{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:55:11Z","timestamp":1784548511438,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"crossref","award":["4906"],"award-info":[{"award-number":["4906"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>SYNE1<\/jats:italic>\n                      ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of\n                      <jats:italic>SYNE1<\/jats:italic>\n                      ataxia is more complex than the first published cases with pure cerebellar signs indicated. The aim of this study was to characterize eye movement alterations in the first diagnosed Hungarian\n                      <jats:italic>SYNE1<\/jats:italic>\n                      ataxia patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Saccades and antisaccades were examined with an eye tracker device in 3\n                      <jats:italic>SYNE1<\/jats:italic>\n                      (one patient has two frameshift mutations [c.8515_8516insA, p.Met2839Asnfs*53 and c.11594_11595insG, p.Glu3866*] in a compound heterozygous state, whereas two subjects have a splicing variant [c.23146-2A\u2009&gt;\u2009G] in a homozygous state), 6 Friedreich ataxia (FA) patients and 12 healthy controls. Besides that, detailed clinical phenotyping and comprehensive neuropsychological assessment were carried out in all patients with ataxia.\n                    <\/jats:p>\n                    <jats:p>\n                      In addition to the characteristic cerebellar alterations, pyramidal signs and polyneuropathy were observed at least in 2\n                      <jats:italic>SYNE1<\/jats:italic>\n                      ataxia patients, for which no other underlying reason was found. The eye tracking assessment revealed hypometric saccades in the longer amplitude (18.4\u00b0) saccadic paradigm in all\n                      <jats:italic>SYNE1<\/jats:italic>\n                      patients, whereas 2 out of 3\n                      <jats:italic>SYNE1<\/jats:italic>\n                      subjects performed slow saccades as well. In the antisaccade task, higher incorrect ratios of antisaccades were demonstrated in\n                      <jats:italic>SYNE1<\/jats:italic>\n                      patients compared to healthy controls, showing inverse correlation with working memory test results. The corresponding data of FA patients was dispersed over a wide range, partially overlapping with control data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The current study draws attention to the presence of eye movement disorders in patients with\n                      <jats:italic>SYNE1<\/jats:italic>\n                      ataxia and demonstrates that alterations in the antisaccade paradigm may be related to working memory deficits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12868-021-00612-9","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T12:22:21Z","timestamp":1612182141000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study"],"prefix":"10.1186","volume":"22","author":[{"given":"Laszlo","family":"Szpisjak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Szaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Salamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola L.","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Szepfalusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Veres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balint","family":"Kincses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Maroti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Kalmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Rydzanicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Ploski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Klivenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7980","authenticated-orcid":false,"given":"Denes","family":"Zadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"612_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/ng1927","volume":"39","author":"F Gros-Louis","year":"2007","unstructured":"Gros-Louis F, Dupr\u00e9 N, Dion P, Fox MA, Laurent S, Verreault S, et al. Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia. Nat Genet. 2007;39:80\u20135.","journal-title":"Nat Genet"},{"key":"612_CR2","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1093\/brain\/aww079","volume":"139","author":"M Synofzik","year":"2016","unstructured":"Synofzik M, Smets K, Mallaret M, Di Bella D, Gallenm\u00fcller C, Baets J, et al. SYNE1 ataxia is common recessive ataxia with major non-cerebellar features: a large multi-centre study. Brain. 