{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:43Z","timestamp":1760029063001,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>COVID-19 can induce acute respiratory distress syndrome (ARDS). In patients with congenital heart disease, established treatment strategies are often limited due to their unique cardiovascular anatomy and passive pulmonary perfusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We report the first case of an adult with single-ventricle physiology and bidirectional cavopulmonary shunt who suffered from severe COVID-19 ARDS. Treatment strategies were successfully adopted, and pulmonary vascular resistance was reduced, both medically and through prone positioning, leading to a favorable outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ARDS treatment strategies including ventilatory settings, prone positioning therapy and cannulation techniques for extracorporeal oxygenation must be adopted carefully considering the passive venous return in patients with single-ventricle physiology.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-021-01504-5","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T05:02:59Z","timestamp":1636779779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe COVID-19 acute respiratory distress syndrome in an adult with single-ventricle physiology: a case report"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-4265","authenticated-orcid":false,"given":"G\u00f6tz","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"1504_CR1","doi-asserted-by":"publisher","unstructured":"Diller G-P, Gatzoulis MA, Broberg CS, Aboulhosn J, Brida M, Schwerzmann M, et al. Coronavirus disease 2019 In adults with congenital heart disease: a position paper from the ESC working group of adult congenital heart disease, and the International Society for Adult Congenital Heart Disease. Eur Heart J 2020;1\u20138. doi:https:\/\/doi.org\/10.1093\/eurheartj\/ehaa960.","DOI":"10.1093\/eurheartj\/ehaa960"},{"key":"1504_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jaccas.2020.10.032","volume":"3","author":"SS Vaikunth","year":"2021","unstructured":"Vaikunth SS, Bykhovsky MR, Romfh AW, Haeffele CL, Rogers IS, Dong E, et al. A 40-year-old man with tricuspid atresia, status post-Fontan, with severe COVID-19 pneumonia and pneumothorax. JACC Case Reports. 2021;3:187\u201391. https:\/\/doi.org\/10.1016\/j.jaccas.2020.10.032.","journal-title":"JACC Case Reports"},{"key":"1504_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjresp-2019-000420","volume":"6","author":"MJD Griffiths","year":"2019","unstructured":"Griffiths MJD, McAuley DF, Perkins GD, Barrett N, Blackwood B, Boyle A, et al. Guidelines on the management of acute respiratory distress syndrome. BMJ Open Respir Res. 2019;6:1\u201327. https:\/\/doi.org\/10.1136\/bmjresp-2019-000420.","journal-title":"BMJ Open Respir Res"},{"key":"1504_CR4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1164\/rccm.201703-0548ST","volume":"195","author":"E Fan","year":"2017","unstructured":"Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, et al. An official American Thoracic Society\/European society of intensive care medicine\/society of critical care medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195:1253\u201363. https:\/\/doi.org\/10.1164\/rccm.201703-0548ST.","journal-title":"Am J Respir Crit Care Med"},{"key":"1504_CR5","doi-asserted-by":"publisher","unstructured":"Perier F, Tuffet S, Maraffi T, Alcala G, Victor M, Haudebourg AF, et al. Effect of positive end-expiratory pressure and Proning on ventilation and perfusion in COVID-19 acute respiratory distress syndrome. Am J Respir Crit Care Med. 2020:1713\u20137. https:\/\/doi.org\/10.1164\/rccm.202008-3058LE.","DOI":"10.1164\/rccm.202008-3058LE"},{"key":"1504_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/icvts\/ivw126","volume":"23","author":"J Huang","year":"2016","unstructured":"Huang J, Zhou Y, Zhu D. Systemic haemodynamics and regional tissue oxygen saturation after bidirectional cavopulmonary shunt: positive pressure ventilation versus spontaneous breathing. Interact Cardiovasc Thorac Surg. 2016;23:235\u20139. https:\/\/doi.org\/10.1093\/icvts\/ivw126.