{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:21:34Z","timestamp":1774675294329,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Young Scholar Research Grant from the Chinese Anesthesiologist Association","award":["220160900008"],"award-info":[{"award-number":["220160900008"]}]},{"name":"the Young Scholar Research Grant from Shanghai Chilren\u2019s Medical Center","award":["YJ-SCMC-2017-13"],"award-info":[{"award-number":["YJ-SCMC-2017-13"]}]},{"name":"the Shanghai Committee of Science and Technology","award":["16411967500"],"award-info":[{"award-number":["16411967500"]}]},{"name":"the Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines","award":["015ZB0106"],"award-info":[{"award-number":["015ZB0106"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12871-019-0774-y","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T23:03:44Z","timestamp":1560294224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Newborn infant parasympathetic evaluation (NIPE) as a predictor of hemodynamic response in children younger than 2 years under general anesthesia: an observational pilot study"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-8952","authenticated-orcid":false,"given":"Kan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2019an","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-9557","authenticated-orcid":false,"given":"Jijian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"issue":"3","key":"774_CR1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/EJA.0000000000000742","volume":"35","author":"A Defresne","year":"2018","unstructured":"Defresne A, Barvais L, Clement F, Bonhomme V. Standardised noxious stimulation-guided individual adjustment of remifentanil target-controlled infusion to prevent haemodynamic responses to laryngoscopy and surgical incision: a randomised controlled trial. Eur J Anaesthesiol. 2018;35(3):173\u201383.","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"774_CR2","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/j.1532-2149.2012.00211.x","volume":"17","author":"J Fechner","year":"2013","unstructured":"Fechner J, Ihmsen H, Schuttler J, Jeleazcov C. The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery. Eur J Pain. 2013;17(4):562\u201370.","journal-title":"Eur J Pain"},{"issue":"6","key":"774_CR3","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1093\/bja\/aeu137","volume":"112","author":"D Fletcher","year":"2014","unstructured":"Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis. Br J Anaesth. 2014;112(6):991\u20131004.","journal-title":"Br J Anaesth"},{"issue":"1","key":"774_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1213\/ANE.0000000000002145","volume":"125","author":"G Daccache","year":"2017","unstructured":"Daccache G, Jeanne M, Fletcher D. The analgesia nociception index: tailoring opioid administration. Anesth Analg. 2017;125(1):15\u20137.","journal-title":"Anesth Analg"},{"issue":"4","key":"774_CR5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/bja\/aet407","volume":"112","author":"E Boselli","year":"2014","unstructured":"Boselli E, Bouvet L, Begou G, Dabouz R, Davidson J, Deloste JY, Rahali N, Zadam A, Allaouchiche B. Prediction of immediate postoperative pain using the analgesia\/nociception index: a prospective observational study. Br J Anaesth. 2014;112(4):715\u201321.","journal-title":"Br J Anaesth"},{"key":"774_CR6","first-page":"1194","volume":"2010","author":"R Logier","year":"2010","unstructured":"Logier R, Jeanne M, De Jonckheere J, Dassonneville A, Delecroix M, Tavernier B. PhysioDoloris: a monitoring device for analgesia \/ nociception balance evaluation using heart rate variability analysis. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1194\u20137.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"5","key":"774_CR7","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1093\/bja\/aeu116","volume":"112","author":"E Boselli","year":"2014","unstructured":"Boselli E, Jeanne M. Analgesia\/nociception index for the assessment of acute postoperative pain. Br J Anaesth. 2014;112(5):936\u20137.","journal-title":"Br J Anaesth"},{"issue":"9","key":"774_CR8","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/AJP.0b013e3181ed1058","volume":"26","author":"PM Faye","year":"2010","unstructured":"Faye PM, De Jonckheere J, Logier R, Kuissi E, Jeanne M, Rakza T, Storme L. Newborn infant pain assessment using heart rate variability analysis. Clin J Pain. 2010;26(9):777\u201382.","journal-title":"Clin J Pain"},{"issue":"5","key":"774_CR9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/AJP.0000000000000572","volume":"34","author":"T Rakza","year":"2018","unstructured":"Rakza T, Butruille L, Thirel L, Houfflin-Debarge V, Logier R, Storme L, De Jonckheere J. Short-term impact of assisted deliveries: evaluation based on behavioral pain scoring and heart rate variability. Clin J Pain. 2018;34(5):445\u20139.","journal-title":"Clin J Pain"},{"issue":"3","key":"774_CR10","first-page":"288","volume":"81","author":"E Boselli","year":"2015","unstructured":"Boselli E, Bouvet L, Begou G, Torkmani S, Allaouchiche B. Prediction of hemodynamic reactivity during total intravenous anesthesia for suspension laryngoscopy using analgesia\/nociception index (ANI): a prospective observational study. Minerva Anestesiol. 