{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:29:02Z","timestamp":1768472942412,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"DOI":"10.1186\/s12871-025-03081-3","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:18:10Z","timestamp":1746530290000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of different inspired oxygen concentrations combined with nebulized prostaglandin E1 on oxygenation in patients undergoing one-lung ventilation: a randomized controlled trial"],"prefix":"10.1186","volume":"25","author":[{"given":"Lingxi","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halisa","family":"Paerhati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianbing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"issue":"1\u20132","key":"3081_CR1","first-page":"3","volume":"75","author":"E Cohen","year":"2009","unstructured":"Cohen E. Recommendations for airway control and difficult airway management in thoracic anesthesia and lung separation procedures. Are we ready for the challenge? Minerva Anestesiol. 2009;75(1\u20132):3\u20135.","journal-title":"Minerva Anestesiol"},{"issue":"3","key":"3081_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.bpa.2015.08.001","volume":"29","author":"M \u015eent\u00fcrk","year":"2015","unstructured":"\u015eent\u00fcrk M, Slinger P, Cohen E. Intraoperative mechanical ventilation strategies for one-lung ventilation. Best Pract Res Clin Anaesthesiol. 2015;29(3):357\u201369.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"1","key":"3081_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12931-020-01380-6","volume":"21","author":"P Li","year":"2020","unstructured":"Li P, Gu L, Bian Q, Tan J, Jiao D, Wu F, et al. Effects of prostaglandin E(1) nebulization of ventilated lung under 60%O(2) one lung ventilation on patients\u2019 oxygenation and oxidative stress: a randomised controlled trial. Respir Res. 2020;21(1):113.","journal-title":"Respir Res"},{"issue":"6","key":"3081_CR4","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1097\/ALN.0000000000001100","volume":"124","author":"RS Blank","year":"2016","unstructured":"Blank RS, Colquhoun DA, Durieux ME, Kozower BD, McMurry TL, Bender SP, et al. Management of One-lung ventilation: impact of tidal volume on complications after thoracic surgery. Anesthesiology. 2016;124(6):1286\u201395.","journal-title":"Anesthesiology"},{"issue":"1","key":"3081_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12871-018-0476-x","volume":"18","author":"S Okahara","year":"2018","unstructured":"Okahara S, Shimizu K, Suzuki S, Ishii K, Morimatsu H. Associations between intraoperative ventilator settings during one-lung ventilation and postoperative pulmonary complications: a prospective observational study. BMC Anesthesiol. 2018;18(1):13.","journal-title":"BMC Anesthesiol"},{"issue":"14","key":"3081_CR6","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1001\/jama.2009.1452","volume":"302","author":"CS Meyhoff","year":"2009","unstructured":"Meyhoff CS, Wetterslev J, Jorgensen LN, Henneberg SW, H\u00f8gdall C, Lundvall L, et al. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial. JAMA. 2009;302(14):1543\u201350.","journal-title":"JAMA"},{"issue":"5","key":"3081_CR7","first-page":"534","volume":"77","author":"G Della Rocca","year":"2011","unstructured":"Della Rocca G, Coccia C. Ventilatory management of one-lung ventilation. Minerva Anestesiol. 2011;77(5):534\u20136.","journal-title":"Minerva Anestesiol"},{"issue":"1","key":"3081_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","volume":"151","author":"KJ Dunham-Snary","year":"2017","unstructured":"Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, et al. Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine. Chest. 2017;151(1):181\u201392.","journal-title":"Chest"},{"issue":"3","key":"3081_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1378\/chest.09-2293","volume":"139","author":"M Yang","year":"2011","unstructured":"Yang M, Ahn HJ, Kim K, Kim JA, Yi CA, Kim MJ, et al. Does A protective ventilation strategy reduce the risk of pulmonary complications after lung cancer surgery? A randomized controlled trial. Chest. 2011;139(3):530\u20137.","journal-title":"Chest"},{"issue":"4","key":"3081_CR10","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1097\/ALN.0000000000000569","volume":"122","author":"AB Lumb","year":"2015","unstructured":"Lumb AB, Slinger P. Hypoxic pulmonary vasoconstriction: physiology and anesthetic implications. Anesthesiology. 2015;122(4):932\u201346.","journal-title":"Anesthesiology"},{"issue":"4","key":"3081_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/00000542-198604000-00001","volume":"64","author":"JL Benumof","year":"1986","unstructured":"Benumof JL. Isoflurane anesthesia and arterial oxygenation during one-lung ventilation. Anesthesiology. 1986;64(4):419\u201322.","journal-title":"Anesthesiology"},{"issue":"4","key":"3081_CR12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/00000542-198604000-00002","volume":"64","author":"KB Domino","year":"1986","unstructured":"Domino KB, Borowec L, Alexander CM, Williams JJ, Chen L, Marshall C, et al. Influence of isoflurane on hypoxic pulmonary vasoconstriction in dogs. Anesthesiology. 1986;64(4):423\u20139.","journal-title":"Anesthesiology"},{"issue":"5","key":"3081_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/00000542-198305000-00001","volume":"58","author":"JL Benumof","year":"1983","unstructured":"Benumof JL. Intermittent hypoxia increases Lobar hypoxic pulmonary vasoconstriction. Anesthesiology. 