{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:05:53Z","timestamp":1762272353020,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12872-018-0966-2","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T08:38:11Z","timestamp":1545122291000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac autotransplantation and ex vivo surgical repair of giant left atrium: a case presentation"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-092X","authenticated-orcid":false,"given":"Zan","family":"Mitrev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milka","family":"Klincheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Anguseva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Zdravkovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney Alexander","family":"Rosalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"issue":"10","key":"966_CR1","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/ijcp.12321","volume":"68","author":"R Ray","year":"2014","unstructured":"Ray R, Chambers J. Mitral valve disease. Int J Clin Pract. 2014;68(10):1216\u201320.","journal-title":"Int J Clin Pract"},{"issue":"2","key":"966_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4103\/1995-705X.99227","volume":"13","author":"A Maghraby El","year":"2012","unstructured":"El Maghraby A, Hajar R. Giant left atrium: a review. Heart views : the official journal of the Gulf Heart Association. 2012;13(2):46\u201352.","journal-title":"Heart views : the official journal of the Gulf Heart Association"},{"issue":"3","key":"966_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/1010-7940(88)90063-2","volume":"2","author":"G Eusanio Di","year":"1988","unstructured":"Di Eusanio G, Gregorini R, Mazzola A, Clementi G, Procaccini B, Cavarra F, Taraschi F, Esposito G, Di Nardo W, Di Luzio V. Giant left atrium and mitral valve replacement: risk factor analysis. Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery. 1988;2(3):151\u20139.","journal-title":"Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery"},{"issue":"6","key":"966_CR4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jacc.2013.10.055","volume":"63","author":"BD Hoit","year":"2014","unstructured":"Hoit BD. Left atrial size and function: role in prognosis. J Am Coll Cardiol. 2014;63(6):493\u2013505.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"966_CR5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ejcts.2007.11.003","volume":"33","author":"E Apostolakis","year":"2008","unstructured":"Apostolakis E, Shuhaiber JH. The surgical management of giant left atrium. Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery. 2008;33(2):182\u201390.","journal-title":"Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery"},{"issue":"19","key":"966_CR6","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1161\/01.CIR.102.19.2378","volume":"102","author":"E Schwammenthal","year":"2000","unstructured":"Schwammenthal E, Vered Z, Agranat O, Kaplinsky E, Rabinowitz B, Feinberg MS. Impact of atrioventricular compliance on pulmonary artery pressure in mitral stenosis: an exercise echocardiographic study. Circulation. 2000;102(19):2378\u201384.","journal-title":"Circulation"},{"issue":"6","key":"966_CR7","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1161\/CIRCIMAGING.112.000328","volume":"6","author":"MC Nunes","year":"2013","unstructured":"Nunes MC, Hung J, Barbosa MM, Esteves WA, Carvalho VT, Lodi-Junqueira L, Fonseca Neto CP, Tan TC, Levine RA. Impact of net atrioventricular compliance on clinical outcome in mitral stenosis. Circ Cardiovasc Imaging. 2013;6(6):1001\u20138.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"4","key":"966_CR8","first-page":"252","volume":"14","author":"Y Tamura","year":"2008","unstructured":"Tamura Y, Nagasaka S, Abe T, Taniguchi S. Reasonable and effective volume reduction of a giant left atrium associated with mitral valve disease. Ann Thorac Cardiovasc Surg : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2008;14(4):252\u20135.","journal-title":"Ann Thorac Cardiovasc Surg : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia"},{"issue":"1","key":"966_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1477-9560-11-5","volume":"11","author":"AK Darwazah","year":"2013","unstructured":"Darwazah AK, El Sayed H. Giant left atrium associated with massive thrombus formation. Thromb J. 2013;11(1):5.","journal-title":"Thromb J"},{"issue":"22","key":"966_CR10","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1093\/eurheartj\/eht500","volume":"35","author":"DK Gupta","year":"2014","unstructured":"Gupta DK, Shah AM, Giugliano RP, Ruff CT, Antman EM, Grip LT, Deenadayalu N, Hoffman E, Patel I, Shi M, et al. Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48. Eur Heart J. 2014;35(22):1457\u201365.","journal-title":"Eur Heart J"},{"issue":"25","key":"966_CR11","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1016\/j.jacc.2017.10.063","volume":"70","author":"V Delgado","year":"2017","unstructured":"Delgado V, Di Biase L, Leung M, Romero J, Tops LF, Casadei B, Marrouche N, Bax JJ. Structure and function of the left atrium and left atrial appendage: AF and Stroke Implications. J Am Coll Cardiol. 2017;70(25):3157\u201372.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"966_CR12","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.ejcts.2008.06.039","volume":"34","author":"Z Mitrev","year":"2008","unstructured":"Mitrev Z, Hristov N. Cardiac silhouette following a mitral valve replacement, tricuspid annuloplasty and atrioplasty of both atria. Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery. 2008;34(4):905.","journal-title":"Eur J Cardiothoracic Surg : official journal of the European Association for Cardio-thoracic Surgery"},{"issue":"1","key":"966_CR13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1161\/01.CIR.86.1.328","volume":"86","author":"JK Oh","year":"1992","unstructured":"Oh JK. Echocardiographic evaluation of morphological and hemodynamic significance of giant left atrium. An important lesson. Circulation. 1992;86(1):328\u201330.","journal-title":"Circulation"},{"issue":"9","key":"966_CR14","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.3346\/jkms.2017.32.9.1548","volume":"32","author":"HO Park","year":"2017","unstructured":"Park HO, Yang JH, Kim SH, Moon SH, Byun JH, Choi JY, Lee CE, Yang JW, Kim JW. Autotransplantation of the heart for recurrent inflammatory Myofibroblastic tumor. J Korean Med Sci. 2017;32(9):1548\u201351.","journal-title":"J Korean Med Sci"},{"issue":"3","key":"966_CR15","first-page":"229","volume":"13","author":"U Andrushchuk","year":"2016","unstructured":"Andrushchuk U, Ostrovsky Y, Zharkov V, Amelchanka S, Krutau V, Yudina O, Ilyina T, Grinchuk I. Surgery for massive malignant tumors of the left atrium - one center\u2019s experience. Kardiochir Torakochirurgia Pol. 2016;13(3):229\u201335.","journal-title":"Kardiochir Torakochirurgia Pol"},{"issue":"2","key":"966_CR16","first-page":"105","volume":"29","author":"LD Conklin","year":"2002","unstructured":"Conklin LD, Reardon MJ. Autotransplantation of the heart for primary cardiac malignancy: development and surgical technique. Tex Heart Inst J. 2002;29(2):105\u20138 discussion 108.","journal-title":"Tex Heart Inst J"},{"issue":"12","key":"966_CR17","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s00595-015-1140-4","volume":"45","author":"T Sueda","year":"2015","unstructured":"Sueda T. History and development of surgical procedures for atrial fibrillation. Surg Today. 2015;45(12):1475\u201380.","journal-title":"Surg Today"},{"issue":"12","key":"966_CR18","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"RM Lang","year":"2005","unstructured":"Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440\u201363.","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"966_CR19","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/S0735-1097(02)02981-9","volume":"41","author":"AM Pritchett","year":"2003","unstructured":"Pritchett AM, Jacobsen SJ, Mahoney DW, Rodeheffer RJ, Bailey KR, Redfield MM. Left atrial volume as an index of left atrial size: a population-based study. J Am Coll Cardiol. 2003;41(6):1036\u201343.","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"966_CR20","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1161\/CIRCULATIONAHA.110.955039","volume":"122","author":"SD Solomon","year":"2010","unstructured":"Solomon SD, Foster E, Bourgoun M, Shah A, Viloria E, Brown MW, Hall WJ, Pfeffer MA, Moss AJ, Investigators M-C. Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy. Circulation. 2010;122(10):985\u201392.","journal-title":"Circulation"},{"issue":"2","key":"966_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/clc.22081","volume":"36","author":"A Dogliotti","year":"2013","unstructured":"Dogliotti A, Paolasso E, Giugliano RP. Novel oral anticoagulants in atrial fibrillation: a meta-analysis of large, randomized, controlled trials vs warfarin. Clin Cardiol. 