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"1504_CR7","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1056\/nejmoa1214103","volume":"368","author":"C Gu\u00e9rin","year":"2013","unstructured":"Gu\u00e9rin C, Reignier J, Richard J-C, Beuret P, Gacouin A, Boulain T, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013;368:2159\u201368. https:\/\/doi.org\/10.1056\/nejmoa1214103.","journal-title":"N Engl J Med"},{"key":"1504_CR8","doi-asserted-by":"publisher","unstructured":"Reynolds AS, Lee AG, Renz J, DeSantis K, Liang J, Powell CA, et al. Pulmonary vascular dilatation detected by automated transcranial doppler in COVID-19 pneumonia. Am J Respir Crit Care Med. 2020:1037\u20139. https:\/\/doi.org\/10.1164\/rccm.202006-2219LE.","DOI":"10.1164\/rccm.202006-2219LE"},{"key":"1504_CR9","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1152\/JAPPLPHYSIOL.00871.2020","volume":"130","author":"M Busana","year":"2021","unstructured":"Busana M, Giosa L, Cressoni M, Gasperetti A, Di Girolamo L, Martinelli A, et al. The impact of ventilation\u2013perfusion inequality in COVID-19: a computational model. J Appl Physiol. 2021;130:865\u201376. https:\/\/doi.org\/10.1152\/JAPPLPHYSIOL.00871.2020.","journal-title":"J Appl Physiol"},{"key":"1504_CR10","doi-asserted-by":"publisher","unstructured":"Galambos C, Bush D, Abman SH. Intrapulmonary bronchopulmonary anastomoses in COVID-19 respiratory failure. Eur Respir J. 2021. https:\/\/doi.org\/10.1183\/13993003.04397-2020.","DOI":"10.1183\/13993003.04397-2020"},{"key":"1504_CR11","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.athoracsur.2003.09.042","volume":"77","author":"KL Booth","year":"2004","unstructured":"Booth KL, Roth SJ, Thiagarajan RR, Almodovar MC, Del Nido PJ, Laussen PC. Extracorporeal membrane oxygenation support of the Fontan and bidirectional Glenn circulations. Ann Thorac Surg. 2004;77:1341\u20138. https:\/\/doi.org\/10.1016\/j.athoracsur.2003.09.042.","journal-title":"Ann Thorac Surg"},{"key":"1504_CR12","doi-asserted-by":"publisher","unstructured":"Smith MJ, Hayward SA, Innes SM, Miller ASC. Point-of-care lung ultrasound in patients with COVID-19 \u2013 a narrative review. Anaesthesia. 2020:1096\u2013104. https:\/\/doi.org\/10.1111\/anae.15082.","DOI":"10.1111\/anae.15082"},{"key":"1504_CR13","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/jum.15285","volume":"39","author":"G Soldati","year":"2020","unstructured":"Soldati G, Smargiassi A, Inchingolo R, Buonsenso D, Perrone T, Briganti DF, et al. Proposal for international standardization of the use of lung ultrasound for patients with COVID-19. J Ultrasound Med. 2020;39:1413\u20139. https:\/\/doi.org\/10.1002\/jum.15285.","journal-title":"J Ultrasound Med"},{"key":"1504_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M20-2003","volume":"173","author":"D Wichmann","year":"2020","unstructured":"Wichmann D, Sperhake JP, L\u00fctgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med. 2020;173:268\u201377. https:\/\/doi.org\/10.7326\/M20-2003.","journal-title":"Ann Intern Med"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-021-01504-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12871-021-01504-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-021-01504-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T05:04:34Z","timestamp":1636779874000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-021-01504-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1504"],"URL":"https:\/\/doi.org\/10.1186\/s12871-021-01504-5","relation":{},"ISSN":["1471-2253"],"issn-type":[{"type":"electronic","value":"1471-2253"}],"subject":[],"published":{"date-parts":[[2021,11,13]]},"assertion":[{"value":"5 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal representative for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"280"}}