{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:19:01Z","timestamp":1789733941161,"version":"4.0.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12872-018-0839-8","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T07:29:28Z","timestamp":1526887768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Physical activity intervention for elderly patients with reduced physical performance after acute coronary syndrome (HULK study): rationale and design of a randomized clinical trial"],"prefix":"10.1186","volume":"18","author":[{"given":"Elisabetta","family":"Tonet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Maietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Chiaranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vitali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Serenelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bugani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Quinto","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Corvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pasanisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Biscaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Pavasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Ricci","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Sella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-188X","authenticated-orcid":false,"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"839_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/ijerph9020391","volume":"9","author":"J Li","year":"2012","unstructured":"Li J, Siegrist J. Physical activity and risk of cardiovascular disease--a meta-analysis of prospective cohort studies. Int J Environ Res Public Health. 2012;9:391\u2013407.","journal-title":"Int J Environ Res Public Health"},{"key":"839_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.amjcard.2011.08.042","volume":"109","author":"HM Ahmed","year":"2012","unstructured":"Ahmed HM, Blaha MJ, Nasir K, Rivera JJ, Blumenthal JS. Effects of physical activity on cardiovascular disease. Am J Cardiol. 2012;109:288\u201395.","journal-title":"Am J Cardiol"},{"key":"839_CR3","unstructured":"Gambassi G, Cesari M, Tosato M, Bernabei R, In 6 min al cuore della fragilit\u00e0, G Ital Cardiol 2013;14:19\u201325."},{"key":"839_CR4","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0140-6736(05)67702-1","volume":"366","author":"PM Rothwell","year":"2005","unstructured":"Rothwell PM, Coull AJ, Silver AJ, Fairhead JF, Giles MF, Lovelock CE, et al. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford vascular study). Lancet. 2005;366:1773\u201383.","journal-title":"Lancet"},{"key":"839_CR5","unstructured":"Campbell Colleen Marie, Methods of physical activity assessment in older adults, 2012, Graduate Theses and Dissertations, Paper 12809 \n                    https:\/\/lib.dr.iastate.edu\/cgi\/viewcontent.cgi?article=3816&context=etd"},{"key":"839_CR6","first-page":"223","volume":"13","author":"JL Fleg","year":"2012","unstructured":"Fleg JL. Aerobic exercise in the elderly: a key to successful aging. Discov Med. 2012;13:223\u20138.","journal-title":"Discov Med"},{"key":"839_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3724\/SP.J.1263.2012.00068","volume":"9","author":"AR Menezes","year":"2012","unstructured":"Menezes AR, Lavie CJ, Milani RV, Arena RA, Church TS. Cardiac rehabilitation and exercise therapy in the elderly: should we invest in the aged? J Geriatr Cardiol. 2012;9:68\u201375.","journal-title":"J Geriatr Cardiol"},{"issue":"6","key":"839_CR8","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.ejvs.2012.09.009","volume":"44","author":"GC Makris","year":"2012","unstructured":"Makris GC, Lattimer CR, Lavida A, Geroulakos G. Availability of supervised exercise programs and the role of structured home-based exercise in peripheral arterial disease. Eur J Vasc Endovasc Surg. 2012;44(6):569\u201375.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"2","key":"839_CR9","first-page":"85","volume":"42","author":"J Guralnik","year":"1994","unstructured":"Guralnik J, Simonsick E, Ferrucci L, et al. A SPPB assessing lower extremity function: association with self reported disability and prediction of mortality and nursing home admission, J of Gerontol medical. Sciences. 1994;42(2):85\u201394.","journal-title":"Sciences"},{"issue":"9","key":"839_CR10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1056\/NEJM199503023320902","volume":"332","author":"JM Guralnik","year":"1995","unstructured":"Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332(9):556\u201361.","journal-title":"N Engl J Med"},{"issue":"1","key":"839_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/gerona\/glq167","volume":"66(","author":"S Volpato","year":"2011","unstructured":"Volpato S, Cavalieri M, Sioulis F, Guerra G, Maraldi C, Zuliani G, et al. Predictive value of the short physical performance battery following hospitalization in older patients. J Gerontol A Biol Sci Med Sci. 2011;66((1):89\u201396.