{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:53:56Z","timestamp":1794099236981,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this systematic review and network meta-analysis was to compare the effects of single-shot ultrasound-guided regional anesthesia techniques on postoperative opioid consumption in patients undergoing open cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review and network meta-analysis involved cardiac surgical patients (age\u2009&gt;\u200918 y) requiring median sternotomy. We searched PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Web of Science. The effects of the single-shot ultrasound-guided regional anesthesia technique were compared with those of placebo and no intervention. We conducted a risk assessment of bias for eligible studies and assessed the overall quality of evidence for each outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary outcome was opioid consumption during the first 24\u00a0h after surgery. The secondary outcomes were pain after extubation at 12 and 24\u00a0h, postoperative nausea and vomiting, extubation time, intensive care unit discharge time, and length of hospital stay. Fifteen studies with 849 patients were included. The regional anesthesia techniques included pecto-intercostal fascial block, transversus thoracis muscle plane block, erector spinae plane (ESP) block, and pectoralis nerve block I. All the regional anesthesia techniques included significantly reduced postoperative opioid consumption at 24\u00a0h, expressed as morphine milligram equivalents (MME). The ESP block was the most effective treatment (-22.93 MME [-34.29;-11.56]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this meta-analysis, we concluded that fascial plane blocks were better than placebo when\u00a0evaluating 24\u00a0h MMEs. However, it is still challenging to determine which is better, given the paucity of studies available in the literature. More randomized controlled trials are required to determine which regional anesthesia technique is better.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>PROSPERO; CRD42022315497.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12871-022-01952-7","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:03:03Z","timestamp":1672272183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Effects of ultrasound-guided regional anesthesia in cardiac surgery: a systematic review and network meta-analysis"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-1172","authenticated-orcid":false,"given":"Burhan","family":"Dost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"De Cassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Balzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Tulgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahiskalioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"25 Suppl","key":"1952_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jacc.2012.11.002","volume":"60","author":"LJ Laslett","year":"2012","unstructured":"Laslett LJ, Alagona P Jr, Clark BA 3rd, Drozda JP Jr, Saldivar F, Wilson SR, Poe C, Hart M. The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology. J Am Coll Cardiol. 2012;60(25 Suppl):S1-49.","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"1952_CR2","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1001\/jamasurg.2017.0898","volume":"152","author":"EC Wick","year":"2017","unstructured":"Wick EC, Grant MC, Wu CL. Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review. JAMA Surg. 2017;152(7):691\u20137.","journal-title":"JAMA Surg"},{"key":"1952_CR3","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.2147\/JPR.S162067","volume":"11","author":"M Zubrzycki","year":"2018","unstructured":"Zubrzycki M, Liebold A, Skrabal C, Reinelt H, Ziegler M, Perdas E, Zubrzycka M. Assessment and pathophysiology of pain in cardiac surgery. J Pain Res. 2018;11:1599\u2013611.","journal-title":"J Pain Res"},{"issue":"2","key":"1952_CR4","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1053\/j.jvca.2018.09.017","volume":"33","author":"AJC Mittnacht","year":"2019","unstructured":"Mittnacht AJC, Shariat A, Weiner MM, Malhotra A, Miller MA, Mahajan A, Bhatt HV. Regional Techniques for Cardiac and Cardiac-Related Procedures. J Cardiothorac Vasc Anesth. 2019;33(2):532\u201346.