{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:15:43Z","timestamp":1789002943357,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Siriraj Grant for Research Development","award":["R15433024"],"award-info":[{"award-number":["R15433024"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The leading cause of mortality of thalassemia major patients is iron overload cardiomyopathy. Early diagnosis with searching for left ventricular diastolic dysfunction before the systolic dysfunction ensued might yield better prognosis. This study aimed to define the prevalence of the left ventricular diastolic dysfunction (LVDD) in thalassemia major patients with normal left ventricular systolic function and the associated factors.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Adult thalassemia major patients with normal left ventricular systolic function who were referred for cardiac T2* at Siriraj Hospital \u2013 Thailand\u2019s largest national tertiary referral center \u2013 during the October 2014 to January 2017 study period. Left ventricular diastolic function was defined by mitral valve filling parameters and left atrial volume index using CMR. Patients with moderate to severe valvular heart disease, pericardial disease, or incomplete data were excluded. Baseline characteristics, comorbid diseases, current medication, and laboratory results were recorded and analyzed.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred and sixteen patients were included, with a mean age of 27.5\u2009\u00b1\u200913.5\u2009years, 57.8% were female, and 87.9% were transfusion dependent. Proportions of homozygous beta-thalassemia and beta-thalassemia hemoglobin E were 12.1 and 87.9%, respectively. The baseline hematocrit was 26.3\u2009\u00b1\u20093.3%. The prevalence of LVDD was 20.7% (95% CI: 13.7\u201329.2%). Cardiac T2* was abnormal in 7.8% (95% CI: 3.6\u201314.2%). Multivariate analysis revealed age, body surface area, homozygous beta-thalassemia, splenectomy, heart rate, and diastolic blood pressure to be significantly associated with LVDD.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>LVDD already exists from the early stages of the disease before the abnormal heart T2 * is detected. Homozygous beta-thalassemia and splenectomy were strong predictors of LVDD. These data may increase awareness of the disease, especially in the high risk groups.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-019-1235-8","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T10:03:34Z","timestamp":1573034614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence of left ventricular diastolic dysfunction by cardiac magnetic resonance imaging in thalassemia major patients with normal left ventricular systolic function"],"prefix":"10.1186","volume":"19","author":[{"given":"Benjaporn","family":"Chinprateep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithima","family":"Ratanasit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yodying","family":"Kaolawanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khemajira","family":"Karaketklang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pairash","family":"Saiviroonporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vip","family":"Viprakasit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-2361","authenticated-orcid":false,"given":"Rungroj","family":"Krittayaphong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"issue":"3","key":"1235_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1161\/CIR.0b013e31829b2be6","volume":"128","author":"DJ Pennell","year":"2013","unstructured":"Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, Hoffman TM, Kiernan MS, Lerakis S, Piga A, et al. Cardiovascular function and treatment in beta-thalassemia major: a consensus statement from the American Heart Association. Circulation. 2013;128(3):281\u2013308.","journal-title":"Circulation"},{"issue":"3","key":"1235_CR2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1161\/CIRCHEARTFAILURE.109.913863","volume":"3","author":"DT Kremastinos","year":"2010","unstructured":"Kremastinos DT, Farmakis D, Aessopos A, Hahalis G, Hamodraka E, Tsiapras D, Keren A. Beta-thalassemia cardiomyopathy: history, present considerations, and future perspectives. Circ Heart Fail. 2010;3(3):451\u20138.","journal-title":"Circ Heart Fail"},{"issue":"5","key":"1235_CR3","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.echo.2009.02.003","volume":"22","author":"JB Somaratne","year":"2009","unstructured":"Somaratne JB, Whalley GA, Poppe KK, Gamble GD, Doughty RN. Pseudonormal mitral filling is associated with similarly poor prognosis as restrictive filling in patients with heart failure and coronary heart disease: a systematic review and meta-analysis of prospective studies. J Am Soc Echocardiogr. 