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Left and right SctO<jats:sub>2<\/jats:sub> were collected during anesthesia. The primary outcome was the correlation between left and right SctO<jats:sub>2<\/jats:sub> at 30\u00a0min after OLV which was analysed by Pearson correlation and linear regression model. Secondary outcomes included the trend of left\u2013right SctO<jats:sub>2<\/jats:sub> change over the first 30\u00a0min after OLV, correlation of left\u2013right SctO<jats:sub>2<\/jats:sub> during OLV for each patient; maximal difference between left\u2013right SctO<jats:sub>2<\/jats:sub> and its relationship with postoperative delirium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Left\u2013right SctO<jats:sub>2<\/jats:sub> was moderately correlated at baseline (<jats:italic>r<\/jats:italic>\u2009=\u20090.690, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and poorly correlated at 30\u00a0min after OLV (<jats:italic>r<\/jats:italic>\u2009=\u20090.383, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the Pearson correlation analysis. Linear regression analysis showed a poor correlation between left and right SctO<jats:sub>2<\/jats:sub> at 30\u00a0min after OLV (<jats:italic>r<\/jats:italic>\u2009=\u20090.323, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) after adjusting for confounders. The linear mixed model showed a change in left\u2013right SctO<jats:sub>2<\/jats:sub> over the first 30\u00a0min after OLV that was statistically significant (coefficient, -0.042; 95% CI, -0.070\u2013-0.014; <jats:italic>P<\/jats:italic>\u2009=\u20090.004). For the left\u2013right SctO<jats:sub>2<\/jats:sub> correlation during OLV in each patient, 62.9% (78\/124) patients showed a strong correlation, 19.4% (24\/124) a medium correlation, and the rest a poor correlation. The maximal difference between the left and right SctO<jats:sub>2<\/jats:sub> was 13.5 (9.0, 20.0). Multivariate analysis showed that it was not associated with delirium (odds ratio [OR], 1.023; 95% CI, 0.963\u20131.087; <jats:italic>P<\/jats:italic>\u2009=\u20090.463).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The correlation between left and right SctO<jats:sub>2<\/jats:sub> was affected by one-lung ventilation in patients undergoing lung cancer surgery. This result indicates the requirement of bilateral SctO<jats:sub>2<\/jats:sub> monitoring to reflect brain oxygenation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This study was a secondary analysis of a cohort study approved by the Clinical Research Review Board of Peking University First Hospital (#2017\u20131378) and was registered in the Chinese Clinical Trial Registry on 10\/09\/2017 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\">http:\/\/www.chictr.org.cn<\/jats:ext-link>, ChiCTR-ROC-17012627).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-023-02001-7","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:04:36Z","timestamp":1675836276000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of one-lung ventilation on the correlation between left and right cerebral saturation"],"prefix":"10.1186","volume":"23","author":[{"given":"Cai-Juan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Qun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Liang","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"issue":"6","key":"2001_CR1","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/ACO.0000000000000256","volume":"28","author":"A Moerman","year":"2015","unstructured":"Moerman A, De Hert S. 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Written informed consent was obtained from all subjects and\/or their legal guardians. This study was registered in the Chinese Clinical Trial Registry on 10\/09\/2017 (, ChiCTR-ROC-17012627). All methods were performed in accordance with the relevant guidelines and regulations at Peking University First Hospital and Fourth Hospital of Hebei Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"50"}}