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"4","key":"1952_CR5","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1097\/00000542-200610000-00026","volume":"105","author":"P Lahtinen","year":"2006","unstructured":"Lahtinen P, Kokki H, Hynynen M. Pain after cardiac surgery: a prospective cohort study of 1-year incidence and intensity. Anesthesiology. 2006;105(4):794\u2013800.","journal-title":"Anesthesiology"},{"issue":"1","key":"1952_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bja\/85.1.109","volume":"85","author":"JP Desborough","year":"2000","unstructured":"Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85(1):109\u201317.","journal-title":"Br J Anaesth"},{"issue":"4","key":"1952_CR7","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ccc.2020.06.003","volume":"36","author":"LF Barr","year":"2020","unstructured":"Barr LF, Boss MJ, Mazzeffi MA, Taylor BS, Salenger R. Postoperative Multimodal Analgesia in Cardiac Surgery. Crit Care Clin. 2020;36(4):631\u201351.","journal-title":"Crit Care Clin"},{"issue":"1","key":"1952_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11916-022-01001-5","volume":"26","author":"R Sharma","year":"2022","unstructured":"Sharma R, Louie A, Thai CP, Dizdarevic A. Chest Wall Nerve Blocks for Cardiothoracic, Breast Surgery, and Rib-Related Pain. Curr Pain Headache Rep. 2022;26(1):43\u201356.","journal-title":"Curr Pain Headache Rep"},{"issue":"36","key":"1952_CR9","doi-asserted-by":"publisher","first-page":"5794","DOI":"10.2174\/1381612820666140204112011","volume":"20","author":"H Ishii","year":"2014","unstructured":"Ishii H. Cardioprotection with opioids\u2013 trusted old friends -clinical science. Curr Pharm Des. 2014;20(36):5794\u20138.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"1952_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1213\/ANE.0000000000004682","volume":"131","author":"M Kelava","year":"2020","unstructured":"Kelava M, Alfirevic A, Bustamante S, Hargrave J, Marciniak D. Regional Anesthesia in Cardiac Surgery: An Overview of Fascial Plane Chest Wall Blocks. Anesth Analg. 2020;131(1):127\u201335.","journal-title":"Anesth Analg"},{"key":"1952_CR11","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.aan.2021.08.001","volume":"39","author":"MJ Ritter","year":"2021","unstructured":"Ritter MJ, Christensen JM, Yalamuri SM. Regional Anesthesia for Cardiac Surgery: A Review of Fascial Plane Blocks and Their Uses. Adv Anesth. 2021;39:215\u201340.","journal-title":"Adv Anesth"},{"key":"1952_CR12","doi-asserted-by":"crossref","unstructured":"Li J, Lin L, Peng J, He S, Wen Y, Zhang M. Efficacy of ultrasound-guided parasternal block in adult cardiac surgery: a meta-analysis of randomized controlled trials. Minerva Anestesiol. 2022;88(9):719\u201328.","DOI":"10.23736\/S0375-9393.22.16272-3"},{"issue":"7","key":"1952_CR13","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","volume":"6","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.","journal-title":"PLoS Med"},{"key":"1952_CR14","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.","journal-title":"BMJ"},{"key":"1952_CR15","doi-asserted-by":"publisher","first-page":"g5630","DOI":"10.1136\/bmj.g5630","volume":"349","author":"MA Puhan","year":"2014","unstructured":"Puhan MA, Sch\u00fcnemann HJ, Murad MH, Li T, Brignardello-Petersen R, Singh JA, Kessels AG, Guyatt GH. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ. 2014;349:g5630.","journal-title":"BMJ"},{"key":"1952_CR16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12874-015-0060-8","volume":"15","author":"G R\u00fccker","year":"2015","unstructured":"R\u00fccker G, Schwarzer G. Ranking treatments in frequentist network meta-analysis works without resampling methods. BMC Med Res Methodol. 2015;15:58.","journal-title":"BMC Med Res Methodol"},{"key":"1952_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.","journal-title":"BMC Med Res Methodol"},{"issue":"7414","key":"1952_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557\u201360.","journal-title":"BMJ"},{"issue":"1","key":"1952_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12871-021-01391-w","volume":"21","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Gong H, Zhan B, Chen S. Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study. BMC Anesthesiol. 