{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:10:22Z","timestamp":1781100622294,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shanghai Pulmonary Hospital Discipline Construction Fund","award":["202509-5576"],"award-info":[{"award-number":["202509-5576"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272394"],"award-info":[{"award-number":["82272394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Pujiang Program","award":["24PJD094"],"award-info":[{"award-number":["24PJD094"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04620-1","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:33:13Z","timestamp":1766057593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dissemination of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae ST656 in Eastern China"],"prefix":"10.1186","volume":"26","author":[{"given":"Zhixuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiana","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyou","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"4620_CR1","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3390\/antibiotics12020234","volume":"12","author":"T Karampatakis","year":"2023","unstructured":"Karampatakis T, Tsergouli K, Behzadi P. Carbapenem-resistant Klebsiella pneumoniae: virulence factors, molecular epidemiology and latest updates in treatment options. Antibiotics. 2023;12:234.","journal-title":"Antibiotics"},{"key":"4620_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.10.014","volume":"55","author":"AA Agyeman","year":"2020","unstructured":"Agyeman AA, Bergen PJ, Rao GG, Nation RL, Landersdorfer CB. A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections. Int J Antimicrob Agents. 2020;55:105833.","journal-title":"Int J Antimicrob Agents"},{"key":"4620_CR3","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1038\/s41564-019-0492-8","volume":"4","author":"S David","year":"2019","unstructured":"David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol. 2019;4:1919\u201329.","journal-title":"Nat Microbiol"},{"key":"4620_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1080\/22221751.2021.1906163","volume":"10","author":"Y Yang","year":"2021","unstructured":"Yang Y, Yang Y, Chen G, Lin M, Chen Y, He R, et al. Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China. Emerg Microbes Infect. 2021;10:700\u20139. https:\/\/doi.org\/10.1080\/22221751.2021.1906163.","journal-title":"Emerg Microbes Infect"},{"key":"4620_CR5","doi-asserted-by":"crossref","unstructured":"van David MD, Arias CA, Komarow L, Chen L, Hanson BM, Weston G et al. Molecular and clinical epidemiology of Carbapenem-Resistant Enterobacteriaceae in the united states: a prospective cohort study. Lancet Infect Dis. 2020;20(6):731-41.","DOI":"10.1016\/S1473-3099(19)30755-8"},{"key":"4620_CR6","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3201\/eid1710.110655","volume":"17","author":"P Nordmann","year":"2011","unstructured":"Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis. 2011;17:1791\u20138. https:\/\/doi.org\/10.3201\/eid1710.110655.","journal-title":"Emerg Infect Dis"},{"key":"4620_CR7","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.2174\/1389450117666160310144501","volume":"17","author":"T Naas","year":"2016","unstructured":"Naas T, Dortet L, Iorga I. Structural and functional aspects of class A carbapenemases. Curr Drug Targets. 2016;17:1006\u201328.","journal-title":"Curr Drug Targets"},{"key":"4620_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1098\/rstb.1980.0049","volume":"289","author":"RP Ambler","year":"1997","unstructured":"Ambler RP. The structure of \u03b2-lactamases. Philosophical Transactions of the Royal Society of London B, Biological Sciences. 1997;289:321\u201331. https:\/\/doi.org\/10.1098\/rstb.1980.0049.","journal-title":"Philosophical Transactions of the Royal Society of London B, Biological Sciences"},{"issue":"suppl_1","key":"4620_CR9","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1093\/infdis\/jiw282","volume":"215","author":"LK Logan","year":"2017","unstructured":"Logan LK, Weinstein RA. The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace. J Infect Dis. 2017;215(suppl_1):S28-36.","journal-title":"J Infect Dis"},{"key":"4620_CR10","doi-asserted-by":"publisher","first-page":"e00047","DOI":"10.1128\/CMR.00047-19","volume":"33","author":"K Bush","year":"2020","unstructured":"Bush