{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T08:48:07Z","timestamp":1794473287403,"version":"4.9.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12872-016-0251-1","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T13:57:56Z","timestamp":1461333476000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bleeding complications during cardiac electronic device implantation in patients receiving antithrombotic therapy: is there any value of local tranexamic acid?"],"prefix":"10.1186","volume":"16","author":[{"given":"Osman","family":"Beton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Saricam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakki","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Yucel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Dogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan Onur","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ocal","family":"Berkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzet","family":"Tandogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Birhan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"251_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.hlc.2014.09.017","volume":"24","author":"HG Mond","year":"2015","unstructured":"Mond HG, Crozier I. The Australian and New Zealand cardiac pacemaker and implantable cardioverter-defibrillator survey: calendar year 2013. Heart Lung Circ. 2015;24:291\u20137.","journal-title":"Heart Lung Circ"},{"key":"251_CR2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1161\/CIR.0000000000000056","volume":"130","author":"FM Kusumoto","year":"2014","unstructured":"Kusumoto FM, Calkins H, Boehmer J, Buxton AE, Chung MK, Gold MR, Hohnloser SH, et al. HRS\/ACC\/AHA expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or not well represented in clinical trials. Circulation. 2014;130:94\u2013125.","journal-title":"Circulation"},{"key":"251_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1161\/CIR.0b013e318276ce9b","volume":"127","author":"AE Epstein","year":"2013","unstructured":"Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, Gillinov AM, et al. 2012 ACCF\/AHA\/HRS focused update incorporated into the ACCF\/AHA\/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation. 2013;127:283\u2013352.","journal-title":"Circulation"},{"key":"251_CR4","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1016\/j.jacc.2009.12.056","volume":"55","author":"C Tompkins","year":"2010","unstructured":"Tompkins C, Cheng A, Dalal D, Brinker JA, Leng CT, Marine JE, Nazarian S, et al. Dual antiplatelet therapy and heparin \u201cbridging\u201d significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation. J Am Coll Cardiol. 2010;55:2376\u201382.","journal-title":"J Am Coll Cardiol"},{"key":"251_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1378\/chest.11-2298","volume":"141","author":"JD Douketis","year":"2012","unstructured":"Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, et al. Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:326\u201350.","journal-title":"Chest"},{"key":"251_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1161\/CIRCEP.111.969105","volume":"5","author":"ML Bernard","year":"2012","unstructured":"Bernard ML, Shotwell M, Nietert PJ, Gold MR. Meta-analysis of bleeding complications associated with cardiac rhythm device implantation. Circ Arrhythm Electrophysiol. 2012;5:468\u201374.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"251_CR7","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1378\/chest.126.4.1177","volume":"126","author":"UK Wiegand","year":"2004","unstructured":"Wiegand UK, LeJeune D, Boguschewski F, Bonnemeier H, Eberhardt F, Schunkert H, Bode F. Pocket hematoma after pacemaker or implantable cardioverter defibrillator surgery: influence of patient morbidity, operation strategy, and perioperative antiplatelet\/anticoagulation therapy. Chest. 2004;126:1177\u201386.","journal-title":"Chest"},{"key":"251_CR8","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1540-8159.2012.03354.x","volume":"35","author":"S Boul\u00e9","year":"2012","unstructured":"Boul\u00e9 S, Marqui\u00e9 C, Vanesson-Bricout C, Kouakam C, Brigadeau F, Gu\u00e9don-Moreau L, Acher\u00e9 C. Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures. Pacing Clin Electrophysiol. 2012;35:605\u201311.","journal-title":"Pacing Clin Electrophysiol"},{"key":"251_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1540-8159.2009.02674.x","volume":"33","author":"S Thal","year":"2010","unstructured":"Thal S, Moukabary T, Boyella R, Shanmugasundaram M, Pierce MK, Thai H, Goldman S. The relationship between warfarin, aspirin, and clopidogrel continuation in the peri-procedural period and the incidence of hematoma formation after device implantation. Pacing Clin Electrophysiol. 