2013;36(2):61\u20137.","journal-title":"Clin Cardiol"},{"issue":"6","key":"966_CR22","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/j.athoracsur.2011.02.035","volume":"91","author":"JM Stulak","year":"2011","unstructured":"Stulak JM, Dearani JA, Sundt TM 3rd, Daly RC, Schaff HV. Ablation of atrial fibrillation: comparison of catheter-based techniques and the cox-maze III operation. Ann Thorac Surg. 2011;91(6):1882\u20138 discussion 1888-1889.","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"966_CR23","first-page":"15","volume":"3","author":"K Kearney","year":"2014","unstructured":"Kearney K, Stephenson R, Phan K, Chan WY, Huang MY, Yan TD. A systematic review of surgical ablation versus catheter ablation for atrial fibrillation. Ann Cardiothorac Surg. 2014;3(1):15\u201329.","journal-title":"Ann Cardiothorac Surg"},{"issue":"5","key":"966_CR24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0300-8932(02)76642-6","volume":"55","author":"OA Garcia-Villarreal","year":"2002","unstructured":"Garcia-Villarreal OA, Gouveia AB, Gonzalez R, Arguero R. Left atrial reduction. A new concept in surgery for chronic atrial fibrillation. Rev Esp Cardiol. 2002;55(5):499\u2013504.","journal-title":"Rev Esp Cardiol"},{"key":"966_CR25","doi-asserted-by":"crossref","unstructured":"Kang DH, Heo R, Lee S, Baek S, Kim DH, Song JM, Song JK, Lee JW. Initial surgery versus conservative management of symptomatic severe mitral regurgitation in the elderly. Heart. 2018;104(10):849-54.","DOI":"10.1136\/heartjnl-2017-311759"},{"issue":"5","key":"966_CR26","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/icvts\/ivt287","volume":"17","author":"J Pan","year":"2013","unstructured":"Pan J, Li QG, Li J, Wang DJ. Partial cardiac autotransplantation with a concomitant mitral valve, aortic valve replacement and tricuspid plasty. Interact Cardiovasc Thorac Surg. 2013;17(5):906\u20137.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"2","key":"966_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/021849230401200206","volume":"12","author":"HB Erdogan","year":"2004","unstructured":"Erdogan HB, Kirali K, Omeroglu SN, Goksedef D, Isik O, Yakut C. Partial cardiac autotransplantation for reduction of the left atrium. Asian Cardiovasc Thorac Ann. 2004;12(2):111\u20134.","journal-title":"Asian Cardiovasc Thorac Ann"},{"issue":"5","key":"966_CR28","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/icvts\/ivt377","volume":"17","author":"OA Garcia-Villarreal","year":"2013","unstructured":"Garcia-Villarreal OA. eComment. Mini-partial heart autotransplantation for atrial fibrillation and mitral valve surgery. Interact Cardiovasc Thorac Surg. 2013;17(5):907\u20138.","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"966_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14503\/THIJ-12-2948","volume":"41","author":"SY Boldyrev","year":"2014","unstructured":"Boldyrev SY, Lepshokov MK, Yakuba II, Barbukhatty KO, Porhanov VA. A patient with giant left atrium undergoes orthotopic heart transplantation. Tex Heart Inst J. 2014;41(1):87\u201390.","journal-title":"Tex Heart Inst J"},{"issue":"3","key":"966_CR30","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.athoracsur.2014.04.125","volume":"98","author":"B Ramlawi","year":"2014","unstructured":"Ramlawi B, Al-Jabbari O, Blau LN, Davies MG, Bruckner BA, Blackmon SH, Ravi V, Benjamin R, Rodriguez L, Shapira OM, et al. Autotransplantation for the resection of complex left heart tumors. Ann Thorac Surg. 2014;98(3):863\u20138.","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"966_CR31","first-page":"171","volume":"12","author":"DA Cooley","year":"1985","unstructured":"Cooley DA, Reardon MJ, Frazier OH, Angelini P. Human cardiac explantation and autotransplantation: application in a patient with a large cardiac pheochromocytoma. Tex Heart Inst J. 1985;12(2):171\u20136.","journal-title":"Tex Heart Inst J"},{"issue":"5","key":"966_CR32","first-page":"424","volume":"6","author":"D Novitzky","year":"2003","unstructured":"Novitzky D, Perry R, Ndaba D, Bowen T. Cardiac autotransplantation for mitral valve replacement. The heart surgery forum. 2003;6(5):424\u20138.","journal-title":"The heart surgery forum"},{"issue":"4","key":"966_CR33","first-page":"328","volume":"25","author":"GP Piccoli","year":"1984","unstructured":"Piccoli GP, Massini C, Di Eusanio G, Ballerini L, Iacobone G, Soro A, Palminiello A. Giant left atrium and mitral valve disease: early and late results of surgical treatment in 40 cases. J Cardiovasc Surg. 1984;25(4):328\u201336.","journal-title":"J Cardiovasc Surg"},{"issue":"1","key":"966_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.athoracsur.2016.05.009","volume":"102","author":"V Badhwar","year":"2016","unstructured":"Badhwar V, Rankin JS, Jacobs JP, Shahian DM, Habib RH, D'Agostino RS, Thourani VH, Suri RM, Prager RL, Edwards