{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:47:09Z","timestamp":1787932029731,"version":"build-2784847793"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comparison of whether intrathecal dexmedetomidine prolongs spinal anesthesia-associated sensorimotor blockade more than intravenous infusion during knee arthroscopy procedures performed under subarachnoid blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety patients aged 18\u201375\u00a0years, ASA class I-II, who underwent knee arthroscopy between October 2022 and April 2023 were randomized into intrathecal\u3001intravenous and control groups.Subjects received three modes of administration: an intrathecal group (2\u00a0ml of 1% ropivacaine\u2009+\u20091\u00a0ml of 5\u00a0\u03bcg dexmedetomidine, along with intravenous saline infusion), an intravenous group (intrathecal 2\u00a0ml of 1% ropivacaine\u2009+\u20091\u00a0ml of 0.9% saline, with dexmedetomidine pumped intravenously at a dose of 0.5\u00a0\u03bcg\/kg\/h), and a control group (intrathecal 2\u00a0ml of 1% ropivacaine\u2009+\u20091\u00a0ml of 0.9% saline, along with intravenous saline infusion). Total analgesic duration, duration of sensory and motor blockade, Ramsay sedation score, Visual Analogue Score (VAS) at different postoperative time points, and occurrence of adverse effects were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total analgesia duration was significantly longer in the intrathecal group than in the intravenous and control groups (352.13\u2009\u00b1\u200951.70\u00a0min\n                      <jats:italic>VS<\/jats:italic>\n                      273.47\u2009\u00b1\u200962.57\u00a0min\n                      <jats:italic>VS<\/jats:italic>\n                      241.41\u2009\u00b1\u200959.22\u00a0min,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).The onset of sensory block was shorter in the intrathecal group than in the intravenous and control groups (4 [3\u20134]min\n                      <jats:italic>VS<\/jats:italic>\n                      5 [4\u20135]min\n                      <jats:italic>VS<\/jats:italic>\n                      5 [4\u20135]min;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001);the onset of motor block was shorter in the intrathecal group than in the intravenous group and the control group (5 [4\u20135]min\n                      <jats:italic>VS<\/jats:italic>\n                      5 [5\u20136]min\n                      <jats:italic>VS<\/jats:italic>\n                      6[5.5\u20137]min;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).Sedation scores were higher in the intravenous group than in the intrathecal and control groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 5\u00a0h postoperatively, the VAS score in the intrathecal group was lower than that in the intravenous and control groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 24\u00a0h postoperatively, the VAS score in the intrathecal group was lower than that in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In addition, the incidence of bradycardia was significantly higher in the intravenous group than in the intrathecal and control groups (30%, 6.5%, and 3.4%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intrathecal administration of dexmedetomidine did prolong the total analgesia duration, as well as accelerate the onset of sensory-motor blockade compared with intravenous infusion, and did not result in any hemodynamic instability or other adverse events at the doses studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>This single-center, prospective, RCT has completed the registration of the Chinese Clinical Trial Center at 26\/09\/2023 with the registration number ChiCTR2300076170.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12871-023-02401-9","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T02:02:09Z","timestamp":1704420129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the effect of dexmedetomidine intrathecal injection and intravenous infusion on subarachnoid blockade during knee arthroscopy procedures: a randomized controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Shujiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaorui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YeWen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"issue":"2","key":"2401_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00167-016-4407-4","volume":"25","author":"P Beaufils","year":"2017","unstructured":"Beaufils P, Becker R, Kopf S, et al. 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