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"839_CR12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/HCR.0b013e3182663507","volume":"32","author":"G Chiaranda","year":"2012","unstructured":"Chiaranda G, Myers J, Mazzoni G, Terranova F, Bernardi E, Grossi G, et al. Peak oxygen uptake prediction from a moderate, perceptually regulated, 1-km treadmill walk in male cardiac patients. J Cardiopulm Rehabil Prev. 2012;32:262\u20139.","journal-title":"J Cardiopulm Rehabil Prev"},{"issue":"10","key":"839_CR13","doi-asserted-by":"publisher","first-page":"e003446","DOI":"10.1136\/bmjopen-2013-003446","volume":"3","author":"G Chiaranda","year":"2013","unstructured":"Chiaranda G, Bernardi E, Codec\u00e0 L, Conconi F, Myers J, Terranova F, et al. Treadmill walking speed and survival prediction in men with cardiovascular disease: a 10-year follow-up study. BMJ Open. 2013;3(10):e003446.","journal-title":"BMJ Open"},{"issue":"37","key":"839_CR14","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1093\/eurheartj\/ehu278","volume":"35","author":"S Windecker","year":"2014","unstructured":"Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, et al. 2014 ESC\/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2014;35(37):2541\u2013619.","journal-title":"Eur Heart J"},{"issue":"14","key":"839_CR15","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.jacc.2016.01.056","volume":"67","author":"Y Kobayashi","year":"2016","unstructured":"Kobayashi Y, Nam CW, Tonino PA, Kimura T, De Bruyne B, Pijls NH, et al. The prognostic value of residual coronary Stenoses after functionally complete revascularization. J Am Coll Cardiol. 2016;67(14):1701\u201311.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"839_CR16","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s40520-016-0662-y","volume":"29","author":"G Campo","year":"2016","unstructured":"Campo G, Pavasini R, Maietti E, Tonet E, Cimaglia P, Scillitani G, et al. The frailty in elderly patients receiving cardiac interventional procedures (FRASER) program: rational and design of a multicenter prospective study. Aging Cln Exp Res. 2016;29(5):895\u2013903.","journal-title":"Aging Cln Exp Res"},{"issue":"21","key":"839_CR17","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1001\/archinternmed.2011.536","volume":"171","author":"G Campo","year":"2011","unstructured":"Campo G, Saia F, Guastaroba P, Marchesini J, Varani E, Manari A, et al. Prognostic impact of hospital readmissions after primary percutaneous coronary intervention. Arch Int Med. 2011;171(21):1948\u20139.","journal-title":"Arch Int Med"},{"issue":"5","key":"839_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/HCR.0000000000000266","volume":"37","author":"G Grazzi","year":"2017","unstructured":"Grazzi G, Chiaranda G, Myers J, Pasanisi G, Lordi R, Conconi F, et al. Outdoor reproducibility of a 1-km treadmill walking test to predict peak oxygen uptake in cardiac patients. J Cardiopulm Rehabil Prev. 2017;37(5):347\u20139.","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"839_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ijcard.2014.02.039","volume":"173","author":"G Grazzi","year":"2014","unstructured":"Grazzi G, Myers J, Bernardi E, Terranova F, Grossi G, Codec\u00e0 L, et al. Association between VO2peak estimated by a 1-km treadmill walk and mortality. A 10-year follow-up study in patients with cardiovascular disease. Int J Cardiol. 2014;173:248\u201352.","journal-title":"Int J Cardiol"},{"issue":"3","key":"839_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jsams.2017.06.003","volume":"21","author":"G Grazzi","year":"2018","unstructured":"Grazzi G, Mazzoni G, Myers J, Codec\u00e0 L, Pasanisi G, Mandini S, et al. Determining the best percent-predicted equation for estimated VO2 peak by a 1-km moderate perceptually-regulated treadmill walk to predict mortality in outpatients with cardiovascular disease. J Sci Med Sport. 2018;21(3):307\u201311.","journal-title":"J Sci Med Sport"},{"issue":"23","key":"839_CR21","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1136\/heartjnl-2015-309126","volume":"102","author":"G Grazzi","year":"2016","unstructured":"Grazzi G, Mazzoni G, Myers J, Codec\u00e0 L, Pasanisi G, Napoli N, et al. Improved walking speed is associated with lower hospitalisation rates in patients in an exercise-based secondary prevention programme. Heart. 2016;102(23):1902\u20138.","journal-title":"Heart"},{"issue":"5","key":"839_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jchf.2016.12.019","volume":"5","author":"GR Revees","year":"2017","unstructured":"Revees GR, Whellan D, O\u2019Connor CM, Duncan P, Eggebeen JD, Morgan TM, et al. A novel rehabilitation intervention for older patients with acute decompensated heart failure. The REHAB-HF Pilot Study, JACC Heart Fail. 2017;5(5):359\u201366.","journal-title":"The REHAB-HF Pilot Study, JACC Heart Fail"},{"issue":"23","key":"839_CR23","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1001\/jama.2014.5616","volume":"311","author":"M Pahor","year":"2014","unstructured":"Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, et al. