-title":"Antimicrob Agents Chemother"},{"issue":"Pt 8","key":"4565_CR63","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1099\/jmm.0.044156-0","volume":"61","author":"BS Lopes","year":"2012","unstructured":"Lopes BS, Amyes SGB. Role of ISAba1 and ISAba125 in governing the expression of blaADC in clinically relevant Acinetobacter baumannii strains resistant to cephalosporins. J Med Microbiol. 2012;61(Pt 8):1103\u20138.","journal-title":"J Med Microbiol"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04565-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04565-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04565-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:02:31Z","timestamp":1767834151000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-025-04565-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4565"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04565-5","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"1 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The project was approved by Kerman University of Medical Sciences, Kerman, Iran, Ethical Committee with Ethic approval Code IR.KMU.REC. IR.KMU. REC.1403.514. All methods or experiments were performed following relevant guidelines of the Declaration of Helsinki. Bacterial isolates were collected from teaching hospital laboratories as part of routine hospital procedure and written informed consent was obtained from all the patients enrolled in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}