{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:10Z","timestamp":1792787830173,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82304044"],"award-info":[{"award-number":["82304044"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2024CX04 and 2025CX06"],"award-info":[{"award-number":["2024CX04 and 2025CX06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-026-05355-3","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:18:10Z","timestamp":1782789490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic shifts in cutaneous bacterial and fungal communities throughout human aging: a pilot study"],"prefix":"10.1186","volume":"26","author":[{"given":"Tingting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganglian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"5355_CR1","doi-asserted-by":"crossref","unstructured":"Min M, Egli C, Sivamani RK. The gut and skin microbiome and its association with aging clocks. Int J Mol Sci. 2024;25(13):7471.","DOI":"10.3390\/ijms25137471"},{"issue":"10","key":"5355_CR2","doi-asserted-by":"publisher","first-page":"e0237207","DOI":"10.1371\/journal.pone.0237207","volume":"15","author":"C Sala","year":"2020","unstructured":"Sala C, et al. Gut microbiota ecology: biodiversity estimated from hybrid neutral-niche model increases with health status and aging. PLoS ONE. 2020;15(10):e0237207.","journal-title":"PLoS ONE"},{"issue":"2","key":"5355_CR3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s42255-021-00348-0","volume":"3","author":"T Wilmanski","year":"2021","unstructured":"Wilmanski T, et al. Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nat Metabolism. 2021;3(2):274\u201386.","journal-title":"Nat Metabolism"},{"issue":"6","key":"5355_CR4","doi-asserted-by":"publisher","first-page":"101199","DOI":"10.1016\/j.isci.2020.101199","volume":"23","author":"F Galkin","year":"2020","unstructured":"Galkin F, et al. Human gut microbiome aging clock based on taxonomic profiling and deep learning. IScience. 2020;23(6):101199.","journal-title":"IScience"},{"issue":"1","key":"5355_CR5","doi-asserted-by":"publisher","first-page":"108538","DOI":"10.1016\/j.isci.2023.108538","volume":"27","author":"V Gopu","year":"2024","unstructured":"Gopu V, et al. An accurate aging clock developed from large-scale gut microbiome and human gene expression data. IScience. 2024;27(1):108538.","journal-title":"IScience"},{"issue":"7689","key":"5355_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature25177","volume":"553","author":"YE Chen","year":"2018","unstructured":"Chen YE, Fischbach MA, Belkaid Y. Skin microbiota-host interactions. Nature. 2018;553(7689):427\u201336.","journal-title":"Nature"},{"key":"5355_CR7","doi-asserted-by":"crossref","unstructured":"Scharschmidt TC, Segre JA. Skin microbiome and dermatologic disorders. J Clin Investig. 2025;135(3):e184315.","DOI":"10.1172\/JCI184315"},{"issue":"3","key":"5355_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","volume":"16","author":"AL Byrd","year":"2018","unstructured":"Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Nat Rev Microbiol. 2018;16(3):143\u201355.","journal-title":"Nat Rev Microbiol"},{"issue":"7838","key":"5355_CR9","doi-asserted-by":"publisher","first-page":"S209","DOI":"10.1038\/d41586-020-03523-7","volume":"588","author":"M Eisenstein","year":"2020","unstructured":"Eisenstein M. The skin microbiome. Nature. 2020;588(7838):S209.","journal-title":"Nature"},{"key":"5355_CR10","first-page":"1694","volume-title":"Bacterial community variation in human body habitats across space and time","author":"EK Costello","year":"2009","unstructured":"Costello EK, et al. Bacterial community variation in human body habitats across space and time. Volume 326. New York, N.Y.): Science; 2009. pp. 1694\u20137. 5960."},{"key":"5355_CR11","doi-asserted-by":"crossref","unstructured":"Li T, et al. Upadacitinib outperforms dupilumab in restoring the fungal microbiome in atopic dermatitis. Br J Dermatol. 2025;193(1):176\u20138.","DOI":"10.1093\/bjd\/ljaf095"},{"issue":"1","key":"5355_CR12","doi-asserted-by":"publisher","first-page":"2470379","DOI":"10.1080\/09546634.2025.2470379","volume":"36","author":"L Tingting","year":"2025","unstructured":"Tingting L, et al. The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis. J Dermatolog Treat. 