{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:04:45Z","timestamp":1792523085917,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370075"],"award-info":[{"award-number":["82370075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32370696"],"award-info":[{"award-number":["32370696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-026-04710-8","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:24:43Z","timestamp":1771680283000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A target-guided drug repurposing strategy for antibacterial discovery"],"prefix":"10.1186","volume":"26","author":[{"given":"Dongdong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Biao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"issue":"5","key":"4710_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41579-024-01124-z","volume":"23","author":"RT Giorgio","year":"2025","unstructured":"Giorgio RT, Helaine S. Antibiotic-recalcitrant Salmonella during infection. Nat Rev Microbiol. 2025;23(5):276\u201387. https:\/\/doi.org\/10.1038\/s41579-024-01124-z.","journal-title":"Nat Rev Microbiol"},{"key":"4710_CR2","unstructured":"WHO. 2020 Antibacterial agents in clinical and preclinical development: an overview and analysis. World Health Organization. 2021.\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240021303."},{"issue":"4","key":"4710_CR3","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.cell.2020.01.021","volume":"180","author":"JM Stokes","year":"2020","unstructured":"Stokes JM, et al. A deep learning approach to antibiotic discovery. Cell. 2020;180(4):688-702.e13. https:\/\/doi.org\/10.1016\/j.cell.2020.01.021.","journal-title":"Cell"},{"issue":"19","key":"4710_CR4","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1016\/j.cell.2023.07.038","volume":"186","author":"R Shukla","year":"2023","unstructured":"Shukla R, et al. An antibiotic from an uncultured bacterium binds to an immutable target. Cell. 2023;186(19):4059-4073.e27. https:\/\/doi.org\/10.1016\/j.cell.2023.07.038.","journal-title":"Cell"},{"issue":"6684","key":"4710_CR5","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1126\/science.adk8013","volume":"383","author":"KJY Wu","year":"2024","unstructured":"Wu KJY, et al. An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science. 2024;383(6684):721\u20136. https:\/\/doi.org\/10.1126\/science.adk8013.","journal-title":"Science"},{"issue":"11","key":"4710_CR6","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/s41589-023-01349-8","volume":"19","author":"G Liu","year":"2023","unstructured":"Liu G, et al. Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii. Nat Chem Biol. 2023;19(11):1342\u201350. https:\/\/doi.org\/10.1038\/s41589-023-01349-8.","journal-title":"Nat Chem Biol"},{"issue":"12","key":"4710_CR7","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1038\/s41591-024-03233-x","volume":"30","author":"K Huang","year":"2024","unstructured":"Huang K, et al. A foundation model for clinician-centered drug repurposing. Nat Med. 2024;30(12):3601\u201313. https:\/\/doi.org\/10.1038\/s41591-024-03233-x.","journal-title":"Nat Med"},{"issue":"12","key":"4710_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104215","volume":"29","author":"T Xu","year":"2024","unstructured":"Xu T, et al. The identification of essential cellular genes is critical for validating drug targets. Drug Discov Today. 2024;29(12):104215. https:\/\/doi.org\/10.1016\/j.drudis.2024.104215.","journal-title":"Drug Discov Today"},{"issue":"1","key":"4710_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.157","volume":"3","author":"YT Liang","year":"2024","unstructured":"Liang YT, et al. Recent advances in the characterization of essential genes and development of a database of essential genes. Imeta. 2024;3(1):e157. https:\/\/doi.org\/10.1002\/imt2.157.","journal-title":"Imeta"},{"issue":"18","key":"4710_CR10","doi-asserted-by":"publisher","first-page":"8897","DOI":"10.1093\/nar\/gkw699","volume":"44","author":"V Stojkovi\u0107","year":"2016","unstructured":"Stojkovi\u0107 V, et al. Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. Nucleic Acids Res. 2016;44(18):8897\u2013907. https:\/\/doi.org\/10.1093\/nar\/gkw699.