{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:53:41Z","timestamp":1776401621455,"version":"3.51.2"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82002207"],"award-info":[{"award-number":["82002207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-026-04933-9","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:25:03Z","timestamp":1773199503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A temperate phage encoding a catalytically active endolysin: characterization of phage P7869 and its Lys7869 against Pseudomonas aeruginosa"],"prefix":"10.1186","volume":"26","author":[{"given":"Jiao","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuexue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenrui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"4933_CR1","doi-asserted-by":"publisher","first-page":"926758","DOI":"10.3389\/fcimb.2022.926758","volume":"12","author":"C Liao","year":"2022","unstructured":"Liao C, Huang X, Wang Q, Yao D, Lu W. Virulence Factors of Pseudomonas aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance. Front Cell Infect Microbiol. 2022;12:926758.","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"4933_CR2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s15010-019-01319-0","volume":"47","author":"N Law","year":"2019","unstructured":"Law N, Logan C, Yung G, Furr CL, Lehman SM, Morales S, Rosas F, Gaidamaka A, Bilinsky I, Grint P, et al. Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient. Infection. 2019;47(4):665\u20138.","journal-title":"Infection"},{"issue":"3","key":"4933_CR3","doi-asserted-by":"publisher","first-page":"106270","DOI":"10.1016\/j.ijantimicag.2020.106270","volume":"57","author":"B Balandin","year":"2021","unstructured":"Balandin B, Ballesteros D, Ruiz de Luna R, L\u00f3pez-Vergara L, Pintado V, Sancho-Gonz\u00e1lez M, Soriano-Cuesta C, P\u00e9rez-Pedrero MJ, Asensio-Mart\u00edn MJ, Fern\u00e1ndez-Sim\u00f3n I, et al. Multicenter study of ceftolozane\/tazobactam for treatment of Pseudomonas aeruginosa infections in critically ill patients. Int J Antimicrob Agents. 2021;57(3):106270.","journal-title":"Int J Antimicrob Agents"},{"issue":"12","key":"4933_CR4","first-page":"3357","volume":"70","author":"A Ribera","year":"2015","unstructured":"Ribera A, Benavent E, Lora-Tamayo J, Tubau F, Pedrero S, Cabo X, Ariza J, Murillo O. Osteoarticular infection caused by MDR Pseudomonas aeruginosa: the benefits of combination therapy with colistin plus \u03b2-lactams. J Antimicrob Chemother. 2015;70(12):3357\u201365.","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"4933_CR5","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1093\/cid\/ciz223","volume":"69","author":"V Fabre","year":"2019","unstructured":"Fabre V, Amoah J, Cosgrove SE, Tamma PD. Antibiotic Therapy for Pseudomonas aeruginosa Bloodstream Infections: How Long Is Long Enough? Clin Infect Dis. 2019;69(11):2011\u20134.","journal-title":"Clin Infect Dis"},{"key":"4933_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3389\/fmicb.2018.00685","volume":"9","author":"C L\u00f3pez-Causap\u00e9","year":"2018","unstructured":"L\u00f3pez-Causap\u00e9 C, Cabot G, Del Barrio-Tofi\u00f1o E, Oliver A. The Versatile Mutational Resistome of Pseudomonas aeruginosa. Front Microbiol. 2018;9:685.","journal-title":"Front Microbiol"},{"issue":"4","key":"4933_CR7","doi-asserted-by":"publisher","first-page":"e01362","DOI":"10.1128\/mBio.01362-19","volume":"10","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhou CM, Pu Q, Wu Q, Tan S, Shao X, Zhang W, Xie Y, Li R, Yu XJ, et al. Pseudomonas aeruginosa Regulatory Protein AnvM Controls Pathogenicity in Anaerobic Environments and Impacts Host Defense. mBio. 2019;10(4):e01362\u201319.","journal-title":"mBio"},{"issue":"6799","key":"4933_CR8","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/35023079","volume":"406","author":"CK Stover","year":"2000","unstructured":"Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000;406(6799):959\u201364.","journal-title":"Nature"},{"issue":"3","key":"4933_CR9","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2165\/00003495-200767030-00003","volume":"67","author":"JA