2025;36(1):2470379.","journal-title":"J Dermatolog Treat"},{"issue":"10","key":"5355_CR13","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1111\/exd.14450","volume":"30","author":"R Tao","year":"2021","unstructured":"Tao R, Li R, Wang R. Skin microbiome alterations in seborrheic dermatitis and dandruff: a systematic review. Exp Dermatol. 2021;30(10):1546\u201353.","journal-title":"Exp Dermatol"},{"key":"5355_CR14","doi-asserted-by":"crossref","unstructured":"Smythe P, Wilkinson HN. The skin microbiome: current landscape and future opportunities. Int J Mol Sci. 2023;24(4):3950.","DOI":"10.3390\/ijms24043950"},{"key":"5355_CR15","doi-asserted-by":"crossref","unstructured":"Huang S, et al. Human skin, oral, and gut microbiomes predict chronological age. MSystems. 2020;5(1):e00630\u201319.","DOI":"10.1128\/msystems.00630-19"},{"issue":"1","key":"5355_CR16","doi-asserted-by":"publisher","first-page":"10567","DOI":"10.1038\/s41598-017-10834-9","volume":"7","author":"N Shibagaki","year":"2017","unstructured":"Shibagaki N, et al. Aging-related changes in the diversity of women\u2019s skin microbiomes associated with oral bacteria. Sci Rep. 2017;7(1):10567.","journal-title":"Sci Rep"},{"issue":"3","key":"5355_CR17","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/jam.13929","volume":"125","author":"R Jug\u00e9","year":"2018","unstructured":"Jug\u00e9 R, et al. Shift in skin microbiota of Western European women across aging. J Appl Microbiol. 2018;125(3):907\u201316.","journal-title":"J Appl Microbiol"},{"issue":"4","key":"5355_CR18","first-page":"253","volume":"6","author":"A Prohic","year":"2014","unstructured":"Prohic A, et al. Distribution of Malassezia species on healthy human skin in Bosnia and Herzegovina: correlation with body part, age and gender. Iran J Microbiol. 2014;6(4):253\u201362.","journal-title":"Iran J Microbiol"},{"key":"5355_CR19","doi-asserted-by":"crossref","unstructured":"Wu L, et al. Age-related variation of bacterial and fungal communities in different body habitats across the young, elderly, and centenarians in Sardinia. MSphere. 2020;5(1):e00558\u201319.","DOI":"10.1128\/mSphere.00558-19"},{"issue":"1","key":"5355_CR20","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1038\/s41598-022-06189-5","volume":"12","author":"H-J Kim","year":"2022","unstructured":"Kim H-J, et al. Aged related human skin microbiome and mycobiome in Korean women. Sci Rep. 2022;12(1):2351.","journal-title":"Sci Rep"},{"issue":"21","key":"5355_CR21","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Mago\u010d","year":"2011","unstructured":"Mago\u010d T, Salzberg SL. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics. 2011;27(21):2957\u201363.","journal-title":"Bioinformatics"},{"issue":"1","key":"5355_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nmeth.2276","volume":"10","author":"NA Bokulich","year":"2013","unstructured":"Bokulich NA, Subramanian S, Faith JJ, et al. Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods. 2013;10(1):57\u20139.","journal-title":"Nat Methods"},{"issue":"5","key":"5355_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v028.i05","volume":"28","author":"M Kuhn","year":"2008","unstructured":"Kuhn M. Building predictive models in R using the caret package. J Stat Softw. 2008;28(5):1\u201326.","journal-title":"J Stat Softw"},{"issue":"3","key":"5355_CR24","first-page":"18","volume":"2","author":"A Liaw","year":"2002","unstructured":"Liaw A, Wiener M. Classification and regression by randomForest. R News. 2002;2(3):18\u201322.","journal-title":"R News"},{"key":"5355_CR25","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2023","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. 2023."},{"key":"5355_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S\u2009+\u2009to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.","journal-title":"BMC Bioinformatics"},{"key":"5355_CR27","doi-asserted-by":"crossref","unstructured":"Garlet A, et al. Facial skin microbiome composition and functional shift with aging. Microorganisms. 2024;12(5):1021.","DOI":"10.3390\/microorganisms12051021"},{"key":"5355_CR28","doi-asserted-by":"crossref","unstructured":"Howard B, et al. Aging-associated changes in the adult human skin microbiome and the host factors that affect skin microbiome composition. J Invest Dermatol. 