{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:42:10Z","timestamp":1792600930650,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":86,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92163213, 81970085 and 82471301"],"award-info":[{"award-number":["92163213, 81970085 and 82471301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin science and Technology program","award":["17ZXMFSY00080"],"award-info":[{"award-number":["17ZXMFSY00080"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurosci"],"DOI":"10.1186\/s12868-026-01030-5","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:14:10Z","timestamp":1785114850000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-transcriptome sequencing reveals Alzheimer\u2019s disease\u2013associated ceRNA regulatory networks and downstream pathways"],"prefix":"10.1186","volume":"27","author":[{"given":"KeFei","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoteng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"1030_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jconrel.2024.09.012","volume":"375","author":"Y JIN","year":"2024","unstructured":"Jin Y, Du Q, Song M, et al. Amyloid-beta-targeting immunotherapies for Alzheimer\u2019s disease [J]. J Control Release. 2024;375:346\u201365.","journal-title":"J Control Release"},{"issue":"5","key":"1030_CR2","doi-asserted-by":"publisher","first-page":"e209753","DOI":"10.1212\/WNL.0000000000209753","volume":"103","author":"A BIEGER","year":"2024","unstructured":"Bieger A, Brum W S, Borelli W V, et al. Influence of different diagnostic criteria on Alzheimer disease clinical research [J]. Neurology. 2024;103(5):e209753.","journal-title":"Neurology"},{"issue":"1","key":"1030_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41398-021-01380-0","volume":"11","author":"H STOCKER","year":"2021","unstructured":"Stocker H, Nabers A, Perna L, et al. Genetic predisposition, Abeta misfolding in blood plasma, and Alzheimer\u2019s disease [J]. Transl Psychiatry. 2021;11(1):261.","journal-title":"Transl Psychiatry"},{"issue":"3","key":"1030_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","volume":"25","author":"K NEMETH","year":"2024","unstructured":"Nemeth K, Bayraktar R, Ferracin M, et al. Non-coding RNAs in disease: from mechanisms to therapeutics [J]. Nat Rev Genet. 2024;25(3):211\u201332.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"1030_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00109-024-02503-y","volume":"103","author":"A YILMAZ","year":"2025","unstructured":"Yilmaz A, Ari yuka S. The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications [J]. J Mol Med (Berl). 2025;103(1):33\u201349.","journal-title":"J Mol Med (Berl)"},{"key":"1030_CR6","doi-asserted-by":"crossref","unstructured":"Kim S. LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials [J]. Front Physiol, 2023, 14: 1303151.","DOI":"10.3389\/fphys.2023.1303151"},{"key":"1030_CR7","doi-asserted-by":"crossref","unstructured":"Moreno-garcia L, Lopez-royo T, Calvo A C et al. Competing endogenous RNA networks as biomarkers in neurodegenerative diseases [J]. Int J Mol Sci, 2020, 21(24).","DOI":"10.3390\/ijms21249582"},{"issue":"1","key":"1030_CR8","doi-asserted-by":"publisher","first-page":"7552","DOI":"10.1038\/s41467-023-42819-w","volume":"14","author":"V CHOU","year":"2023","unstructured":"Chou V, Pearse R V Aylwardaj 2ND, et al. INPP5D regulates inflammasome activation in human microglia [J]. Nat Commun. 2023;14(1):7552.","journal-title":"Nat Commun"},{"key":"1030_CR9","doi-asserted-by":"publisher","first-page":"105345","DOI":"10.1016\/j.bioorg.2021.105345","volume":"116","author":"R HAN","year":"2021","unstructured":"Han R, Yuan T, Yang Z, et al. Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway [J]. Bioorg Chem. 2021;116:105345.","journal-title":"Bioorg Chem"},{"key":"1030_CR10","doi-asserted-by":"publisher","first-page":"111405","DOI":"10.1016\/j.biopha.2021.111405","volume":"138","author":"A LINDSAY","year":"2021","unstructured":"Lindsay A, Hickman D. A nuclear factor-kappa B inhibiting peptide suppresses innate immune receptors and gliosis in a transgenic mouse model of Alzheimer\u2019s disease [J]. Biomed Pharmacother. 2021;138:111405.","journal-title":"Biomed Pharmacother"},{"issue":"12","key":"1030_CR11","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"W LOVE M I, HUBER","year":"2014","unstructured":"Love M I, Huber W. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 [J]. Genome Biol. 2014;15(12):550.","journal-title":"Genome Biol"},{"key":"1030_CR12","doi-asserted-by":"publisher","first-page":"1462003","DOI":"10.3389\/fimmu.2024.1462003","volume":"15","author":"W WANG","year":"2024","unstructured":"Wang W, Lu J, Pan N, et al. Identification of early Alzheimer\u2019s disease subclass and signature genes based on PANoptosis genes [J]. Front Immunol. 2024;15:1462003.","journal-title":"Front Immunol"},{"issue":"12","key":"1030_CR13","doi-asserted-by":"publisher","first-page":"16383","DOI":"10.1007\/s12035-025-05212-w","volume":"62","author":"W REN","year":"2025","unstructured":"Ren W. Using blood-based biomarkers to facilitate the diagnosis of Alzheimer\u2019s disease: insights from a novel pyroptosis-associated molecular signature model [J]. Mol Neurobiol. 2025;62(12):16383\u201396.","journal-title":"Mol Neurobiol"},{"issue":"3","key":"1030_CR14","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L GALLUZZI","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 [J]. Cell Death Differ. 