{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:45Z","timestamp":1792787865794,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["No.2024AAC03108"],"award-info":[{"award-number":["No.2024AAC03108"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China","award":["82360319"],"award-info":[{"award-number":["82360319"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China Joint Fund Project","award":["U22A20505"],"award-info":[{"award-number":["U22A20505"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-026-05430-9","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:27:02Z","timestamp":1784341622000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["cAMP-response element binding protein (CREB)-mediated glycolysis enhancement promotes apoptosis of RAW264.7 macrophages infected with BCG under high glucose conditions"],"prefix":"10.1186","volume":"26","author":[{"given":"Yiming","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FuYang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"5430_CR1","doi-asserted-by":"crossref","unstructured":"Orgeur M, Sous C, Madacki J, Brosch R. Evolution and emergence of Mycobacterium tuberculosis. FEMS Microbiol Rev. 2024;48(2):fuae006.","DOI":"10.1093\/femsre\/fuae006"},{"issue":"23","key":"5430_CR2","doi-asserted-by":"publisher","first-page":"e25122","DOI":"10.1002\/jcla.25122","volume":"38","author":"N Mohammadnabi","year":"2024","unstructured":"Mohammadnabi N, Shamseddin J, Emadi M, Bodaghi AB, Varseh M, Shariati A, et al. Mycobacterium tuberculosis: The Mechanism of Pathogenicity, Immune Responses, and Diagnostic Challenges. J Clin Lab Anal. 2024;38(23):e25122.","journal-title":"J Clin Lab Anal"},{"key":"5430_CR3","doi-asserted-by":"crossref","unstructured":"Yorke E, Atiase Y, Akpalu J, Sarfo-Kantanka O, Boima V, Dey ID. The Bidirectional Relationship between Tuberculosis and Diabetes. Tuberc Res Treat. 2017;2017:1702578.","DOI":"10.1155\/2017\/1702578"},{"key":"5430_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1741-7015-9-81","volume":"9","author":"MA Baker","year":"2011","unstructured":"Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, L\u00f6nnroth K, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011;9:81.","journal-title":"BMC Med"},{"issue":"5","key":"5430_CR5","first-page":"384","volume":"30","author":"J Cheng","year":"2017","unstructured":"Cheng J, Zhang H, Zhao YL, Wang LX, Chen MT. Mutual Impact of Diabetes Mellitus and Tuberculosis in China. Biomed Environ Sci. 2017;30(5):384\u20139.","journal-title":"Biomed Environ Sci"},{"issue":"1","key":"5430_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1128\/iai.28.1.127-131.1980","volume":"28","author":"O Saiki","year":"1980","unstructured":"Saiki O, Negoro S, Tsuyuguchi I, Yamamura Y. Depressed immunological defence mechanisms in mice with experimentally induced diabetes. Infect Immun. 1980;28(1):127\u201331.","journal-title":"Infect Immun"},{"issue":"5","key":"5430_CR7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1165\/rcmb.2006-0478OC","volume":"37","author":"GW Martens","year":"2007","unstructured":"Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol. 2007;37(5):518\u201324.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"5430_CR8","doi-asserted-by":"publisher","first-page":"101959","DOI":"10.1016\/j.smim.2025.101959","volume":"78","author":"PM Thong","year":"2025","unstructured":"Thong PM, Wong YH, Kornfeld H, Goletti D, Ong CWM. Immune dysregulation of diabetes in tuberculosis. Semin Immunol. 2025;78:101959.","journal-title":"Semin Immunol"},{"key":"5430_CR9","doi-asserted-by":"publisher","first-page":"107140","DOI":"10.1016\/j.ijid.2024.107140","volume":"146","author":"AA Boadu","year":"2024","unstructured":"Boadu AA, Yeboah-Manu M, Osei-Wusu S, Yeboah-Manu D. Tuberculosis and diabetes mellitus: The complexity of the comorbid interactions. Int J Infect Dis. 2024;146:107140.","journal-title":"Int J Infect Dis"},{"key":"5430_CR10","doi-asserted-by":"publisher","first-page":"6196532","DOI":"10.1155\/2019\/6196532","volume":"2019","author":"B Ayelign","year":"2019","unstructured":"Ayelign B, Negash M, Genetu M, Wondmagegn T, Shibabaw T. Immunological Impacts of Diabetes on the Susceptibility of Mycobacterium tuberculosis. J Immunol Res. 2019;2019:6196532.","journal-title":"J Immunol Res"},{"issue":"1","key":"5430_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/imm.12762","volume":"152","author":"P Kumar Nathella","year":"2017","unstructured":"Kumar Nathella P, Babu S. Influence of diabetes mellitus on immunity to human tuberculosis. Immunology. 