{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:27:41Z","timestamp":1777487261688,"version":"3.51.4"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DA007027"],"award-info":[{"award-number":["T32DA007027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH084894"],"award-info":[{"award-number":["R01MH084894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"DOI":"10.1186\/s12868-026-01003-8","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:05:21Z","timestamp":1774325121000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice"],"prefix":"10.1186","volume":"27","author":[{"given":"Michael","family":"Fiorillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Gonz\u00e1lez-Maeso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"1003_CR1","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/jamapsychiatry.2024.2185","volume":"81","author":"Y Zeng","year":"2024","unstructured":"Zeng Y, Chourpiliadis C, Hammar N, Seitz C, Valdimarsd\u00f3ttir UA, Fang F, et al. Inflammatory Biomarkers and Risk of Psychiatric Disorders. JAMA Psychiatry. 2024;81:1118\u201329. https:\/\/doi.org\/10.1001\/jamapsychiatry.2024.2185.","journal-title":"JAMA Psychiatry"},{"key":"1003_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","volume":"8","author":"W Zhang","year":"2023","unstructured":"Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther. 2023;8:267. https:\/\/doi.org\/10.1038\/s41392-023-01486-5.","journal-title":"Signal Transduct Target Ther"},{"key":"1003_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","volume":"13","author":"RG Baker","year":"2011","unstructured":"Baker RG, Hayden MS, Ghosh S. NF-\u03baB, inflammation, and metabolic disease. Cell Metab. 2011;13:11\u201322. https:\/\/doi.org\/10.1016\/j.cmet.2010.12.008.","journal-title":"Cell Metab"},{"key":"1003_CR4","doi-asserted-by":"publisher","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","volume":"16","author":"A Adamu","year":"2024","unstructured":"Adamu A, Li S, Gao F, Xue G. The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets. Front Aging Neurosci. 2024;16:1347987. https:\/\/doi.org\/10.3389\/fnagi.2024.1347987.","journal-title":"Front Aging Neurosci"},{"key":"1003_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s13205-025-04468-2","volume":"15","author":"V Blossom","year":"2025","unstructured":"Blossom V, Ullal SD, D\u2019Souza MM, Ranade AV, Kumar NA, Rai R. Implicating neuroinflammation in hippocampus, prefrontal cortex and amygdala with cognitive deficit: a narrative review. 3 Biotech. 2025;15:320. https:\/\/doi.org\/10.1007\/s13205-025-04468-2.","journal-title":"3 Biotech"},{"key":"1003_CR6","doi-asserted-by":"publisher","first-page":"1181973","DOI":"10.3389\/fimmu.2023.1181973","volume":"14","author":"R Yin","year":"2023","unstructured":"Yin R, Zhang K, Li Y, Tang Z, Zheng R, Ma Y, et al. Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation. Front Immunol. 2023;14:1181973. https:\/\/doi.org\/10.3389\/fimmu.2023.1181973.","journal-title":"Front Immunol"},{"key":"1003_CR7","doi-asserted-by":"publisher","unstructured":"Skrzypczak-Wiercioch A, Sa\u0142at K. Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use. Mol Basel Switz. 2022;27. https:\/\/doi.org\/10.3390\/molecules27175481.","DOI":"10.3390\/molecules27175481"},{"key":"1003_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O\u2019Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46\u201356. https:\/\/doi.org\/10.1038\/nrn2297.","journal-title":"Nat Rev Neurosci"},{"key":"1003_CR9","doi-asserted-by":"publisher","first-page":"6547","DOI":"10.1038\/s41598-023-32798-9","volume":"13","author":"H Jung","year":"2023","unstructured":"Jung H, Lee D, You H, Lee M, Kim H, Cheong E, et al. LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment. Sci Rep. 2023;13:6547. https:\/\/doi.org\/10.1038\/s41598-023-32798-9.","journal-title":"Sci Rep"},{"key":"1003_CR10","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.2337\/dc13-0451","volume":"36","author":"M Tr\u00f8seid","year":"2013","unstructured":"Tr\u00f8seid M, Nestvold TK, Rudi K, Thoresen H, Nielsen EW, Lappeg\u00e5rd KT. Plasma lipopolysaccharide is closely associated with glycemic control and abdominal obesity: evidence from bariatric surgery. Diabetes Care. 2013;36:3627\u201332. https:\/\/doi.org\/10.2337\/dc13-0451.","journal-title":"Diabetes Care"},{"key":"1003_CR11","doi-asserted-by":"publisher","first-page":"594150","DOI":"10.3389\/fimmu.2020.594150","volume":"11","author":"S Mohammad","year":"2020","unstructured":"Mohammad S, Thiemermann C. Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions. Front Immunol. 2020;11:594150. https:\/\/doi.org\/10.3389\/fimmu.2020.594150.","journal-title":"Front Immunol"},{"key":"1003_CR12","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3389\/fimmu.2017.01064","volume":"8","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Cong L, Jaber V, Lukiw WJ. Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer\u2019s Disease Brain. Front Immunol. 2017;8:1064. https:\/\/doi.org\/10.3389\/fimmu.2017.01064.","journal-title":"Front Immunol"},{"key":"1003_CR13","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1136\/gutjnl-2017-314759","volume":"67","author":"BR Stevens","year":"2018","unstructured":"Stevens BR, Goel R, Seungbum K, Richards EM, Holbert RC, Pepine CJ, et al. Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression. Gut. 2018;67:1555\u20137. https:\/\/doi.org\/10.1136\/gutjnl-2017-314759.","journal-title":"Gut"},{"key":"1003_CR14","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1038\/s41380-023-02274-x","volume":"28","author":"AM Jaster","year":"2023","unstructured":"Jaster AM, Gonz\u00e1lez-Maeso J. Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics. Mol Psychiatry. 2023;28:3595\u2013612. https:\/\/doi.org\/10.1038\/s41380-023-02274-x.","journal-title":"Mol Psychiatry"},{"key":"1003_CR15","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/s41593-022-01177-4","volume":"25","author":"AC Kwan","year":"2022","unstructured":"Kwan AC, Olson DE, Preller KH, Roth BL. The neural basis of psychedelic action. Nat Neurosci. 