2010;33:385\u20138.","journal-title":"Pacing Clin Electrophysiol"},{"key":"251_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ijcard.2011.02.042","volume":"159","author":"MA Ohlow","year":"2012","unstructured":"Ohlow MA, Lauer B, Buchter B, Schreiber M, Geller JC. Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. Int J Cardiol. 2012;159:177\u201380.","journal-title":"Int J Cardiol"},{"key":"251_CR11","first-page":"CD010562","volume":"7","author":"K Ker","year":"2013","unstructured":"Ker K, Beecher D, Roberts I. Topical application of tranexamic acid for the reduction of bleeding. Cochrane Database Syst Rev. 2013;7:CD010562.","journal-title":"Cochrane Database Syst Rev"},{"key":"251_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/CIRCEP.109.917625","volume":"3","author":"IB Kutinsky","year":"2010","unstructured":"Kutinsky IB, Jarandilla R, Jewett M, Haines DE. Risk of hematoma complications after device implant in the clopidogrel era. Circ Arrhythm Electrophysiol. 2010;3:312\u20138.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"251_CR13","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1056\/NEJMoa1302946","volume":"368","author":"DH Birnie","year":"2013","unstructured":"Birnie DH, Healey JS, Wells GA, Verma A, Tang AS, Krahn AD, Simpson CS, et al. Pacemaker or defibrillator surgery without interruption of anticoagulation. N Engl J Med. 2013;368:2084\u201393.","journal-title":"N Engl J Med"},{"key":"251_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3109\/07853890.2014.894285","volume":"46","author":"W Nammas","year":"2014","unstructured":"Nammas W, Raatikainen MJ, Korkeila P, Lund J, Ylitalo A, Karjalainen P, Virtanen V, et al. Predictors of pocket hematoma in patients on antithrombotic therapy undergoing cardiac rhythm device implantation: insights from the FinPAC trial. Ann Med. 2014;46:177\u201381.","journal-title":"Ann Med"},{"key":"251_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","volume":"72","author":"PL McCormack","year":"2012","unstructured":"McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs. 2012;72:585\u2013617.","journal-title":"Drugs"},{"key":"251_CR16","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/SLA.0b013e3181f09191","volume":"252","author":"JL Kashuk","year":"2010","unstructured":"Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffl WL, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010;252:434\u201342.","journal-title":"Ann Surg"},{"key":"251_CR17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10006-014-0479-9","volume":"19","author":"EC Soares","year":"2015","unstructured":"Soares EC, Costa FW, Bezerra TP, Nogueira CB, de Barros Silva PG, Batista SH, Sousa FB. Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease: a prospective, randomized study. Oral Maxillofac Surg. 2015;19:209\u201316.","journal-title":"Oral Maxillofac Surg"},{"key":"251_CR18","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1001\/jamasurg.2013.1560","volume":"148","author":"J Shi","year":"2013","unstructured":"Shi J, Ji H, Ren F, Wang G, Xu M, Xue Y, Chen M, et al. Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial. JAMA Surg. 2013;148:538\u201347.","journal-title":"JAMA Surg"},{"key":"251_CR19","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.eupc.2005.03.007","volume":"7","author":"DJ Milic","year":"2005","unstructured":"Milic DJ, Perisic ZD, Zivic SS, Stanojkovic ZA, Stojkovic AM, Karanovic ND, Krstic NH, et al. Prevention of pocket related complications with fibrin sealant in patients undergoing pacemaker implantation who are receiving anticoagulant treatment. Europace. 2005;7:374\u20139.","journal-title":"Europace"},{"key":"251_CR20","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1093\/europace\/euu357","volume":"17","author":"V Zac\u00e0","year":"2015","unstructured":"Zac\u00e0 V, Marcucci R, Parodi G, Limbruno U, Notarstefano P, Pieragnoli P, Di Cori A, et al.. Management of antithrombotic therapy in patients undergoing electrophysiological device surgery. Europace. 2015;17:840\u201354.","journal-title":"Europace"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-016-0251-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12872-016-0251-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-016-0251-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-016-0251-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T11:58:31Z","timestamp":1655553511000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-016-0251-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["251"],"URL":"https:\/\/doi.org\/10.1186\/s12872-016-0251-1","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]},"article-number":"73"}}