{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:12:28Z","timestamp":1785795148323,"version":"3.56.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05130"],"award-info":[{"award-number":["16H05130"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K13112"],"award-info":[{"award-number":["16K13112"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients. Narcolepsy model mice also show cataplexy, and its incidence increases in response to positive emotion-inducing stimuli such as chocolate and female courtship. Although such observation indicates a positive emotion-related nature of cataplexy in narcolepsy mice, they also show cataplexy without any apparent triggering stimulus\u2009~\u2009(spontaneous cataplexy). Therefore, we hypothesized that some spontaneous cataplexy in narcoleptic mice might indicate the remembering of happy moments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>To test our hypothesis, we did a conditioned place preference test on orexin\/hypocretin neuron-ablated (ORX-AB) mice, one of the animal models of human narcolepsy, and counted the number of cataplexy-like behaviors. ORX-AB mice successfully remembered the chocolate-associated chamber, and the number of cataplexy-like behaviors significantly increased in the chocolate-associated chamber but not in the control chamber. In addition, ORX-AB mice remembered the aversive odor-associated chamber and avoided entering without affecting the number of cataplexy-like behaviors. Finally, similar activation of the nucleus accumbens, a positive emotion-related nucleus, was observed during both spontaneous and chocolate-induced cataplexy behaviors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results support our hypothesis and will promote the usefulness of a narcolepsy mice model in emotion research and serve as a basis for a better understanding of cataplexy in narcolepsy patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12868-022-00772-2","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T16:03:20Z","timestamp":1672243400000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test"],"prefix":"10.1186","volume":"23","author":[{"given":"Mayuko","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-3610","authenticated-orcid":false,"given":"Tomoyuki","family":"Kuwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"772_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","volume":"27","author":"TC Thannickal","year":"2000","unstructured":"Thannickal TC, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27:469\u201374.","journal-title":"Neuron"},{"key":"772_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","volume":"98","author":"RM Chemelli","year":"1999","unstructured":"Chemelli RM, et al. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation. Cell. 1999;98:437\u201351.","journal-title":"Cell"},{"key":"772_CR3","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1073\/pnas.0400590101","volume":"101","author":"M Mieda","year":"2004","unstructured":"Mieda M, et al. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci USA. 2004;101:4649\u201354.","journal-title":"Proc Natl Acad Sci USA"},{"key":"772_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","volume":"98","author":"L Lin","year":"1999","unstructured":"Lin L, et al. 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J Neuropsychi Clin Neurosci. 2005;17:45\u201350.","journal-title":"J Neuropsychi Clin Neurosci"},{"key":"772_CR7","doi-asserted-by":"publisher","first-page":"4958","DOI":"10.1038\/s41598-020-61823-4","volume":"10","author":"J Su","year":"2020","unstructured":"Su J, et al. Involvement of the nucleus accumbens in chocolate-induced cataplexy. Sci Rep. 2020;10:4958.","journal-title":"Sci Rep"},{"key":"772_CR8","doi-asserted-by":"publisher","first-page":"9743","DOI":"10.1523\/JNEUROSCI.0499-13.2013","volume":"33","author":"Y Oishi","year":"2013","unstructured":"Oishi Y, et al. Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013;33:9743\u201351.","journal-title":"J Neurosci"},{"key":"772_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s42003-021-01696-z","volume":"4","author":"T Kuwaki","year":"2021","unstructured":"Kuwaki T, Kanno K. Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice. Comm Biol. 2021;4:165.","journal-title":"Comm Biol"},{"key":"772_CR10","doi-asserted-by":"publisher","first-page":"6495","DOI":"10.1523\/JNEUROSCI.0073-14.2014","volume":"34","author":"S Tabuchi","year":"2014","unstructured":"Tabuchi S, et al. Conditional ablation of orexin\/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J Neurosci. 2014;34:6495\u2013509.","journal-title":"J Neurosci"},{"key":"772_CR11","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/sleep\/30.11.1417","volume":"30","author":"RA Espa\u00f1a","year":"2007","unstructured":"Espa\u00f1a RA, et al. Running promotes wakefulness and increases cataplexy in orexin knockout mice. 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