FH. The Society of Thoracic Surgeons adult cardiac surgery database: 2016 update on research. Ann Thorac Surg. 2016;102(1):7\u201313.","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"966_CR35","doi-asserted-by":"crossref","first-page":"205846011665189","DOI":"10.1177\/2058460116651899","volume":"5","author":"S Terpenning","year":"2016","unstructured":"Terpenning S, Ketai LH, Teague SD, Rissing SM. Prevalence of left atrial abnormalities in atrial fibrillation versus normal sinus patients. Acta Radiol Open. 2016;5(6):2058460116651899.","journal-title":"Acta Radiol Open"},{"issue":"11","key":"966_CR36","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S1010-7940(96)80401-5","volume":"10","author":"AT Kawaguchi","year":"1996","unstructured":"Kawaguchi AT, Kosakai Y, Isobe F, Sasako Y, Eishi K, Nakano K, Kobayashi J, Kawashima Y. Surgical stratification of patients with atrial fibrillation secondary to organic cardiac lesions. Eur J Cardiothorac Surg. 1996;10(11):983\u20139 discussion 989-990.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"966_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1053\/j.optechstcvs.2010.03.002","volume":"15","author":"SH Blackmon","year":"2010","unstructured":"Blackmon SH, Reardon MJ. Cardiac Autotransplantation. Oper Tech Thorac Cardiovasc Surg. 2010;15(2):147\u201361.","journal-title":"Oper Tech Thorac Cardiovasc Surg"},{"issue":"2","key":"966_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/ejechocard\/jeq119","volume":"12","author":"H Vyas","year":"2011","unstructured":"Vyas H, Jackson K, Chenzbraun A. Switching to volumetric left atrial measurements: impact on routine echocardiographic practice. Eur J Echocardiogr. 2011;12(2):107\u201311.","journal-title":"Eur J Echocardiogr"},{"issue":"1","key":"966_CR39","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jcmg.2016.11.003","volume":"10","author":"L Thomas","year":"2017","unstructured":"Thomas L, Abhayaratna WP. Left atrial reverse remodeling: mechanisms, evaluation, And Clinical Significance. JACC Cardiovasc Imaging. 2017;10(1):65\u201377.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"966_CR40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/cvr\/cvr060","volume":"90","author":"KK Baskin","year":"2011","unstructured":"Baskin KK, Taegtmeyer H. Taking pressure off the heart: the ins and outs of atrophic remodelling. Cardiovasc Res. 2011;90(2):243\u201350.","journal-title":"Cardiovasc Res"},{"key":"966_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nrcardio.2017.139","volume":"15","author":"GH Kim","year":"2017","unstructured":"Kim GH, Uriel N, Burkhoff D. Reverse remodelling and myocardial recovery in heart failure. Nat Rev Cardiol. 2017;15:83.","journal-title":"Nat Rev Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-018-0966-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12872-018-0966-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-018-0966-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T19:11:31Z","timestamp":1576609891000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-018-0966-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["966"],"URL":"https:\/\/doi.org\/10.1186\/s12872-018-0966-2","relation":{},"ISSN":["1471-2261"],"issn-type":[{"type":"electronic","value":"1471-2261"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"8 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The clinical practice and treatment procedures described in this case series were approved by the ethical committee of the Zan Mitrev Clinic.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written and signed informed consent was obtained from patient #4, hospitalised on 28\/09\/2017, for publication of this case report and any accompanying images. A copy of the signed consent can be submitted upon request for review by the Editor-in-Chief of this journal. The ZMC ethical committee approved the publication of clinical data of the deceased patients #1, #2 and #3 on the condition that full animosity.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. Zan Mitrev is the hospital director at the Zan Mitrev Clinic. The authors of scientific publications receive financial incentives, as a function of the scientific impact of the journal, awarded by the ZMC board.The ZMC chief scientific officer, R.A. Rosalia, is exempt from any financial incentive system and attests that all clinical and patient data described in this manuscript is devoid of any deliberate falsification or other fraudulent practices. The authors declare no other competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"239"}}