{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:13:17Z","timestamp":1788394397416,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"DFG Open Access Publication Funds of the Ruhr-Universit\u00e4t Bochum","award":["IN-1214264"],"award-info":[{"award-number":["IN-1214264"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12871-017-0376-5","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T09:35:13Z","timestamp":1497432913000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Moxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-6288","authenticated-orcid":false,"given":"Tim","family":"Rahmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Asmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Karlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Adamzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"376_CR1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/CLEP.S28800","volume":"4","author":"AJ Walkey","year":"2012","unstructured":"Walkey AJ, Summer R, Ho V, Alkana P. Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol. 2012;4:159\u201369.","journal-title":"Clin Epidemiol"},{"key":"376_CR2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","volume":"353","author":"GD Rubenfeld","year":"2005","unstructured":"Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353:1685\u201393.","journal-title":"N Engl J Med"},{"key":"376_CR3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","volume":"315","author":"G Bellani","year":"2016","unstructured":"Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016;315:788\u2013800.","journal-title":"JAMA"},{"key":"376_CR4","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1055\/s-0032-1333051","volume":"138","author":"S Braune","year":"2013","unstructured":"Braune S, Kluge S. ARDS--an update. Dtsch Med Wochenschr. 2013;138:1019\u201322.","journal-title":"Dtsch Med Wochenschr"},{"key":"376_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00134-003-2022-6","volume":"30","author":"C Brun-Buisson","year":"2004","unstructured":"Brun-Buisson C, Minelli C, Bertolini G, et al. Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med. 2004;30:51\u201361.","journal-title":"Intensive Care Med"},{"key":"376_CR6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1055\/s-0029-1215037","volume":"63","author":"G Hoffken","year":"2009","unstructured":"Hoffken G, Lorenz J, Kern W, et al. Epidemiology, diagnosis, antimicrobial therapy and management of community-acquired pneumonia and lower respiratory tract infections in adults. Guidelines of the Paul-Ehrlich-Society for Chemotherapy, the German Respiratory Society, the German Society for Infectiology and the Competence Network CAPNETZ Germany. Pneumologie. 2009;63:e1\u201368.","journal-title":"Pneumologie"},{"key":"376_CR7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1055\/s-0042-101873","volume":"70","author":"S Ewig","year":"2016","unstructured":"Ewig S, Hoffken G, Kern WV, et al. Management of Adult Community-acquired Pneumonia and Prevention - Update 2016. Pneumologie. 2016;70:151\u2013200.","journal-title":"Pneumologie"},{"key":"376_CR8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00134-016-4325-4","volume":"42","author":"T Bein","year":"2016","unstructured":"Bein T, Grasso S, Moerer O, et al. The standard of care of patients with ARDS: ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med. 2016;42:699\u2013711.","journal-title":"Intensive Care Med"},{"issue":"Suppl 2","key":"376_CR9","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27\u201372.","journal-title":"Clin Infect Dis"},{"key":"376_CR10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clinthera.2010.02.006","volume":"32","author":"CR Frei","year":"2010","unstructured":"Frei CR, Attridge RT, Mortensen EM, et al. Guideline-concordant antibiotic use and survival among patients with community-acquired pneumonia admitted to the intensive care unit. Clin Ther. 2010;32:293\u20139.","journal-title":"Clin Ther"},{"key":"376_CR11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.CCM.0000266755.75844.05","volume":"35","author":"A Rodriguez","year":"2007","unstructured":"Rodriguez A, Mendia A, Sirvent JM, et al. Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Crit Care Med. 2007;35:1493\u20138.","journal-title":"Crit Care Med"},{"key":"376_CR12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1164\/rccm.200311-1578OC","volume":"170","author":"LM Baddour","year":"2004","unstructured":"Baddour LM, Yu VL, Klugman KP, et al. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med. 2004;170:440\u20134.","journal-title":"Am J Respir Crit Care Med"},{"key":"376_CR13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003495-200262010-00002","volume":"62","author":"GG Zhanel","year":"2002","unstructured":"Zhanel GG, Ennis K, Vercaigne L, et al. A critical review of the fluoroquinolones: focus on respiratory infections. Drugs. 2002;62:13\u201359.","journal-title":"Drugs"},{"key":"376_CR14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2165\/00151829-200605060-00009","volume":"5","author":"GG Zhanel","year":"2006","unstructured":"Zhanel GG, Fontaine S, Adam H, et al. A Review of New Fluoroquinolones : Focus on their Use in Respiratory Tract Infections. Treat Respir Med. 2006;5:437\u201365.","journal-title":"Treat Respir Med"},{"key":"376_CR15","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1128\/AAC.46.6.1746-1754.2002","volume":"46","author":"R Finch","year":"2002","unstructured":"Finch R, Schurmann D, Collins O, et al. Randomized controlled trial of sequential intravenous (i.v.) and oral moxifloxacin compared with sequential i.v. and oral co-amoxiclav with or without clarithromycin in patients with community-acquired pneumonia requiring initial parenteral treatment. Antimicrob Agents Chemother. 