Driscoll","year":"2007","unstructured":"Driscoll JA, Brody SL, Kollef MH. The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs. 2007;67(3):351\u201368.","journal-title":"Drugs"},{"issue":"Suppl 5","key":"4933_CR10","doi-asserted-by":"publisher","first-page":"S352","DOI":"10.1093\/cid\/ciad539","volume":"77","author":"SR Grigson","year":"2023","unstructured":"Grigson SR, Giles SK, Edwards RA, Papudeshi B. Knowing and Naming: Phage Annotation and Nomenclature for Phage Therapy. Clin Infect Dis. 2023;77(Suppl 5):S352\u20139.","journal-title":"Clin Infect Dis"},{"issue":"11","key":"4933_CR11","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3390\/v11111080","volume":"11","author":"D Tan","year":"2019","unstructured":"Tan D, Zhang Y, Cheng M, Le S, Gu J, Bao J, Qin J, Guo X, Zhu T. Characterization of Klebsiella pneumoniae ST11 Isolates and Their Interactions with Lytic Phages. Viruses. 2019;11(11):1080.","journal-title":"Viruses"},{"issue":"2","key":"4933_CR12","doi-asserted-by":"publisher","first-page":"158","DOI":"10.5582\/bst.2022.01147","volume":"16","author":"P Chen","year":"2022","unstructured":"Chen P, Liu Z, Tan X, Wang H, Liang Y, Kong Y, Sun W, Sun L, Ma Y, Lu H. Bacteriophage therapy for empyema caused by carbapenem-resistant Pseudomonas aeruginosa. Biosci Trends. 2022;16(2):158\u201362.","journal-title":"Biosci Trends"},{"issue":"7","key":"4933_CR13","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.3390\/v16071080","volume":"16","author":"C Teney","year":"2024","unstructured":"Teney C, Poupelin JC, Briot T, Le Bouar M, Fevre C, Brosset S, Martin O, Valour F, Roussel-Gaillard T, Leboucher G, et al. Phage Therapy in a Burn Patient Colonized with Extensively Drug-Resistant Pseudomonas aeruginosa Responsible for Relapsing Ventilator-Associated Pneumonia and Bacteriemia. Viruses. 2024;16(7):1080.","journal-title":"Viruses"},{"issue":"9","key":"4933_CR14","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1164\/rccm.201904-0839LE","volume":"200","author":"S Maddocks","year":"2019","unstructured":"Maddocks S, Fabijan AP, Ho J, Lin RCY, Ben Zakour NL, Dugan C, Kliman I, Branston S, Morales S, Iredell JR. Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema Caused by Pseudomonas aeruginosa. Am J Respir Crit Care Med. 2019;200(9):1179\u201381.","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"4933_CR15","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/1751-7915.14217","volume":"16","author":"L Li","year":"2023","unstructured":"Li L, Zhong Q, Zhao Y, Bao J, Liu B, Zhong Z, Wang J, Yang L, Zhang T, Cheng M, et al. First-in-human application of double-stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection. Microb Biotechnol. 2023;16(4):862\u20137.","journal-title":"Microb Biotechnol"},{"key":"4933_CR16","doi-asserted-by":"publisher","first-page":"105490","DOI":"10.1016\/j.micpath.2022.105490","volume":"165","author":"Z Nawel","year":"2022","unstructured":"Nawel Z, Rima O, Amira B. An overview on Vibrio temperate phages: Integration mechanisms, pathogenicity, and lysogeny regulation. Microb Pathog. 2022;165:105490.","journal-title":"Microb Pathog"},{"issue":"6","key":"4933_CR17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ismej.2008.35","volume":"2","author":"JH Paul","year":"2008","unstructured":"Paul JH. Prophages in marine bacteria: dangerous molecular time bombs or the key to survival in the seas? Isme j. 2008;2(6):579\u201389.","journal-title":"Isme j"},{"issue":"12","key":"4933_CR18","doi-asserted-by":"publisher","first-page":"101002","DOI":"10.1002\/bies.201700112","volume":"39","author":"E Harrison","year":"2017","unstructured":"Harrison E, Brockhurst MA. Ecological and Evolutionary Benefits of Temperate Phage: What Does or Doesn\u2019t Kill You Makes You Stronger. BioEssays. 2017;39(12):101002.","journal-title":"BioEssays"},{"issue":"6","key":"4933_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ijmm.2010.04.002","volume":"300","author":"VA Fischetti","year":"2010","unstructured":"Fischetti VA. Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol. 2010;300(6):357\u201362.","journal-title":"Int J Med Microbiol"},{"issue":"4","key":"4933_CR20","doi-asserted-by":"publisher","first-page":"e01379","DOI":"10.1128\/mBio.01379-14","volume":"5","author":"Y Briers","year":"2014","unstructured":"Briers Y, Walmagh M, Van Puyenbroeck V, Cornelissen A, Cenens W, Aertsen A, Oliveira H, Azeredo J, Verween G, Pirnay JP, et al. Engineered endolysin-based Artilysins to combat multidrug-resistant gram-negative pathogens. mBio. 2014;5(4):e01379\u201301314.","journal-title":"mBio"},{"issue":"11","key":"4933_CR21","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.3390\/antibiotics10111277","volume":"10","author":"MU Rahman","year":"2021","unstructured":"Rahman MU, Wang W, Sun Q, Shah JA, Li C, Sun Y, Li Y, Zhang B, Chen W, Wang S. Endolysin, a Promising Solution against Antimicrobial Resistance. Antibiot (Basel). 2021;10(11):1277.","journal-title":"Antibiot (Basel)"},{"issue":"6","key":"4933_CR22","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/1040841X.2020.1825333","volume":"46","author":"AV Grishin","year":"2020","unstructured":"Grishin AV, Karyagina AS, Vasina DV, Vasina IV, Gushchin VA, Lunin VG. Resistance to peptidoglycan-degrading enzymes. Crit Rev Microbiol. 2020;46(6):703\u201326.","journal-title":"Crit Rev Microbiol"},{"issue":"Pt 4","key":"4933_CR23","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1107\/S2059798322000936","volume":"78","author":"R V\u00e1zquez","year":"2022","unstructured":"V\u00e1zquez R, Seoane-Blanco M, Rivero-Buceta V, Ruiz S, van Raaij MJ, Garc\u00eda P. Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain. Acta Crystallogr D Struct Biol. 2022;78(Pt 4):435\u201354.","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"4933_CR24","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.3389\/fmicb.2018.01778","volume":"9","author":"Y Yang","year":"2018","unstructured":"Yang Y, Le S, Shen W, Chen Q, Huang Y, Lu S, Tan Y, Li M, Hu F, Li Y. Antibacterial Activity of a Lytic Enzyme Encoded by Pseudomonas aeruginosa Double Stranded RNA Bacteriophage phiYY. Front Microbiol. 2018;9:1778.","journal-title":"Front Microbiol"},{"issue":"5","key":"4933_CR25","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1111\/j.1365-2958.2007.05870.x","volume":"65","author":"Y Briers","year":"2007","unstructured":"Briers Y, Volckaert G, Cornelissen A, Lagaert S, Michiels CW, Hertveldt K, Lavigne R. Muralytic activity and modular structure of the endolysins of Pseudomonas aeruginosa bacteriophages phiKZ and EL. Mol Microbiol. 2007;65(5):1334\u201344.","journal-title":"Mol Microbiol"},{"issue":"10","key":"4933_CR26","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1007\/s00253-012-4294-7","volume":"97","author":"M Walmagh","year":"2013","unstructured":"Walmagh M, Boczkowska B, Grymonprez B, Briers Y, Drulis-Kawa Z, Lavigne R. Characterization of five novel endolysins from Gram-negative infecting bacteriophages. Appl Microbiol Biotechnol. 2013;97(10):4369\u201375.","journal-title":"Appl Microbiol Biotechnol"},{"issue":"13","key":"4933_CR27","doi-asserted-by":"publisher","first-page":"e00555","DOI":"10.1128\/AEM.00555-19","volume":"85","author":"H Zhang","year":"2019","unstructured":"Zhang H, Buttaro BA, Fouts DE, Sanjari S, Evans BS, Stevens RH. Bacteriophage \u03c6Ef11 ORF28 Endolysin, a Multifunctional Lytic Enzyme with Properties Distinct from All Other Identified Enterococcus faecalis Phage Endolysins. Appl Environ Microbiol. 2019;85(13):e00555\u201319.","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"4933_CR28","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s10068-021-00910-2","volume":"30","author":"DW Park","year":"2021","unstructured":"Park DW, Lee YD, Park JH. Characteristics for phage-encoded cell wall hydrolase of LysSAP27 to reduce staphylococcal food poisoning. Food Sci Biotechnol. 