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4710_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1021\/ja510375f","volume":"137","author":"CM Chang","year":"2015","unstructured":"Chang CM, et al. Avenaciolides: potential MurA-targeted inhibitors against peptidoglycan biosynthesis in methicillin-resistant Staphylococcus aureus (MRSA). J Am Chem Soc. 2015;137(1):267\u201375. https:\/\/doi.org\/10.1021\/ja510375f.","journal-title":"J Am Chem Soc"},{"issue":"1","key":"4710_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-022-02666-z","volume":"22","author":"I Nathania","year":"2022","unstructured":"Nathania I, et al. Hotspots sequences of gyrA, gyrB, parC, and parE genes encoded for fluoroquinolones resistance from local Salmonella Typhi strains in Jakarta. BMC Microbiol. 2022;22(1):250. https:\/\/doi.org\/10.1186\/s12866-022-02666-z.","journal-title":"BMC Microbiol"},{"issue":"2","key":"4710_CR13","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tips.2014.12.001","volume":"36","author":"YC Chen","year":"2015","unstructured":"Chen YC. Beware of docking! Trends Pharmacol Sci. 2015;36(2):78\u201395. https:\/\/doi.org\/10.1016\/j.tips.2014.12.001.","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"4710_CR14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41579-020-0379-y","volume":"18","author":"DA van Bergeijk","year":"2020","unstructured":"van Bergeijk DA, et al. Ecology and genomics of Actinobacteria: new concepts for natural product discovery. Nat Rev Microbiol. 2020;18(10):546\u201358. https:\/\/doi.org\/10.1038\/s41579-020-0379-y.","journal-title":"Nat Rev Microbiol"},{"key":"4710_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa112","volume":"2020","author":"S Liu","year":"2020","unstructured":"Liu S, et al. CEG 2.0: an updated database of clusters of essential genes including eukaryotic organisms. Database (Oxford). 2020;2020:baaa112. https:\/\/doi.org\/10.1093\/database\/baaa112.","journal-title":"Database (Oxford)"},{"issue":"D1","key":"4710_CR16","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46(D1):D1074\u201382. https:\/\/doi.org\/10.1093\/nar\/gkx1037.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4710_CR17","doi-asserted-by":"publisher","first-page":"D564","DOI":"10.1093\/nar\/gkae1091","volume":"53","author":"SK Burley","year":"2025","unstructured":"Burley SK, et al. Updated resources for exploring experimentally-determined PDB structures and computed structure models at the RCSB Protein Data Bank. Nucleic Acids Res. 2025;53(D1):D564\u201374. https:\/\/doi.org\/10.1093\/nar\/gkae1091.","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"4710_CR18","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen EF, et al. UCSF chimera\u2013a visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605\u201312. https:\/\/doi.org\/10.1002\/jcc.20084.","journal-title":"J Comput Chem"},{"issue":"1","key":"4710_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O'Boyle","year":"2011","unstructured":"O\u2019Boyle NM, et al. Open babel: an open chemical toolbox. J Cheminform. 2011;3(1):33. https:\/\/doi.org\/10.1186\/1758-2946-3-33.","journal-title":"J Cheminform"},{"issue":"11","key":"4710_CR20","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.molp.2023.09.010","volume":"16","author":"C Chen","year":"2023","unstructured":"Chen C, et al. TBtools-II: a \u201cone for all, all for one\u201d bioinformatics platform for biological big-data mining. Mol Plant. 2023;16(11):1733\u201342. https:\/\/doi.org\/10.1016\/j.molp.2023.09.010.","journal-title":"Mol Plant"},{"issue":"10","key":"4710_CR21","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.1021\/acs.jafc.3c06953","volume":"72","author":"M Huang","year":"2024","unstructured":"Huang M, et al. Cytochrome P450 CYP6EM1 underpins dinotefuran resistance in the whitefly Bemisia tabaci. J Agric Food Chem. 2024;72(10):5153\u201364. https:\/\/doi.org\/10.1021\/acs.jafc.3c06953.","journal-title":"J Agric Food Chem"},{"key":"4710_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112705","volume":"207","author":"M Maqbool","year":"2020","unstructured":"Maqbool M, et al. Diphenyl triazine hybrids inhibit \u03b1-synuclein fibrillogenesis: design, synthesis and in vitro efficacy studies. Eur J Med Chem. 2020;207:112705. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112705.","journal-title":"Eur J Med Chem"},{"key":"4710_CR23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ijbiomac.2021.07.144","volume":"187","author":"C Modak","year":"2021","unstructured":"Modak C, et al. Chitosan derivatives: a suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus. Int J Biol Macromol. 2021;187:492\u2013512. https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.07.144.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"4710_CR24","first-page":"57","volume":"17","author":"MF Sanner","year":"1999","unstructured":"Sanner MF. Python: a programming language for software integration and development. J Mol Graph Model. 1999;17(1):57\u201361.","journal-title":"J Mol Graph Model"},{"issue":"7","key":"4710_CR25","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/acs.jcim.2c01504","volume":"63","author":"J Ding","year":"2023","unstructured":"Ding J, et al. Vina-GPU 2.0: further accelerating AutoDock Vina and its derivatives with graphics processing units. J Chem Inf Model. 2023;63(7):1982\u201398. https:\/\/doi.org\/10.1021\/acs.jcim.2c01504.","journal-title":"J Chem Inf Model"},{"issue":"18","key":"4710_CR26","doi-asserted-by":"publisher","first-page":"12964","DOI":"10.1039\/c6cp01555g","volume":"18","author":"Z Wang","year":"2016","unstructured":"Wang Z, et al. Comprehensive evaluation of ten docking programs on a diverse set of protein-ligand complexes: the prediction accuracy of sampling power and scoring power. Phys Chem Chem Phys. 2016;18(18):12964\u201375. https:\/\/doi.org\/10.1039\/c6cp01555g.","journal-title":"Phys Chem Chem Phys"},{"issue":"W1","key":"4710_CR27","doi-asserted-by":"publisher","first-page":"W422","DOI":"10.1093\/nar\/gkae236","volume":"52","author":"L Fu","year":"2024","unstructured":"Fu L, et al. ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support. Nucleic Acids Res. 2024;52(W1):W422\u201331. https:\/\/doi.org\/10.1093\/nar\/gkae236.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4710_CR28","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01038-14","volume":"2","author":"F Grenier","year":"2014","unstructured":"Grenier F, et al. Complete genome sequence of Escherichia coli BW25113. Genome Announc. 2014;2(5):e01038-14. https:\/\/doi.org\/10.1128\/genomeA.01038-14.","journal-title":"Genome Announc"},{"key":"4710_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.581986","volume":"10","author":"T Li","year":"2020","unstructured":"Li T, et al. Identification of novel genes involved in Escherichia coli persistence to tosufloxacin. Front Cell Infect Microbiol. 2020;10:581986. https:\/\/doi.org\/10.3389\/fcimb.2020.581986.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"4710_CR30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00865-20","volume":"65","author":"KA Milner","year":"2020","unstructured":"Milner KA, et al. Identification and characterization of a novel FosA7 member from fosfomycin-resistant Escherichia coli clinical isolates from Canadian hospitals. Antimicrob Agents Chemother. 2020;65(1):e00865-20. https:\/\/doi.org\/10.1128\/AAC.00865-20.","journal-title":"Antimicrob Agents Chemother"},{"key":"4710_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152686","volume":"784","author":"H Meng","year":"2025","unstructured":"Meng H, et al. Folate disorder in the atdfb mutant triggers a compensatory nitrogen starvation response by altering nitrate transport and assimilation. Biochem Biophys Res Commun. 2025;784:152686. https:\/\/doi.org\/10.1016\/j.bbrc.2025.152686.","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"4710_CR32","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1016\/j.ophtha.2015.08.001","volume":"122","author":"J Tauber","year":"2015","unstructured":"Tauber J, et al. Lifitegrast ophthalmic solution 5.0% versus placebo for treatment of dry eye disease: results of the randomized phase III OPUS-2 study. Ophthalmology. 2015;122(12):2423\u201331. https:\/\/doi.org\/10.1016\/j.ophtha.2015.08.001.","journal-title":"Ophthalmology"},{"issue":"5","key":"4710_CR33","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chembiol.2022.04.006","volume":"29","author":"T Warrier","year":"2022","unstructured":"Warrier T, et al. Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation. Cell Chem Biol. 2022;29(5):716\u201329. https:\/\/doi.org\/10.1016\/j.chembiol.2022.04.006.","journal-title":"Cell Chem Biol"},{"key":"4710_CR34","doi-asserted-by":"publisher","unstructured":"Zhang D, Guo FB, Li H. A computer-aided drug repurposing: the antibacterial agents targeting GroEL. Br J Pharmacol. https:\/\/doi.org\/10.1111\/bph.70252. Published online November 14, 2025.","DOI":"10.1111\/bph.70252"},{"key":"4710_CR35","doi-asserted-by":"publisher","unstructured":"Meng H. AI-Driven Discovery and Design of Antimicrobial Peptides: Progress, Challenges, and Opportunities. Probiotics Antimicrob Proteins. https:\/\/doi.org\/10.1007\/s12602-025-10856-0. Published online November 22, 2025.","DOI":"10.1007\/s12602-025-10856-0"},{"issue":"1","key":"4710_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ophtha.2016.09.025","volume":"124","author":"EJ Holland","year":"2017","unstructured":"Holland EJ, et al. Lifitegrast for the treatment of dry eye disease: results of a phase III, randomized, double-masked, placebo-controlled trial (OPUS-3). Ophthalmology. 2017;124(1):53\u201360. https:\/\/doi.org\/10.1016\/j.ophtha.2016.09.025.","journal-title":"Ophthalmology"},{"issue":"3","key":"4710_CR37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1021\/ml2002482","volume":"3","author":"M Zhong","year":"2012","unstructured":"Zhong M, et al. Discovery and development of potent LFA-1\/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye. ACS Med Chem Lett. 2012;3(3):203\u20136. https:\/\/doi.org\/10.1021\/ml2002482.","journal-title":"ACS Med Chem Lett"},{"issue":"5","key":"4710_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/s0966-842x(03)00101-x","volume":"11","author":"H Myllykallio","year":"2003","unstructured":"Myllykallio H, et al. Life without dihydrofolate reductase FolA. Trends Microbiol. 2003;11(5):220\u20133. https:\/\/doi.org\/10.1016\/s0966-842x(03)00101-x.","journal-title":"Trends Microbiol"},{"issue":"10","key":"4710_CR39","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr1713","volume":"11","author":"M Br\u00fcderlin","year":"2025","unstructured":"Br\u00fcderlin M, et al. Pseudomonas aeruginosa assembles H1\u2013T6SS in response to physical and chemical damage of the outer membrane. Sci Adv. 2025;11(10):eadr1713. https:\/\/doi.org\/10.1126\/sciadv.adr1713.","journal-title":"Sci Adv"},{"issue":"4","key":"4710_CR40","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03687-23","volume":"12","author":"SJ Kim","year":"2024","unstructured":"Kim SJ, et al. Polymyxin B nonapeptide potentiates the eradication of Gram-negative bacterial persisters. Microbiol Spectr. 2024;12(4):e0368723. https:\/\/doi.org\/10.1128\/spectrum.03687-23.","journal-title":"Microbiol Spectr"},{"key":"4710_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107903","volume":"207","author":"D Chen","year":"2025","unstructured":"Chen D, et al. Nitazoxanide potentiates polymyxin B against Escherichia coli by inhibiting energy metabolism enzymes. Microb Pathog. 2025;207:107903. https:\/\/doi.org\/10.1016\/j.micpath.2025.107903.","journal-title":"Microb Pathog"},{"key":"4710_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.108007","volume":"208","author":"N Yang","year":"2025","unstructured":"Yang N, et al. Synergistic efficacy of polymyxin B and indole-3-carbinol against Klebsiella pneumoniae bloodstream infection. Microb Pathog. 2025;208:108007. https:\/\/doi.org\/10.1016\/j.micpath.2025.108007.","journal-title":"Microb Pathog"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-026-04710-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-04710-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-04710-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:52:50Z","timestamp":1774615970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-026-04710-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4710"],"URL":"https:\/\/doi.org\/10.1186\/s12866-026-04710-8","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]},"assertion":[{"value":"9 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"282"}}