{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:55:14Z","timestamp":1778781314024,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Thoracotomy procedures can result in significant pain and cause nausea\/vomiting. Glucocorticoids have anti-emetic and analgesic effects due to their anti-inflammatory and nerve-blocking properties. This study investigates the additive effect of local dexamethasone with bupivacaine as sole analgesic medication through a peripleural catheter after thoracotomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>The study was conducted as a randomized control trial on 82 patients. Participants were allocated to receive either 2.5\u00a0mg\/kg of bupivacaine plus 0.2\u00a0mg\/kg of dexamethasone or 2.5\u00a0mg\/kg of bupivacaine plus the same amount of normal saline as placebo through a 6 French peripleural catheter implemented above the parietal pleura and beneath the musculoskeletal structure of the chest wall. The primary outcome was the severity of pain 24\u00a0h after the operation in the visual analogue scale (VAS) score. Secondary outcomes were the incidence of nausea\/vomiting, opioid consumption for pain control, and incidence of any adverse effects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>: A total of 50 participants were randomized to each group, and the baseline characteristics were similar between the groups. Median of VAS score (6 (3-8) vs. 8 (6-9), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), postoperative opioid consumption (9 (36%) vs. 17 (68%) patients, <jats:italic>p<\/jats:italic>=0.024), and median length of hospital stay (4 (3-8) vs. 6 (3-12) days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly lower in the dexamethasone group. However, postoperative nausea\/vomiting (<jats:italic>p<\/jats:italic>=0.26 for nausea and <jats:italic>p<\/jats:italic>=0.71 for vomiting) and surgical site infection (<jats:italic>p<\/jats:italic> = 0.55) were similar between the two groups. <\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In thoracotomy patients, administering local dexamethasone\u2009+\u2009bupivacaine through a peripleural catheter can reduce postoperative pain, analgesic consumption, and length of hospital stay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>Iranian Registry of Clinical Trials (IRCT20220309054226N1, registration date: 3\/21\/2022.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12871-024-02625-3","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:02:04Z","timestamp":1721113324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pain management after thoracotomy with dexamethasone and bupivacaine through a peripleural cather: a randomized controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Hamid","family":"Talebzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Eslamian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erfan","family":"Sheikhbahaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Esparham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Zefreh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooria","family":"Sarblook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Firouzfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"1","key":"2625_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/msj.21286","volume":"79","author":"Y Khelemsky","year":"2012","unstructured":"Khelemsky Y, Noto CJ. 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Written informed consent was obtained from all of the participants before the enrollment. The protocol of this study was approved by the institutional review board (IRB) of the Isfahan University of Medical Sciences and received approval number \u201cIR.MUI.MED.REC.1400.811\u201d. The trial protocol was submitted, registered, and approved by the Iranian Registry of Clinical Trials (IRCT, a WHO-accredited organization) and received the code of \u201cIRCT20220309054226N1\u201d (registration date: 3\/21\/2022), which is available online through their website (irct.ir).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Ethics and Consent to participate"}},{"value":"Authors declare no conflict of interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"240"}}