{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:15:16Z","timestamp":1766574916973,"version":"3.48.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Anesthesiol"],"DOI":"10.1186\/s12871-025-03552-7","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:12:09Z","timestamp":1766574729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Routine flumazenil administration confounds emergence time comparisons between remimazolam and propofol: a methodological concern"],"prefix":"10.1186","volume":"25","author":[{"given":"Haishan","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"issue":"1","key":"3552_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12871-025-03050-w","volume":"25","author":"J Qin","year":"2025","unstructured":"Qin J, Gan W, Liu Q, et al. Emergence profiles of remimazolam-flumazenil versus Propofol in pediatric general anesthesia for strabismus correction: a randomized clinical trial. BMC Anesthesiol. 2025;25(1):218. https:\/\/doi.org\/10.1186\/s12871-025-03050-w. Published 2025 Apr 28.","journal-title":"BMC Anesthesiol"},{"issue":"5","key":"3552_CR2","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1097\/ALN.0b013e31819db2c4","volume":"110","author":"AA Dahaba","year":"2009","unstructured":"Dahaba AA, Bornemann H, Rehak PH, Wang G, Wu XM, Metzler H. Effect of Flumazenil on bispectral index monitoring in unpremedicated patients. Anesthesiology. 2009;110(5):1036\u201340. https:\/\/doi.org\/10.1097\/ALN.0b013e31819db2c4.","journal-title":"Anesthesiology"},{"key":"3552_CR3","doi-asserted-by":"publisher","first-page":"111223","DOI":"10.1016\/j.jclinane.2023.111223","volume":"90","author":"EJ Oh","year":"2023","unstructured":"Oh EJ, Chung YJ, Lee JH, et al. Comparison of Propofol vs. remimazolam on emergence profiles after general anesthesia: A randomized clinical trial. J Clin Anesth. 2023;90:111223. https:\/\/doi.org\/10.1016\/j.jclinane.2023.111223.","journal-title":"J Clin Anesth"},{"issue":"1","key":"3552_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/bcpt.12434","volume":"118","author":"EI Penninga","year":"2016","unstructured":"Penninga EI, Graudal N, Ladekarl MB, J\u00fcrgens G. Adverse events associated with Flumazenil treatment for the management of suspected benzodiazepine Intoxication\u2013A systematic review with Meta-Analyses of randomised trials. Basic Clin Pharmacol Toxicol. 2016;118(1):37\u201344. https:\/\/doi.org\/10.1111\/bcpt.12434.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"3","key":"3552_CR5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/anae.16475","volume":"80","author":"YB Fang","year":"2025","unstructured":"Fang YB, Zhong JW, Szmuk P, et al. Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single-blind, controlled trial. Anaesthesia. 2025;80(3):259\u201368. https:\/\/doi.org\/10.1111\/anae.16475.","journal-title":"Anaesthesia"},{"key":"3552_CR6","doi-asserted-by":"publisher","first-page":"111356","DOI":"10.1016\/j.jclinane.2023.111356","volume":"93","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhang J, Wang Y, et al. Effect of remimazolam vs Propofol on emergence from general anesthesia in patients undergoing cerebral endovascular procedures: A randomized controlled, non-inferiority trial. J Clin Anesth. 2024;93:111356. https:\/\/doi.org\/10.1016\/j.jclinane.2023.111356.","journal-title":"J Clin Anesth"}],"container-title":["BMC Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-025-03552-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12871-025-03552-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12871-025-03552-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:12:09Z","timestamp":1766574729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12871-025-03552-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3552"],"URL":"https:\/\/doi.org\/10.1186\/s12871-025-03552-7","relation":{},"ISSN":["1471-2253"],"issn-type":[{"value":"1471-2253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"23 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"615"}}