{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:34:16Z","timestamp":1788806056388,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Desflurane is not recommended during anesthesia induction because of its sympathetic stimulation effect, particularly in patients with myocardial ischemic disease. To date, the hemodynamic response to 1 MAC desflurane inhalation in combination with remifentanil infusion during anesthesia induction has rarely been reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This investigation was designed to compare hemodynamic responses to 1 MAC desflurane (group D, <jats:italic>n<\/jats:italic>\u2009=\u2009200) with sevoflurane (group S, <jats:italic>n<\/jats:italic>\u2009=\u2009200) during anesthesia induction and endotracheal intubation in adult patients undergoing elective spine surgery. Subgroup analysis of the different age subgroups was also performed. With continuous infusion of remifentanil 0.1\u00a0\u03bcg\/kg\/min, anesthesia was induced with propofol bolus, and endotracheal intubation was performed after muscle relaxation. Heart rate (HR) and mean arterial blood pressure (MAP) were measured every minute for 5\u00a0min after anesthesia induction (T1-5) and after endotracheal intubation (T6-10).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>HR was significantly higher in group D (<jats:italic>n<\/jats:italic>\u2009=\u2009182) than in group S (<jats:italic>n<\/jats:italic>\u2009=\u2009173) at T3-10 except at T6 (1\u00a0min after intubation) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the age-based subgroup analyses, which subdivided the group D and S into four subgroups based on patient\u2019s age, the changes in HR from baseline values were significantly different between the coeval subgroups of patients in their 20\u201329\u00a0years and 30\u201339\u00a0years of age (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). MAP was reduced from baseline value, irrespective of group and age.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Inhalation of 1 MAC desflurane during anesthesia induction with propofol bolus and remifentanil continuous infusion and during endotracheal intubation was more likely to induce elevations in HR more likely than 1 MAC sevoflurane, especially in younger patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This study was registered in the Clinical Research Information Service (CRIS, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cris.nih.go.kr\">http:\/\/cris.nih.go.kr<\/jats:ext-link>) of the Republic of Korea on Feb 12, 2016 (Registration No. KCT 0,001,813).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-023-02002-6","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T06:32:57Z","timestamp":1677047577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemodynamic responses to 1 MAC desflurane inhalation during anesthesia induction with propofol bolus and remifentanil continuous infusion: a prospective randomized single-blind clinical investigation"],"prefix":"10.1186","volume":"23","author":[{"given":"Jong Wha","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"issue":"2","key":"2002_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1213\/00000539-199108000-00007","volume":"73","author":"RB Weiskopf","year":"1991","unstructured":"Weiskopf RB, Cahalan MK, Eger EI 2nd, et al. Cardiovascular actions of desflurane in normocarbic volunteers. Anesth Analg. 1991;73(2):143\u201356.","journal-title":"Anesth Analg"},{"issue":"2","key":"2002_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1213\/00000539-199108000-00008","volume":"73","author":"MK Cahalan","year":"1991","unstructured":"Cahalan MK, Weiskopf RB, Eger EI 2nd, et al. Hemodynamic effects of desflurane\/nitrous oxide anesthesia in volunteers. Anesth Analg. 1991;73(2):157\u201364.","journal-title":"Anesth Analg"},{"issue":"3","key":"2002_CR3","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/00000542-199309000-00006","volume":"79","author":"TJ Ebert","year":"1993","unstructured":"Ebert TJ, Muzi M. Sympathetic hyperactivity during desflurane anesthesia in healthy volunteers a comparison with isoflurane. 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This study was registered in the Clinical Research Information Service (CRIS, ) of the Republic of Korea (KCT 0001813) on 12\/02\/2016. This investigation has been conducted in accordance with the Declaration of Helsinki (1964) and its successive amendments. Informed consent to participate was obtained from all the participants of this investigation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}