2022;25:1407\u201319. https:\/\/doi.org\/10.1038\/s41593-022-01177-4.","journal-title":"Nat Neurosci"},{"key":"1003_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/bs.irn.2025.04.011","volume":"181","author":"CD Nichols","year":"2025","unstructured":"Nichols CD, Foster TP. Serotonin, immune function, and psychedelics as potent anti-inflammatories. Int Rev Neurobiol. 2025;181:45\u201376. https:\/\/doi.org\/10.1016\/bs.irn.2025.04.011.","journal-title":"Int Rev Neurobiol"},{"key":"1003_CR17","doi-asserted-by":"publisher","first-page":"111278","DOI":"10.1016\/j.pnpbp.2025.111278","volume":"137","author":"JL de Deus","year":"2025","unstructured":"de Deus JL, Maia JM, Soriano RN, Amorim MR, Branco LGS. Psychedelics in neuroinflammation: Mechanisms and therapeutic potential. Prog Neuropsychopharmacol Biol Psychiatry. 2025;137:111278. https:\/\/doi.org\/10.1016\/j.pnpbp.2025.111278.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1003_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/7854_2017_478","volume":"36","author":"JF L\u00f3pez-Gim\u00e9nez","year":"2018","unstructured":"L\u00f3pez-Gim\u00e9nez JF, Gonz\u00e1lez-Maeso J. Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways. Curr Top Behav Neurosci. 2018;36:45\u201373. https:\/\/doi.org\/10.1007\/7854_2017_478.","journal-title":"Curr Top Behav Neurosci"},{"key":"1003_CR19","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.pharmr.2025.100059","volume":"77","author":"BR Cummins","year":"2025","unstructured":"Cummins BR, Billac GB, Nichols DE, Nichols CD. 5-HT2A receptors: Pharmacology and functional selectivity. Pharmacol Rev. 2025;77:100059. https:\/\/doi.org\/10.1016\/j.pharmr.2025.100059.","journal-title":"Pharmacol Rev"},{"key":"1003_CR20","doi-asserted-by":"publisher","first-page":"e106533","DOI":"10.1371\/journal.pone.0106533","volume":"9","author":"A Szabo","year":"2014","unstructured":"Szabo A, Kovacs A, Frecska E, Rajnavolgyi E. Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS ONE. 2014;9:e106533. https:\/\/doi.org\/10.1371\/journal.pone.0106533.","journal-title":"PLoS ONE"},{"key":"1003_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/psychoactives3010004","author":"E Ghasemi Gojani","year":"2024","unstructured":"Ghasemi Gojani E, Wang B, Li D, Kovalchuk O, Kovalchuk I. The Effects of Psilocybin on Lipopolysaccharide-Induced Inflammation in THP-1 Human Macrophages. Psychoactives. 2024. https:\/\/doi.org\/10.3390\/psychoactives3010004.","journal-title":"Psychoactives"},{"key":"1003_CR22","doi-asserted-by":"publisher","first-page":"111753","DOI":"10.1016\/j.intimp.2024.111753","volume":"130","author":"S Laabi","year":"2024","unstructured":"Laabi S, LeMmon C, Vogel C, Chacon M, Jimenez VM. Deciphering psilocybin: Cytotoxicity, anti-inflammatory effects, and mechanistic insights. Int Immunopharmacol. 2024;130:111753. https:\/\/doi.org\/10.1016\/j.intimp.2024.111753.","journal-title":"Int Immunopharmacol"},{"key":"1003_CR23","doi-asserted-by":"publisher","unstructured":"Koz\u0142owska U, Klimczak A, Wiatr K, Figiel M. The DMT and psilocin treatment changes CD11b+ activated microglia immunological phenotype. bioRxiv. 2021;2021.03.07.434103. https:\/\/doi.org\/10.1101\/2021.03.07.434103","DOI":"10.1101\/2021.03.07.434103"},{"key":"1003_CR24","doi-asserted-by":"publisher","first-page":"114940","DOI":"10.1016\/j.intimp.2025.114940","volume":"159","author":"S Laabi","year":"2025","unstructured":"Laabi S, LeMmon C, Vogel C, Chacon M, Jimenez VM. Psilocybin and psilocin regulate microglial immunomodulation and support neuroplasticity via serotonergic and AhR signaling. Int Immunopharmacol. 2025;159:114940. https:\/\/doi.org\/10.1016\/j.intimp.2025.114940.","journal-title":"Int Immunopharmacol"},{"key":"1003_CR25","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/jpet.108.143461","volume":"327","author":"B Yu","year":"2008","unstructured":"Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther. 2008;327:316\u201323. https:\/\/doi.org\/10.1124\/jpet.108.143461.","journal-title":"J Pharmacol Exp Ther"},{"key":"1003_CR26","doi-asserted-by":"publisher","unstructured":"Robinson GI, Li D, Wang B, Rahman T, Gerasymchuk M, Hudson D, et al. Psilocybin and eugenol reduce inflammation in human 3D epiintestinal tissue. Life Basel Switz. 2023;13. https:\/\/doi.org\/10.3390\/life13122345.","DOI":"10.3390\/life13122345"},{"key":"1003_CR27","doi-asserted-by":"publisher","first-page":"22314","DOI":"10.1038\/s41598-020-79328-5","volume":"10","author":"SM Nkadimeng","year":"2020","unstructured":"Nkadimeng SM, Steinmann CML, Eloff JN. Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes. Sci Rep. 2020;10:22314. https:\/\/doi.org\/10.1038\/s41598-020-79328-5.","journal-title":"Sci Rep"},{"key":"1003_CR28","doi-asserted-by":"publisher","unstructured":"Zanikov T, Gerasymchuk M, Ghasemi Gojani E, Robinson GI, Asghari S, Groves A, et al. The effect of combined treatment of psilocybin and eugenol on lipopolysaccharide-induced brain inflammation in mice. Mol Basel Switz. 2023;28. https:\/\/doi.org\/10.3390\/molecules28062624.","DOI":"10.3390\/molecules28062624"},{"key":"1003_CR29","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1021\/acsptsci.3c00297","volume":"7","author":"TW Flanagan","year":"2024","unstructured":"Flanagan TW, Foster TP, Galbato TE, Lum PY, Louie B, Song G, et al. Serotonin-2 Receptor Agonists Produce Anti-inflammatory Effects through Functionally Selective Mechanisms That Involve the Suppression of Disease-Induced Arginase 1 Expression. ACS Pharmacol Transl Sci. 2024;7:478\u201392. https:\/\/doi.org\/10.1021\/acsptsci.3c00297.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"1003_CR30","doi-asserted-by":"publisher","first-page":"e75426","DOI":"10.1371\/journal.pone.0075426","volume":"8","author":"F Nau Jr","year":"2013","unstructured":"Nau F Jr, Yu B, Martin D, Nichols CD. Serotonin 5-HT2A Receptor Activation Blocks TNF-\u03b1 Mediated Inflammation In Vivo. PLoS ONE. 2013;8:e75426. https:\/\/doi.org\/10.1371\/journal.pone.0075426.","journal-title":"PLoS ONE"},{"key":"1003_CR31","doi-asserted-by":"publisher","first-page":"L191","DOI":"10.1152\/ajplung.00138.2013","volume":"308","author":"FJ Nau","year":"2015","unstructured":"Nau FJ, Miller J, Saravia J, Ahlert T, Yu B, Happel KI, et al. Serotonin 5-HT\u2082 receptor activation prevents allergic asthma in a mouse model. Am J Physiol Lung Cell Mol Physiol. 