{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:03Z","timestamp":1791227343216,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Foundation of The First Hospital of Lanzhou University","award":["ldyyyn2023-95"],"award-info":[{"award-number":["ldyyyn2023-95"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"DOI":"10.1186\/s12871-024-02791-4","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:29:49Z","timestamp":1731043789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative efficacy of ciprofol and propofol in reducing respiratory depression during ERCP anesthesia: a randomized controlled trial"],"prefix":"10.1186","volume":"24","author":[{"given":"Juanhong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"2791_CR1","doi-asserted-by":"crossref","unstructured":"Ishii S, Isayama H, Ushio M et al. Best Procedure for the management of common bile Duct stones via the papilla: Literature Review and Analysis of Procedural Efficacy and Safety. J Clin Med 2020; 9(12).","DOI":"10.3390\/jcm9123808"},{"issue":"44","key":"2791_CR2","doi-asserted-by":"publisher","first-page":"7597","DOI":"10.3748\/wjg.v27.i44.7597","volume":"27","author":"A Tringali","year":"2021","unstructured":"Tringali A, Costa D, Fugazza A, et al. Endoscopic management of difficult common bile duct stones: where are we now? A comprehensive review. World J Gastroenterol. 2021;27(44):7597\u2013611.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2791_CR3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1055\/a-1075-4080","volume":"52","author":"JM Dumonceau","year":"2020","unstructured":"Dumonceau JM, Kapral C, Aabakken L, et al. ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2020;52(2):127\u201349.","journal-title":"Endoscopy"},{"key":"2791_CR4","doi-asserted-by":"crossref","unstructured":"Alzanbagi AB, Jilani TL, Qureshi LA et al. Randomized trial comparing general anesthesia with anesthesiologist-administered deep sedation for ERCP in average-risk patients. Gastrointest Endosc 2022; 96(6): 983\u2009\u2013\u200990.e2.","DOI":"10.1016\/j.gie.2022.06.003"},{"issue":"9","key":"2791_CR5","doi-asserted-by":"publisher","first-page":"3606","DOI":"10.1021\/acs.jmedchem.7b00254","volume":"60","author":"L Qin","year":"2017","unstructured":"Qin L, Ren L, Wan S, et al. Design, synthesis, and evaluation of Novel 2,6-Disubstituted phenol derivatives as general anesthetics. J Med Chem. 2017;60(9):3606\u201317.","journal-title":"J Med Chem"},{"issue":"6","key":"2791_CR6","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0016-5107(02)70353-2","volume":"56","author":"T Wehrmann","year":"2002","unstructured":"Wehrmann T, Grotkamp J, Stergiou N, et al. Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial. Gastrointest Endosc. 2002;56(6):817\u201324.","journal-title":"Gastrointest Endosc"},{"issue":"12","key":"2791_CR7","doi-asserted-by":"publisher","first-page":"e2347886","DOI":"10.1001\/jamanetworkopen.2023.47886","volume":"6","author":"N Song","year":"2023","unstructured":"Song N, Yang Y, Zheng Z, et al. Effect of Esketamine added to Propofol Sedation on Desaturation and Hypotension in Bidirectional Endoscopy: a Randomized Clinical Trial. JAMA Netw open. 2023;6(12):e2347886.","journal-title":"JAMA Netw open"},{"issue":"20","key":"2791_CR8","doi-asserted-by":"publisher","first-page":"8580","DOI":"10.1021\/acs.jmedchem.7b01133","volume":"60","author":"Y Wei","year":"2017","unstructured":"Wei Y, Qiu G, Lei B, et al. Oral delivery of Propofol with Methoxymethylphosphonic Acid as the delivery vehicle. J Med Chem. 2017;60(20):8580\u201390.","journal-title":"J Med Chem"},{"key":"2791_CR9","doi-asserted-by":"publisher","first-page":"111474","DOI":"10.1016\/j.jclinane.2024.111474","volume":"95","author":"SH Gao","year":"2024","unstructured":"Gao SH, Tang QQ, Wang CM, et al. The efficacy and safety of ciprofol and propofol in patients undergoing colonoscopy: a double-blind, randomized, controlled trial. J Clin Anesth. 2024;95:111474.","journal-title":"J Clin Anesth"},{"issue":"2","key":"2791_CR10","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1213\/ANE.0b013e31823f0c28","volume":"115","author":"LJ Antonik","year":"2012","unstructured":"Antonik LJ, Goldwater DR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part I. Safety, efficacy, and basic pharmacokinetics. Anesth Analg. 2012;115(2):274\u201383.","journal-title":"Anesth Analg"},{"key":"2791_CR11","doi-asserted-by":"publisher","first-page":"102402","DOI":"10.1016\/j.eclinm.2023.102402","volume":"67","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wang D, Zhang Z, et al. Effect of intubation in lateral position on placement of a double-lumen tube in patients undergoing unilateral video-assisted thoracic surgery: a randomied clinical trial. EClinicalMedicine. 2024;67:102402.","journal-title":"EClinicalMedicine"},{"issue":"2","key":"2791_CR12","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.gie.2017.07.018","volume":"87","author":"DS Early","year":"2018","unstructured":"Early DS, Lightdale JR, Vargo JJ 2, et al. Guidelines for sedation and anesthesia in GI endoscopy. Gastrointest Endosc. 2018;87(2):327\u201337.","journal-title":"Gastrointest Endosc"},{"issue":"8","key":"2791_CR13","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/j.1399-6576.2011.02462.x","volume":"55","author":"H Kapoor","year":"2011","unstructured":"Kapoor H. Anaesthesia for endoscopic retrograde cholangiopancreatography. Acta Anaesthesiol Scand. 2011;55(8):918\u201326.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3","key":"2791_CR14","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s10620-013-2932-2","volume":"59","author":"SA Sorser","year":"2014","unstructured":"Sorser SA, Fan DS, Tommolino EE, et al. Complications of ERCP in patients undergoing general anesthesia versus MAC. Dig Dis Sci. 2014;59(3):696\u20137.