K, Bradford PA. Epidemiology of \u03b2-lactamase-producing pathogens. Clin Microbiol Rev. 2020;33:e00047-19. https:\/\/doi.org\/10.1128\/CMR.00047-19.","journal-title":"Clin Microbiol Rev"},{"key":"4620_CR11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40121-020-00395-2","volume":"10","author":"GT Hansen","year":"2021","unstructured":"Hansen GT. Continuous evolution: perspective on the epidemiology of carbapenemase resistance among enterobacterales and other Gram-Negative bacteria. Infect Dis Ther. 2021;10:75\u201392. https:\/\/doi.org\/10.1007\/s40121-020-00395-2.","journal-title":"Infect Dis Ther"},{"issue":"Supplement_7","key":"4620_CR12","doi-asserted-by":"publisher","first-page":"S521","DOI":"10.1093\/cid\/ciz824","volume":"69","author":"P Nordmann","year":"2019","unstructured":"Nordmann P, Poirel L. Epidemiology and diagnostics of carbapenem resistance in gram-negative bacteria. Clin Infect Dis. 2019;69(Supplement_7):S521-8.","journal-title":"Clin Infect Dis"},{"key":"4620_CR13","doi-asserted-by":"publisher","first-page":"e01882","DOI":"10.1128\/AAC.01882-17","volume":"62","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Wang Q, Yin Y, Chen H, Jin L, Gu B, et al. Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from the China CRE network. Antimicrob Agents Chemother. 2018;62:e01882-17. https:\/\/doi.org\/10.1128\/AAC.01882-17.","journal-title":"Antimicrob Agents Chemother"},{"key":"4620_CR14","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1128\/AAC.01053-06","volume":"51","author":"Z-Q Wei","year":"2007","unstructured":"Wei Z-Q, Du X-X, Yu Y-S, Shen P, Chen Y-G, Li L-J. Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Antimicrob Agents Chemother. 2007;51:763\u20135. https:\/\/doi.org\/10.1128\/AAC.01053-06.","journal-title":"Antimicrob Agents Chemother"},{"key":"4620_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ebiom.2017.04.032","volume":"19","author":"R Zhang","year":"2017","unstructured":"Zhang R, Liu L, Zhou H, Chan EW, Li J, Fang Y, et al. Nationwide surveillance of clinical carbapenem-resistant Enterobacteriaceae (CRE) strains in China. EBioMedicine. 2017;19:98\u2013106.","journal-title":"EBioMedicine"},{"key":"4620_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41579-019-0315-1","volume":"18","author":"KL Wyres","year":"2020","unstructured":"Wyres KL, Lam MM, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020;18:344\u201359.","journal-title":"Nat Rev Microbiol"},{"key":"4620_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.tim.2020.04.012","volume":"29","author":"X Yang","year":"2021","unstructured":"Yang X, Dong N, Chan EW-C, Zhang R, Chen S. Carbapenem resistance-encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae. Trends Microbiol. 2021;29:65\u201383.","journal-title":"Trends Microbiol"},{"key":"4620_CR18","doi-asserted-by":"publisher","first-page":"25043","DOI":"10.1073\/pnas.2003407117","volume":"117","author":"S David","year":"2020","unstructured":"David S, Cohen V, Reuter S, Sheppard AE, Giani T, Parkhill J, et al. Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae. Proc Natl Acad Sci USA. 2020;117:25043\u201354.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4620_CR19","doi-asserted-by":"publisher","first-page":"e0133727","DOI":"10.1371\/journal.pone.0133727","volume":"10","author":"JR Bowers","year":"2015","unstructured":"Bowers JR, Kitchel B, Driebe EM, MacCannell DR, Roe C, Lemmer D, et al. Genomic analysis of the emergence and rapid global dissemination of the clonal group 258 Klebsiella pneumoniae pandemic. PLoS One. 2015;10:e0133727. https:\/\/doi.org\/10.1371\/journal.pone.0133727.","journal-title":"PLoS One"},{"key":"4620_CR20","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.001082","volume":"9","author":"AO Afolayan","year":"2023","unstructured":"Afolayan AO, Rigatou A, Grundmann H, Pantazatou A, Daikos G, Reuter S. Three Klebsiella pneumoniae lineages causing bloodstream infections variably dominated within a Greek hospital over a 15 year period. Microb Genom. 2023;9:mgen001082. https:\/\/doi.org\/10.1099\/mgen.0.001082.","journal-title":"Microb Genom"},{"key":"4620_CR21","doi-asserted-by":"publisher","first-page":"5092","DOI":"10.1038\/s41467-024-49349-z","volume":"15","author":"M Budia-Silva","year":"2024","unstructured":"Budia-Silva M, Kostyanev T, Ayala-Monta\u00f1o S, Bravo-Ferrer Acosta J, Garcia-Castillo M, Cant\u00f3n R, et al. International and regional spread of carbapenem-resistant Klebsiella pneumoniae in Europe. Nat Commun. 