2021;30(5):745\u201353.","journal-title":"Food Sci Biotechnol"},{"issue":"11","key":"4933_CR29","doi-asserted-by":"publisher","first-page":"e0242657","DOI":"10.1371\/journal.pone.0242657","volume":"15","author":"AV Skorynina","year":"2020","unstructured":"Skorynina AV, Piligrimova EG, Kazantseva OA, Kulyabin VA, Baicher SD, Ryabova NA, Shadrin AM. Bacillus-infecting bacteriophage Izhevsk harbors thermostable endolysin with broad range specificity. PLoS ONE. 2020;15(11):e0242657.","journal-title":"PLoS ONE"},{"issue":"7","key":"4933_CR30","doi-asserted-by":"publisher","first-page":"e00024","DOI":"10.1128\/AAC.00024-19","volume":"63","author":"A Raz","year":"2019","unstructured":"Raz A, Serrano A, Hernandez A, Euler CW, Fischetti VA. Isolation of Phage Lysins That Effectively Kill Pseudomonas aeruginosa in Mouse Models of Lung and Skin Infection. Antimicrob Agents Chemother. 2019;63(7):e00024\u201319.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"4933_CR31","doi-asserted-by":"publisher","first-page":"377","DOI":"10.2217\/fmb.15.8","volume":"10","author":"Y Briers","year":"2015","unstructured":"Briers Y, Lavigne R. Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria. Future Microbiol. 2015;10(3):377\u201390.","journal-title":"Future Microbiol"},{"key":"4933_CR32","doi-asserted-by":"publisher","first-page":"198506","DOI":"10.1016\/j.virusres.2021.198506","volume":"303","author":"J Feng","year":"2021","unstructured":"Feng J, Gao L, Li L, Zhang Z, Wu C, Li F, Tong Y. Characterization and genome analysis of novel Klebsiella phage BUCT556A with lytic activity against carbapenemase-producing Klebsiella pneumoniae. Virus Res. 2021;303:198506.","journal-title":"Virus Res"},{"issue":"2","key":"4933_CR33","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11262-020-01818-5","volume":"57","author":"W Zhang","year":"2021","unstructured":"Zhang W, Zhang R, Hu Y, Liu Y, Wang L, An X, Song L, Shi T, Fan H, Tong Y, et al. Biological characteristics and genomic analysis of a Stenotrophomonas maltophilia phage vB_SmaS_BUCT548. Virus Genes. 2021;57(2):205\u201316.","journal-title":"Virus Genes"},{"key":"4933_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2164-9-75","volume":"9","author":"RK Aziz","year":"2008","unstructured":"Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, Formsma K, Gerdes S, Glass EM, Kubal M, et al. The RAST Server: rapid annotations using subsystems technology. BMC Genomics. 2008;9:75.","journal-title":"BMC Genomics"},{"issue":"W1","key":"4933_CR35","doi-asserted-by":"publisher","first-page":"W16","DOI":"10.1093\/nar\/gkw387","volume":"44","author":"D Arndt","year":"2016","unstructured":"Arndt D, Grant JR, Marcu A, Sajed T, Pon A, Liang Y, Wishart DS. PHASTER: a better, faster version of the PHAST phage search tool. Nucleic Acids Res. 2016;44(W1):W16\u201321.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4933_CR36","doi-asserted-by":"publisher","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","volume":"49","author":"U Consortium","year":"2021","unstructured":"Consortium U. UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res. 2021;49(D1):D480\u20139.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"4933_CR37","doi-asserted-by":"publisher","first-page":"W54","DOI":"10.1093\/nar\/gkw413","volume":"44","author":"TM Lowe","year":"2016","unstructured":"Lowe TM, Chan PP. tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes. Nucleic Acids Res. 2016;44(W1):W54\u201357.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4933_CR38","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004;32(5):1792\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"4933_CR39","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 2016;33(7):1870\u20134.","journal-title":"Mol Biol Evol"},{"issue":"18","key":"4933_CR40","doi-asserted-by":"publisher","first-page":"4963","DOI":"10.1128\/JB.00339-11","volume":"193","author":"S Kiljunen","year":"2011","unstructured":"Kiljunen S, Datta N, Dentovskaya SV, Anisimov AP, Knirel YA, Bengoechea JA, Holst O, Skurnik M. Identification of the lipopolysaccharide core of Yersinia pestis and Yersinia pseudotuberculosis as the receptor for bacteriophage \u03c6A1122. J Bacteriol. 