2015;308:L191\u2013198. https:\/\/doi.org\/10.1152\/ajplung.00138.2013.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1003_CR32","doi-asserted-by":"publisher","first-page":"13444","DOI":"10.1038\/s41598-019-49987-0","volume":"9","author":"TW Flanagan","year":"2019","unstructured":"Flanagan TW, Sebastian MN, Battaglia DM, Foster TP, Maillet EL, Nichols CD. Activation of 5-HT2 Receptors Reduces Inflammation in Vascular Tissue and Cholesterol Levels in High-Fat Diet-Fed Apolipoprotein E Knockout Mice. Sci Rep. 2019;9:13444. https:\/\/doi.org\/10.1038\/s41598-019-49987-0.","journal-title":"Sci Rep"},{"key":"1003_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08880-9","author":"EN Chung","year":"2025","unstructured":"Chung EN, Lee J, Polonio CM, Choi J, Akl CF, Kilian M, et al. Psychedelic control of neuroimmune interactions governing fear. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-08880-9.","journal-title":"Nature"},{"key":"1003_CR34","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1038\/s41380-024-02788-y","volume":"30","author":"G Floris","year":"2025","unstructured":"Floris G, Dabrowski KR, Zanda MT, Daws SE. Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. Mol Psychiatry. 2025;30:1801\u201316. https:\/\/doi.org\/10.1038\/s41380-024-02788-y.","journal-title":"Mol Psychiatry"},{"key":"1003_CR35","doi-asserted-by":"publisher","unstructured":"Borb\u00e9ly E, Varga V, Sz\u00f6gi T, Schuster I, Bozs\u00f3 Z, Penke B, et al. Impact of two neuronal sigma-1 receptor modulators, PRE084 and DMT, on neurogenesis and neuroinflammation in an A\u03b2(1\u201342)-injected, wild-type mouse model of AD. Int J Mol Sci. 2022;23. https:\/\/doi.org\/10.3390\/ijms23052514.","DOI":"10.3390\/ijms23052514"},{"key":"1003_CR36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13195-024-01462-3","volume":"16","author":"D Cheng","year":"2024","unstructured":"Cheng D, Lei Z-G, Chu K, Lam OJH, Chiang CY, Zhang Z-JN. N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer\u2019s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk. Alzheimers Res Ther. 2024;16:95. https:\/\/doi.org\/10.1186\/s13195-024-01462-3.","journal-title":"Alzheimers Res Ther"},{"key":"1003_CR37","doi-asserted-by":"publisher","first-page":"113245","DOI":"10.1016\/j.expneurol.2020.113245","volume":"327","author":"S Nardai","year":"2020","unstructured":"Nardai S, L\u00e1szl\u00f3 M, Szab\u00f3 A, Alp\u00e1r A, Hanics J, Zahola P, et al. N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats. Exp Neurol. 2020;327:113245. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113245.","journal-title":"Exp Neurol"},{"key":"1003_CR38","doi-asserted-by":"publisher","first-page":"115521","DOI":"10.1016\/j.bbr.2025.115521","volume":"485","author":"L da Silva Joaquim","year":"2025","unstructured":"da Silva Joaquim L, da Rosa LR, Strickert Y, Machado RS, Lanzzarin E, Bernardes G, et al. Ayahuasca reverses ischemic stroke-induced neuroinflammation and oxidative stress. Behav Brain Res. 2025;485:115521. https:\/\/doi.org\/10.1016\/j.bbr.2025.115521.","journal-title":"Behav Brain Res"},{"key":"1003_CR39","doi-asserted-by":"publisher","first-page":"108612","DOI":"10.1016\/j.neuropharm.2021.108612","volume":"192","author":"\u00cd Szab\u00f3","year":"2021","unstructured":"Szab\u00f3 \u00cd, Varga V\u00c9, Dvor\u00e1csk\u00f3 S, Farkas AE, K\u00f6rm\u00f6czi T, Berkecz R, et al. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology. 2021;192:108612. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108612.","journal-title":"Neuropharmacology"},{"key":"1003_CR40","doi-asserted-by":"publisher","first-page":"eadx5958","DOI":"10.1126\/sciadv.adx5958","volume":"11","author":"MJ L\u00e1szl\u00f3","year":"2025","unstructured":"L\u00e1szl\u00f3 MJ, Vigh JP, Kocsis AE, Porkol\u00e1b G, Hoyk Z, Polg\u00e1r T, et al. N,N-dimethyltryptamine mitigates experimental stroke by stabilizing the blood-brain barrier and reducing neuroinflammation. Sci Adv. 2025;11:eadx5958. https:\/\/doi.org\/10.1126\/sciadv.adx5958.","journal-title":"Sci Adv"},{"key":"1003_CR41","unstructured":"Algernon Pharmaceuticals Inc. DMT Program for Stroke. 2023."},{"key":"1003_CR42","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1139\/jpn.0441","volume":"29","author":"S Campbell","year":"2004","unstructured":"Campbell S, Macqueen G. The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci JPN. 2004;29:417\u201326.","journal-title":"J Psychiatry Neurosci JPN"},{"key":"1003_CR43","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/nn.4661","volume":"20","author":"J Lisman","year":"2017","unstructured":"Lisman J, Buzs\u00e1ki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20:1434\u201347. https:\/\/doi.org\/10.1038\/nn.4661.","journal-title":"Nat Neurosci"},{"key":"1003_CR44","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.1007\/s12035-024-04597-4","volume":"62","author":"RW de Camargo","year":"2025","unstructured":"de Camargo RW, Joaquim L, Machado RS, de Souza Ramos S, da Rosa LR, de Novais Junior LR, et al. Ayahuasca Pretreatment Prevents Sepsis-Induced Anxiety-Like Behavior, Neuroinflammation, and Oxidative Stress, and Increases Brain-Derived Neurotrophic Factor. Mol Neurobiol. 2025;62:5695\u2013719. https:\/\/doi.org\/10.1007\/s12035-024-04597-4.","journal-title":"Mol Neurobiol"},{"key":"1003_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jad.2023.02.016","volume":"328","author":"L Shi","year":"2023","unstructured":"Shi L, Xia Z, Guo J, Wang L, Peng Z, Qiu D, et al. Maresin-1 improves LPS-induced depressive-like behavior by inhibiting hippocampal microglial activation. J Affect Disord. 