{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:39:59Z","timestamp":1791301199541,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Korean Health Technology R&D Project","award":["A111436"],"award-info":[{"award-number":["A111436"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2014R1A2A1A11049588"],"award-info":[{"award-number":["2014R1A2A1A11049588"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2014-0420"],"award-info":[{"award-number":["2014-0420"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12868-015-0202-2","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T12:47:52Z","timestamp":1446209272000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death"],"prefix":"10.1186","volume":"16","author":[{"given":"Dong Ho","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok Won","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-ok","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwajin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwa","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu Seob","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"202_CR1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.yebeh.2013.05.012","volume":"28","author":"J Janousek","year":"2013","unstructured":"Janousek J, Barber A, Goldman L, Klein P. Obesity in adults with epilepsy. Epilepsy Behav. 2013;28:391\u20134.","journal-title":"Epilepsy Behav"},{"key":"202_CR2","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1111\/j.1467-789X.2010.00800.x","volume":"12","author":"A Verrotti","year":"2011","unstructured":"Verrotti A, D\u2019Egidio C, Mohn A, Coppola G, Chiarelli F. Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. Obes Rev. 2011;12:e32\u201343.","journal-title":"Obes Rev"},{"key":"202_CR3","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1212\/WNL.0b013e3181ab2b11","volume":"73","author":"ZS Daniels","year":"2009","unstructured":"Daniels ZS, Nick TG, Liu C, Cassedy A, Glauser TA. Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy. Neurology. 2009;73:658\u201364.","journal-title":"Neurology."},{"key":"202_CR4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1684\/epd.2014.0677","volume":"16","author":"LD Ladino","year":"2014","unstructured":"Ladino LD, Hern\u00e1ndez-Ronquillo L, T\u00e9llez-Zenteno JF. Obesity and its association with generalised epilepsy, idiopathic syndrome, and family history of epilepsy. Epileptic Disord. 2014;16:343\u201353.","journal-title":"Epileptic Disord."},{"key":"202_CR5","doi-asserted-by":"crossref","first-page":"14361","DOI":"10.1523\/JNEUROSCI.3171-11.2011","volume":"31","author":"EB Lee","year":"2011","unstructured":"Lee EB, Warmann G, Dhir R, Ahima RS. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. J Neurosci. 2011;31:14361\u20136.","journal-title":"J Neurosci"},{"key":"202_CR6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nbd.2014.03.011","volume":"67","author":"SE Arnold","year":"2014","unstructured":"Arnold SE, Lucki I, Brookshire BR, Carlson GC, Browne CA, Kazi H, et al. High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiol Dis. 2014;67:79\u201387.","journal-title":"Neurobiol Dis"},{"key":"202_CR7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm724","volume":"8","author":"N Maeda","year":"2002","unstructured":"Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, et al. Diet-induced insulin resistance in mice lacking adiponectin\/ACRP30. Nat Med. 2002;8:731\u20137.","journal-title":"Nat Med"},{"key":"202_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresrev.2009.05.002","volume":"61","author":"BT Jeon","year":"2009","unstructured":"Jeon BT, Shin HJ, Kim JB, Kim YK, Lee DH, Kim KH, et al. Adiponectin protects hippocampal neurons against kainic acid-induced excitotoxicity. Brain Res Rev. 2009;61:81\u20138.","journal-title":"Brain Res Rev"},{"key":"202_CR9","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0306-4522(02)00306-8","volume":"115","author":"K Sriram","year":"2002","unstructured":"Sriram K, Benkovic SA, Miller DB, O\u2019Callaghan JP. Obesity exacerbates chemically induced neurodegeneration. Neuroscience. 2002;115:1335\u201346.","journal-title":"Neuroscience"},{"key":"202_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2007.01.060","volume":"416","author":"HJ Shin","year":"2007","unstructured":"Shin HJ, Lee JY, Son E, Lee DH, Kim HJ, Kang SS, et al. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neurosci Lett. 2007;416:49\u201354.","journal-title":"Neurosci Lett"},{"key":"202_CR11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00702-008-0158-9","volume":"116","author":"JY Lee","year":"2009","unstructured":"Lee JY, Jeon BT, Shin HJ, Lee DH, Han JY, Kim HJ, et al. Temporal expression of AMP-activated protein kinase activation during the kainic acid-induced hippocampal cell death. J Neural Transm. 2009;116:33\u201340.","journal-title":"J Neural Transm."},{"key":"202_CR12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.eplepsyres.2011.12.002","volume":"99","author":"YS Kim","year":"2012","unstructured":"Kim YS, Choi MY, Ryu JH, Lee DH, Jeon BT, Roh GS, et al. Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal death. Epilepsy Res. 2012;99:240\u201351.","journal-title":"Epilepsy Res"},{"key":"202_CR13","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00702-014-1208-0","volume":"121","author":"JS Kim","year":"2014","unstructured":"Kim JS, Heo RW, Kim H, Yi CO, Shin HJ, Han JW, Roh GS. Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death. J Neural Transm. 2014;121:1233\u201343.","journal-title":"J Neural Transm."},{"key":"202_CR14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/cdd.2014.29","volume":"21","author":"HJ Shin","year":"2014","unstructured":"Shin HJ, Kim H, Heo RW, Kim HJ, Choi WS, Kwon HM, Roh GS. Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-\u03baB-mediated neuroinflammation in kainic acid-induced seizures. Cell Death Differ. 2014;21:1095\u2013106.","journal-title":"Cell Death Differ"},{"key":"202_CR15","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1111\/j.1471-4159.2006.04019.x","volume":"98","author":"AD Kraft","year":"2006","unstructured":"Kraft AD, Lee JM, Johnson DA, Kan YW, Johnson JA. Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element. J Neurochem. 2006;98:1852\u201365.","journal-title":"J Neurochem"},{"key":"202_CR16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","volume":"236","author":"K Itoh","year":"1997","unstructured":"Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997;236:313\u201322.","journal-title":"Biochem Biophys Res Commun."},{"key":"202_CR17","first-page":"2077","volume":"58","author":"W Xu","year":"2011","unstructured":"Xu W, Shao L, Zhou C, Wang H, Guo J. Upregulation of Nrf2 expression in non-alcoholic fatty liver and steatohepatitis. Hepatogastroenterology. 2011;58:2077\u201380.","journal-title":"Hepatogastroenterology"},{"key":"202_CR18","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1089\/ars.2013.5349","volume":"21","author":"S Balosso","year":"2014","unstructured":"Balosso S, Liu J, Bianchi ME, Vezzani A. Disulfide-containing high mobility group box-1 promotes N-methyl-d-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons. Antioxid Redox Signal. 2014;21:1726\u201340.","journal-title":"Antioxid Redox Signal"},{"key":"202_CR19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2127","volume":"16","author":"M Maroso","year":"2010","unstructured":"Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, et al. Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med. 2010;16:413\u20139.","journal-title":"Nat Med"},{"key":"202_CR20","doi-asserted-by":"crossref","first-page":"16938","DOI":"10.1523\/JNEUROSCI.1598-10.2010","volume":"30","author":"Z Galehdar","year":"2010","unstructured":"Galehdar Z, Swan P, Fuerth B, Callaghan SM, Park DS, Cregan SP. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010;30:16938\u201348.","journal-title":"J Neurosci"},{"key":"202_CR21","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1038\/srep07002","volume":"4","author":"Y Ding","year":"2014","unstructured":"Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, et al. Neuroprotection by acetyl-11-keto-\u03b2-Boswellic acid, in ischemic brain injury involves the Nrf2\/HO-1 defense pathway. Sci Rep. 2014;4:7002.","journal-title":"Sci Rep."},{"key":"202_CR22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89\u2013116.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"202_CR23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2007.12.051","volume":"433","author":"E Erbayat-Altay","year":"2008","unstructured":"Erbayat-Altay E, Yamada KA, Wong M, Thio LL. Increased severity of pentylenetetrazol induced seizures in leptin deficient ob\/ob mice. Neurosci Lett. 2008;433:82\u20136.","journal-title":"Neurosci Lett"},{"key":"202_CR24","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/08830738050200101501","volume":"20","author":"K Aydin","year":"2005","unstructured":"Aydin K, Serdaroglu A, Okuyaz C, Bideci A, Gucuyener K. Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate. J Child Neurol. 2005;20:848\u201351.","journal-title":"J Child Neurol"},{"key":"202_CR25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1528-1157.1998.tb01400.x","volume":"39","author":"JM Freeman","year":"1998","unstructured":"Freeman JM, Vining EP. Ketogenic diet: a time-tested, effective, and safe method for treatment of intractable childhood epilepsy. Epilepsia. 1998;39:450\u20131.","journal-title":"Epilepsia."},{"key":"202_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10863-014-9570-z","volume":"47","author":"JE Selfridge","year":"2015","unstructured":"Selfridge JE, Wilkins HM, Lezi E, Carl SM, Koppel S, Funk E, et al. Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure. J Bioenerg Biomembr. 2015;47:1\u201311 (Epub ahead of print).","journal-title":"J Bioenerg Biomembr."