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The main outcome was the incidence of postoperative delirium, and the secondary outcomes were side effects of haloperidol and the length of hospital stay. The meta-analyses were conducted using the Review Manager Version 5.1. This study was conducted based on the PRISMA statement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eight RCTs (1569 patients) were included in the meta-analysis. There was a significant difference in the incidence of postoperative delirium between haloperidol and control groups (OR\u2009=\u20090.62, 95%CI 0.48\u20130.80, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002, I<jats:sup>2<\/jats:sup>\u2009=\u200920%). In addition, side effects of haloperidol and the duration of hospitalization were comparable (OR\u2009=\u20090.58, 95%CI 0.25\u20131.35, <jats:italic>P<\/jats:italic>\u2009=\u20090.21, I<jats:sup>2<\/jats:sup>\u2009=\u20090%; MD =-0.01, 95%CI -0.16-0.15, <jats:italic>P<\/jats:italic>\u2009=\u20090.92, I<jats:sup>2<\/jats:sup>\u2009=\u200928%). Subgroup analysis implied the effect of haloperidol on postoperative delirium might vary with the dose (5\u00a0mg daily: OR\u2009=\u20090.40, 95%CI 0.22\u20130.71, <jats:italic>P<\/jats:italic>\u2009=\u20090.002, I<jats:sup>2<\/jats:sup>\u2009=\u20090%; &lt;5\u00a0mg daily: OR\u2009=\u20090.72, 95%CI 0.42\u20131.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.23, I<jats:sup>2<\/jats:sup>\u2009=\u20090%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The meta-analysis revealed perioperative application of haloperidol could decrease the occurrence of postoperative delirium without obvious side effects in elderly people, and high-dose haloperidol (5\u00a0mg daily) possessed a greater positive effect.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-024-02434-8","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T04:58:55Z","timestamp":1706936335000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of haloperidol\u2019s perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"24","author":[{"given":"Meinv","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"issue":"6","key":"2434_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.23736\/S0375-9393.22.16076-1","volume":"88","author":"A Fanelli","year":"2022","unstructured":"Fanelli A, Balzani E, Memtsoudis S, Abdallah FW, Mariano ER. 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