2024;15:5092. https:\/\/doi.org\/10.1038\/s41467-024-49349-z.","journal-title":"Nat Commun"},{"key":"4620_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11091253","volume":"11","author":"H Debergh","year":"2022","unstructured":"Debergh H, Maex M, Garcia-Graells C, Boland C, Saulmont M, Van Hoorde K, et al. First Belgian report of ertapenem resistance in an ST11 Klebsiella pneumoniae strain isolated from a dog carrying blaSCO-1 and blaDHA-1 combined with permeability defects. Antibiotics. 2022;11:1253. https:\/\/doi.org\/10.3390\/antibiotics11091253.","journal-title":"Antibiotics"},{"key":"4620_CR23","doi-asserted-by":"publisher","first-page":"e01355","DOI":"10.1128\/mBio.01355-14","volume":"5","author":"L Chen","year":"2014","unstructured":"Chen L, Mathema B, Pitout JDD, DeLeo FR, Kreiswirth BN. Epidemic Klebsiella pneumoniae ST258 is a hybrid strain. mBio. 2014;5:e01355-01314. https:\/\/doi.org\/10.1128\/mBio.01355-14.","journal-title":"mBio"},{"key":"4620_CR24","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1093\/gbe\/evz236","volume":"11","author":"F Comandatore","year":"2019","unstructured":"Comandatore F, Sassera D, Bayliss SC, Scaltriti E, Gaiarsa S, Cao X, et al. Gene composition as a potential barrier to large recombinations in the bacterial pathogen Klebsiella pneumoniae. Genome Biol Evol. 2019;11:3240\u201351. https:\/\/doi.org\/10.1093\/gbe\/evz236.","journal-title":"Genome Biol Evol"},{"key":"4620_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jgar.2020.09.004","volume":"23","author":"W Liao","year":"2020","unstructured":"Liao W, Liu Y, Zhang W. Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: a review over the last 10 years. J Glob Antimicrob Resist. 2020;23:174\u201380. https:\/\/doi.org\/10.1016\/j.jgar.2020.09.004.","journal-title":"J Glob Antimicrob Resist"},{"key":"4620_CR26","doi-asserted-by":"publisher","first-page":"e857","DOI":"10.1016\/S2666-5247(22)00181-1","volume":"3","author":"LW Roberts","year":"2022","unstructured":"Roberts LW, Khokhar FA, Hoa NT, Van Giang T, Bui C, Ninh TH, et al. Genomic characterisation of multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and acinetobacter baumannii in two intensive care units in Hanoi, Viet nam: a prospective observational cohort study. Lancet Microbe. 2022;3:e857\u201366.","journal-title":"Lancet Microbe"},{"key":"4620_CR27","doi-asserted-by":"publisher","first-page":"922031","DOI":"10.3389\/fcimb.2022.922031","volume":"12","author":"J Zhao","year":"2022","unstructured":"Zhao J, Li Z, Zhang Y, Liu X, Lu B, Cao B. Convergence of MCR-8.2 and chromosome-mediated resistance to colistin and Tigecycline in an NDM-5-producing ST656 Klebsiella pneumoniae isolate from a lung transplant patient in China. Front Cell Infect Microbiol. 2022;12:922031.","journal-title":"Front Cell Infect Microbiol"},{"key":"4620_CR28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2147\/IDR.S290434","volume":"14","author":"H Liu","year":"2021","unstructured":"Liu H, Lin H, Sun Z, Zhu X, Zhang X, Li Q, et al. Distribution of \u03b2-Lactamase genes and genetic context of blaKPC-2 in clinical carbapenemase-producing Klebsiella pneumoniae isolates. IDR. 2021;14:237\u201347. https:\/\/doi.org\/10.2147\/IDR.S290434.","journal-title":"IDR"},{"key":"4620_CR29","doi-asserted-by":"publisher","first-page":"1122532","DOI":"10.3389\/fcimb.2023.1122532","volume":"13","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhou J, Liu H, Wang Q, Zhang P, Zhu J, et al. Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and CrrB mutations, combined with Tigecycline resistance in an ST656 Klebsiella pneumoniae. Front Cell Infect Microbiol. 2023;13:1122532.","journal-title":"Front Cell Infect Microbiol"},{"key":"4620_CR30","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1128\/JCM.00001-14","volume":"52","author":"D Marchaim","year":"2014","unstructured":"Marchaim D, Pogue JM, Tzuman O, Hayakawa K, Lephart PR, Salimnia H, et al. Major variation in mics of Tigecycline in Gram-Negative bacilli as a function of testing method. J Clin Microbiol. 2014;52:1617\u201321. https:\/\/doi.org\/10.1128\/JCM.00001-14.","journal-title":"J Clin Microbiol"},{"key":"4620_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/1756-0500-5-337","volume":"5","author":"S Lindgreen","year":"2012","unstructured":"Lindgreen S. Adapterremoval: easy cleaning of next-generation sequencing reads. BMC Res Notes. 