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BIS-guided anaesthesia, by reducing the consumption of anaesthetics, leads to a decrease in PONV in adult patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study objective<\/jats:title>\n                <jats:p>Evaluate the role of BIS-guided anaesthesia in reducing the incidence of paediatric PONV.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Design<\/jats:title>\n                <jats:p>Prospective, randomized, double-blind study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Setting<\/jats:title>\n                <jats:p>A single center study in university hospital in Czech republic, from June 2021 to November 2022.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients<\/jats:title>\n                <jats:p>A total of 163 children, aged 3\u20138 years with ASA I-II who underwent endoscopic adenoidectomy under general anaesthesia were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Interventions<\/jats:title>\n                <jats:p>In the intervention group, the depth of anaesthesia was maintained to values between 40 and 60 of BIS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Main outcome measure<\/jats:title>\n                <jats:p>The primary outcome was the incidence of postoperative nausea and vomiting during 24\u00a0h after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The use of BIS-guided anaesthesia led to a significant decrease in the incidence of nausea and vomiting compared to the control group [17% vs. 53%; RR (95%CI) 0.48 (0.27\u20130.86); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001and 16% vs. 34%; RR (95%CI) 0.33 (0.20\u20130.54); <jats:italic>p<\/jats:italic>\u2009=\u20090.01, respectively].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BIS-guided anaesthesia decreases the incidence of postoperative nausea and vomiting in children undergoing adenoidectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov identifier: NCT04466579.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-024-02610-w","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:02:12Z","timestamp":1720512132000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of BIS-guided anaesthesia on the incidence of postoperative nausea and vomiting in children: a prospective randomized double-blind study"],"prefix":"10.1186","volume":"24","author":[{"given":"Michal","family":"Frelich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sklienka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Romanov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"N\u011bmcov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"B\u00edlen\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Strakov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol\u00edna","family":"Le\u010dbychov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Jor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Form\u00e1nek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Bur\u0161a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"2610_CR1","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.2147\/tcrm.s256234","volume":"16","author":"Z Jin","year":"2020","unstructured":"Jin Z, Gan TJ, Bergese SD. 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