2002;46:1746\u201354.","journal-title":"Antimicrob Agents Chemother"},{"key":"376_CR16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2466-14-105","volume":"14","author":"I Kuzman","year":"2014","unstructured":"Kuzman I, Bezlepko A, Kondova Topuzovska I, et al. Efficacy and safety of moxifloxacin in community acquired pneumonia: a prospective, multicenter, observational study (CAPRIVI). BMC Pulm Med. 2014;14:105.","journal-title":"BMC Pulm Med"},{"key":"376_CR17","first-page":"554","volume":"72","author":"C Forstner","year":"2016","unstructured":"Forstner C, Rohde G, Rupp J, et al. Community-acquired Haemophilus influenzae pneumonia - New insights from the CAPNETZ study. J Inf Secur. 2016;72:554\u201363.","journal-title":"J Inf Secur"},{"key":"376_CR18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1086\/587519","volume":"46","author":"A Torres","year":"2008","unstructured":"Torres A, Garau J, Arvis P, et al. Moxifloxacin monotherapy is effective in hospitalized patients with community-acquired pneumonia: the MOTIV study--a randomized clinical trial. Clin Infect Dis. 2008;46:1499\u2013509.","journal-title":"Clin Infect Dis"},{"key":"376_CR19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s15010-006-5120-x","volume":"34","author":"C Wenisch","year":"2006","unstructured":"Wenisch C, Krause R, Szell M, Laferl H. Moxifloxacin versus standard therapy in patients with pneumonia hospitalized after failure of preclinical anti-infective treatment. Infection. 2006;34:190\u20135.","journal-title":"Infection"},{"key":"376_CR20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1742-1241.2009.02239.x","volume":"64","author":"TE Albertson","year":"2010","unstructured":"Albertson TE, Dean NC, El Solh AA, Gotfried MH, Kaplan C, Niederman MS. Fluoroquinolones in the management of community-acquired pneumonia. Int J Clin Pract. 2010;64:378\u201388.","journal-title":"Int J Clin Pract"},{"key":"376_CR21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1503\/cmaj.080358","volume":"179","author":"KZ Vardakas","year":"2008","unstructured":"Vardakas KZ, Siempos II, Grammatikos A, Athanassa Z, Korbila IP, Falagas ME. Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: a meta-analysis of randomized controlled trials. CMAJ. 2008;179:1269\u201377.","journal-title":"CMAJ"},{"key":"376_CR22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1378\/chest.128.1.172","volume":"128","author":"O Leroy","year":"2005","unstructured":"Leroy O, Saux P, Bedos JP, Caulin E. Comparison of levofloxacin and cefotaxime combined with ofloxacin for ICU patients with community-acquired pneumonia who do not require vasopressors. Chest. 2005;128:172\u201383.","journal-title":"Chest"},{"key":"376_CR23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1586\/eri.09.46","volume":"7","author":"O Burkhardt","year":"2009","unstructured":"Burkhardt O, Welte T. 10 years' experience with the pneumococcal quinolone moxifloxacin. Expert Rev Anti-Infect Ther. 2009;7:645\u201368.","journal-title":"Expert Rev Anti-Infect Ther"},{"key":"376_CR24","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1517\/14656566.9.10.1755","volume":"9","author":"M Miravitlles","year":"2008","unstructured":"Miravitlles M, Anzueto A. Moxifloxacin: a respiratory fluoroquinolone. Expert Opin Pharmacother. 2008;9:1755\u201372.","journal-title":"Expert Opin Pharmacother"},{"key":"376_CR25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1179\/1973947812Y.0000000028","volume":"24","author":"X Yuan","year":"2012","unstructured":"Yuan X, Liang BB, Wang R, et al. Treatment of community-acquired pneumonia with moxifloxacin: a meta-analysis of randomized controlled trials. J Chemother. 2012;24:257\u201367.","journal-title":"J Chemother"},{"key":"376_CR26","doi-asserted-by":"crossref","unstructured":"Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. Report of the American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med. 1994;20:225-232.","DOI":"10.1007\/BF01704707"},{"key":"376_CR27","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/thx.2003.017756","volume":"59","author":"R Menendez","year":"2004","unstructured":"Menendez R, Torres A, Zalacain R, et al. Risk factors of treatment failure in community acquired pneumonia: implications for disease outcome. Thorax. 2004;59:960\u20135.","journal-title":"Thorax"},{"key":"376_CR28","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1164\/ajrccm.152.6.8520742","volume":"152","author":"RL Doyle","year":"1995","unstructured":"Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 1995;152:1818\u201324.","journal-title":"Am J Respir Crit Care Med"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-017-0376-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T09:35:31Z","timestamp":1497432931000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-017-0376-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["376"],"URL":"https:\/\/doi.org\/10.1186\/s12871-017-0376-5","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727720228.793548192","asserted-by":"object"}]},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]},"article-number":"78"}}