2018;25(3):486\u2013541.","journal-title":"Cell Death Differ"},{"issue":"6586","key":"1030_CR15","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P TSVETKOV","year":"2022","unstructured":"Tsvetkov P, Coy S. Copper induces cell death by targeting lipoylated TCA cycle proteins [J]. Science. 2022;375(6586):1254\u201361.","journal-title":"Science"},{"issue":"3","key":"1030_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","volume":"17","author":"F LENG","year":"2021","unstructured":"Leng F. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? [J]. Nat Rev Neurol. 2021;17(3):157\u201372.","journal-title":"Nat Rev Neurol"},{"key":"1030_CR17","doi-asserted-by":"publisher","first-page":"742242","DOI":"10.3389\/fnagi.2021.742242","volume":"13","author":"H SABAIE","year":"2021","unstructured":"Sabaie H, Amirinejad N Asadimr, et al. Molecular insight into the therapeutic potential of long Non-coding RNA-associated competing endogenous RNA axes in Alzheimer\u2019s disease: A Systematic Scoping Review [J]. Front Aging Neurosci. 2021;13:742242.","journal-title":"Front Aging Neurosci"},{"key":"1030_CR18","doi-asserted-by":"crossref","unstructured":"Malhotra S, Miras M C M, Pappolla A et al. Liquid Biopsy Neurol Dis [J] Cells, 2023, 12(14).","DOI":"10.3390\/cells12141911"},{"issue":"1","key":"1030_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.14283\/jpad.2023.3","volume":"10","author":"Z QIU","year":"2023","unstructured":"Qiu Z, Zhang H, Xia M, et al. Programmed Death of Microglia in Alzheimer\u2019s Disease: Autophagy, Ferroptosis, and Pyroptosis [J]. J Prev Alzheimers Dis. 2023;10(1):95\u2013103.","journal-title":"J Prev Alzheimers Dis"},{"key":"1030_CR20","doi-asserted-by":"crossref","unstructured":"Guo D, Liu Z, Zhou J et al. Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases [J]. Int J Mol Sci, 2024, 25(18).","DOI":"10.3390\/ijms25189947"},{"key":"1030_CR21","doi-asserted-by":"crossref","unstructured":"Yu C, Chen P. Miao L, The Role of the NLRP3 Inflammasome and Programmed Cell Death in Acute Liver Injury [J]. Int J Mol Sci, 2023, 24(4).","DOI":"10.3390\/ijms24043067"},{"issue":"9","key":"1030_CR22","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y HUANG","year":"2021","unstructured":"Huang Y, Xu W. NLRP3 inflammasome activation and cell death [J]. Cell Mol Immunol. 2021;18(9):2114\u201327.","journal-title":"Cell Mol Immunol"},{"issue":"12","key":"1030_CR23","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1007\/s11064-021-03436-5","volume":"46","author":"X WEI","year":"2021","unstructured":"Wei X, Xu S. LncRNA Neat1\/miR-298-5p\/Srpk1 Contributes to Sevoflurane-Induced Neurotoxicity [J]. Neurochem Res. 2021;46(12):3356\u201364.","journal-title":"Neurochem Res"},{"key":"1030_CR24","doi-asserted-by":"crossref","unstructured":"Gao F, Yang X, Yang Z et al. Novel LncRNA Gm44763 Regulates Morphine-Induced Reward Memory via MiR-298-5p-Mediated eIF4E Translation Control [J]. Research (Wash D C), 2026, 9: 1032.","DOI":"10.34133\/research.1032"},{"issue":"10","key":"1030_CR25","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1038\/s41380-019-0610-2","volume":"26","author":"N CHOPRA","year":"2021","unstructured":"Chopra N, Wang R, Maloney B, et al. MicroRNA-298 reduces levels of human amyloid-beta precursor protein (APP), beta-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties [J]. Mol Psychiatry. 2021;26(10):5636\u201357.","journal-title":"Mol Psychiatry"},{"issue":"1","key":"1030_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13024-021-00498-5","volume":"16","author":"T WALLACH","year":"2021","unstructured":"Wallach T, Mossmann Z J, Szczepek M, et al. MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7\/8 ligands that contribute to neurodegeneration [J]. Mol Neurodegener. 2021;16(1):80.","journal-title":"Mol Neurodegener"},{"issue":"78","key":"1030_CR27","doi-asserted-by":"publisher","first-page":"eadd0665","DOI":"10.1126\/sciimmunol.add0665","volume":"7","author":"J MUENDLEIN H I, CONNOLLY W M, CAMERO","year":"2022","unstructured":"Muendlein H I, Connolly W M, Cameron J, et al. Neutrophils and macrophages drive TNF-induced lethality via TRIF\/CD14-mediated responses [J]. Sci Immunol. 2022;7(78):eadd0665.","journal-title":"Sci Immunol"},{"issue":"1","key":"1030_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12031-013-0140-3","volume":"52","author":"J TU","year":"2014","unstructured":"Tu J, Yang L, Zhou X, et al. PrP106-126 and Abeta 1\u201342 peptides induce BV-2 microglia chemotaxis and proliferation [J]. J Mol Neurosci. 2014;52(1):107\u201316.","journal-title":"J Mol Neurosci"}],"container-title":["BMC Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12868-026-01030-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-026-01030-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12868-026-01030-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:45Z","timestamp":1792598565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12868-026-01030-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1030"],"URL":"https:\/\/doi.org\/10.1186\/s12868-026-01030-5","relation":{},"ISSN":["1471-2202"],"issn-type":[{"value":"1471-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures were approved by the institutional animal ethics committee and conducted in accordance with national guidelines for the care and use of laboratory animals as well as the ARRIVE recommendations.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Patient consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"47"}}