2015;81(3):288\u201397.","journal-title":"Minerva Anestesiol"},{"issue":"2","key":"774_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/ALN.0000000000001670","volume":"127","author":"S Funcke","year":"2017","unstructured":"Funcke S, Sauerlaender S, Pinnschmidt HO, Saugel B, Bremer K, Reuter DA, Nitzschke R. Validation of innovative techniques for monitoring nociception during general anesthesia: a clinical study using tetanic and Intracutaneous electrical stimulation. Anesthesiology. 2017;127(2):272\u201383.","journal-title":"Anesthesiology"},{"issue":"5","key":"774_CR12","first-page":"480","volume":"81","author":"M Gruenewald","year":"2015","unstructured":"Gruenewald M, Herz J, Schoenherr T, Thee C, Steinfath M, Bein B. Measurement of the nociceptive balance by analgesia nociception index and surgical Pleth index during sevoflurane-remifentanil anesthesia. Minerva Anestesiol. 2015;81(5):480\u20139.","journal-title":"Minerva Anestesiol"},{"issue":"12","key":"774_CR13","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1097\/AJP.0000000000000083","volume":"30","author":"M Jeanne","year":"2014","unstructured":"Jeanne M, Delecroix M, De Jonckheere J, Keribedj A, Logier R, Tavernier B. Variations of the analgesia nociception index during propofol anesthesia for total knee replacement. Clin J Pain. 2014;30(12):1084\u20138.","journal-title":"Clin J Pain"},{"issue":"6","key":"774_CR14","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1002\/ejp.1191","volume":"22","author":"C. Cremillieux","year":"2018","unstructured":"Cremillieux C, Makhlouf A, Pichot V, Trombert B, Patural H. Objective assessment of induced acute pain in neonatology with the newborn infant parasympathetic evaluation index. Eur J Pain. 2018;22(6):1071\u20139.","journal-title":"European Journal of Pain"},{"key":"774_CR15","doi-asserted-by":"publisher","unstructured":"De Jonckheere J, Storme L. NIPE is related to parasympathetic activity. Is it also related to comfort? J Clin Monit Comput. 2019; https:\/\/doi.org\/10.1007\/s10877-019-00276-1 .","DOI":"10.1007\/s10877-019-00276-1"},{"issue":"4 Pt 1","key":"774_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1203\/00006450-199904010-00011","volume":"45","author":"TF Oberlander","year":"1999","unstructured":"Oberlander TF, Grunau RE, Pitfield S, Whitfield MF, Saul JP. The developmental character of cardiac autonomic responses to an acute noxious event in 4- and 8-month-old healthy infants. Pediatr Res. 1999;45(4 Pt 1):519\u201325.","journal-title":"Pediatr Res"},{"issue":"1","key":"774_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/pan.12586","volume":"25","author":"I Constant","year":"2015","unstructured":"Constant I, Sabourdin N. Monitoring depth of anesthesia: from consciousness to nociception. A window on subcortical brain activity. Paediatr Anaesth. 2015;25(1):73\u201382.","journal-title":"Paediatr Anaesth"},{"issue":"3","key":"774_CR18","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/ALN.0000000000001452","volume":"126","author":"Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration","year":"2017","unstructured":"Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration. Application to healthy patients undergoing elective procedures: an updated report by the American Society of Anesthesiologists Task Force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology. 2017;126(3):376\u201393.","journal-title":"Anesthesiology"},{"key":"774_CR19","first-page":"7747","volume":"2011","author":"J De Jonckheere","year":"2011","unstructured":"De Jonckheere J, Rakza T, Logier R, Jeanne M, Jounwaz R, Storme L. Heart rate variability analysis for newborn infants prolonged pain assessment. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7747\u201350.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"6","key":"774_CR20","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/j.1460-9592.2006.02162.x","volume":"17","author":"FS Xue","year":"2007","unstructured":"Xue FS, Liu KP, Liu Y, Xu YC, Liao X, Zhang GH, Li CW, Yang QY, Sun HT. Assessment of small-dose fentanyl and sufentanil blunting the cardiovascular responses to laryngoscopy and intubation in children. Paediatr Anaesth. 