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Various clinical features have been observed among patients who have the same <jats:italic>LMNA<\/jats:italic> mutation. Here, we show a family with cardiac laminopathy with a c.475G\u2009&gt;\u2009T, p.E159* <jats:italic>LMNA<\/jats:italic> mutation, and a family history of conduction disorder, DCM, VT, and SCD.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A proband (female) with atrial fibrillation and bradycardia was implanted with a pacemaker in her fifties. Twenty years later, she experienced a loss of consciousness due to polymorphic VT. She had a serious family history; her mother and elder sister died suddenly in their fifties and sixties, respectively, and her nephew and son were diagnosed as having DCM. Genetic screening of the proband, her son, and nephew identified a nonsense mutation (c.475G\u2009&gt;\u2009T, p.E159*) in the <jats:italic>LMNA<\/jats:italic> gene. Although the proband\u2019s left ventricular ejection fraction remained relatively preserved, her son and nephew\u2019s left ventricular ejection fraction were reduced, resulting in cardiac resynchronization therapy by implantation of a defibrillator.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In this family with cardiac laminopathy with a c.475G\u2009&gt;\u2009T, p.E159* <jats:italic>LMNA<\/jats:italic> mutation, DCM, SCD, and malignant VT occurred. Clinical manifestation of various atrial and ventricular arrhythmias and heart failure with reduced ejection fraction occurred in an age-dependent manner in all family members who had the nonsense mutation. It appears highly likely that the E159* <jats:italic>LMNA<\/jats:italic> mutation is related to various cardiac problems in the family of the current report.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-019-01282-6","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T13:02:48Z","timestamp":1576587768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Case reports of a c.475G&gt;T, p.E159* lamin A\/C mutation with a family history of conduction disorder, dilated cardiomyopathy and sudden cardiac death"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-3274","authenticated-orcid":false,"given":"Tetsuro","family":"Yokokawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Hijioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kaneshiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiomi","family":"Yoshihisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kunii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuchika","family":"Takeishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"1282_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","volume":"10","author":"RE Hershberger","year":"2013","unstructured":"Hershberger RE, Hedges DJ, Morales A. 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Written informed consent was provided by the patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Tetsuro Yokokawa belongs to a department supported by Actelion Pharmaceuticals Japan. Takashi Kaneshiro belongs to a department supported by Biotronic Japan and Abbot Japan. Akiomi Yoshihisa belongs to a department supported by Fukuda Denshi Co. Ltd. These companies were not associated with the contents of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"298"}}