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387\u201396.","journal-title":"JAMA"},{"issue":"11","key":"839_CR24","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1093\/gerona\/61.11.1157","volume":"61","author":"M Pahor","year":"2006","unstructured":"Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, et al. Effects of a physical activity intervention on measures of physical performance: results of the lifestyle interventions and independence for elders pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006;61(11):1157\u201365.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"839_CR25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1532-5415.1975.tb00927.x","volume":"23","author":"E Pfeiffer","year":"1975","unstructured":"Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatrics Soc. 1975;23(10):433\u201341.","journal-title":"J Am Geriatrics Soc"},{"issue":"4","key":"839_CR26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/ageing\/afr051","volume":"40","author":"HC Roberts","year":"2011","unstructured":"Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardized approach. Age Ageing. 2011;40(4):423\u20139.","journal-title":"Age Ageing"},{"key":"839_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11136-004-0614-4","volume":"14","author":"D Nowels","year":"2005","unstructured":"Nowels D, McGloin J, Westfall JM, Holcomb S. Validation of the EQ-5D quality of life instrument in patients after myocardial infarction. Qual Life Res. 2005;14:95\u2013105.","journal-title":"Qual Life Res"},{"key":"839_CR28","first-page":"5","volume":"6","author":"A Kiessling","year":"2007","unstructured":"Kiessling A, Henriksson P. Time trends of chest pain symptoms and health related quality of life in coronary artery disease. Health Qual Life Outcomes. 2007;6:5\u201313.","journal-title":"Health Qual Life Outcomes"},{"key":"839_CR29","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1185\/030079905X56349","volume":"21","author":"JJ Ellis","year":"2005","unstructured":"Ellis JJ, Eagle KA, Kline-Rogers EM, Erickson SR. Validation of the EQ-5D in patients with a history of acute coronary syndrome. Cur Med Res Opin. 2005;21:1209\u201316.","journal-title":"Cur Med Res Opin"},{"key":"839_CR30","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.ahj.2004.12.010","volume":"150","author":"J Spertus","year":"2005","unstructured":"Spertus J, Peterson E, Conard MW, Heidenreich PA, Krumholz HM, Jones P, et al. Monitoring clinical changes in patients with heart failure: a comparison of methods. Am Heart J. 2005;150:707\u201315.","journal-title":"Am Heart J"},{"key":"839_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1477-7525-4-89","volume":"4","author":"DT Eurich","year":"2006","unstructured":"Eurich DT, Johnson JA, Reid KJ, Spertus JA. Assessing responsiveness of generic and specific health related quality of life measures in heart failure. Health Qual Life Outcomes. 2006;4:89\u2013103.","journal-title":"Health Qual Life Outcomes"},{"key":"839_CR32","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.transproceed.2006.08.017","volume":"38","author":"M Almenar-Pertejo","year":"2006","unstructured":"Almenar-Pertejo M, Almenar L, Martinez-Dolz L, Campos J, Gal\u00e0n J, Giron\u00e9s P, et al. Study on health-related quality of life in patients with advanced heart failure before and after transplantation. Transplant Proc. 2006;38:2524.","journal-title":"Transplant Proc"},{"key":"839_CR33","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/j.1532-5415.1990.tb05699.x","volume":"38","author":"DB Reuben","year":"1990","unstructured":"Reuben DB, Laliberte L, Hiris J, et al. A hierarchical exercise scale to measure function at the advanced activities of daily living (AADL) level. J Am Geriatr Soc. 1990;38:855\u201361.","journal-title":"J Am Geriatr Soc"},{"key":"839_CR34","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1093\/geronj\/21.4.556","volume":"21","author":"I Rosow","year":"1966","unstructured":"Rosow I, Breslau N. A Guttman health scale for the aged. J Gerontol. 1966;21:556\u20139.","journal-title":"J Gerontol"},{"key":"839_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/oxfordjournals.aje.a113987","volume":"121","author":"JF Sallis","year":"1985","unstructured":"Sallis JF, Haskell WL, Wood PD, Fortmann SP, Rogers T, Blair SN, et al. Physical activity assessment methodology in the Five-City project. Am J Epidemiol. 1985;121:91\u2013106.","journal-title":"Am J Epidemiol"},{"key":"839_CR36","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","volume":"115","author":"DE Cutlip","year":"2007","unstructured":"Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, et al. Clinical end points in coronary stent trials a case for standardized definitions. Circulation. 