1983;58(5):399\u2013404.","journal-title":"Anesthesiology"},{"issue":"2","key":"3081_CR14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1213\/ANE.0000000000000808","volume":"121","author":"J Lohser","year":"2015","unstructured":"Lohser J, Slinger P. Lung injury after One-Lung ventilation: A review of the pathophysiologic mechanisms affecting the ventilated and the collapsed lung. Anesth Analg. 2015;121(2):302\u201318.","journal-title":"Anesth Analg"},{"issue":"8","key":"3081_CR15","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s10439-014-1011-y","volume":"42","author":"KS Burrowes","year":"2014","unstructured":"Burrowes KS, Clark AR, Wilsher ML, Milne DG, Tawhai MH. Hypoxic pulmonary vasoconstriction as a contributor to response in acute pulmonary embolism. Ann Biomed Eng. 2014;42(8):1631\u201343.","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"3081_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/0971-9784.197840","volume":"20","author":"K Chigurupati","year":"2017","unstructured":"Chigurupati K, Raman SP, Pappu UK, Madathipat U. Effectiveness of ventilation of nondependent lung for a brief period in improving arterial oxygenation during one-lung ventilation: A prospective study. Ann Card Anaesth. 2017;20(1):72\u20135.","journal-title":"Ann Card Anaesth"},{"issue":"6","key":"3081_CR17","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1097\/ALN.0b013e31819fb15d","volume":"110","author":"W Karzai","year":"2009","unstructured":"Karzai W, Schwarzkopf K. Hypoxemia during one-lung ventilation: prediction, prevention, and treatment. Anesthesiology. 2009;110(6):1402\u201311.","journal-title":"Anesthesiology"},{"issue":"6","key":"3081_CR18","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1399-6576.2010.02238.x","volume":"54","author":"LL Szegedi","year":"2010","unstructured":"Szegedi LL, D\u2019Hollander AA, Vermassen FE, Deryck F, Wouters PF. Gravity is an important determinant of oxygenation during one-lung ventilation. Acta Anaesthesiol Scand. 2010;54(6):744\u201350.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"11","key":"3081_CR19","first-page":"627","volume":"74","author":"G Della Rocca","year":"2008","unstructured":"Della Rocca G, Coccia C, Pompei L, Costa MG, Di Marco P, Pietropaoli P. Inhaled aerosolized prostaglandin E1, pulmonary hemodynamics, and oxygenation during lung transplantation. Minerva Anestesiol. 2008;74(11):627\u201333.","journal-title":"Minerva Anestesiol"},{"issue":"6","key":"3081_CR20","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1177\/0310057X0903700618","volume":"37","author":"E Farrokhnia","year":"2009","unstructured":"Farrokhnia E, Makarem J, Khan ZH, Mohagheghi M, Maghsoudlou M, Abdollahi A. The effects of prostaglandin E1 on interleukin-6, pulmonary function and postoperative recovery in oesophagectomised patients. Anaesth Intensive Care. 2009;37(6):937\u201343.","journal-title":"Anaesth Intensive Care"},{"issue":"9","key":"3081_CR21","doi-asserted-by":"publisher","first-page":"L965","DOI":"10.1152\/ajplung.00292.2011","volume":"302","author":"AA Birukova","year":"2012","unstructured":"Birukova AA, Tian Y, Meliton A, Leff A, Wu T, Birukov KG. Stimulation of Rho signaling by pathologic mechanical stretch is a second hit to Rho-independent lung injury induced by IL-6. Am J Physiol Lung Cell Mol Physiol. 2012;302(9):L965\u201375.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3081_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1476-9255-8-32","volume":"8","author":"A Breunig","year":"2011","unstructured":"Breunig A, Gambazzi F, Beck-Schimmer B, Tamm M, Lardinois D, Oertli D, et al. Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilation. J Inflamm (Lond). 2011;8:32.","journal-title":"J Inflamm (Lond)"},{"issue":"6","key":"3081_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/iji.12148","volume":"41","author":"F Li","year":"2014","unstructured":"Li F, Gao J, Sokolove J, Xu J, Zheng J, Zhu K, et al. Polymorphisms in the TNF-\u03b1, TNFR1 gene and risk of rheumatoid arthritis in Chinese Han population. Int J Immunogenet. 2014;41(6):499\u2013502.","journal-title":"Int J Immunogenet"},{"issue":"1","key":"3081_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/1753425908100500","volume":"15","author":"I Garcia-Verdugo","year":"2009","unstructured":"Garcia-Verdugo I, Garcia de Paco E, Espinassous Q, Gonzalez-Horta A, Synguelakis M, Kanellopoulos J, et al. Synthetic peptides representing the N-terminal segment of surfactant protein C modulate LPS-stimulated TNF-alpha production by macrophages. Innate Immun. 2009;15(1):53\u201362.","journal-title":"Innate Immun"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-025-03081-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12871-025-03081-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-025-03081-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:18:11Z","timestamp":1746530291000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcanesthesiol.biomedcentral.com\/articles\/10.1186\/s12871-025-03081-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3081"],"URL":"https:\/\/doi.org\/10.1186\/s12871-025-03081-3","relation":{},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were performed in accordance with relevant international and local guidelines and regulations. The study protocol was approved by the Ethics Committee of Nanjing Medical University. Informed consent was obtained from all participants prior to conducting any study-related procedures. The study was conducted in strict compliance with the Helsinki Declaration. And this manuscript reporting adheres to CONSORT guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"229"}}