{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:25:21Z","timestamp":1787955921586,"version":"build-2784847793"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Research Division Faculty of Medicine Siriraj Hospital","award":["R015834003"],"award-info":[{"award-number":["R015834003"]}]},{"name":"Health System Research Institute (HSRI), Nonthaburi, Thailand","award":["59-009"],"award-info":[{"award-number":["59-009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ischemic cardiomyopathy is a high-cost, resource-intensive public health burden that is associated with a 1-year mortality rate of about 16% in western population. Different in patient ethnicity and pattern of practice may impact the clinical outcome. We aim to determine 1-year mortality and to identify factors that significantly predicts 1-year mortality of Thai patients with ischemic cardiomyopathy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This prospective multicenter registry enrolled consecutive Thai patients that were diagnosed with ischemic cardiomyopathy at 9 institutions located across Thailand. Patients with left ventricular function &lt;\u200940% and one of the following criteria were included: 1) presence of epicardial coronary stenoses &gt;\u200975% in the left main or proximal left anterior descending artery or coronary angiography, and\/or two major epicardial coronary stenoses; 2) prior myocardial infarction; 3) prior revascularization by coronary artery bypass graft or percutaneous coronary intervention; or, 4) magnetic resonance imaging pattern compatible with ischemic cardiomyopathy. Baseline clinical characteristics, coronary and echocardiographic data were recorded. The 1-year clinical outcome was pre-specified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Four hundred and nineteen patients were enrolled. Thirty-nine patients (9.9%) had died at 1\u2009year, with 27 experiencing cardiovascular death, and 12 experiencing non-cardiovascular death. A comparison between patients who were alive and patients who were dead at 1\u2009year revealed lower baseline left ventricular ejection fraction (LVEF) (26.7\u2009\u00b1\u20097.6% vs 30.2\u2009\u00b1\u20097.8%; <jats:italic>p<\/jats:italic>\u2009=\u20090.021), higher left ventricular end-diastolic volume (LVEDV) (185.8\u2009\u00b1\u200973.2\u2009ml vs 155.6\u2009\u00b1\u200964.2\u2009ml; <jats:italic>p<\/jats:italic>\u2009=\u20090.014), shorter mitral valve deceleration time (142.9\u2009\u00b1\u200957.5\u2009ml vs 182.4\u2009\u00b1\u200985.7\u2009ml; <jats:italic>p<\/jats:italic>\u2009=\u20090.041), and lower use of statins (94.7% vs 99.7%; <jats:italic>p<\/jats:italic>\u2009=\u20090.029) among deceased patients. Patients receiving guideline-recommended \u03b2-blockers had lower mortality than patients receiving non-guideline-recommended \u03b2-blockers (8.1% vs 18.2%; <jats:italic>p<\/jats:italic>\u2009=\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results of this study revealed a 9.9% 1-year mortality rate among Thai ischemic cardiomyopathy patients. Doppler echocardiographic parameters significantly associated with 1-year mortality were LVEF, LVEDV, mitral E velocity, and mitral valve deceleration time. The use of non-guideline-recommended \u03b2-blockers rather than guideline recommended \u03b2-blockers were associated with increased with 1-year mortality. Guidelines recommended \u03b2-blockers should be preferred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Thai Clinical Trials Registry TCTR20190722002. Registered 22 July 2019. \u201cRetrospectively registered\u201d.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-019-01311-4","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T12:02:42Z","timestamp":1578571362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of guideline-recommended versus non-guideline-recommended \u03b2-blocker and Doppler echocardiographic parameters on 1-year mortality in Thai ischemic cardiomyopathy patients: A prospective multicenter registry"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-3313","authenticated-orcid":false,"given":"Nattawut","family":"Wongpraparut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarawut","family":"Siwamogsatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomorn","family":"Thongsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornchai","family":"Ngamjanyaporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kompoj","family":"Jirajarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarinee","family":"Tangcharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kid","family":"Bhumimuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinij","family":"Kaewsuwanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungroj","family":"Krittayaphong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungtiwa","family":"Pongakasira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey D.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"1311_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0002-8703(70)90416-3","volume":"79","author":"GE Burch","year":"1970","unstructured":"Burch GE, Giles TD, Colcolough HL. 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All study participants provided written informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}