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Dexmedetomidine (DEX), an \u03b1\n                      <jats:sub>2<\/jats:sub>\n                      -adrenoreceptor agonist, has been proven having lung protection effects. However, since now, there has not been final conclusion about whether DEX can reduce the incidence of PPCs. We hypothesize that, in oral and maxillofacial surgery with fibular free flap reconstruction patients, DEX may decrease the incidence of PPCs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, double-blind, randomized, placebo-controlled, single-centered trial with two parallel arms. A total of 160 patients at intermediate-to-high risk of PPCs undergoing oral and maxillofacial surgery with fibular free flap reconstruction and tracheotomy were enrolled and randomized to receive continuous infusion of either DEX or placebo (normal saline). 0.4 \u03bcg\/kg of DEX was given over 10mins as an initial dose followed by a maintaining dose of 0.4 \u03bcg\/kg\/h till the second day morning after surgery. At the same time, the normal saline was administered a similar quantity. The primary outcome was the incidence of PPCs according to Clavien-Dindo score within 7\u2009days after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups had similar characteristics at baseline. 18(22.5%) of 80 patients administered DEX, and 32(40.0%) of 80 patient administered placebo experienced PPCs within the first 7\u2009days after surgery (relative risk [RR] 0.563,95% confidence interval [CI] 0.346\u20130.916;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017). In the first 7\u2009days after surgery, the DEX group had a lower incidence of PPCs and a better postoperative survival probability (Log-rank test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.019), and was less prone to occur PPCs (Cox regression,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.025, HR\u2009=\u20090.516). When the total dose of DEX was more than 328\u2009\u03bcg, the patients were unlikely to have PPCs (ROC curve, AUC\u2009=\u20090.614,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients undergoing oral and maxillofacial surgery with fibular free flap reconstruction and tracheotomy who were at intermediate or high risk of developing PPCs, continuous infusion of DEX could decrease the occurrence of PPCs during the first 7\u2009days after surgery and shorten the length of hospital stay after surgery, but did not increase the prevalence of bradycardia or hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Chinese Clinical Trial Registry,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>\n                      , number: ChiCTR1800016153; Registered on May 15, 2018.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12871-020-01045-3","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:02:48Z","timestamp":1590555768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dexmedetomidine for prevention of postoperative pulmonary complications in patients after oral and maxillofacial surgery with fibular free flap reconstruction:a prospective, double-blind, randomized, placebo-controlled trial"],"prefix":"10.1186","volume":"20","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-8831","authenticated-orcid":false,"given":"Xi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"1045_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/ACO.0000000000000730","volume":"32","author":"SG Nijbroek","year":"2019","unstructured":"Nijbroek SG, Schultz MJ, Hemmes SNT. 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