2012;5:337. https:\/\/doi.org\/10.1186\/1756-0500-5-337.","journal-title":"BMC Res Notes"},{"key":"4620_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/2047-217X-1-18","volume":"1","author":"R Luo","year":"2012","unstructured":"Luo R, Liu B, Xie Y, Li Z, Huang W, Yuan J, et al. SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience. 2012;1:2047-217X-1\u201318. https:\/\/doi.org\/10.1186\/2047-217X-1-18.","journal-title":"Gigascience"},{"key":"4620_CR33","doi-asserted-by":"publisher","unstructured":"SPAdes: A. Oct New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing | Journal of Computational Biology. https:\/\/www.liebertpub.com\/doi\/abs\/https:\/\/doi.org\/10.1089\/cmb.2012.0021. Accessed 7 2025.","DOI":"10.1089\/cmb.2012.0021"},{"key":"4620_CR34","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/bioinformatics\/btu661","volume":"31","author":"D Coil","year":"2015","unstructured":"Coil D, Jospin G, Darling AE. A5-miseq: an updated pipeline to assemble microbial genomes from illumina miseq data. Bioinformatics. 2015;31:587\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btu661.","journal-title":"Bioinformatics"},{"key":"4620_CR35","unstructured":"Seemann T Snippy: rapid haploid variant calling and core genome alignment. GitHub repository, version 4.6.0. 2025. https:\/\/github.com\/tseemann\/snippy."},{"key":"4620_CR36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1196","volume":"43","author":"NJ Croucher","year":"2015","unstructured":"Croucher NJ, Page AJ, Connor TR, Delaney AJ, Keane JA, Bentley SD, et al. Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins. Nucleic Acids Res. 2015;43:e15. https:\/\/doi.org\/10.1093\/nar\/gku1196.","journal-title":"Nucleic Acids Res"},{"key":"4620_CR37","doi-asserted-by":"crossref","unstructured":"37. Wong TK, Ly-Trong N, Ren H, Ba\u00f1os H, Roger AJ, Susko E, et al. IQ-TREE 3: Phylogenomic inference software using complex evolutionary models. Software. 2025. https:\/\/github.com\/iqtree\/iqtree3.","DOI":"10.32942\/X2P62N"},{"key":"4620_CR38","doi-asserted-by":"publisher","first-page":"W587","DOI":"10.1093\/nar\/gkad359","volume":"51","author":"J Xie","year":"2023","unstructured":"Xie J, Chen Y, Cai G, Cai R, Hu Z, Wang H. Tree visualization by one table (tvBOT): a web application for visualizing, modifying and annotating phylogenetic trees. Nucleic Acids Res. 2023;51:W587\u201392. https:\/\/doi.org\/10.1093\/nar\/gkad359.","journal-title":"Nucleic Acids Res"},{"key":"4620_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1108818","volume":"13","author":"W Wang","year":"2023","unstructured":"Wang W, Tian D, Hu D, Chen W, Zhou Y, Jiang X. Different regulatory mechanisms of the capsule in hypervirulent Klebsiella pneumonia:\u201cdirect\u201d wcaJ variation vs.\u201cindirect\u201d rmpA regulation. Front Cell Infect Microbiol. 2023;13:1108818.","journal-title":"Front Cell Infect Microbiol"},{"key":"4620_CR40","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1038\/s41564-019-0492-8","volume":"4","author":"S David","year":"2019","unstructured":"David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol. 2019;4:1919\u201329. https:\/\/doi.org\/10.1038\/s41564-019-0492-8.","journal-title":"Nat Microbiol"},{"key":"4620_CR41","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-genet-112414-055018","volume":"49","author":"CM Johnson","year":"2015","unstructured":"Johnson CM, Grossman AD. Integrative and conjugative elements (ICEs): what they do and how they work. Annu Rev Genet. 2015;49:577\u2013601. https:\/\/doi.org\/10.1146\/annurev-genet-112414-055018.","journal-title":"Annu Rev Genet"},{"key":"4620_CR42","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.tim.2014.09.003","volume":"22","author":"L Chen","year":"2014","unstructured":"Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014;22:686\u201396.","journal-title":"Trends Microbiol"},{"key":"4620_CR43","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000073","volume":"2","author":"R Follador","year":"2016","unstructured":"Follador R, Heinz E, Wyres KL, Ellington MJ, Kowarik M, Holt KE, et al. The diversity of Klebsiella pneumoniae surface polysaccharides. Microb Genom. 