2017;152(1):13\u201324.","journal-title":"Immunology"},{"issue":"11","key":"5430_CR12","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.4049\/jimmunol.1000304","volume":"184","author":"T Vallerskog","year":"2010","unstructured":"Vallerskog T, Martens GW, Kornfeld H. Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 2010;184(11):6275\u201382.","journal-title":"J Immunol"},{"issue":"12","key":"5430_CR13","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/cmi.2017.88","volume":"14","author":"CH Liu","year":"2017","unstructured":"Liu CH, Liu H, Ge B. Innate immunity in tuberculosis: host defense vs pathogen evasion. Cell Mol Immunol. 2017;14(12):963\u201375.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"5430_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3109\/08830185.2014.969421","volume":"34","author":"L Zhu","year":"2015","unstructured":"Zhu L, Zhao Q, Yang T, Ding W, Zhao Y. Cellular metabolism and macrophage functional polarization. Int Rev Immunol. 2015;34(1):82\u2013100.","journal-title":"Int Rev Immunol"},{"key":"5430_CR15","doi-asserted-by":"crossref","unstructured":"Watanabe R, Hilhorst M, Zhang H, Zeisbrich M, Berry GJ, Wallis BB et al. Glucose metabolism controls disease-specific signatures of macrophage effector functions. JCI Insight. 2018;3(20):e123047.","DOI":"10.1172\/jci.insight.123047"},{"issue":"5","key":"5430_CR16","doi-asserted-by":"publisher","first-page":"E723","DOI":"10.1152\/ajpendo.00009.2025","volume":"328","author":"MI Dar","year":"2025","unstructured":"Dar MI, Hussain Y, Pan X. Roles of circadian clocks in macrophage metabolism: implications in inflammation and metabolism of lipids, glucose, and amino acids. Am J Physiol Endocrinol Metab. 2025;328(5):E723\u201341.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"5430_CR17","doi-asserted-by":"publisher","first-page":"746151","DOI":"10.3389\/fimmu.2021.746151","volume":"12","author":"S Russo","year":"2021","unstructured":"Russo S, Kwiatkowski M, Govorukhina N, Bischoff R, Melgert BN. Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites. Front Immunol. 2021;12:746151.","journal-title":"Front Immunol"},{"key":"5430_CR18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3389\/fimmu.2017.00289","volume":"8","author":"X Geeraerts","year":"2017","unstructured":"Geeraerts X, Bolli E, Fendt SM, Van Ginderachter JA. Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity. Front Immunol. 2017;8:289.","journal-title":"Front Immunol"},{"issue":"4","key":"5430_CR19","doi-asserted-by":"publisher","first-page":"520","DOI":"10.2337\/diab.42.4.520","volume":"42","author":"G Wu","year":"1993","unstructured":"Wu G, Marliss EB. Enhanced glucose metabolism and respiratory burst in peritoneal macrophages from spontaneously diabetic BB rats. Diabetes. 1993;42(4):520\u20139.","journal-title":"Diabetes"},{"issue":"3","key":"5430_CR20","doi-asserted-by":"publisher","first-page":"105271","DOI":"10.1016\/j.micinf.2023.105271","volume":"26","author":"AK Rana","year":"2024","unstructured":"Rana AK, Kumar Saraswati SS, Anang V, Singh A, Singh A, Verma C, et al. Butyrate induces oxidative burst mediated apoptosis via Glucose-6-Phosphate Dehydrogenase (G6PDH) in macrophages during mycobacterial infection. Microbes Infect. 2024;26(3):105271.","journal-title":"Microbes Infect"},{"issue":"3","key":"5430_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/08830185.2020.1712379","volume":"39","author":"Y Liu","year":"2020","unstructured":"Liu Y, Liang S, Ding R, Hou Y, Deng F, Ma X, et al. BCG-induced trained immunity in macrophage: reprograming of glucose metabolism. Int Rev Immunol. 2020;39(3):83\u201396.","journal-title":"Int Rev Immunol"},{"key":"5430_CR22","doi-asserted-by":"publisher","first-page":"12906","DOI":"10.1038\/srep12906","volume":"5","author":"V Singh","year":"2015","unstructured":"Singh V, Kaur C, Chaudhary VK, Rao KV, Chatterjee SM. tuberculosis Secretory Protein ESAT-6 Induces Metabolic Flux Perturbations to Drive Foamy Macrophage Differentiation. Sci Rep. 2015;5:12906.","journal-title":"Sci Rep"},{"key":"5430_CR23","doi-asserted-by":"publisher","first-page":"18176","DOI":"10.1038\/srep18176","volume":"5","author":"L Shi","year":"2015","unstructured":"Shi L, Salamon H, Eugenin EA, Pine R, Cooper A, Gennaro ML. Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs. Sci Rep. 2015;5:18176.","journal-title":"Sci Rep"},{"issue":"10","key":"5430_CR24","doi-asserted-by":"publisher","first-page":"e1005972","DOI":"10.1371\/journal.ppat.1005972","volume":"12","author":"SS Cheekatla","year":"2016","unstructured":"Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, et al. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PLoS Pathog. 2016;12(10):e1005972.","journal-title":"PLoS Pathog"},{"key":"5430_CR25","doi-asserted-by":"publisher","first-page":"1408949","DOI":"10.3389\/fnmol.2024.1408949","volume":"17","author":"MAR Chowdhury","year":"2024","unstructured":"Chowdhury MAR, Haq MM, Lee JH, Jeong S. Multi-faceted regulation of CREB family transcription factors. Front Mol Neurosci. 2024;17:1408949.","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"5430_CR26","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.17219\/acem\/151026","volume":"31","author":"N Zhang","year":"2022","unstructured":"Zhang N, Shi L, Wang Y. CREB-associated glycosylation and function in human disease. Adv Clin Exp Med. 2022;31(11):1289\u201397.","journal-title":"Adv Clin Exp Med"},{"issue":"3","key":"5430_CR27","doi-asserted-by":"publisher","first-page":"e1011297","DOI":"10.1371\/journal.ppat.1011297","volume":"19","author":"CM Leopold Wager","year":"2023","unstructured":"Leopold Wager CM, Bonifacio JR, Simper J, Naoun AA, Arnett E, Schlesinger LS. Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling. PLoS Pathog. 2023;19(3):e1011297.","journal-title":"PLoS Pathog"},{"issue":"3","key":"5430_CR28","doi-asserted-by":"publisher","first-page":"653","DOI":"10.2337\/dbi20-0006","volume":"70","author":"A Cui","year":"2021","unstructured":"Cui A, Ding D, Li Y. Regulation of Hepatic Metabolism and Cell Growth by the ATF\/CREB Family of Transcription Factors. Diabetes. 2021;70(3):653\u201364.","journal-title":"Diabetes"},{"issue":"1","key":"5430_CR29","first-page":"94","volume":"69","author":"S Rao","year":"2019","unstructured":"Rao S, Rahim M, Iqbal K, Haroon F, Hasan Z. Impact of diabetes on mechanisms of immunity against Mycobacterium tuberculosis. J Pak Med Assoc. 2019;69(1):94\u20138.","journal-title":"J Pak Med Assoc"},{"issue":"4","key":"5430_CR30","doi-asserted-by":"publisher","first-page":"e448","DOI":"10.1016\/S2214-109X(18)30487-X","volume":"7","author":"JJ Noubiap","year":"2019","unstructured":"Noubiap JJ, Nansseu JR, Nyaga UF, Nkeck JR, Endomba FT, Kaze AD, et al. Global prevalence of diabetes in active tuberculosis: a systematic review and meta-analysis of data from 2\u00b73 million patients with tuberculosis. Lancet Glob Health. 2019;7(4):e448\u201360.","journal-title":"Lancet Glob Health"},{"issue":"1","key":"5430_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/2251-6581-11-28","volume":"11","author":"AK Niazi","year":"2012","unstructured":"Niazi AK, Kalra S. Diabetes and tuberculosis: a review of the role of optimal glycemic control. J Diabetes Metab Disord. 2012;11(1):28.","journal-title":"J Diabetes Metab Disord"},{"issue":"1","key":"5430_CR32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/cid\/ciaa751","volume":"72","author":"C Eckold","year":"2021","unstructured":"Eckold C, Kumar V, Weiner J, Alisjahbana B, Riza AL, Ronacher K, et al. Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis. Clin Infect Dis. 2021;72(1):69\u201378.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"5430_CR33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jinf.2016.08.021","volume":"74","author":"NP Kumar","year":"2017","unstructured":"Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, et al. Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors. J Infect. 2017;74(1):10\u201321.","journal-title":"J Infect"},{"issue":"8","key":"5430_CR34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.micinf.2020.03.004","volume":"22","author":"MA Alim","year":"2020","unstructured":"Alim MA, Kupz A, Sikder S, Rush C, Govan B, Ketheesan N. Increased susceptibility to Mycobacterium tuberculosis infection in a diet-induced murine model of type 2 diabetes. Microbes Infect. 2020;22(8):303\u201311.","journal-title":"Microbes Infect"},{"issue":"3","key":"5430_CR35","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/eji.201344301","volume":"44","author":"N Martinez","year":"2014","unstructured":"Martinez N, Kornfeld H. Diabetes and immunity to tuberculosis. Eur J Immunol. 