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This study aims to investigate the potential correlation between dental caries and malnutrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Record the lifestyle variables, oral health conditions, and growth parameters of the subjects. Dental plaque and fecal samples were collected for 16\u00a0S rDNA sequencing to analyze the characteristics of the oral and gut microbiota. Furthermore, untargeted metabolomics was employed to investigate changes in the serum metabolome of patients with severe dental caries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Poor lifestyle can alter the oral microbial composition, increasing the risk of developing dental caries. Changes in the oral microbiota of patients with dental caries affect the gut microbiota, resulting in an increased abundance of genera such as\n                      <jats:italic>Dialister<\/jats:italic>\n                      ,\n                      <jats:italic>Megasphaera<\/jats:italic>\n                      , and\n                      <jats:italic>Agathobacter<\/jats:italic>\n                      . Sphingomyelin, phosphatidylcholine, lysophosphatidylcholine, lysophosphatidylethanolamine, and phosphatidylethanolamine exhibited a significant positive correlation with the height-for-age Z-score. In patients with severe dental caries, the serum concentrations of these phospholipids were notably reduced, which was closely related to changes in the gut microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dental caries disrupted the gut microbiota by altering the oral microbiota, leading to changes in the serum phospholipid profile of individuals with severe dental caries, ultimately raising the risk of stunting in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-026-04804-3","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:34:41Z","timestamp":1770453281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The intrinsic link between the double burden of dental caries and stunting in children: the gut microbiota plays a key role"],"prefix":"10.1186","volume":"26","author":[{"given":"Wenqing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"4804_CR1","volume-title":"Global oral health status report: towards universal health coverage for oral health by 2030","author":"WHO","year":"2022","unstructured":"WHO. 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