2009;22(5):494\u20138.","journal-title":"J Am Soc Echocardiogr"},{"issue":"5","key":"1235_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cardfail.2007.01.010","volume":"13","author":"JB Somaratne","year":"2007","unstructured":"Somaratne JB, Whalley GA, Gamble GD, Doughty RN. Restrictive filling pattern is a powerful predictor of heart failure events postacute myocardial infarction and in established heart failure: a literature-based meta-analysis. J Card Fail. 2007;13(5):346\u201352.","journal-title":"J Card Fail"},{"issue":"5","key":"1235_CR5","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0894-7317(98)70025-2","volume":"11","author":"DG Hurrell","year":"1998","unstructured":"Hurrell DG, Oh JK, Mahoney DW, Miller FA Jr, Seward JB. Short deceleration time of mitral inflow E velocity: prognostic implication with atrial fibrillation versus sinus rhythm. J Am Soc Echocardiogr. 1998;11(5):450\u20137.","journal-title":"J Am Soc Echocardiogr"},{"issue":"20","key":"1235_CR6","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.111.050773","volume":"124","author":"DT Kremastinos","year":"2011","unstructured":"Kremastinos DT, Farmakis D. Iron overload cardiomyopathy in clinical practice. Circulation. 2011;124(20):2253\u201363.","journal-title":"Circulation"},{"issue":"3","key":"1235_CR7","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/01.CIR.88.3.1127","volume":"88","author":"DT Kremastinos","year":"1993","unstructured":"Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation. 1993;88(3):1127\u201335.","journal-title":"Circulation"},{"issue":"1","key":"1235_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1161\/01.CIR.82.1.88","volume":"82","author":"P Spirito","year":"1990","unstructured":"Spirito P, Lupi G, Melevendi C, Vecchio C. Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major. Circulation. 1990;82(1):88\u201394.","journal-title":"Circulation"},{"issue":"5","key":"1235_CR9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.jcmg.2008.04.005","volume":"1","author":"B Leonardi","year":"2008","unstructured":"Leonardi B, Margossian R, Colan SD, Powell AJ. Relationship of magnetic resonance imaging estimation of myocardial iron to left ventricular systolic and diastolic function in thalassemia. JACC Cardiovasc Imaging. 2008;1(5):572\u20138.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"1235_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/jmri.20379","volume":"22","author":"MA Westwood","year":"2005","unstructured":"Westwood MA, Wonke B, Maceira AM, Prescott E, Walker JM, Porter JB, Pennell DJ. Left ventricular diastolic function compared with T2* cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major. J Magn Reson Imaging. 2005;22(2):229\u201333.","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"1235_CR11","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/eurheartj\/14.3.351","volume":"14","author":"DT Kremastinos","year":"1993","unstructured":"Kremastinos DT, Rentoukas E, Mavrogeni S, Kyriakides ZS, Politis C, Toutouzas P. Left ventricular filling pattern in beta-thalassaemia major--a Doppler echocardiographic study. Eur Heart J. 1993;14(3):351\u20137.","journal-title":"Eur Heart J"},{"issue":"9","key":"1235_CR12","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3324\/haematol.2013.083634","volume":"98","author":"JP Carpenter","year":"2013","unstructured":"Carpenter JP, Roughton M, Pennell DJ. International survey of T2* cardiovascular magnetic resonance in beta-thalassemia major. Haematologica. 2013;98(9):1368\u201374.","journal-title":"Haematologica"},{"key":"1235_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bcmd.2017.08.002","volume":"66","author":"R Krittayaphong","year":"2017","unstructured":"Krittayaphong R, Viprakasit V, Saiviroonporn P, Siritanaratkul N, Siripornpitak S, Meekaewkunchorn A, Kirawittaya T, Sripornsawan P, Jetsrisuparb A, Srinakarin J, et al. Prevalence and predictors of cardiac and liver iron overload in patients with thalassemia: a multicenter study based on real-world data. Blood Cells Mol Dis. 2017;66:24\u201330.","journal-title":"Blood Cells Mol Dis"},{"issue":"2","key":"1235_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1067\/mhj.2001.112090","volume":"141","author":"HI Karvounis","year":"2001","unstructured":"Karvounis