2007;17(6):568\u201374.","journal-title":"Paediatr Anaesth"},{"issue":"6","key":"774_CR21","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s10877-015-9802-8","volume":"30","author":"E Boselli","year":"2016","unstructured":"Boselli E, Logier R, Bouvet L, Allaouchiche B. Prediction of hemodynamic reactivity using dynamic variations of analgesia\/nociception index (ANI). J Clin Monit Comput. 2016;30(6):977\u201384.","journal-title":"J Clin Monit Comput"},{"issue":"1","key":"774_CR22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/aas.12216","volume":"58","author":"T Ledowski","year":"2014","unstructured":"Ledowski T, Averhoff L, Tiong WS, Lee C. Analgesia nociception index (ANI) to predict intraoperative haemodynamic changes: results of a pilot investigation. Acta Anaesthesiol Scand. 2014;58(1):74\u20139.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"12","key":"774_CR23","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/pan.12236","volume":"23","author":"M Janda","year":"2013","unstructured":"Janda M, Bajorat J, Kudlik C, Pohl B, Schubert A, Noldge-Schomburg G, Hofmockel R. Comparison of heart rate variability response in children undergoing elective endotracheal intubation with and without neuromuscular blockade: a randomized controlled trial. Paediatr Anaesth. 2013;23(12):1153\u20139.","journal-title":"Paediatr Anaesth"},{"key":"774_CR24","first-page":"222","volume":"4","author":"GE Billman","year":"2013","unstructured":"Billman GE. The effect of heart rate on the heart rate variability response to autonomic interventions. Front Physiol. 2013;4:222.","journal-title":"Front Physiol"},{"issue":"5","key":"774_CR25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/psyp.12027","volume":"50","author":"GA Reyes del Paso","year":"2013","unstructured":"Reyes del Paso GA, Langewitz W, Mulder LJ, van Roon A, Duschek S. The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: a review with emphasis on a reanalysis of previous studies. Psychophysiology. 2013;50(5):477\u201387.","journal-title":"Psychophysiology"},{"issue":"3","key":"774_CR26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ijpsycho.2013.12.006","volume":"91","author":"IM Lin","year":"2014","unstructured":"Lin IM, Tai LY, Fan SY. Breathing at a rate of 5.5 breaths per minute with equal inhalation-to-exhalation ratio increases heart rate variability. Int J Psychophysiol. 2014;91(3):206\u201311.","journal-title":"Int J Psychophysiol"},{"issue":"1\u20132","key":"774_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.autneu.2008.11.010","volume":"145","author":"AC Miu","year":"2009","unstructured":"Miu AC, Heilman RM, Miclea M. Reduced heart rate variability and vagal tone in anxiety: trait versus state, and the effects of autogenic training. Auton Neurosci. 2009;145(1\u20132):99\u2013103.","journal-title":"Auton Neurosci"},{"issue":"8","key":"774_CR28","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/j.1399-6576.1995.tb04229.x","volume":"39","author":"JW Sleigh","year":"1995","unstructured":"Sleigh JW, Henderson JD. Heart rate variability and preoperative anxiety. Acta Anaesthesiol Scand. 1995;39(8):1059\u201361.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"4","key":"774_CR29","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1017\/S0265021505000487","volume":"22","author":"T Ledowski","year":"2005","unstructured":"Ledowski T, Bein B, Hanss R, Tonner PH, Roller N, Scholz J. Pseudocholinesterase activity increases and heart rate variability decreases with preoperative anxiety. Eur J Anaesthesiol. 2005;22(4):289\u201392.","journal-title":"Eur J Anaesthesiol"},{"issue":"1\u20132","key":"774_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.autneu.2005.07.001","volume":"121","author":"AJ Terkelsen","year":"2005","unstructured":"Terkelsen AJ, Molgaard H, Hansen J, Andersen OK, Jensen TS. Acute pain increases heart rate: differential mechanisms during rest and mental stress. Auton Neurosci. 2005;121(1\u20132):101\u20139.","journal-title":"Auton Neurosci"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-019-0774-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12871-019-0774-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-019-0774-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T15:39:45Z","timestamp":1721403585000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-019-0774-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["774"],"URL":"https:\/\/doi.org\/10.1186\/s12871-019-0774-y","relation":{},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"assertion":[{"value":"27 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This observational prospective study was approved by the Local Ethics Committee of Shanghai Children\u2019s Medical Center affiliated to Shanghai Jiao Tong University (SCMCIRB-K2018049) and all parents or guardians of the patients signed the written informed consent voluntarily.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}