2011;193(18):4963\u201372.","journal-title":"J Bacteriol"},{"issue":"18","key":"4933_CR41","doi-asserted-by":"publisher","first-page":"e0092021","DOI":"10.1128\/JVI.00920-21","volume":"95","author":"Q Gong","year":"2021","unstructured":"Gong Q, Wang X, Huang H, Sun Y, Qian X, Xue F, Ren J, Dai J, Tang F. Novel Host Recognition Mechanism of the K1 Capsule-Specific Phage of Escherichia coli: Capsular Polysaccharide as the First Receptor and Lipopolysaccharide as the Secondary Receptor. J Virol. 2021;95(18):e0092021.","journal-title":"J Virol"},{"issue":"15","key":"4933_CR42","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1021\/acs.biochem.5c00142","volume":"64","author":"PK Thoren Edvardsen","year":"2025","unstructured":"Thoren Edvardsen PK, Englund AN, Kjendseth Ro\u0337hr A, Mesnage S, Vaaje-Kolstad G. Pseudomonas aeruginosa Cryptic Prophage Endolysin Is a Highly Active Muramidase. Biochemistry. 2025;64(15):3446\u201358.","journal-title":"Biochemistry"},{"issue":"1","key":"4933_CR43","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1128\/AEM.02279-13","volume":"80","author":"H Shin","year":"2014","unstructured":"Shin H, Lee JH, Yoon H, Kang DH, Ryu S. Genomic investigation of lysogen formation and host lysis systems of the Salmonella temperate bacteriophage SPN9CC. Appl Environ Microbiol. 2014;80(1):374\u201384.","journal-title":"Appl Environ Microbiol"},{"key":"4933_CR44","doi-asserted-by":"publisher","first-page":"127412","DOI":"10.1016\/j.micres.2023.127412","volume":"273","author":"D Gao","year":"2023","unstructured":"Gao D, Ji H, Li X, Ke X, Li X, Chen P, Qian P. Host receptor identification of a polyvalent lytic phage GSP044, and preliminary assessment of its efficacy in the clearance of Salmonella. Microbiol Res. 2023;273:127412.","journal-title":"Microbiol Res"},{"issue":"12","key":"4933_CR45","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1002\/jobm.201600116","volume":"56","author":"L Li","year":"2016","unstructured":"Li L, Pan X, Cui X, Sun Q, Yang X, Yang H. Characterization of Pseudomonas aeruginosa phage K5 genome and identification of its receptor related genes. J Basic Microbiol. 2016;56(12):1344\u201353.","journal-title":"J Basic Microbiol"},{"issue":"1","key":"4933_CR46","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1006\/abio.1998.2961","volume":"267","author":"CH Lee","year":"1999","unstructured":"Lee CH, Tsai CM. Quantification of bacterial lipopolysaccharides by the purpald assay: measuring formaldehyde generated from 2-keto-3-deoxyoctonate and heptose at the inner core by periodate oxidation. Anal Biochem. 1999;267(1):161\u20138.","journal-title":"Anal Biochem"},{"issue":"9","key":"4933_CR47","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1128\/AEM.02483-08","volume":"75","author":"SF Lan","year":"2009","unstructured":"Lan SF, Huang CH, Chang CH, Liao WC, Lin IH, Jian WN, Wu YG, Chen SY, Wong HC. Characterization of a new plasmid-like prophage in a pandemic Vibrio parahaemolyticus O3:K6 strain. Appl Environ Microbiol. 2009;75(9):2659\u201367.","journal-title":"Appl Environ Microbiol"},{"issue":"17","key":"4933_CR48","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1128\/JB.00599-07","volume":"189","author":"AV Mardanov","year":"2007","unstructured":"Mardanov AV, Ravin NV. The antirepressor needed for induction of linear plasmid-prophage N15 belongs to the SOS regulon. J Bacteriol. 2007;189(17):6333\u20138.","journal-title":"J Bacteriol"},{"issue":"1","key":"4933_CR49","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ijmm.2015.11.004","volume":"306","author":"M Chatterjee","year":"2016","unstructured":"Chatterjee M, Anju CP, Biswas L, Anil Kumar V, Gopi Mohan C, Biswas R. Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options. Int J Med Microbiol. 