HI, Zaglavara TA, Parharidis GE, Nouskas IG, Hassapopoulou EP, Gemitzis KD, Louridas GE. An angiotensin-converting enzyme inhibitor improves left ventricular systolic and diastolic function in transfusion-dependent patients with beta-thalassemia major. Am Heart J. 2001;141(2):281.","journal-title":"Am Heart J"},{"issue":"5","key":"1235_CR15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ejheart.2006.11.004","volume":"9","author":"DT Kremastinos","year":"2007","unstructured":"Kremastinos DT, Tsiapras DP, Kostopoulou AG, Hamodraka ES, Chaidaroglou AS, Kapsali ED. NT-proBNP levels and diastolic dysfunction in beta-thalassaemia major patients. Eur J Heart Fail. 2007;9(5):531\u20136.","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"1235_CR16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11886-017-0816-3","volume":"19","author":"M Kinno","year":"2017","unstructured":"Kinno M, Nagpal P, Horgan S, Waller AH. Comparison of echocardiography, cardiac magnetic resonance, and computed tomographic imaging for the evaluation of left ventricular myocardial function: part 2 (diastolic and regional assessment). Curr Cardiol Rep. 2017;19(1):6.","journal-title":"Curr Cardiol Rep"},{"key":"1235_CR17","first-page":"171","volume":"17","author":"R Krittayaphong","year":"2004","unstructured":"Krittayaphong R, Saiviroonporn P, Boonyasirinant T, Nakyen S, Kangkagate C. Gender differences on the left and right ventricular volume, systolic function and mass assessed by cardiac magnetic resonance imaging. Thai Heart J. 2004;17:171\u20138.","journal-title":"Thai Heart J"},{"key":"1235_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12968-016-0236-3","volume":"18","author":"TT Le","year":"2016","unstructured":"Le TT, Tan RS, De Deyn M, Goh EP, Han Y, Leong BR, Cook SA, Chin CW. Cardiovascular magnetic resonance reference ranges for the heart and aorta in Chinese at 3T. J Cardiovasc Magn Reson. 2016;18:21.","journal-title":"J Cardiovasc Magn Reson"},{"issue":"6","key":"1235_CR19","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/jmri.20929","volume":"25","author":"T He","year":"2007","unstructured":"He T, Gatehouse PD, Kirk P, Tanner MA, Smith GC, Keegan J, Mohiaddin RH, Pennell DJ, Firmin DN. Black-blood T2* technique for myocardial iron measurement in thalassemia. J Magn Reson Imaging. 2007;25(6):1205\u20139.","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"1235_CR20","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/RCT.0b013e31820eaaf2","volume":"35","author":"P Saiviroonporn","year":"2011","unstructured":"Saiviroonporn P, Viprakasit V, Boonyasirinant T, Khuhapinant A, Wood JC, Krittayaphong R. Comparison of the region-based and pixel-wise methods for cardiac T2* analysis in 50 transfusion-dependent Thai thalassemia patients. J Comput Assist Tomogr. 2011;35(3):375\u201381.","journal-title":"J Comput Assist Tomogr"},{"issue":"4","key":"1235_CR21","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/jmri.23937","volume":"38","author":"MR Ferguson","year":"2013","unstructured":"Ferguson MR, Otto RK, Bender MA, Kolokythas O, Friedman SD. Liver and heart MR relaxometry in iron loading: reproducibility of three methods. J Magn Reson Imaging. 2013;38(4):987\u201390.","journal-title":"J Magn Reson Imaging"},{"issue":"23","key":"1235_CR22","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22(23):2171\u20139.","journal-title":"Eur Heart J"},{"key":"1235_CR23","first-page":"370","volume-title":"Cardiac MRI","author":"R Krittayaphong","year":"2015","unstructured":"Krittayaphong R. MRI in thalassemia. In: Boonyasirinant T, Krittayaphong R, editors. Cardiac MRI. Bangkok: Parbpim; 2015. p. 370\u201395."},{"key":"1235_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1532-429X-10-36","volume":"10","author":"VK Rathi","year":"2008","unstructured":"Rathi VK, Doyle M, Yamrozik J, Williams RB, Caruppannan K, Truman C, Vido D, Biederman RW. Routine evaluation of left ventricular diastolic function by cardiovascular magnetic resonance: a practical approach. J Cardiovasc Magn Reson. 2008;10:36.","journal-title":"J Cardiovasc Magn Reson"},{"issue":"2","key":"1235_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/jmri.22424","volume":"33","author":"A Brandts","year":"2011","unstructured":"Brandts A, Bertini M, van Dijk EJ, Delgado V, Marsan NA, van der Geest RJ, Siebelink HM, de Roos A, Bax JJ, Westenberg JJ. Left ventricular diastolic function assessment from three-dimensional three-directional velocity-encoded MRI with retrospective valve tracking. J Magn Reson Imaging. 