2016;139:1378\u201393.","journal-title":"Brain"},{"key":"612_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ana.21143","volume":"62","author":"N Dupr\u00e9","year":"2007","unstructured":"Dupr\u00e9 N, Gros-Louis F, Chrestian N, Verreault S, Brunet D, de Verteuil D, et al. Clinical and genetic study of autosomal recessive cerebellar ataxia type 1. Ann Neurol. 2007;62:93\u20138.","journal-title":"Ann Neurol"},{"key":"612_CR4","first-page":"1296","volume":"70","author":"A Noreau","year":"2013","unstructured":"Noreau A, Bourassa CV, Szuto A, Levert A, Dobrzeniecka S, Gauthier J, et al. SYNE1 mutations in autosomal recessive cerebellar ataxia. JAMA Neurol. 2013;70:1296\u2013331.","journal-title":"JAMA Neurol"},{"key":"612_CR5","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1212\/WNL.0b013e3182815529","volume":"80","author":"Y Izumi","year":"2013","unstructured":"Izumi Y, Miyamoto R, Morino H, Yoshizawa A, Nishinaka K, Udaka F, et al. Cerebellar ataxia with SYNE1 mutation accompanying motor neuron disease. Neurology. 2013;80:600\u20131.","journal-title":"Neurology"},{"key":"612_CR6","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/jamaneurol.2014.1944","volume":"71","author":"BL Fogel","year":"2014","unstructured":"Fogel BL, Lee H, Deignan JL, Strom SP, Kantarci S, Wang X, et al. Exome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia. JAMA Neurol. 2014;71:1237\u201346.","journal-title":"JAMA Neurol"},{"key":"612_CR7","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12881-015-0180-3","volume":"16","author":"W Hamza","year":"2015","unstructured":"Hamza W, Ali Pacha L, Hamadouche T, Muller J, Drouot N, Ferrat F, et al. Molecular and clinical study of a cohort of 110 Algerian patients with autosomal recessive ataxia. BMC Med Genet. 2015;16:36.","journal-title":"BMC Med Genet"},{"key":"612_CR8","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1093\/brain\/aww115","volume":"139","author":"I Mademan","year":"2016","unstructured":"Mademan I, Harmuth F, Giordano I, Timmann D, Magri S, Deconinck T, et al. Multisystemic SYNE1 ataxia: confirming the high frequency and extending the mutational and phenotypic spectrum. Brain. 2016;139:e46.","journal-title":"Brain"},{"key":"612_CR9","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1093\/hmg\/ddp290","volume":"18","author":"R Attali","year":"2009","unstructured":"Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, et al. Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis. Hum Mol Genet. 2009;18:3462\u20139.","journal-title":"Hum Mol Genet"},{"key":"612_CR10","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1093\/hmg\/ddm238","volume":"16","author":"Q Zhang","year":"2007","unstructured":"Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, et al. Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum Mol Genet. 2007;16:2816\u201333.","journal-title":"Hum Mol Genet"},{"key":"612_CR11","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.yjmcc.2009.11.006","volume":"48","author":"MJ Puckelwartz","year":"2010","unstructured":"Puckelwartz MJ, Kessler EJ, Kim G, Dewitt MM, Zhang Y, Earley JU, et al. Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol. 2010;48:600\u20138.","journal-title":"J Mol Cell Cardiol"},{"key":"612_CR12","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1136\/jmedgenet-2013-101644","volume":"50","author":"JH Schuurs-Hoeijmakers","year":"2013","unstructured":"Schuurs-Hoeijmakers JH, Vulto-van Silfhout AT, Vissers LE, van de Vondervoort II, van Bon BW, de Ligt J, et al. Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing. J Med Genet. 2013;50:802\u201311.","journal-title":"J Med Genet"},{"key":"612_CR13","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3389\/fneur.2019.01387","volume":"10","author":"H Dong","year":"2020","unstructured":"Dong H, Luo Y, Fan S, Yin B, Weng C, Peng B. Screening gene mutations in Chinese patients with benign essential blepharospasm. Front Neurol. 2020;10:1387.","journal-title":"Front Neurol"},{"key":"612_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.neuron.2012.11.002","volume":"77","author":"TW Yu","year":"2013","unstructured":"Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, et al. Using whole-exome sequencing to identify inherited causes of autism. Neuron. 2013;77:259\u201373.","journal-title":"Neuron"},{"key":"612_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13229-015-0034-z","volume":"6","author":"AJ Griswold","year":"2015","unstructured":"Griswold AJ, Dueker ND, Van Booven D, Rantus JA, Jaworski JM, Slifer SH, et al. Targeted massively parallel sequencing of autism spectrum disorder-associated genes in a case control cohort reveals rare loss-of-function risk variants. Mol Autism. 