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The<jats:italic>HCFC1<\/jats:italic>gene encodes a transcriptional co-factor that regulates cell proliferation, and previous studies suggest that HCFC1 regulates NPC number and differentiation. However, the molecular mechanism underlying these cellular deficits has not been completely characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here we created a zebrafish harboring mutations in the<jats:italic>hcfc1a<\/jats:italic>gene (the<jats:italic>hcfc1a<\/jats:italic><jats:sup>co60\/+<\/jats:sup>allele), one ortholog of<jats:italic>HCFC1<\/jats:italic>, and utilized immunohistochemistry and RNA-sequencing technology to understand the function of<jats:italic>hcfc1a<\/jats:italic>during neural development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The<jats:italic>hcfc1a<\/jats:italic><jats:sup>co60\/+<\/jats:sup>allele results in an increased number of NPCs and increased expression of neuronal and glial markers. These neural developmental deficits are associated with larval hypomotility and the abnormal expression of<jats:italic>asxl1<\/jats:italic>, a polycomb transcription factor, which we identified as a downstream effector of<jats:italic>hcfc1a<\/jats:italic>. Inhibition of<jats:italic>asxl1<\/jats:italic>activity and\/or expression in larvae harboring the<jats:italic>hcfc1a<\/jats:italic><jats:sup>co60\/+<\/jats:sup>allele completely restored the number of NPCs to normal levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, our data demonstrate that<jats:italic>hcfc1a<\/jats:italic>regulates NPC number, NPC proliferation, motor behavior, and brain development.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12868-020-00577-1","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T14:02:53Z","timestamp":1591797773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain"],"prefix":"10.1186","volume":"21","author":[{"given":"Victoria L.","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel F.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeli G.","family":"Reyes-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-1587","authenticated-orcid":false,"given":"Anita M.","family":"Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"issue":"8","key":"577_CR1","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1093\/hmg\/ddr033","volume":"20","author":"S Trazzi","year":"2011","unstructured":"Trazzi S, Mitrugno VM, Valli E, Fuchs C, Rizzi S, Guidi S, et al. 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