2022;142(7):1934\u20131946.e21.","DOI":"10.1016\/j.jid.2021.11.029"},{"issue":"10","key":"5355_CR29","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s43587-022-00287-9","volume":"2","author":"PJ Larson","year":"2022","unstructured":"Larson PJ, et al. Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults. Nat Aging. 2022;2(10):941\u201355.","journal-title":"Nat Aging"},{"key":"5355_CR30","doi-asserted-by":"publisher","first-page":"1304705","DOI":"10.3389\/fragi.2023.1304705","volume":"4","author":"T Myers","year":"2023","unstructured":"Myers T, et al. A multi-study analysis enables identification of potential microbial features associated with skin aging signs. Front Aging. 2023;4:1304705. https:\/\/doi.org\/10.3389\/fragi.2023.1304705.","journal-title":"Front Aging"},{"issue":"1","key":"5355_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12915-019-0660-6","volume":"17","author":"A Bouslimani","year":"2019","unstructured":"Bouslimani A, et al. The impact of skin care products on skin chemistry and microbiome dynamics. BMC Biol. 2019;17(1):47.","journal-title":"BMC Biol"},{"issue":"5","key":"5355_CR32","doi-asserted-by":"publisher","first-page":"e1236","DOI":"10.1002\/mbo3.1236","volume":"10","author":"BK Hwang","year":"2021","unstructured":"Hwang BK, et al. Effect of the skincare product on facial skin microbial structure and biophysical parameters: a pilot study. MicrobiologyOpen. 2021;10(5):e1236.","journal-title":"MicrobiologyOpen"},{"key":"5355_CR33","doi-asserted-by":"crossref","unstructured":"Markle JGM, et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science. (New York, N.Y.) 6123. 2013;339:1084\u20138.","DOI":"10.1126\/science.1233521"},{"key":"5355_CR34","first-page":"30","volume":"19","author":"JQ Del Rosso","year":"2020","unstructured":"Del Rosso JQ, Kircik LH, Gold S, L., Thiboutot D, Androgens. Androgen receptors, and the skin: from the laboratory to the clinic with emphasis on clinical and therapeutic implications. J Drugs Dermatol. 2020;19:30\u20135.","journal-title":"J Drugs Dermatol"},{"key":"5355_CR35","doi-asserted-by":"crossref","unstructured":"Pyle HJ, et al. Assessment of the cutaneous hormone landscapes and microbiomes in vulvar lichen sclerosus. J Invest Dermatol. 2024;144(8):1808\u20131816.e11.","DOI":"10.1016\/j.jid.2024.01.027"},{"issue":"4","key":"5355_CR36","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1023\/A:1001500310537","volume":"73","author":"P Mayser","year":"1998","unstructured":"Mayser P, Pape B. Decreased susceptibility of Malassezia furfur to UV light by synthesis of tryptophane derivatives. Antonie Van Leeuwenhoek. 1998;73(4):315\u20139.","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"5","key":"5355_CR37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1439-0507.2006.01265.x","volume":"49","author":"A Machowinski","year":"2006","unstructured":"Machowinski A, et al. Pityriacitrin\u2013a potent UV filter produced by Malassezia furfur and its effect on human skin microflora. Mycoses. 2006;49(5):388\u201392.","journal-title":"Mycoses"},{"issue":"7\u20138","key":"5355_CR38","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1439-0507.1998.tb00336.x","volume":"41","author":"P Mayser","year":"1998","unstructured":"Mayser P, et al. Synthesis of fluorochromes and pigments in Malassezia furfur by use of tryptophan as the single nitrogen source. Mycoses. 1998;41(7\u20138):265\u201371.","journal-title":"Mycoses"},{"key":"5355_CR39","doi-asserted-by":"crossref","unstructured":"Lee H, et al. First report of eight milkcap species belonging to lactarius and lactifluus in Korea. Mycobiology. 2018;46(1):1\u201312.","DOI":"10.1080\/12298093.2018.1454012"},{"key":"5355_CR40","doi-asserted-by":"crossref","unstructured":"Kosti\u0107 M, et al. A comparative study of lactarius mushrooms: chemical characterization, antibacterial, antibiofilm, antioxidant and cytotoxic activity. J Fungi (Basel Switzerland). 2023;9(1):70.","DOI":"10.3390\/jof9010070"},{"issue":"12","key":"5355_CR41","doi-asserted-by":"publisher","first-page":"20650","DOI":"10.3390\/molecules191220650","volume":"19","author":"V Vieira","year":"2014","unstructured":"Vieira V, et al. Expanding current knowledge on the chemical composition and antioxidant activity of the genus Lactarius. Molecules. 