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Ethylene response factors (ERF) regulate plant growth, development, and responses to biotic and abiotic stress. In a previous study, the\n                      <jats:italic>ERF2<\/jats:italic>\n                      gene was significantly upregulated in both resistant and susceptible tomato cultivars in response to\n                      <jats:italic>Stemphylium lycopersici<\/jats:italic>\n                      . The main purpose of this study was to systematically analyze the\n                      <jats:italic>ERF<\/jats:italic>\n                      family and to explore the mechanism of\n                      <jats:italic>ERF2<\/jats:italic>\n                      in tomato plants resisting pathogen infection by the Virus-induced Gene Silencing technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this experiment, 134\n                      <jats:italic>ERF<\/jats:italic>\n                      genes were explored and subjected to bioinformatic analysis and divided into twelve groups. The spatiotemporal expression characteristics of\n                      <jats:italic>ERF<\/jats:italic>\n                      transcription factor gene family in tomato were diverse. Combined with RNA-seq, we found that the expression of 18\n                      <jats:italic>ERF<\/jats:italic>\n                      transcription factors increased after inoculation with\n                      <jats:italic>S. lycopersici<\/jats:italic>\n                      . In\n                      <jats:italic>ERF2<\/jats:italic>\n                      -silenced plants, the susceptible phenotype was observed after inoculation with\n                      <jats:italic>S. lycopersici<\/jats:italic>\n                      . The hypersensitive response and ROS production were decreased in the\n                      <jats:italic>ERF2<\/jats:italic>\n                      -silenced plants. Physiological analyses showed that the superoxide dismutase, peroxidase and catalase activities were lower in\n                      <jats:italic>ERF2<\/jats:italic>\n                      -silenced plants than in control plants\n                      <jats:italic>,<\/jats:italic>\n                      and the SA and JA contents were lower in\n                      <jats:italic>ERF2<\/jats:italic>\n                      -silenced plants than in control plants after inoculation with\n                      <jats:italic>S. lycopersici<\/jats:italic>\n                      . Furthermore, the results indicated that\n                      <jats:italic>ERF2<\/jats:italic>\n                      may directly or indirectly regulate\n                      <jats:italic>Pto<\/jats:italic>\n                      ,\n                      <jats:italic>PR1b1<\/jats:italic>\n                      and\n                      <jats:italic>PR-P2<\/jats:italic>\n                      expression and enhance tomato resistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study, we identified and analyzed members of the tomato\n                      <jats:italic>ERF<\/jats:italic>\n                      family by bioinformatics methods and classified, described and analyzed these genes. Subsequently, we used VIGS technology to significantly reduce the expression of\n                      <jats:italic>ERF2<\/jats:italic>\n                      in tomatoes. The results showed that\n                      <jats:italic>ERF2<\/jats:italic>\n                      had a positive effect on tomato resistance to\n                      <jats:italic>S. lycopersici<\/jats:italic>\n                      . Interestingly,\n                      <jats:italic>ERF2<\/jats:italic>\n                      played a key role in multiple SA, JA and ROS signaling pathways to confer resistance to invasion by\n                      <jats:italic>S. lycopersici.<\/jats:italic>\n                      In addition,\n                      <jats:italic>ERF2<\/jats:italic>\n                      may directly or indirectly regulate\n                      <jats:italic>Pto<\/jats:italic>\n                      ,\n                      <jats:italic>PR1b1<\/jats:italic>\n                      and\n                      <jats:italic>PR-P2<\/jats:italic>\n                      expression and enhance tomato resistance to\n                      <jats:italic>S. lycopersici.<\/jats:italic>\n                      In summary, this study provides gene resources for breeding for disease resistance in tomato.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12870-021-02848-3","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T16:07:19Z","timestamp":1612282039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Genome-wide identification and functional analysis of the ERF2 gene family in response to disease resistance against Stemphylium lycopersici in tomato"],"prefix":"10.1186","volume":"21","author":[{"given":"Huanhuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"2848_CR1","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1093\/emboj\/16.11.3207","volume":"16","author":"J Zhou","year":"1997","unstructured":"Zhou J, Tang X, Martin GB. 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