2021;21(1):175.","journal-title":"BMC Anesthesiol"},{"issue":"12","key":"1952_CR20","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1053\/j.jvca.2021.03.009","volume":"35","author":"M Athar","year":"2021","unstructured":"Athar M, Parveen S, Yadav M, Siddiqui OA, Nasreen F, Ali S, Haseen MA. A Randomized Double-Blind Controlled Trial to Assess the Efficacy of Ultrasound-Guided Erector Spinae Plane Block in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2021;35(12):3574\u201380.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"1952_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1053\/j.jvca.2020.07.074","volume":"35","author":"AK Kumar","year":"2021","unstructured":"Kumar AK, Chauhan S, Bhoi D, Kaushal B. Pectointercostal Fascial Block (PIFB) as a Novel Technique for Postoperative Pain Management in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2021;35(1):116\u201322.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"3","key":"1952_CR22","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1053\/j.jvca.2020.07.058","volume":"35","author":"T Khera","year":"2021","unstructured":"Khera T, Murugappan KR, Leibowitz A, Bareli N, Shankar P, Gilleland S, Wilson K, Oren-Grinberg A, Novack V, Venkatachalam S, et al. Ultrasound-Guided Pecto-Intercostal Fascial Block for Postoperative Pain Management in Cardiac Surgery: A Prospective, Randomized Placebo-Controlled Trial. J Cardiothorac Vasc Anesth. 2021;35(3):896\u2013903.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"11","key":"1952_CR23","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1053\/j.jvca.2020.06.044","volume":"34","author":"ME Aydin","year":"2020","unstructured":"Aydin ME, Ahiskalioglu A, Ates I, Tor IH, Borulu F, Erguney OD, Celik M, Dogan N. Efficacy of Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Postoperative Opioid Consumption After Cardiac Surgery: A Prospective, Randomized Double-Blind Study. J Cardiothorac Vasc Anesth. 2020;34(11):2996\u20133003.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"2","key":"1952_CR24","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1053\/j.jvca.2018.05.050","volume":"33","author":"SN Krishna","year":"2019","unstructured":"Krishna SN, Chauhan S, Bhoi D, Kaushal B, Hasija S, Sangdup T, Bisoi AK. Bilateral Erector Spinae Plane Block for Acute Post-Surgical Pain in Adult Cardiac Surgical Patients: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. 2019;33(2):368\u201375.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"1952_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12871-021-01291-z","volume":"21","author":"H Chen","year":"2021","unstructured":"Chen H, Song W, Wang W, Peng Y, Zhai C, Yao L, Xia Z. Ultrasound-guided parasternal intercostal nerve block for postoperative analgesia in mediastinal mass resection by median sternotomy: a randomized, double-blind, placebo-controlled trial. BMC Anesthesiol. 2021;21(1):98.","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"1952_CR26","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/AJP.0000000000001022","volume":"38","author":"MA Hamed","year":"2022","unstructured":"Hamed MA, Abdelhady MA, Hassan A, Boules ML. The Analgesic Effect of Ultrasound-guided Bilateral Pectointercostal Fascial Plane Block on Sternal Wound Pain After Open Heart Surgeries: A Randomized Controlled Study. Clin J Pain. 2022;38(4):279\u201384.","journal-title":"Clin J Pain"},{"key":"1952_CR27","doi-asserted-by":"crossref","unstructured":"Kaya C, Dost B, Dokmeci O, Yucel SM, Karakaya D. Comparison of Ultrasound-Guided Pectointercostal Fascial Block and Transversus Thoracic Muscle Plane Block for Acute Poststernotomy Pain Management After Cardiac Surgery: A Prospective, Randomized, Double-Blind Pilot Study. J Cardiothorac Vasc Anesth. 2022;36(8 Pt A):2313\u201321.","DOI":"10.1053\/j.jvca.2021.09.041"},{"key":"1952_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2147\/LRA.S338685","volume":"14","author":"H Shokri","year":"2021","unstructured":"Shokri H, Ali I, Kasem AA. Evaluation of the Analgesic Efficacy of Bilateral Ultrasound-Guided Transversus Thoracic Muscle Plane Block on Post-Sternotomy Pain: A Randomized Controlled Trial. Local Reg Anesth. 