2023;328:261\u201372. https:\/\/doi.org\/10.1016\/j.jad.2023.02.016.","journal-title":"J Affect Disord"},{"key":"1003_CR46","doi-asserted-by":"publisher","first-page":"136836","DOI":"10.1016\/j.neulet.2022.136836","volume":"788","author":"AM Jaster","year":"2022","unstructured":"Jaster AM, Younkin J, Cuddy T, de la Fuente Revenga M, Poklis JL, Dozmorov MG, et al. Differences across sexes on head-twitch behavior and 5-HT(2A) receptor signaling in C57BL\/6J mice. Neurosci Lett. 2022;788:136836. https:\/\/doi.org\/10.1016\/j.neulet.2022.136836.","journal-title":"Neurosci Lett"},{"key":"1003_CR47","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","volume":"53","author":"J Gonz\u00e1lez-Maeso","year":"2007","unstructured":"Gonz\u00e1lez-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, et al. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007;53:439\u201352. https:\/\/doi.org\/10.1016\/j.neuron.2007.01.008.","journal-title":"Neuron"},{"key":"1003_CR48","doi-asserted-by":"publisher","first-page":"107933","DOI":"10.1016\/j.neuropharm.2019.107933","volume":"167","author":"AL Halberstadt","year":"2020","unstructured":"Halberstadt AL, Chatha M, Klein AK, Wallach J, Brandt SD. Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology. 2020;167:107933. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107933.","journal-title":"Neuropharmacology"},{"key":"1003_CR49","doi-asserted-by":"publisher","first-page":"e955","DOI":"10.21769\/bioprotoc.955","volume":"3","author":"FA Sultan","year":"2013","unstructured":"Sultan FA. Dissection of Different Areas from Mouse Hippocampus. Bio-Protoc. 2013;3:e955. https:\/\/doi.org\/10.21769\/bioprotoc.955.","journal-title":"Bio-Protoc"},{"key":"1003_CR50","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/bs.mie.2019.06.001","volume":"629","author":"JS Lehmann","year":"2019","unstructured":"Lehmann JS, Rughwani P, Kolenovic M, Ji S, Sun B. LEGENDplex\u2122: Bead-assisted multiplex cytokine profiling by flow cytometry. Methods Enzymol. 2019;629:151\u201376. https:\/\/doi.org\/10.1016\/bs.mie.2019.06.001.","journal-title":"Methods Enzymol"},{"key":"1003_CR51","doi-asserted-by":"publisher","first-page":"109836","DOI":"10.1016\/j.celrep.2021.109836","volume":"37","author":"M de la Fuente Revenga","year":"2021","unstructured":"de la Fuente Revenga M, Zhu B, Guevara CA, Naler LB, Saunders JM, Zhou Z, et al. Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice. Cell Rep. 2021;37:109836. https:\/\/doi.org\/10.1016\/j.celrep.2021.109836.","journal-title":"Cell Rep"},{"key":"1003_CR52","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1021\/acschemneuro.5c00932","volume":"17","author":"M de la Fuente Revenga","year":"2026","unstructured":"de la Fuente Revenga M, Gonz\u00e1lez-Maeso J. Snapshot IP(1) Detection Following 5-HT(2)A Receptor Stimulation in the Mouse Brain. ACS Chem Neurosci. 2026;17:440\u20139. https:\/\/doi.org\/10.1021\/acschemneuro.5c00932.","journal-title":"ACS Chem Neurosci"},{"key":"1003_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-025-02313-x","author":"MC Gaines-Smith","year":"2026","unstructured":"Gaines-Smith MC, Silverman JM, Fiorillo M, Younkin J, Moore KN, Maltman JL, et al. Stereoselective, sex-dependent 5-HT(2A) receptor modulation of cortical plasticity by MDMA in mice. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2026. https:\/\/doi.org\/10.1038\/s41386-025-02313-x.","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"1003_CR54","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1021\/acschemneuro.5c00468","volume":"16","author":"JM Silverman","year":"2025","unstructured":"Silverman JM, Fiorillo M, Younkin J, Jones CB, Maltman JL, Herszenhorn I, et al. Dual Modulation of 5-HT(2A) Receptors and SERT by \u03b1-Ethyltryptamine and Its Optical Isomers. ACS Chem Neurosci. 2025;16:4592\u2013601. https:\/\/doi.org\/10.1021\/acschemneuro.5c00468.","journal-title":"ACS Chem Neurosci"},{"key":"1003_CR55","doi-asserted-by":"publisher","first-page":"10206","DOI":"10.1038\/s41467-025-64887-w","volume":"16","author":"AM Jaster","year":"2025","unstructured":"Jaster AM, Hadlock TM, Buzzi B, Maltman JL, Silva GM, Saha S, et al. Sex-specific role of the 5-HT(2A) receptor in psilocybin-induced extinction of opioid reward. Nat Commun. 2025;16:10206. https:\/\/doi.org\/10.1038\/s41467-025-64887-w.","journal-title":"Nat Commun"},{"key":"1003_CR56","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1471-2105-7-123","volume":"7","author":"HJ Motulsky","year":"2006","unstructured":"Motulsky HJ, Brown RE. Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate. BMC Bioinformatics. 2006;7:123. https:\/\/doi.org\/10.1186\/1471-2105-7-123.","journal-title":"BMC Bioinformatics"},{"key":"1003_CR57","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1600-065X.2008.00697.x","volume":"226","author":"KK Hoyer","year":"2008","unstructured":"Hoyer KK, Dooms H, Barron L, Abbas AK. Interleukin-2 in the development and control of inflammatory disease. Immunol Rev. 2008;226:19\u201328. https:\/\/doi.org\/10.1111\/j.1600-065X.2008.00697.x.","journal-title":"Immunol Rev"},{"key":"1003_CR58","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/s41590-022-01208-z","volume":"23","author":"L Yshii","year":"2022","unstructured":"Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol. 2022;23:878\u201391. https:\/\/doi.org\/10.1038\/s41590-022-01208-z.","journal-title":"Nat Immunol"},{"key":"1003_CR59","doi-asserted-by":"publisher","first-page":"e30013","DOI":"10.1016\/j.heliyon.2024.e30013","volume":"10","author":"J Liu","year":"2024","unstructured":"Liu J, Qi B, Ye Y, Shen Y, Lin Y, Chen Y, et al. Low-dose IL-2 treatment confers anti-inflammatory effect against subarachnoid hemorrhage in mice. Heliyon. 2024;10:e30013. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e30013.","journal-title":"Heliyon"},{"key":"1003_CR60","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1212\/WNL.0b013e318225ae07","volume":"77","author":"C Holmes","year":"2011","unstructured":"Holmes C, Cunningham C, Zotova E, Culliford D, Perry VH. Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology. 