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The present study aimed to compare the analgesic efficacy and postoperative pulmonary function recovery of modified serratus anterior plane block (MSAP) and conventional serratus anterior plane block (CSAP) in patients undergoing video-assisted thoracoscopic surgery (VATS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A total of 99 patients who underwent thoracoscopic surgery were randomly divided into three equal groups: a control group (C group) that received no block, a CSAP group that received preoperative conventional serratus anterior plane block, and an MSAP group that received preoperative modified serratus anterior plane block. The primary outcome was the first 24-hour tramadol consumption. The secondary outcomes were first-time-to-rescue analgesia, postoperative visual analogue score (VAS), postoperative respiratory function, and perioperative hemodynamics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The lowest tramadol consumption and longest time to first rescue analgesia were observed in the MSAP group. The postoperative VAS score at 2, 4, and 6\u00a0h was significantly greater in the control group, but it was comparable between the two block groups. At 8\u00a0h, the VAS score was the lowest in the MSAP group. At 12, 16, and 24\u00a0h, the VAS scores were comparable among the three groups. The MSAP group presented the best respiratory function during the first postoperative 8\u00a0h. Heart rate and mean arterial blood pressure were similar in both block groups but were greater in the control group during the intraoperative period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The modified serratus anterior plane block is more efficient than the conventional serratus anterior plane block at reducing opioid consumption, prolonging rescue analgesic time, and improving pulmonary function recovery in patients undergoing video-assisted thoracoscopic surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>This clinical trial was approved by the Zagazig University Institutional Review Board (IRB #10060\/30-10-2022), was first submitted to clinical trials.gov on 1\/12\/2022 and was subsequently registered retrospectively on 22\/12\/2022 (NCT05661253). The first research participant was enrolled on 2\/12\/2022.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12871-025-03314-5","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T03:19:05Z","timestamp":1756437545000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound-guided modified versus conventional serratus anterior plane block as a preemptive analgesic for unilateral video-assisted thoracoscopic surgery"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-2480","authenticated-orcid":false,"given":"Shereen E.","family":"Abd Ellatif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa M.","family":"Galal Eldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab Sabry","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.","family":"Fathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"issue":"4","key":"3314_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.thorsurg.2015.07.005","volume":"25","author":"B Elmore","year":"2015","unstructured":"Elmore B, Nguyen V, Blank R, Yount K, Lau C. 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Ethical approval from the institutional review board (the research ethical committee of the Faculty of Medicine, Zagazig University) was obtained with reference number IRB #10060\/30-10-2022. This study has a clinicaltrials.gov registration number (NCT05661253). All the participants provided written informed consent once they had a clear understanding of the research's purpose. Following the rules and criteria of the Declaration of Helsinki, the study was conducted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"435"}}