2007;115:2344\u201351.","journal-title":"Circulation"},{"key":"839_CR37","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","volume":"66","author":"GW Stone","year":"2015","unstructured":"Stone GW, Adams DH, Abraham WT, Kappetein AP, G\u00e9n\u00e9reux P, Vranckx P, et al. Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 2: endpoint definitions. J Am Coll Cardiol. 2015;66:308\u201321.","journal-title":"J Am Coll Cardiol"},{"key":"839_CR38","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.ijcard.2016.07.125","volume":"221","author":"G Campo","year":"2016","unstructured":"Campo G, Morciano G, Pavasini R, Bonora M, Sbano L, Biscaglia S, et al. Fo ATP synthase C subunit serum levels in patients with ST-segment elevation myocardial infarction: preliminary findings. Int J Cardiol. 2016;221:993\u20137.","journal-title":"Int J Cardiol"},{"issue":"12","key":"839_CR39","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1161\/01.ATV.0000247249.82030.94","volume":"26","author":"G Campo","year":"2006","unstructured":"Campo G, Valgimigli M, Ferraresi P, Malagutti P, Baroni M, Arcozzi C, et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler Thromb Vasc Biol. 2006;26(12):2800\u20136.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"839_CR40","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1111\/j.1538-7836.2011.04457.x","volume":"9","author":"G Campo","year":"2011","unstructured":"Campo G, Ferraresi P, Marchesini J, Bernardi F, Valgimigli M. Relationship between paraoxonase Q192R gene polymorphism and on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention. J Thromb Haemost. 2011;9(10):2106\u20138.","journal-title":"J Thromb Haemost"},{"issue":"3","key":"839_CR41","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s11239-012-0757-z","volume":"34","author":"G Campo","year":"2012","unstructured":"Campo G, Marchesini J, Bristot L, Monti M, Gambetti S, Pavasini R, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012;34(3):318\u201325.","journal-title":"J Thromb Thrombolysis"},{"key":"839_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2015.03.020","volume":"97","author":"G Campo","year":"2015","unstructured":"Campo G, Pavasini R, Biscaglia S, Ferri A, Andrenacci E, Tebaldi M, et al. Platelet aggregation values in patients with cardiovascular risk factors are reduced by verbascoside treatment. A randomized study. Pharmacol Res. 2015;97:1\u20136.","journal-title":"Pharmacol Res"},{"issue":"3","key":"839_CR43","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/jgs.13322","volume":"63","author":"EA Chmelo","year":"2015","unstructured":"Chmelo EA, Crotts C, Newman JC, Brinkley TE, Lyles MF, Leng X, et al. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015;63(3):462\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"839_CR44","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/jgs.14804","volume":"65","author":"AJ Santanasto","year":"2017","unstructured":"Santanasto AJ, Glynn NW, Lovato LC, Blair SN, Fielding RA, Gill TM, et al. Effect of physical activity versus health education on physical function, grip strength and mobility. J Am Geriatr Soc. 2017;65(7):1427\u201333.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"839_CR45","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s12916-016-0763-7","volume":"14","author":"R Pavasini","year":"2016","unstructured":"Pavasini R, Guralnik J, Brown JC, Di Bari M, Cesari M, Landi F, Vaes B, et al. Short physical performance battery and all-cause mortality: systematic review and meta-analysis. BMC Med. 2016;14(1):215.","journal-title":"BMC Med"},{"issue":"4","key":"839_CR46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/1474515114556713","volume":"15","author":"L Weibel","year":"2016","unstructured":"Weibel L, Massarotto P, Hediger H, Mahrer-Imhof R. Early education and counselling of patients with acute coronary syndrome. A pilot study for a randomized controlled trial. Eur J Cardiovasc Nurs. 2016;15(4):213\u201322.","journal-title":"Eur J Cardiovasc Nurs"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-018-0839-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12872-018-0839-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-018-0839-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T19:07:50Z","timestamp":1558379270000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-018-0839-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["839"],"URL":"https:\/\/doi.org\/10.1186\/s12872-018-0839-8","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,21]]},"assertion":[{"value":"13 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol has been approved by the hospitals\u2019 ethics committee prior to the study beginning (November 2016, study ID 161098). An approved written informed consent is obtained from all patients at the time of enrolment.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"98"}}