2011;77:212\u20138. https:\/\/doi.org\/10.1212\/WNL.0b013e318225ae07.","journal-title":"Neurology"},{"key":"1003_CR61","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ynstr.2016.03.003","volume":"4","author":"GE Hodes","year":"2016","unstructured":"Hodes GE, M\u00e9nard C, Russo SJ. Integrating Interleukin-6 into depression diagnosis and treatment. SIStress Inflamm. 2016;4:15\u201322. https:\/\/doi.org\/10.1016\/j.ynstr.2016.03.003.","journal-title":"SIStress Inflamm"},{"key":"1003_CR62","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","volume":"67","author":"Y Dowlati","year":"2010","unstructured":"Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446\u201357. https:\/\/doi.org\/10.1016\/j.biopsych.2009.09.033.","journal-title":"Biol Psychiatry"},{"key":"1003_CR63","doi-asserted-by":"publisher","first-page":"111139","DOI":"10.1016\/j.pnpbp.2024.111139","volume":"136","author":"ZXB Low","year":"2025","unstructured":"Low ZXB, Ng WS, Lim ESY, Goh BH, Kumari Y. The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies. Prog Neuropsychopharmacol Biol Psychiatry. 2025;136:111139. https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111139.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1003_CR64","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s0306-4522(98)00269-3","volume":"88","author":"E Chalecka-Franaszek","year":"1999","unstructured":"Chalecka-Franaszek E, Chen H, Chuang DM. 5-Hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and Jun D as common components in cerebellar neurons. Neuroscience. 1999;88:885\u201398. https:\/\/doi.org\/10.1016\/s0306-4522(98)00269-3.","journal-title":"Neuroscience"},{"key":"1003_CR65","doi-asserted-by":"publisher","first-page":"790213","DOI":"10.3389\/fnmol.2021.790213","volume":"14","author":"LA Desouza","year":"2021","unstructured":"Desouza LA, Benekareddy M, Fanibunda SE, Mohammad F, Janakiraman B, Ghai U, et al. The Hallucinogenic Serotonin(2A) Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex. Front Mol Neurosci. 2021;14:790213. https:\/\/doi.org\/10.3389\/fnmol.2021.790213.","journal-title":"Front Mol Neurosci"},{"key":"1003_CR66","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/nn.4616","volume":"20","author":"D Ibi","year":"2017","unstructured":"Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, et al. Antipsychotic-induced Hdac2 transcription via NF-\u03baB leads to synaptic and cognitive side effects. Nat Neurosci. 2017;20:1247\u201359. https:\/\/doi.org\/10.1038\/nn.4616.","journal-title":"Nat Neurosci"},{"key":"1003_CR67","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.tins.2011.03.001","volume":"34","author":"H Gutierrez","year":"2011","unstructured":"Gutierrez H, Davies AM. Regulation of neural process growth, elaboration and structural plasticity by NF-\u03baB. Trends Neurosci. 2011;34:316\u201325. https:\/\/doi.org\/10.1016\/j.tins.2011.03.001.","journal-title":"Trends Neurosci"},{"key":"1003_CR68","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","volume":"185","author":"AY Wen","year":"2010","unstructured":"Wen AY, Sakamoto KM, Miller LS. The role of the transcription factor CREB in immune function. J Immunol Baltim Md 1950. 2010;185:6413\u20139. https:\/\/doi.org\/10.4049\/jimmunol.1001829.","journal-title":"J Immunol Baltim Md 1950"},{"key":"1003_CR69","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1146\/annurev-biochem-081820-092427","volume":"90","author":"M von Zastrow","year":"2021","unstructured":"von Zastrow M, Sorkin A. Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis. Annu Rev Biochem. 2021;90:709\u201337. https:\/\/doi.org\/10.1146\/annurev-biochem-081820-092427.","journal-title":"Annu Rev Biochem"},{"key":"1003_CR70","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1111\/j.1476-5381.2011.01552.x","volume":"165","author":"AC Magalhaes","year":"2012","unstructured":"Magalhaes AC, Dunn H, Ferguson SS. Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. Br J Pharmacol. 2012;165:1717\u201336. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01552.x.","journal-title":"Br J Pharmacol"},{"key":"1003_CR71","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1074\/mcp.M113.036558","volume":"13","author":"S Karaki","year":"2014","unstructured":"Karaki S, Becamel C, Murat S, Mannoury la Cour C, Millan MJ, Pr\u00e9zeau L, et al. Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists. Mol Cell Proteom MCP. 2014;13:1273\u201385. https:\/\/doi.org\/10.1074\/mcp.M113.036558.","journal-title":"Mol Cell Proteom MCP"},{"key":"1003_CR72","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1124\/mol.112.078626","volume":"83","author":"I Raote","year":"2013","unstructured":"Raote I, Bhattacharyya S, Panicker MM. Functional selectivity in serotonin receptor 2A (5-HT2A) endocytosis, recycling, and phosphorylation. Mol Pharmacol. 2013;83:42\u201350. https:\/\/doi.org\/10.1124\/mol.112.078626.","journal-title":"Mol Pharmacol"},{"key":"1003_CR73","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1038\/npp.2009.29","volume":"34","author":"AL Halberstadt","year":"2009","unstructured":"Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, et al. 5-HT(2A) and 5-HT(2\u00a0C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 2009;34:1958\u201367. https:\/\/doi.org\/10.1038\/npp.2009.29.","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"1003_CR74","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1126\/science.1109237","volume":"308","author":"RJ Lefkowitz","year":"2005","unstructured":"Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science. 2005;308:512\u20137. https:\/\/doi.org\/10.1126\/science.1109237.","journal-title":"Science"},{"key":"1003_CR75","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-062124-012545","author":"D Wacker","year":"2025","unstructured":"Wacker D, McCorvy JD. Biased Signaling in Psychedelic Action. Annu Rev Pharmacol Toxicol. 2025. https:\/\/doi.org\/10.1146\/annurev-pharmtox-062124-012545.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1003_CR76","doi-asserted-by":"publisher","first-page":"109232","DOI":"10.1016\/j.neuropharm.2022.109232","volume":"219","author":"CD Nichols","year":"2022","unstructured":"Nichols CD. Psychedelics as potent anti-inflammatory therapeutics. Neuropharmacology. 