2015;6:43.","journal-title":"Mol Autism"},{"key":"612_CR16","doi-asserted-by":"publisher","first-page":"e112745","DOI":"10.1371\/journal.pone.0112745","volume":"9","author":"M Guipponi","year":"2014","unstructured":"Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, et al. Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. PLoS ONE. 2014;9:e112745.","journal-title":"PLoS ONE"},{"key":"612_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.4081\/cp.2018.1071","volume":"8","author":"L Swan","year":"2018","unstructured":"Swan L, Cardinal J, Coman D. SYNE1-related autosomal recessive cerebellar ataxia, congenital cerebellar hypoplasia, and cognitive impairment. Clin Pract. 2018;8:1071.","journal-title":"Clin Pract"},{"key":"612_CR18","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/mds.26810","volume":"31","author":"MT Gama","year":"2016","unstructured":"Gama MT, Houle G, Noreau A, Dionne-Laporte A, Dion PA, Rouleau GA, et al. SYNE1 mutation cause autosomal-recessive ataxia with retained reflexes in Brazilian patients. Mov Disord. 2016;31:1754\u20136.","journal-title":"Mov Disord"},{"key":"612_CR19","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.parkreldis.2018.08.009","volume":"58","author":"JS Kim","year":"2019","unstructured":"Kim JS, Kim AR, Youn J, Lee C, Kim NS, Park WY, et al. Identifying SYNE1 ataxia and extending the mutational spectrum in Korea. Parkinsonism Relat Disord. 2019;58:74\u20138.","journal-title":"Parkinsonism Relat Disord"},{"key":"612_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13023-019-1013-9","volume":"14","author":"R De Silva","year":"2019","unstructured":"De Silva R, Greenfield J, Cook A, Bonney H, Vallortigara J, Hunt B, et al. Guidelines on the diagnosis of the progressive ataxias. Orphanet J Rare Dis. 2019;14:51.","journal-title":"Orphanet J Rare Dis"},{"key":"612_CR21","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3389\/fneur.2019.00589","volume":"10","author":"B Kincses","year":"2019","unstructured":"Kincses B, Herak BJ, Szabo N, Bozsik B, Farago P, Kiraly A, et al. Gray matter atrophy to explain subclinical oculomotor deficit in multiple sclerosis. Front Neurol. 2019;10:589.","journal-title":"Front Neurol"},{"key":"612_CR22","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00221-006-0462-2","volume":"174","author":"I Evdokimidis","year":"2006","unstructured":"Evdokimidis I, Tsekou H, Smyrnis N. The mirror antisaccade task: direction-amplitude interaction and spatial accuracy characteristics. Exp Brain Res. 2006;174:304\u201311.","journal-title":"Exp Brain Res"},{"key":"612_CR23","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1093\/brain\/awr009","volume":"134","author":"P Federighi","year":"2011","unstructured":"Federighi P, Cevenini G, Dotti MT, Rosini F, Pretegiani E, Federico A, et al. Differences in saccade dynamics between spinocerebellar ataxia 2 and late-onset cerebellar ataxias. Brain. 2011;134:879\u201391.","journal-title":"Brain"},{"key":"612_CR24","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/gps.1610","volume":"21","author":"E Mioshi","year":"2006","unstructured":"Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke\u2019s cognitive examination revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21:1078\u201385.","journal-title":"Int J Geriatr Psychiatry"},{"key":"612_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1076\/clin.12.4.513.7233","volume":"12","author":"H Marilyn","year":"1998","unstructured":"Marilyn H, Guy P. Sources of age differences on the Rey-Osterrieth complex figure test. Clin Neuropsychol. 1998;12:513\u201324.","journal-title":"Clin Neuropsychol"},{"key":"612_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/geronb\/60.5.P223","volume":"60","author":"KL Bopp","year":"2005","unstructured":"Bopp KL, Verhaeghen P. Aging and verbal memory span: a meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2005;60:223\u201333.","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"612_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/WNO.0000000000000167","volume":"35","author":"M Moscovich","year":"2015","unstructured":"Moscovich M, Okun MS, Favilla C, Figueroa KP, Pulst SM, Perlman S, et al. Clinical evaluation of eye movements in spinocerebellar ataxias: a prospective multicenter study. J Neuroophthalmol. 