{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:29:17Z","timestamp":1793039357867,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering symptoms like neck stiffness and subjective hearing changes. While conservative measures are common for treatment, more refractory cases may require invasive interventions such as an epidural blood patch (EBP). Recent studies have shown promise in using nebulized dexmedetomidine (nDEX) for PDPH, offering a non-invasive alternative to EBP. Two case presentations illustrate the efficacy of nDEX in resolving PDPH symptoms rapidly and completely. These cases underscore the need for exploring novel therapeutic options, especially in obstetric patients where safe and prompt relief is essential for maternal and newborn well-being. While the EBP remains the gold standard, its limitations of accessibility and invasiveness highlight the significance of investigating alternatives like nDEX.<\/jats:p>","DOI":"10.1186\/s12871-025-02896-4","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T05:28:29Z","timestamp":1736573309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports"],"prefix":"10.1186","volume":"25","author":[{"given":"Jeffrey","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J.","family":"Soloniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Mehdizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"2896_CR1","doi-asserted-by":"crossref","unstructured":"Arnold M. 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Can J Anesth. 2005;52(9):971\u20137.","journal-title":"Can J Anesth"},{"issue":"5","key":"2896_CR6","doi-asserted-by":"publisher","first-page":"100939","DOI":"10.1016\/j.accpm.2021.100939","volume":"40","author":"J Merrer","year":"2021","unstructured":"Merrer J, Bonnet M, Blondel B, Tafflet M, Khoshnood B, Le Ray C, et al. Predictors of incomplete maternal satisfaction with neuraxial labor analgesia: a nationwide study. Anaesth Crit care pain Med. 2021;40(5):100939.","journal-title":"Anaesth Crit care pain Med"},{"key":"2896_CR7","doi-asserted-by":"crossref","unstructured":"Choi PT, Galinski SE, Takeuchi L, Lucas S, Tamayo C, Jadad AR. PDPH is a common complication of neuraxial blockade in parturients: a meta-analysis of obstetrical studies. Can J Anesth. 2003;50(5):460\u20139.","DOI":"10.1007\/BF03021057"},{"issue":"1","key":"2896_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1365-2044.2007.05285.x","volume":"63","author":"JS Sprigge","year":"2008","unstructured":"Sprigge JS, Harper SJ. Accidental dural puncture and post dural puncture headache in obstetric anaesthesia: presentation and management: a 23-year survey in a district general hospital. Anaesthesia. 2008;63(1):36\u201343.","journal-title":"Anaesthesia"},{"key":"2896_CR9","doi-asserted-by":"crossref","unstructured":"Kumar A, Sinha C, Singh K, Anant M, Kumar A, Kumari P. Comparative evaluation of nebulised dexmedetomidine vs fentanyl for the treatment of post-dural puncture headache (PDPH) in parturients after caesarean section under spinal anaesthesia: a randomised controlled study. Indian J Anaesth. 2024;68(2):159\u201364.","DOI":"10.4103\/ija.ija_789_23"},{"key":"2896_CR10","doi-asserted-by":"crossref","unstructured":"Soliman OM, Aboulfotouh AI, Abdelhafez AM, Abedalmohsen A. Nebulized dexmedetomidine versus neostigmine\/atropine for treating post-dural puncture headache after cesarean section: a double-blind randomized controlled trial. Minerva Anestesiologica. 2023;89(10).","DOI":"10.23736\/S0375-9393.22.16906-3"},{"key":"2896_CR11","doi-asserted-by":"crossref","unstructured":"Paech MJ, Doherty DA, Christmas T, Wong CA. The volume of blood for Epidural Blood Patch in Obstetrics: a Randomized, Blinded Clinical Trial. 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