2016;2:e000073. https:\/\/doi.org\/10.1099\/mgen.0.000073.","journal-title":"Microb Genom"},{"key":"4620_CR44","doi-asserted-by":"publisher","first-page":"894","DOI":"10.3760\/cma.j.issn.0366-6999.2012.05.029","volume":"125","author":"X Wang","year":"2012","unstructured":"Wang X, Chen J, Kang Y, Jiang N, An S, Gao Z. Prevalence and characterization of plasmid-mediatedblaESBL with their genetic environment inEscherichia ColiandKlebsiella pneumoniaein patients with pneumonia. Chin Med J. 2012;125:894. https:\/\/doi.org\/10.3760\/cma.j.issn.0366-6999.2012.05.029.","journal-title":"Chin Med J"},{"key":"4620_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/jac\/dkq431","volume":"66","author":"Y Qi","year":"2011","unstructured":"Qi Y, Wei Z, Ji S, Du X, Shen P, Yu Y. ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. J Antimicrob Chemother. 2011;66:307\u201312.","journal-title":"J Antimicrob Chemother"},{"key":"4620_CR46","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fcimb.2018.00004","volume":"8","author":"RM Martin","year":"2018","unstructured":"Martin RM, Bachman MA. Colonization, infection, and the accessory genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018;8:4.","journal-title":"Front Cell Infect Microbiol"},{"key":"4620_CR47","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/22221751.2021.2013105","volume":"11","author":"Y Tang","year":"2022","unstructured":"Tang Y, Li G, Shen P, Zhang Y, Jiang X. Replicative transposition contributes to the evolution and dissemination of KPC-2-producing plasmid in Enterobacterales. Emerg Microbes Infect. 2022;11:113\u201322. https:\/\/doi.org\/10.1080\/22221751.2021.2013105.","journal-title":"Emerg Microbes Infect"},{"key":"4620_CR48","doi-asserted-by":"publisher","first-page":"6731","DOI":"10.2147\/IDR.S392063","volume":"15","author":"C Chen","year":"2022","unstructured":"Chen C, Shi Q, Hu X, Liu X, Liu Y, Liu R. Co-existence of KPC-2, LAP-2, and CTX-M-65 in an ST1469 multidrug-resistant Klebsiella pneumoniae strain in China. IDR. 2022;15:6731\u20137. https:\/\/doi.org\/10.2147\/IDR.S392063.","journal-title":"IDR"},{"key":"4620_CR49","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12941-024-00757-5","volume":"23","author":"J Ma","year":"2024","unstructured":"Ma J, Gao K, Li M, Zhou J, Song X, Zhang Y, et al. Epidemiological and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae from pediatric patients in Henan, China. Ann Clin Microbiol Antimicrob. 2024;23:98. https:\/\/doi.org\/10.1186\/s12941-024-00757-5.","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"2","key":"4620_CR50","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijantimicag.2019.03.014","volume":"54","author":"P Fu","year":"2019","unstructured":"Fu P, Tang Y, Li G, Yu L, Wang Y, Jiang X. Pandemic spread of bla among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids. Int J Antimicrob Agents. 2019;54(2):117\u201324. https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.03.014.","journal-title":"Int J Antimicrob Agents"},{"key":"4620_CR51","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3390\/antibiotics13080682","volume":"13","author":"Y Yao","year":"2024","unstructured":"Yao Y, Imirzalioglu C, Falgenhauer L, Falgenhauer J, Heinm\u00fcller P, SurvCARE Hesse Working Group. Plasmid-Mediated spread of carbapenem resistance in enterobacterales: A Three-Year Genome-Based survey. Antibiot (Basel). 2024;13:682. https:\/\/doi.org\/10.3390\/antibiotics13080682.","journal-title":"Antibiot (Basel)"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04620-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04620-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04620-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:12:49Z","timestamp":1769598769000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-025-04620-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4620"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04620-1","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"11 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shanghai Pulmonary Hospital (K22-125Y). The informed consent was obtained from all subjects and\/or their legal guardian, authorizing the use of their clinical data for research purposes and publication. As this study does not constitute a clinical trial, clinical trial registration was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}