2014;44(3):617\u201326.","journal-title":"Eur J Immunol"},{"issue":"1","key":"5430_CR36","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/imr.12266","volume":"264","author":"G Weiss","year":"2015","unstructured":"Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev. 2015;264(1):182\u2013203.","journal-title":"Immunol Rev"},{"issue":"6","key":"5430_CR37","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1080\/15548627.2021.1985338","volume":"18","author":"L Ma","year":"2022","unstructured":"Ma L, Li W, Zhang Y, Qi L, Zhao Q, Li N, et al. FLT4\/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2022;18(6):1385\u2013400.","journal-title":"Autophagy"},{"issue":"7","key":"5430_CR38","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/cr.2015.68","volume":"25","author":"B Kelly","year":"2015","unstructured":"Kelly B, O\u2019Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771\u201384.","journal-title":"Cell Res"},{"issue":"20","key":"5430_CR39","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1002\/1873-3468.15001","volume":"598","author":"S Mal","year":"2024","unstructured":"Mal S, Majumder D, Birari P, Sharma AK, Gupta U, Jana K, et al. The miR-26a\/SIRT6\/HIF-1\u03b1 axis regulates glycolysis and inflammatory responses in host macrophages during Mycobacterium tuberculosis infection. FEBS Lett. 2024;598(20):2592\u2013614.","journal-title":"FEBS Lett"},{"key":"5430_CR40","doi-asserted-by":"publisher","first-page":"149920","DOI":"10.1016\/j.bbrc.2024.149920","volume":"711","author":"C Li","year":"2024","unstructured":"Li C, Wang J, Xu JF, Pi J, Zheng B. Roles of HIF-1\u03b1 signaling in Mycobacterium tuberculosis infection: New targets for anti-TB therapeutics? Biochem Biophys Res Commun. 2024;711:149920.","journal-title":"Biochem Biophys Res Commun"},{"key":"5430_CR41","doi-asserted-by":"crossref","unstructured":"Shi L, Jiang Q, Bushkin Y, Subbian S, Tyagi S. Biphasic Dynamics of Macrophage Immunometabolism during Mycobacterium tuberculosis Infection. mBio. 2019;10(2):e02550-18.","DOI":"10.1128\/mBio.02550-18"},{"issue":"8","key":"5430_CR42","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1038\/s41564-024-01734-6","volume":"9","author":"Y Yang","year":"2024","unstructured":"Yang Y, Fang H, Xie Z, Ren F, Yan L, Zhang M, et al. Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice. Nat Microbiol. 2024;9(8):2144\u201359.","journal-title":"Nat Microbiol"},{"issue":"1","key":"5430_CR43","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.1038\/s41467-023-41519-9","volume":"14","author":"N Martinez","year":"2023","unstructured":"Martinez N, Smulan LJ, Jameson ML, Smith CM, Cavallo K, Bellerose M, et al. Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes. Nat Commun. 2023;14(1):5840.","journal-title":"Nat Commun"},{"key":"5430_CR44","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2147\/RMHP.S354377","volume":"15","author":"R Wei","year":"2022","unstructured":"Wei R, Li P, Xue Y, Liu Y, Gong W, Zhao W. Impact of Diabetes Mellitus on the Immunity of Tuberculosis Patients: A Retrospective, Cross-Sectional Study. Risk Manag Healthc Policy. 2022;15:611\u201327.","journal-title":"Risk Manag Healthc Policy"},{"key":"5430_CR45","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.freeradbiomed.2024.10.304","volume":"225","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Chang L, Xin X, Qiao Y, Qiao W, Ping J, et al. Influenza A virus-induced glycolysis facilitates virus replication by activating ROS\/HIF-1\u03b1 pathway. Free Radic Biol Med. 2024;225:910\u201324.","journal-title":"Free Radic Biol Med"},{"key":"5430_CR46","doi-asserted-by":"publisher","first-page":"110074","DOI":"10.1016\/j.vetimm.2020.110074","volume":"226","author":"J Quiroga","year":"2020","unstructured":"Quiroga J, Alarc\u00f3n P, Manosalva C, Taubert A, Hermosilla C, Hidalgo MA, et al. Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes. Vet Immunol Immunopathol. 2020;226:110074.","journal-title":"Vet Immunol Immunopathol"},{"issue":"11","key":"5430_CR47","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","volume":"185","author":"AY Wen","year":"2010","unstructured":"Wen AY, Sakamoto KM, Miller LS. The role of the transcription factor CREB in immune function. J Immunol. 