{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:35:05Z","timestamp":1784885705083,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the effects of low-dose S-ketamine on marker of myocardial injury (BNP, hs-cTnT and HFABP) after thoracoscopic lobectomy in patients aged 70 to 85.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>One hundred patients (four cases excluded) aged 70\u201385\u00a0years, with body mass index 18\u201324\u00a0kg\u00b7m<jats:sup>\u22122<\/jats:sup> and American Society of Anesthesiologists physical status II\u2013III, scheduled for elective lobectomy from April 2022 to April 2023, were selected. The patients were divided into two groups by a random number table method, namely, the low-dose S-ketamine combined with GDFT group (group S) and the control group (group C), with 48 cases in each group. In group S, a low dose of S-ketamine (0.2\u00a0mg\/kg) was given 1\u00a0min before intubation, and the maintenance dose was 0.12\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup>. Fluid therapy, guided by cardiac index (CI), changes in stroke volume (\u25b3SV), and other dynamic indicators, was used for rehydration during the operation. Group C was given the same amount of normal saline (0.2\u00a0mg\/kg) 1\u00a0min before intubation, and the same rehydration therapy was adopted during the operation. The mean arterial pressure (MAP) and heart rate (HR) of the two groups were observed and recorded immediately after entering the operating room (T0), immediately after intubation (T1), immediately after the beginning of one-lung ventilation (OLV) (T2), immediately after the beginning of surgery (T3), immediately after the end of OLV (T4), and at the end of surgery (T5). The intraoperative fluid intake and output and the use of vasoactive drugs were recorded. The plasma levels of heart-type fatty acid\u2013binding protein (HFABP), high-sensitivity troponin T (hs-cTnT), brain natriuretic peptide (BNP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-\u03b1 (TNF-\u03b1) were recorded 24\u00a0h before operation and 24 and 48\u00a0h after operation. Visual analogue scale (VAS) pain scores at rest were recorded at 2 (V1), 6 (V2), 12 (V3), 24 (V4), and 48\u00a0h (V5) after operation, and the occurrence of myocardial ischemia during hospitalization was noted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared with group C, MAP was significantly higher at T1\u2013T5 in group S (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the plasma concentrations of IL-6, IL-8, TNF-\u03b1, BNP, hs-cTnT, and HFABP were significantly lower at 24 and 48\u00a0h after operation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The VAS pain scores at 2, 6, 12, 24, and 48\u00a0h after operation, the number of effective patient-controlled intravenous analgesia (PCIA) compressions, and the total number of PCIA compressions within 48\u00a0h after operation were significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Compared with group C, The hospitalization days, and the incidence of postoperative myocardial ischemia in group S were lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were no significant intergroup differences in urine volume, extubation time, the incidence of postoperative atrial fibrillation, bleeding volume, colloid infusion volume, total fluid infusion volume, and the incidence of rescue analgesia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Low-dose S-ketamine can reduce the levels of hs-cTnT, HFABP, and BNP in older patients after pulmonary lobectomy, which has a positive effect on preventing myocardial injury.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This study was registered on CHICTR (registration No. ChiCTR2300074475). Date of registration: 08\/08\/2023.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-024-02491-z","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T06:17:07Z","timestamp":1710829027000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Positive effects of low-dose S-ketamine on preventing myocardial injury after thoracoscopic lobectomy in patients aged 70 to 85"],"prefix":"10.1186","volume":"24","author":[{"given":"Ziqiang","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"32","key":"2491_CR1","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1093\/eurheartj\/ehz301","volume":"41","author":"PJ Devereaux","year":"2020","unstructured":"Devereaux PJ, Szczeklik W. 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The participants\u2019 or their representatives\u2019 written informed consents were obtained before they were enrolled in the trial. If the protocol or informed consent form was modified, or if the primary investigators were replaced, all of the documents had to be reviewed again and implemented after approval. The ethics committee approval is available from the corresponding authors on reasonable request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"103"}}