2022;219:109232. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109232.","journal-title":"Neuropharmacology"},{"key":"1003_CR77","doi-asserted-by":"publisher","first-page":"e9019","DOI":"10.1371\/journal.pone.0009019","volume":"5","author":"TS Ray","year":"2010","unstructured":"Ray TS. Psychedelics and the human receptorome. PLoS ONE. 2010;5:e9019. https:\/\/doi.org\/10.1371\/journal.pone.0009019.","journal-title":"PLoS ONE"},{"key":"1003_CR78","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1038\/s41380-024-02575-9","volume":"29","author":"K Conn","year":"2024","unstructured":"Conn K, Milton LK, Huang K, Munguba H, Ruuska J, Lemus MB, et al. Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms. Mol Psychiatry. 2024;29:3291\u2013304. https:\/\/doi.org\/10.1038\/s41380-024-02575-9.","journal-title":"Mol Psychiatry"},{"key":"1003_CR79","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41586-024-07403-2","volume":"630","author":"AL Warren","year":"2024","unstructured":"Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, et al. Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature. 2024;630:237\u201346. https:\/\/doi.org\/10.1038\/s41586-024-07403-2.","journal-title":"Nature"},{"key":"1003_CR80","doi-asserted-by":"publisher","first-page":"118348","DOI":"10.1016\/j.biopha.2025.118348","volume":"190","author":"A Bouloufa","year":"2025","unstructured":"Bouloufa A, Delcourte S, Rovera R, Delannay T, Duquet A, Mouledous L, et al. LSD\u2019s rapid antidepressant effects are modulated by 5-HT2B receptors. Biomed Pharmacother. 2025;190:118348. https:\/\/doi.org\/10.1016\/j.biopha.2025.118348.","journal-title":"Biomed Pharmacother"},{"key":"1003_CR81","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00213-010-1784-0","volume":"209","author":"CE Canal","year":"2010","unstructured":"Canal CE, Olaghere da Silva UB, Gresch PJ, Watt EE, Sanders-Bush E, Airey DC. The serotonin 2\u00a0C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen. Psychopharmacology. 2010;209:163\u201374. https:\/\/doi.org\/10.1007\/s00213-010-1784-0.","journal-title":"Psychopharmacology"},{"key":"1003_CR82","doi-asserted-by":"publisher","first-page":"113612","DOI":"10.1016\/j.biopha.2022.113612","volume":"154","author":"I Erkizia-Santamar\u00eda","year":"2022","unstructured":"Erkizia-Santamar\u00eda I, Alles-Pascual R, Horrillo I, Meana JJ, Ortega JE. Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response. Biomed Pharmacother. 2022;154:113612. https:\/\/doi.org\/10.1016\/j.biopha.2022.113612.","journal-title":"Biomed Pharmacother"},{"key":"1003_CR83","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1023\/a:1013627613769","volume":"132","author":"GV Idova","year":"2001","unstructured":"Idova GV, Cheido MA, Zhukova EN, Al\u2019perina EL, Devoino LV. Effects of type 1A serotonin receptor agonist 8-OH-DPAT on immune response. Bull Exp Biol Med. 2001;132:981\u20133. https:\/\/doi.org\/10.1023\/a:1013627613769.","journal-title":"Bull Exp Biol Med"},{"key":"1003_CR84","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s11055-006-0076-y","volume":"36","author":"GV Idova","year":"2006","unstructured":"Idova GV, Davydova SM, Cheido MA, Zhukova EN, Devoino LV. Significance of initial emotional state for neuroimmunomodulation in conditions of activation and blockade of 5-HT(1A) receptors. Neurosci Behav Physiol. 2006;36:703\u20137. https:\/\/doi.org\/10.1007\/s11055-006-0076-y.","journal-title":"Neurosci Behav Physiol"},{"key":"1003_CR85","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.pnpbp.2008.12.006","volume":"33","author":"H Sugino","year":"2009","unstructured":"Sugino H, Futamura T, Mitsumoto Y, Maeda K, Marunaka Y. Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:303\u20137. https:\/\/doi.org\/10.1016\/j.pnpbp.2008.12.006.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1003_CR86","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0166-4328(96)00115-5","volume":"73","author":"J Hennig","year":"1996","unstructured":"Hennig J, Becker H, Netter P. 5-HT agonist-induced changes in peripheral immune cells in healthy volunteers: the impact of personality. Behav Brain Res. 1996;73:359\u201363. https:\/\/doi.org\/10.1016\/0166-4328(96)00115-5.","journal-title":"Behav Brain Res"},{"key":"1003_CR87","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.brainres.2004.10.019","volume":"1030","author":"AJ Ramos","year":"2004","unstructured":"Ramos AJ, Rubio MD, Defagot C, Hischberg L, Villar MJ, Brusco A. The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization. Brain Res. 2004;1030:201\u201320. https:\/\/doi.org\/10.1016\/j.brainres.2004.10.019.","journal-title":"Brain Res"},{"key":"1003_CR88","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.nbd.2013.08.003","volume":"59","author":"I Miyazaki","year":"2013","unstructured":"Miyazaki I, Asanuma M, Murakami S, Takeshima M, Torigoe N, Kitamura Y, et al. Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models. Neurobiol Dis. 2013;59:244\u201356. https:\/\/doi.org\/10.1016\/j.nbd.2013.08.003.","journal-title":"Neurobiol Dis"},{"key":"1003_CR89","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/s41598-018-20173-y","volume":"8","author":"A Szabo","year":"2018","unstructured":"Szabo A, Gogolak P, Koncz G, Foldvari Z, Pazmandi K, Miltner N, et al. Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep. 2018;8:1765. https:\/\/doi.org\/10.1038\/s41598-018-20173-y.","journal-title":"Sci Rep"},{"key":"1003_CR90","doi-asserted-by":"publisher","first-page":"770610","DOI":"10.3389\/fphar.2021.770610","volume":"12","author":"SH Park","year":"2021","unstructured":"Park SH, Lee Y-S, Yang H-J, Song GJ. Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia. Front Pharmacol. 2021;12:770610. https:\/\/doi.org\/10.3389\/fphar.2021.770610.","journal-title":"Front Pharmacol"},{"key":"1003_CR91","doi-asserted-by":"publisher","first-page":"e1006780","DOI":"10.1371\/journal.pgen.1006780","volume":"13","author":"MA El-Brolosy","year":"2017","unstructured":"El-Brolosy MA, Stainier DYR. Genetic compensation: A phenomenon in search of mechanisms. PLoS Genet. 