2021;14:145\u201352.","journal-title":"Local Reg Anesth"},{"issue":"5","key":"1952_CR29","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1136\/rapm-2018-100178","volume":"44","author":"S Fujii","year":"2019","unstructured":"Fujii S, Roche M, Jones PM, Vissa D, Bainbridge D, Zhou JR. Transversus thoracis muscle plane block in cardiac surgery: a pilot feasibility study. Reg Anesth Pain Med. 2019;44(5):556\u201360.","journal-title":"Reg Anesth Pain Med"},{"issue":"8","key":"1952_CR30","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1111\/jocs.15666","volume":"36","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Li X, Chen S. Bilateral transversus thoracis muscle plane block provides effective analgesia and enhances recovery after open cardiac surgery. J Card Surg. 2021;36(8):2818\u201323.","journal-title":"J Card Surg"},{"issue":"3","key":"1952_CR31","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4103\/aca.ACA_15_18","volume":"21","author":"KN Kumar","year":"2018","unstructured":"Kumar KN, Kalyane RN, Singh NG, Nagaraja PS, Krishna M, Babu B, Varadaraju R, Sathish N, Manjunatha N. Efficacy of bilateral pectoralis nerve block for ultrafast tracking and postoperative pain management in cardiac surgery. Ann Card Anaesth. 2018;21(3):333\u20138.","journal-title":"Ann Card Anaesth"},{"key":"1952_CR32","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2147\/JPR.S355231","volume":"15","author":"MA Hamed","year":"2022","unstructured":"Hamed MA, Boules ML, Sobhy MM, Abdelhady MA. The Analgesic Efficacy of Ultrasound-Guided Bilateral Transversus Thoracic Muscle Plane Block After Open-Heart Surgeries: A Randomized Controlled Study. J Pain Res. 2022;15:675\u201382.","journal-title":"J Pain Res"},{"key":"1952_CR33","doi-asserted-by":"crossref","unstructured":"Guven BB, Erturk T, Ersoy A. Postoperative analgesic effectiveness of bilateral erector spinae plane block for adult cardiac surgery: a randomized controlled trial. J Health Sci Med. 2022;5(1):150\u201355.","DOI":"10.32322\/jhsm.1013908"},{"key":"1952_CR34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jclinane.2019.08.005","volume":"60","author":"R Magoon","year":"2020","unstructured":"Magoon R, Makhija N, Sarkar S. Erector spinae plane block and cardiac surgery: \u201ca closer look.\u201d J Clin Anesth. 2020;60:8.","journal-title":"J Clin Anesth"},{"issue":"7","key":"1952_CR35","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/rapm-2020-102451","volume":"46","author":"K El-Boghdadly","year":"2021","unstructured":"El-Boghdadly K, Wolmarans M, Stengel AD, Albrecht E, Chin KJ, Elsharkawy H, Kopp S, Mariano ER, Xu JL, Adhikary S, et al. Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of abdominal wall, paraspinal, and chest wall blocks. Reg Anesth Pain Med. 2021;46(7):571\u201380.","journal-title":"Reg Anesth Pain Med"},{"issue":"1","key":"1952_CR36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1213\/01.ANE.0000139652.84897.BD","volume":"100","author":"SB McDonald","year":"2005","unstructured":"McDonald SB, Jacobsohn E, Kopacz DJ, Desphande S, Helman JD, Salinas F, Hall RA. Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: the effect on postoperative pain, pulmonary function, and tracheal extubation times. Anesth Analg. 2005;100(1):25\u201332.","journal-title":"Anesth Analg"},{"issue":"2","key":"1952_CR37","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/15533506211068930","volume":"29","author":"M Hu","year":"2022","unstructured":"Hu M, Wang Y, Hao B, Gong C, Li Z. Evaluation of Different Pain-Control Procedures for Post-cardiac Surgery: A Systematic Review and Network Meta-Analysis. Surg Innov. 2022;29(2):269\u201377.","journal-title":"Surg Innov"},{"issue":"1","key":"1952_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/rapm-2020-101917","volume":"46","author":"N Hussain","year":"2021","unstructured":"Hussain N, Brull R, Noble J, Weaver T, Essandoh M, McCartney CJ, Abdallah FW. Statistically significant but clinically unimportant: a systematic review and meta-analysis of the analgesic benefits of erector spinae plane block following breast cancer surgery. Reg Anesth Pain Med. 2021;46(1):3\u201312.","journal-title":"Reg Anesth Pain Med"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-022-01952-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12871-022-01952-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-022-01952-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T04:02:32Z","timestamp":1672545752000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-022-01952-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1952"],"URL":"https:\/\/doi.org\/10.1186\/s12871-022-01952-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.165900973.31763770\/v1","asserted-by":"object"}]},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"31 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"409"}}