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Patients diagnosed with Rett syndrome have increased risk for epilepsy as well as problems with anxiety and social communication. Using the zebrafish\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>Q63X<\/jats:italic>\n                      <\/jats:sup>\n                      line, this study aimed to increase our understanding of the role of Mecp2 function in regulation of pharmacologically-induced hyperlocomotion, developmental social preference, and adult socialization, anxiety-related behaviour, and baseline cortisol levels. To determine responses of\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      zebrafish to a stimulating convulsant, general locomotor activity was measured at 5\u00a0days post-fertilization (dpf) in sibling\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>+\/+<\/jats:sup>\n                      ,\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                      , and\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      fish after treatment with a GABA\n                      <jats:sub>A<\/jats:sub>\n                      receptor antagonist pentylenetetrazol (PTZ) at varying concentrations. Responses to social stimulus were investigated in juvenile (21 dpf) and adult\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      and\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>+\/+<\/jats:sup>\n                      fish. Anxiety responses to a novel tank and whole-body cortisol levels were also measured in adult\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      and control\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>+\/+<\/jats:sup>\n                      zebrafish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The behavioural tests showed that\n                      <jats:italic>mecp2<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      zebrafish displayed hypolocomotion at the larval stage, along with increased freezing time and thigmotaxis, and higher whole-body cortisol levels in adulthood. However, the hyper-locomotion response to PTZ at 5 dpf and social preference for visual social stimulus at 21 dpf and in adulthood were not affected by the lack of functional Mecp2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Functional Mecp2 modulated larval locomotion and behavioural anxiety at different ages and adult cortisol levels, but\n                      <jats:italic>mecp2<\/jats:italic>\n                      null-mutation did not alter adult locomotion and socialization, and developmental sociability and PTZ-induced hyperlocomotion in zebrafish. Given the variability reported in patients and in rodent\n                      <jats:italic>Mecp2<\/jats:italic>\n                      knockout models, studies using zebrafish can explore vital elements of MECP2\u2019s role across development and improve our understanding of neural mechanisms underlying neurodevelopmental disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12868-025-00946-8","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:55:34Z","timestamp":1751360134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Zebrafish mecp2 null-mutation increases anxiety and cortisol levels but no change in adult social preference and larval chemically-induced hyperlocomotion"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-2539","authenticated-orcid":false,"given":"Soaleha","family":"Shams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cronell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Landin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-8363","authenticated-orcid":false,"given":"Thomas","family":"Pietri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Ekehorn","family":"Gimdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-3423","authenticated-orcid":false,"given":"Petronella","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-3910","authenticated-orcid":false,"given":"Lars","family":"Westberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"7829","key":"946_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-020-2574-4","volume":"586","author":"CH Li","year":"2020","unstructured":"Li CH, Coffey EL, Dall\u2019Agnese A, Hannett NM, Tang X, Henninger JE, Platt JM, Oksuz O, Zamudio AV, Afeyan LK, et al. 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