2017;13:e1006780. https:\/\/doi.org\/10.1371\/journal.pgen.1006780.","journal-title":"PLoS Genet"},{"key":"1003_CR92","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fcvm.2017.00048","volume":"4","author":"N Herr","year":"2017","unstructured":"Herr N, Bode C, Duerschmied D. The Effects of Serotonin in Immune Cells. Front Cardiovasc Med. 2017;4:48. https:\/\/doi.org\/10.3389\/fcvm.2017.00048.","journal-title":"Front Cardiovasc Med"},{"key":"1003_CR93","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/glia.22772","volume":"63","author":"K Glebov","year":"2015","unstructured":"Glebov K, L\u00f6chner M, Jabs R, Lau T, Merkel O, Schloss P, et al. Serotonin stimulates secretion of exosomes from microglia cells. Glia. 2015;63:626\u201334. https:\/\/doi.org\/10.1002\/glia.22772.","journal-title":"Glia"},{"key":"1003_CR94","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0361-9230(99)00278-6","volume":"51","author":"T Xu","year":"2000","unstructured":"Xu T, Pandey SC. Cellular localization of serotonin2A (5HT2A) receptors in the rat brain. Brain Res Bull. 2000;51:499\u2013505. https:\/\/doi.org\/10.1016\/S0361-9230(99)00278-6.","journal-title":"Brain Res Bull"},{"key":"1003_CR95","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.1038\/s41380-023-02269-8","volume":"28","author":"C Gonz\u00e1lez-Arias","year":"2023","unstructured":"Gonz\u00e1lez-Arias C, S\u00e1nchez-Ruiz A, Esparza J, S\u00e1nchez-Puelles C, Arancibia L, Ram\u00edrez-Franco J, et al. Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states. Mol Psychiatry. 2023;28:3856\u201373. https:\/\/doi.org\/10.1038\/s41380-023-02269-8.","journal-title":"Mol Psychiatry"},{"key":"1003_CR96","doi-asserted-by":"publisher","unstructured":"Tay RE, Ho CM, Ang NDZ, Tay HC, Lopez DZ, Na QR, et al. Serotonin receptor 5-HT(2A) as a potential target for HCC immunotherapy. J Immunother Cancer. 2025;13. https:\/\/doi.org\/10.1136\/jitc-2024-011088.","DOI":"10.1136\/jitc-2024-011088"},{"key":"1003_CR97","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/s0166-2236(02)02154-9","volume":"25","author":"H Neumann","year":"2002","unstructured":"Neumann H, Medana IM, Bauer J, Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 2002;25:313\u20139. https:\/\/doi.org\/10.1016\/s0166-2236(02)02154-9.","journal-title":"Trends Neurosci"},{"key":"1003_CR98","doi-asserted-by":"publisher","first-page":"8544","DOI":"10.1038\/s41467-025-63971-5","volume":"16","author":"YF Tan","year":"2025","unstructured":"Tan YF, Yeh C-Y, Hsu S-Y, Lu C-H, Tsai C-H, Chiang P-C, et al. Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-derived Langerhans cells. Nat Commun. 2025;16:8544. https:\/\/doi.org\/10.1038\/s41467-025-63971-5.","journal-title":"Nat Commun"},{"key":"1003_CR99","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1002\/glia.23918","volume":"69","author":"C B\u00e9chade","year":"2021","unstructured":"B\u00e9chade C, D\u2019Andrea I, Etienne F, Verdonk F, Moutkine I, Banas SM, et al. The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood. Glia. 2021;69:638\u201354. https:\/\/doi.org\/10.1002\/glia.23918.","journal-title":"Glia"},{"key":"1003_CR100","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Gim\u00e9nez JF, Vilar\u00f3 MT, Palacios JM, Mengod G. Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies. J Comp Neurol. 2001;429:571\u201389. https:\/\/doi.org\/10.1002\/1096-9861(20010122)429:4%25;253C571::aid-cne5%25;253E3.0.co;2-x.","DOI":"10.1002\/1096-9861(20010122)429:4<571::AID-CNE5>3.0.CO;2-X"},{"key":"1003_CR101","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1016\/j.neuron.2024.08.016","volume":"112","author":"P Tiwari","year":"2024","unstructured":"Tiwari P, Davoudian PA, Kapri D, Vuruputuri RM, Karaba LA, Sharma M, et al. Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic. DOI Neuron. 2024;112:3697\u2013e37146. https:\/\/doi.org\/10.1016\/j.neuron.2024.08.016.","journal-title":"DOI Neuron"},{"key":"1003_CR102","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-024-07624-5","volume":"632","author":"JS Siegel","year":"2024","unstructured":"Siegel JS, Subramanian S, Perry D, Kay BP, Gordon EM, Laumann TO, et al. Psilocybin desynchronizes the human brain. Nature. 2024;632:131\u20138. https:\/\/doi.org\/10.1038\/s41586-024-07624-5.","journal-title":"Nature"},{"key":"1003_CR103","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.3389\/fimmu.2019.01446","volume":"10","author":"J Hoppst\u00e4dter","year":"2019","unstructured":"Hoppst\u00e4dter J, Ammit AJ. Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses. Front Immunol. 2019;10:1446. https:\/\/doi.org\/10.3389\/fimmu.2019.01446.","journal-title":"Front Immunol"},{"key":"1003_CR104","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C. NF-\u03baB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023. https:\/\/doi.org\/10.1038\/sigtrans.2017.23.","journal-title":"Signal Transduct Target Ther"},{"key":"1003_CR105","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1177\/0269881120959614","volume":"35","author":"OH Jefsen","year":"2021","unstructured":"Jefsen OH, Elfving B, Wegener G, M\u00fcller HK. Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin. J Psychopharmacol Oxf Engl. 2021;35:483\u201393. https:\/\/doi.org\/10.1177\/0269881120959614.","journal-title":"J Psychopharmacol Oxf Engl"},{"key":"1003_CR106","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/jnr.490350310","volume":"35","author":"H Awatsuji","year":"1993","unstructured":"Awatsuji H, Furukawa Y, Nakajima M, Furukawa S, Hayashi K. Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain. J Neurosci Res. 1993;35:305\u201311. https:\/\/doi.org\/10.1002\/jnr.490350310.","journal-title":"J Neurosci Res"},{"key":"1003_CR107","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jneuroim.2004.11.006","volume":"160","author":"RD Beck","year":"2005","unstructured":"Beck RD, King MA, Ha GK, Cushman JD, Huang Z, Petitto JM. IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins. J Neuroimmunol. 