2014;19(12):20650\u201363.","journal-title":"Molecules"},{"issue":"2","key":"5355_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jdermsci.2010.03.003","volume":"58","author":"H Masaki","year":"2010","unstructured":"Masaki H. Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci. 2010;58(2):85\u201390.","journal-title":"J Dermatol Sci"},{"issue":"1","key":"5355_CR43","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1128\/JCM.42.1.445-448.2004","volume":"42","author":"JT Kirby","year":"2004","unstructured":"Kirby JT, et al. Antimicrobial susceptibility and epidemiology of a worldwide collection of Chryseobacterium spp: report from the SENTRY Antimicrobial Surveillance Program (1997\u20132001). J Clin Microbiol. 2004;42(1):445\u20138.","journal-title":"J Clin Microbiol"},{"issue":"6","key":"5355_CR44","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/ics.12997","volume":"46","author":"J Zhou","year":"2024","unstructured":"Zhou J, et al. Age-related changes in the bacterial composition of healthy female facial skin in Beijing area. Int J Cosmet Sci. 2024;46(6):982\u201394.","journal-title":"Int J Cosmet Sci"},{"issue":"5","key":"5355_CR45","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/BCR.0b013e31822ac7e6","volume":"32","author":"EA Azzopardi","year":"2011","unstructured":"Azzopardi EA, et al. Emerging gram-negative infections in burn wounds. J Burn Care Research: Official Publication Am Burn Association. 2011;32(5):570\u20136.","journal-title":"J Burn Care Research: Official Publication Am Burn Association"},{"key":"5355_CR46","doi-asserted-by":"publisher","first-page":"110605","DOI":"10.1016\/j.enzmictec.2025.110605","volume":"186","author":"E-M Kim","year":"2025","unstructured":"Kim E-M, et al. Characterization of keratinase from Chryseobacterium camelliae Dolsongi-HT1 and efficacy on skin exfoliation. Enzym Microb Technol. 2025;186:110605.","journal-title":"Enzym Microb Technol"},{"key":"5355_CR47","doi-asserted-by":"crossref","unstructured":"Kim E-M, Hwang KH, Park J-S. Complete genome sequence of Chryseobacterium camelliae Dolsongi-HT1, a green tea isolate with keratinolytic activity. Genome Announcements. 2018;6(2):e01421\u201317.","DOI":"10.1128\/genomeA.01421-17"},{"key":"5355_CR48","doi-asserted-by":"crossref","unstructured":"Ahsan MJ, et al. Chryseobacterium spp-associated bacteraemia in a haemodialysis patient: a diagnostic challenge. BMJ Case Rep. 2019;12(11):e232000.","DOI":"10.1136\/bcr-2019-232000"},{"issue":"3","key":"5355_CR49","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s12223-017-0491-1","volume":"62","author":"F Andalibi","year":"2017","unstructured":"Andalibi F, Fatahi-Bafghi M. Gordonia: isolation and identification in clinical samples and role in biotechnology. Folia Microbiol. 2017;62(3):245\u201352.","journal-title":"Folia Microbiol"},{"issue":"1","key":"5355_CR50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1021\/acsomega.1c01708","volume":"7","author":"Y Liu","year":"2022","unstructured":"Liu Y, et al. Biological process of alkane degradation by Gordonia sihwaniensis. ACS Omega. 2022;7(1):55\u201363.","journal-title":"ACS Omega"},{"key":"5355_CR51","doi-asserted-by":"crossref","unstructured":"Welter DK, et al. Free-living, psychrotrophic bacteria of the genus psychrobacter are descendants of pathobionts. MSystems. 2021;6(2):e00258\u201321.","DOI":"10.1128\/msystems.00258-21"},{"key":"5355_CR52","doi-asserted-by":"crossref","unstructured":"Ioannou P, et al. Psychrobacter infections in humans-a narrative review of reported cases. Antibiot (Basel Switzerland). 2025;14(2):140.","DOI":"10.3390\/antibiotics14020140"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-026-05355-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-05355-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-05355-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:46:51Z","timestamp":1789598811000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-026-05355-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5355"],"URL":"https:\/\/doi.org\/10.1186\/s12866-026-05355-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8589438\/v1","asserted-by":"object"}]},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"13 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Biomedical Research Ethics Committee of Peking University First Hospital (Approval No. 2024\u2009\u2212\u2009125). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"812"}}