2015;35:16\u201321.","journal-title":"J Neuroophthalmol"},{"key":"612_CR28","doi-asserted-by":"publisher","first-page":"15284","DOI":"10.1038\/s41598-017-15127-9","volume":"7","author":"LL Mariani","year":"2017","unstructured":"Mariani LL, Rivaud-P\u00e9choux S, Charles P, Ewenczyk C, Meneret A, Monga BB, et al. Comparing ataxias with oculomotor apraxia: a multimodal study of AOA1, AOA2 and AT focusing on video-oculography and alpha-fetoprotein. Sci Rep. 2017;7:15284.","journal-title":"Sci Rep"},{"key":"612_CR29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/PL00005749","volume":"11","author":"B Fischer","year":"1997","unstructured":"Fischer B, Weber H. Effects of stimulus conditions on performance of antisaccades in man. Exp Brain Res. 1997;11:191\u2013200.","journal-title":"Exp Brain Res"},{"key":"612_CR30","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00221-006-0817-8","volume":"179","author":"JM Dafoe","year":"2007","unstructured":"Dafoe JM, Armstrong IT, Munoz DP. The influence of stimulus direction and eccentricity on pro- and antisaccades in humans. Exp Brain Res. 2007;179:563\u201370.","journal-title":"Exp Brain Res"},{"key":"612_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00221-002-1207-5","volume":"147","author":"N Smyrnis","year":"2002","unstructured":"Smyrnis N, Evdokimidis I, Stefanis NC, Constantinidis TS, Avramopoulos D, Theleritis C, et al. The antisaccade task in a sample of 2006 young males. II. Effects of task parameters. Exp Brain Res. 2002;147:53\u201363.","journal-title":"Exp Brain Res."},{"key":"612_CR32","first-page":"1","volume":"25","author":"EHX Thomas","year":"2018","unstructured":"Thomas EHX, Rossell SL, Myles JB, Tan EJ, Neill E, Carruthers SP, et al. Working memory and attention influence antisaccade error rate in schizophrenia. J Int Neuropsychol Soc. 2018;25:1\u201310.","journal-title":"J Int Neuropsychol Soc."},{"key":"612_CR33","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3389\/fneur.2018.00274","volume":"9","author":"E Pretegiani","year":"2018","unstructured":"Pretegiani E, Piu P, Rosini F, Federighi P, Serchi V, Tumminelli G, et al. Anti-saccades in cerebellar ataxias reveal a contribution of the cerebellum in executive functions. Front Neurol. 2018;9:274.","journal-title":"Front Neurol"},{"key":"612_CR34","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bandc.2014.07.007","volume":"91","author":"R Rodriguez-Labrada","year":"2014","unstructured":"Rodriguez-Labrada R, Velazquez-Perez L, Aguilera-Rodriguez R, Seifried-Oberschmidt C, Pena-Acosta A, Canales-Ochoa N, et al. Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: evidence from antisaccadic eye movements. Brain Cog. 2014;91:28\u201334.","journal-title":"Brain Cog"},{"key":"612_CR35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/ana.410430306","volume":"43","author":"S Rivaud-Pechoux","year":"1998","unstructured":"Rivaud-Pechoux S, Durr A, Gaymard B, Cancel G, Ploner CJ, Agid Y, et al. Eye movement abnormalities correlate with genotype in autosomal dominant cerebellar ataxia type I. Ann Neurol. 1998;43:297\u2013302.","journal-title":"Ann Neurol"},{"key":"612_CR36","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/brain\/121.4.561","volume":"121","author":"JD Schmahmann","year":"1998","unstructured":"Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561\u201379.","journal-title":"Brain"}],"updated-by":[{"DOI":"10.1186\/s12868-021-00621-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000}}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-021-00612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12868-021-00612-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-021-00612-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:12:49Z","timestamp":1627643569000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurosci.biomedcentral.com\/articles\/10.1186\/s12868-021-00612-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["612"],"URL":"https:\/\/doi.org\/10.1186\/s12868-021-00612-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-79409\/v1","asserted-by":"object"}]},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"assertion":[{"value":"17 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12868-021-00621-8","URL":"https:\/\/doi.org\/10.1186\/s12868-021-00621-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Written informed consent was obtained from the patients for the publication of this study (Regional Human Biomedical Research Ethics Committee of the University of Szeged, registration number 44\/2016). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}