2010;185(11):6413\u20139.","journal-title":"J Immunol"},{"key":"5430_CR48","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1146\/annurev.biochem.68.1.821","volume":"68","author":"AJ Shaywitz","year":"1999","unstructured":"Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem. 1999;68:821\u201361.","journal-title":"Annu Rev Biochem"},{"issue":"8","key":"5430_CR49","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35085068","volume":"2","author":"B Mayr","year":"2001","unstructured":"Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol. 2001;2(8):599\u2013609.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"5430_CR50","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.immuni.2005.08.010","volume":"23","author":"JM Park","year":"2005","unstructured":"Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, et al. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis\u2013CREB and NF-kappaB as key regulators. Immunity. 2005;23(3):319\u201329.","journal-title":"Immunity"},{"issue":"7251","key":"5430_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature08123","volume":"460","author":"N Agarwal","year":"2009","unstructured":"Agarwal N, Lamichhane G, Gupta R, Nolan S, Bishai WR. Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase. Nature. 2009;460(7251):98\u2013102.","journal-title":"Nature"},{"issue":"9","key":"5430_CR52","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/kjm2.12722","volume":"39","author":"XL Fang","year":"2023","unstructured":"Fang XL, Zhang Q, Xue WW, Tao JH, Zou HD, Lin QR, et al. Suppression of cAMP\/PKA\/CREB signaling ameliorates retinal injury in diabetic retinopathy. Kaohsiung J Med Sci. 2023;39(9):916\u201326.","journal-title":"Kaohsiung J Med Sci"},{"issue":"7","key":"5430_CR53","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.molcel.2023.02.007","volume":"83","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Li S, Chen Y, Wang Y, Wei Y, Zhou T, et al. Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting. Mol Cell. 2023;83(7):1093\u2013e1088.","journal-title":"Mol Cell"},{"issue":"10","key":"5430_CR54","doi-asserted-by":"publisher","first-page":"e22541","DOI":"10.1096\/fj.202200870R","volume":"36","author":"F Xiao","year":"2022","unstructured":"Xiao F, Deng J, Jiao F, Hu X, Jiang H, Yuan F, et al. Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB). Faseb j. 2022;36(10):e22541.","journal-title":"Faseb j"},{"issue":"13","key":"5430_CR55","doi-asserted-by":"publisher","first-page":"13594","DOI":"10.18632\/aging.103474","volume":"12","author":"L Wang","year":"2020","unstructured":"Wang L, Nie Q, Gao M, Yang L, Xiang JW, Xiao Y, et al. The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing \u03b1B-crystallin expression. Aging. 2020;12(13):13594\u2013617.","journal-title":"Aging"},{"issue":"1","key":"5430_CR56","doi-asserted-by":"publisher","first-page":"12516","DOI":"10.1038\/s41598-025-97371-y","volume":"15","author":"X Yang","year":"2025","unstructured":"Yang X, Zhang Y, Zhou Y, Liu M, Zhao H, Yang Y, et al. CaMK2A\/CREB pathway activation is associated with enhanced mitophagy and neuronal apoptosis in diabetic retinopathy. Sci Rep. 2025;15(1):12516.","journal-title":"Sci Rep"},{"issue":"1","key":"5430_CR57","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41467-021-27533-9","volume":"13","author":"Y Chen","year":"2022","unstructured":"Chen Y, Wang J, Wang Y, Wang P, Zhou Z, Wu R, et al. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB\/CRTC2 transcriptional complex. Nat Commun. 2022;13(1):246.","journal-title":"Nat Commun"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-026-05430-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-05430-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-026-05430-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:03:15Z","timestamp":1790276595000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-026-05430-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5430"],"URL":"https:\/\/doi.org\/10.1186\/s12866-026-05430-9","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not involve human participants, human data, or human tissue. Therefore, the Declaration of Helsinki is not applicable. The study was conducted in accordance with the local legislation and institutional requirements. All animal experiments were approved by the Ethics Committee of Ningxia University (approval No. 2023-047).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"834"}}