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"2791_CR15","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jclinane.2014.02.003","volume":"26","author":"BG Goudra","year":"2014","unstructured":"Goudra BG, Singh PM. SEDASYS, sedation, and the unknown. J Clin Anesth. 2014;26(4):334\u20136.","journal-title":"J Clin Anesth"},{"issue":"1","key":"2791_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12871-023-02325-4","volume":"23","author":"J Hu","year":"2023","unstructured":"Hu J, Gu X, Zhu W, et al. Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial. BMC Anesthesiol. 2023;23(1):353.","journal-title":"BMC Anesthesiol"},{"key":"2791_CR17","doi-asserted-by":"publisher","first-page":"111609","DOI":"10.1016\/j.jclinane.2024.111609","volume":"99","author":"G Ding","year":"2024","unstructured":"Ding G, Wang L, Zhao W, Diao Y, Song D. Comparison of the efficacy and safety of ciprofol and propofol for ERCP anesthesia in older patients: a single-center randomized controlled clinical study. J Clin Anesth. 2024;99:111609.","journal-title":"J Clin Anesth"},{"issue":"1","key":"2791_CR18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12871-024-02609-3","volume":"24","author":"Y Yang","year":"2024","unstructured":"Yang Y, Lang Z, Wang X, et al. Comparison of the efficacy and safety of ciprofol and propofol in sedating patients in the operating room and outside the operating room: a meta-analysis and systematic review. BMC Anesthesiol. 2024;24(1):218.","journal-title":"BMC Anesthesiol"},{"issue":"2","key":"2791_CR19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/bcpt.13761","volume":"131","author":"J Li","year":"2022","unstructured":"Li J, Wang X, Liu J, et al. Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: a multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial. Basic Clin Pharmacol Toxicol. 2022;131(2):138\u201348.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"2791_CR20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12871-017-0321-7","volume":"17","author":"W Wang","year":"2017","unstructured":"Wang W, Wu L, Zhang C, Sun L. Is propofol injection pain really important to patients? BMC Anesthesiol. 2017;17(1):24.","journal-title":"BMC Anesthesiol"},{"issue":"2","key":"2791_CR21","doi-asserted-by":"publisher","first-page":"e01066","DOI":"10.1002\/prp2.1066","volume":"11","author":"G Duan","year":"2023","unstructured":"Duan G, Lan H, Shan W, et al. Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: a randomized, controlled trial. Pharmacol Res Perspect. 2023;11(2):e01066.","journal-title":"Pharmacol Res Perspect"},{"issue":"3","key":"2791_CR22","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jpainsymman.2010.07.001","volume":"40","author":"S Lundstr\u00f6m","year":"2010","unstructured":"Lundstr\u00f6m S, Twycross R, Mihalyo M, Wilcock A, Propofol. J Pain Symptom Manag. 2010;40(3):466\u201370.","journal-title":"J Pain Symptom Manag"},{"key":"2791_CR23","doi-asserted-by":"publisher","first-page":"111047","DOI":"10.1016\/j.jclinane.2022.111047","volume":"85","author":"J Zhong","year":"2023","unstructured":"Zhong J, Zhang J, Fan Y, et al. Efficacy and safety of Ciprofol for procedural sedation and anesthesia in non-operating room settings. J Clin Anesth. 2023;85:111047.","journal-title":"J Clin Anesth"},{"issue":"10","key":"2791_CR24","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1097\/CCM.0000000000005920","volume":"51","author":"Y Liu","year":"2023","unstructured":"Liu Y, Peng Z, Liu S, et al. Efficacy and safety of Ciprofol Sedation in ICU patients undergoing mechanical ventilation: a Multicenter, Single-Blind, randomized, Noninferiority Trial. Crit Care Med. 2023;51(10):1318\u201327.","journal-title":"Crit Care Med"},{"issue":"3","key":"2791_CR25","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1097\/00000542-199903000-00034","volume":"90","author":"Practice guidelines for preoperative","year":"1999","unstructured":"Practice guidelines for preoperative. Fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: a report by the American Society of Anesthesiologist Task Force on Preoperative Fasting. Anesthesiology. 1999;90(3):896\u2013905.","journal-title":"Anesthesiology"},{"issue":"1","key":"2791_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.gie.2016.06.051","volume":"85","author":"V Chandrasekhara","year":"2017","unstructured":"Chandrasekhara V, Khashab MA, Muthusamy VR, et al. Adverse events associated with ERCP. Gastrointest Endosc. 2017;85(1):32\u201347.","journal-title":"Gastrointest Endosc"},{"issue":"12","key":"2791_CR27","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1097\/CM9.0000000000002820","volume":"137","author":"W Meng","year":"2024","unstructured":"Meng W, Leung JW, Wang Z, et al. Safety of high-carbohydrate fluid diet 2\u00a0h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography: a single-blind, multicenter, randomized controlled trial. Chin Med J. 2024;137(12):1437\u201346.","journal-title":"Chin Med J"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-024-02791-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12871-024-02791-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-024-02791-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:02:19Z","timestamp":1731045739000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-024-02791-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2791"],"URL":"https:\/\/doi.org\/10.1186\/s12871-024-02791-4","relation":{},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"20 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the First Hospital of Lanzhou University (LDYYLL-2021-078). All patients enrolled in this study were evaluated before anesthesia by anesthesiologists above the attending doctor and signed informed consent forms. If the patient refused to participate in the study or the surgical method was changed, the study was stopped.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"404"}}