},{"key":"202_CR27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/ejn.12088","volume":"37","author":"N Pipatpiboon","year":"2013","unstructured":"Pipatpiboon N, Pintana H, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. Eur J Neurosci. 2013;37:839\u201349.","journal-title":"Eur J Neurosci"},{"key":"202_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1742-2094-8-135","volume":"8","author":"J Choi","year":"2011","unstructured":"Choi J, Min HJ, Shin JS. Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures. J Neuroinflammation. 2011;8:135.","journal-title":"J Neuroinflammation."},{"issue":"7","key":"202_CR29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.bbi.2011.03.018","volume":"25","author":"A Vezzani","year":"2011","unstructured":"Vezzani A, Maroso M, Balosso S, Sanchez MA, Bartfai T. IL-1 receptor\/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun. 2011;25(7):1281\u20139.","journal-title":"Brain Behav Immun"},{"key":"202_CR30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004647-200101000-00002","volume":"21","author":"PH Chan","year":"2001","unstructured":"Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21:2\u201314.","journal-title":"J Cereb Blood Flow Metab"},{"key":"202_CR31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2013.03.020","volume":"707","author":"S Suda","year":"2013","unstructured":"Suda S, Katsura K, Kanamaru T, Saito M, Katayama Y. Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation. Eur J Pharmacol. 2013;707:26\u201331.","journal-title":"Eur J Pharmacol"},{"key":"202_CR32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s002040050616","volume":"73","author":"SO Jacobsson","year":"1999","unstructured":"Jacobsson SO, Cassel GE, Persson SA. Increased levels of nitrogen oxides and lipid peroxidation in the rat brain after soman-induced seizures. Arch Toxicol. 1999;73:269\u201373.","journal-title":"Arch Toxicol"},{"key":"202_CR33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.eplepsyres.2011.09.021","volume":"100","author":"J Milder","year":"2012","unstructured":"Milder J, Patel M. Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res. 2012;100:295\u2013303.","journal-title":"Epilepsy Res"},{"key":"202_CR34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ceca.2005.06.019","volume":"38","author":"W Paschen","year":"2005","unstructured":"Paschen W, Mengesdorf T. Endoplasmic reticulum stress response and neurodegeneration. Cell Calcium. 2005;38:409\u201315.","journal-title":"Cell Calcium"},{"key":"202_CR35","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","volume":"181","author":"NG Innamorato","year":"2008","unstructured":"Innamorato NG, Rojo AI, Garc\u00eda-Yag\u00fce AJ, Yamamoto M, de Ceballos ML, Cuadrado A. The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol. 2008;181:680\u20139.","journal-title":"J Immunol."},{"key":"202_CR36","doi-asserted-by":"crossref","first-page":"878030","DOI":"10.1155\/2012\/878030","volume":"2012","author":"S Petri","year":"2012","unstructured":"Petri S, K\u00f6rner S, Kiaei M. Nrf2\/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS. Neurol Res Int. 2012;2012:878030.","journal-title":"Neurol Res Int."},{"key":"202_CR37","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jnr.20444","volume":"80","author":"E Huang","year":"2005","unstructured":"Huang E, Ong WY, Go ML, Garey LJ. Heme oxygenase-1 activity after excitotoxic injury: immunohistochemical localization of bilirubin in neurons and astrocytes and deleterious effects of heme oxygenase inhibition on neuronal survival after kainate treatment. J Neurosci Res. 2005;80:268\u201378.","journal-title":"J Neurosci Res"},{"key":"202_CR38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.expneurol.2011.09.001","volume":"232","author":"EA Jeong","year":"2011","unstructured":"Jeong EA, Jeon BT, Shin HJ, Kim N, Lee DH, Kim HJ, et al. Ketogenic diet-induced peroxisome proliferator-activated receptor-\u03b3 activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. Exp Neurol. 2011;232:195\u2013202.","journal-title":"Exp Neurol"},{"key":"202_CR39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.nbd.2011.08.007","volume":"45","author":"RJ Claycomb","year":"2012","unstructured":"Claycomb RJ, Hewett SJ, Hewett JA. Neuromodulatory role of endogenous interleukin-1\u03b2 in acute seizures: possible contribution of cyclooxygenase-2. Neurobiol Dis. 2012;45:234\u201342.","journal-title":"Neurobiol Dis"}],"updated-by":[{"DOI":"10.1186\/s12868-017-0338-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000}}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-015-0202-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T16:26:26Z","timestamp":1599755186000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2202\/16\/72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,30]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["202"],"URL":"https:\/\/doi.org\/10.1186\/s12868-015-0202-2","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12868-017-0338-3","asserted-by":"object"}]},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,30]]},"article-number":"72"}}