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All participants signed an informed consent declaration. In case where participants were legally minors (<\u200918\u2009years of age), consent to participate was collected from the parents\/guardians.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Conflict of interest statement: An application for a patent is filed (EPA 07024932.1, 08105554) by CSL Behring. M. R. and H-.G. T. are registered as inventors. H.-G. T. received honoraria and travel support from CSL Behring, Hattersheim, Germany. The other authors have nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"10"}}