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The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine group and 83 in the control group. Dexmedetomidine group patients received intravesical instillation of the drug 0.5\u2009\u03bcg\/kg and normal saline 20\u2009mL, while the control group received intravesical instillation of 20\u2009mL normal saline. The catheter was clamped for 30\u2009min after intravesical instillation for all patients. CRBD scores and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30\u2009min (T2), 60\u2009min (T3), 2\u2009h (T4) after intravesical instillation, discharged from PACU (T5), and 6\u2009h (T6) and 24\u2009h (T7) after the operation. Patient satisfaction at discharge from PACU and 24\u2009h post-operation were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRBD scores and urethra pain NRS scores after 30\u2009min of intravesical dexmedetomidine instillation to 24\u2009h post-operation were significantly lower than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001), and patient satisfaction was higher at discharge from PACU and 24\u2009h post-operation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). No differences were detected in Steward score out of PACU (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.213) and from the time of the end of operation to fully awake (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.417).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intravesical dexmedetomidine instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Chinese Clinical Trial Registry (No.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=27947\">ChiCTR1800016429<\/jats:ext-link>\n                      ), date of registration 1st June 2018.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12871-020-01189-2","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T09:03:03Z","timestamp":1603357383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study"],"prefix":"10.1186","volume":"20","author":[{"given":"Hong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-7057","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"issue":"6","key":"1189_CR1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1089\/end.2014.0670","volume":"29","author":"Y Bai","year":"2015","unstructured":"Bai Y, Wang X, Li X, Pu C, Yuan H, Tang Y, et al. 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Is there a relationship between patient satisfaction and favorable surgical outcomes? 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Each patient provided written informed consent before participation in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"267"}}