2016;306(1):48\u201358.","journal-title":"Int J Med Microbiol"},{"issue":"10","key":"4933_CR50","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1080\/23744235.2024.2379492","volume":"56","author":"N Pal","year":"2024","unstructured":"Pal N, Sharma P, Kumawat M, Singh S, Verma V, Tiwari RR, Sarma DK, Nagpal R, Kumar M. Phage therapy: an alternative treatment modality for MDR bacterial infections. Infect Dis (Lond). 2024;56(10):785\u2013817.","journal-title":"Infect Dis (Lond)"},{"issue":"11","key":"4933_CR51","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1016\/j.cell.2022.04.024","volume":"185","author":"JA Nick","year":"2022","unstructured":"Nick JA, Dedrick RM, Gray AL, Vladar EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, et al. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection. Cell. 2022;185(11):1860\u2013e18741812.","journal-title":"Cell"},{"issue":"1","key":"4933_CR52","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12985-025-02679-w","volume":"22","author":"K Ranta","year":"2025","unstructured":"Ranta K, Skurnik M, Kiljunen S. Isolation and characterization of fMGyn-Pae01, a phiKZ-like jumbo phage infecting Pseudomonas aeruginosa. Virol J. 2025;22(1):55.","journal-title":"Virol J"},{"issue":"11","key":"4933_CR53","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.3390\/v14112339","volume":"14","author":"I Akremi","year":"2022","unstructured":"Akremi I, Merabishvili M, Jlidi M, Haj Brahim A, Ben Ali M, Karoui A, Lavigne R, Wagemans J, Pirnay JP, Ben Ali M. Isolation and Characterization of Lytic Pseudomonas aeruginosa Bacteriophages Isolated from Sewage Samples from Tunisia. Viruses. 2022;14(11):2339.","journal-title":"Viruses"},{"issue":"24","key":"4933_CR54","doi-asserted-by":"publisher","first-page":"17390","DOI":"10.3390\/ijms242417390","volume":"24","author":"AV Letarov","year":"2023","unstructured":"Letarov AV. Bacterial Virus Forcing of Bacterial O-Antigen Shields: Lessons from Coliphages. Int J Mol Sci. 2023;24(24):17390.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"4933_CR55","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00284-025-04478-6","volume":"82","author":"F Majlesain","year":"2025","unstructured":"Majlesain F, Abbasifard Semnani A, Abolmaali S, Sadeghi M, Darvish Alipour Astaneh S. Isolation and Characterization of A Novel Pbunavirus with Promising Antibiofilm Activity Against Pseudomonas aeruginosa. Curr Microbiol. 2025;82(11):507.","journal-title":"Curr Microbiol"},{"issue":"3","key":"4933_CR56","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1128\/mr.56.3.395-411.1992","volume":"56","author":"M Vaara","year":"1992","unstructured":"Vaara M. Agents that increase the permeability of the outer membrane. Microbiol Rev. 1992;56(3):395\u2013411.","journal-title":"Microbiol Rev"},{"issue":"Pt B","key":"4933_CR57","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.biochi.2014.09.017","volume":"107","author":"SA Legotsky","year":"2014","unstructured":"Legotsky SA, Vlasova KY, Priyma AD, Shneider MM, Pugachev VG, Totmenina OD, Kabanov AV, Miroshnikov KA, Klyachko NL. Peptidoglycan degrading activity of the broad-range Salmonella bacteriophage S-394 recombinant endolysin. Biochimie. 2014;107(Pt B):293\u20139.","journal-title":"Biochimie"},{"issue":"6","key":"4933_CR58","doi-asserted-by":"publisher","first-page":"816","DOI":"10.4014\/jmb.2205.05009","volume":"32","author":"J Lim","year":"2022","unstructured":"Lim J, Hong J, Jung Y, Ha J, Kim H, Myung H, Song M. Bactericidal Effect of Cecropin A Fused Endolysin on Drug-Resistant Gram-Negative Pathogens. J Microbiol Biotechnol. 2022;32(6):816\u201323.","journal-title":"J Microbiol Biotechnol"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-026-04933-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-04933-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-04933-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:10:13Z","timestamp":1776399013000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-026-04933-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4933"],"URL":"https:\/\/doi.org\/10.1186\/s12866-026-04933-9","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"20 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"373"}}