2005;160:146\u201353. https:\/\/doi.org\/10.1016\/j.jneuroim.2004.11.006.","journal-title":"J Neuroimmunol"},{"key":"1003_CR108","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/brain\/aww330","volume":"140","author":"S Alves","year":"2017","unstructured":"Alves S, Churlaud G, Audrain M, Michaelsen-Preusse K, Fol R, Souchet B, et al. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer\u2019s disease mice. Brain J Neurol. 2017;140:826\u201342. https:\/\/doi.org\/10.1093\/brain\/aww330.","journal-title":"Brain J Neurol"},{"key":"1003_CR109","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41467-023-35806-8","volume":"14","author":"S Li","year":"2023","unstructured":"Li S, olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z, et al. Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. Nat Commun. 2023;14:200. https:\/\/doi.org\/10.1038\/s41467-023-35806-8.","journal-title":"Nat Commun"},{"key":"1003_CR110","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.bbi.2020.03.023","volume":"88","author":"A Quarta","year":"2020","unstructured":"Quarta A, Berneman Z, Ponsaerts P. Neuroprotective modulation of microglia effector functions following priming with interleukin 4 and 13: current limitations in understanding their mode-of-action. Brain Behav Immun. 2020;88:856\u201366. https:\/\/doi.org\/10.1016\/j.bbi.2020.03.023.","journal-title":"Brain Behav Immun"},{"key":"1003_CR111","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"25","author":"D Furman","year":"2019","unstructured":"Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822\u201332. https:\/\/doi.org\/10.1038\/s41591-019-0675-0.","journal-title":"Nat Med"},{"key":"1003_CR112","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.psyneuen.2018.02.031","volume":"91","author":"EF Osimo","year":"2018","unstructured":"Osimo EF, Cardinal RN, Jones PB, Khandaker GM. Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study. Psychoneuroendocrinology. 2018;91:226\u201334. https:\/\/doi.org\/10.1016\/j.psyneuen.2018.02.031.","journal-title":"Psychoneuroendocrinology"},{"key":"1003_CR113","doi-asserted-by":"publisher","first-page":"100130","DOI":"10.1016\/j.jnrt.2024.100130","volume":"12","author":"L Zhang","year":"2024","unstructured":"Zhang L, Cao C, Luo C, Ruan H, Xu C, Wang Y, et al. Comparison of chronic restraint stress-and lipopolysaccharide-induced mouse models of depression: Behavior, c-Fos expression, and microglial and astrocytic activation. J Neurorestoratology. 2024;12:100130. https:\/\/doi.org\/10.1016\/j.jnrt.2024.100130.","journal-title":"J Neurorestoratology"},{"key":"1003_CR114","doi-asserted-by":"publisher","unstructured":"Bao Y, Chen X, Li Y, Yuan S, Han L, Deng X, et al. Chronic low-grade inflammation and brain structure in the middle-aged and elderly adults. Nutrients. 2024;16. https:\/\/doi.org\/10.3390\/nu16142313.","DOI":"10.3390\/nu16142313"},{"issue":"Suppl 2 Suppl 2","key":"1003_CR115","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/jnc.13607","volume":"139","author":"DJ DiSabato","year":"2016","unstructured":"DiSabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem. 2016;139(Suppl 2 Suppl 2):136\u201353. https:\/\/doi.org\/10.1111\/jnc.13607.","journal-title":"J Neurochem"},{"key":"1003_CR116","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbi.2016.01.018","volume":"54","author":"X Liu","year":"2016","unstructured":"Liu X, Nemeth DP, Tarr AJ, Belevych N, Syed ZW, Wang Y, et al. Euflammation attenuates peripheral inflammation-induced neuroinflammation and mitigates immune-to-brain signaling. Brain Behav Immun. 2016;54:140\u20138. https:\/\/doi.org\/10.1016\/j.bbi.2016.01.018.","journal-title":"Brain Behav Immun"},{"key":"1003_CR117","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbi.2014.06.002","volume":"42","author":"AJ Tarr","year":"2014","unstructured":"Tarr AJ, Liu X, Reed NS, Quan N. Kinetic characteristics of euflammation: the induction of controlled inflammation without overt sickness behavior. Brain Behav Immun. 2014;42:96\u2013108. https:\/\/doi.org\/10.1016\/j.bbi.2014.06.002.","journal-title":"Brain Behav Immun"},{"key":"1003_CR118","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1021\/acsptsci.0c00063","volume":"4","author":"TW Flanagan","year":"2021","unstructured":"Flanagan TW, Billac GB, Landry AN, Sebastian MN, Cormier SA, Nichols CD. Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore. ACS Pharmacol Transl Sci. 2021;4:488\u2013502. https:\/\/doi.org\/10.1021\/acsptsci.0c00063.","journal-title":"ACS Pharmacol Transl Sci"},{"key":"1003_CR119","doi-asserted-by":"publisher","first-page":"110619","DOI":"10.1016\/j.neuropharm.2025.110619","volume":"279","author":"AL Zylko","year":"2025","unstructured":"Zylko AL, Rakoczy RJ, Roberts BF, Wilson M, Powell A, Page A, et al. Age- and estrous-dependent effects of psilocybin in rats. Neuropharmacology. 2025;279:110619. https:\/\/doi.org\/10.1016\/j.neuropharm.2025.110619.","journal-title":"Neuropharmacology"}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12868-026-01003-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-026-01003-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-026-01003-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:36:46Z","timestamp":1777387006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12868-026-01003-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":119,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1186\/s12868-026-01003-8","relation":{},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiments were conducted in accordance with NIH guidelines, and were approved by the Virginia Commonwealth University Animal Care and Use Committee (#AD10001212).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The J.G.-M. laboratory has received research support from Noetic Fund, Terran Biosciences, and Gonogo Solutions. J.G.-M. has a consulting agreement with Boston Interactome. M.F. declares no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18"}}