2011;33(2):312\u20139.","journal-title":"J Magn Reson Imaging"},{"issue":"6","key":"1235_CR26","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1161\/CIRCIMAGING.109.879304","volume":"2","author":"K Kawaji","year":"2009","unstructured":"Kawaji K, Codella NC, Prince MR, Chu CW, Shakoor A, LaBounty TM, Min JK, Swaminathan RV, Devereux RB, Wang Y, et al. Automated segmentation of routine clinical cardiac magnetic resonance imaging for assessment of left ventricular diastolic dysfunction. Circ Cardiovasc Imaging. 2009;2(6):476\u201384.","journal-title":"Circ Cardiovasc Imaging"},{"key":"1235_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1532-429X-12-46","volume":"12","author":"DD Mendoza","year":"2010","unstructured":"Mendoza DD, Codella NC, Wang Y, Prince MR, Sethi S, Manoushagian SJ, Kawaji K, Min JK, LaBounty TM, Devereux RB, et al. Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2010;12:46.","journal-title":"J Cardiovasc Magn Reson"},{"issue":"2","key":"1235_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","volume":"22","author":"SF Nagueh","year":"2009","unstructured":"Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009;22(2):107\u201333.","journal-title":"J Am Soc Echocardiogr"},{"issue":"4","key":"1235_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","volume":"29","author":"SF Nagueh","year":"2016","unstructured":"Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277\u2013314.","journal-title":"J Am Soc Echocardiogr"},{"issue":"12","key":"1235_CR30","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/S0002-9149(02)02864-3","volume":"90","author":"TS Tsang","year":"2002","unstructured":"Tsang TS, Barnes ME, Gersh BJ, Bailey KR, Seward JB. Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol. 2002;90(12):1284\u20139.","journal-title":"Am J Cardiol"},{"issue":"4","key":"1235_CR31","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/0735-1097(88)90208-2","volume":"11","author":"CP Appleton","year":"1988","unstructured":"Appleton CP, Hatle LK, Popp RL. Demonstration of restrictive ventricular physiology by Doppler echocardiography. J Am Coll Cardiol. 1988;11(4):757\u201368.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"1235_CR32","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/0735-1097(88)90285-9","volume":"11","author":"RA Nishimura","year":"1988","unstructured":"Nishimura RA, Holmes DR Jr, Reeder GS, Tajik AJ, Hatle LK. Doppler echocardiographic observations during percutaneous aortic balloon valvuloplasty. J Am Coll Cardiol. 1988;11(6):1219\u201326.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"1235_CR33","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1161\/01.CIR.79.1.66","volume":"79","author":"HA Valantine","year":"1989","unstructured":"Valantine HA, Appleton CP, Hatle LK, Hunt SA, Billingham ME, Shumway NE, Stinson EB, Popp RL. A hemodynamic and Doppler echocardiographic study of ventricular function in long-term cardiac allograft recipients. Etiology and prognosis of restrictive-constrictive physiology. Circulation. 1989;79(1):66\u201375.","journal-title":"Circulation"},{"issue":"4","key":"1235_CR34","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0195-668X(02)00428-1","volume":"24","author":"M Fischer","year":"2003","unstructured":"Fischer M, Baessler A, Hense HW, Hengstenberg C, Muscholl M, Holmer S, Doring A, Broeckel U, Riegger G, Schunkert H. Prevalence of left ventricular diastolic dysfunction in the community. Results from a Doppler echocardiographic-based survey of a population sample. Eur Heart J. 2003;24(4):320\u20138.","journal-title":"Eur Heart J"},{"issue":"8","key":"1235_CR35","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.jacc.2003.11.040","volume":"43","author":"M Klapholz","year":"2004","unstructured":"Klapholz M, Maurer M, Lowe AM, Messineo F, Meisner JS, Mitchell J, Kalman J, Phillips RA, Steingart R, Brown EJ Jr, et al. Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York heart failure registry. J Am Coll Cardiol. 2004;43(8):1432\u20138.","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 1","key":"1235_CR36","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.3109\/03630260903347526","volume":"33","author":"JC Wood","year":"2009","unstructured":"Wood JC. Cardiac complications in thalassemia major. Hemoglobin. 2009;33(Suppl 1):S81\u20136.","journal-title":"Hemoglobin"},{"issue":"1","key":"1235_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00004872-199917010-00001","volume":"17","author":"MF O'Rourke","year":"1999","unstructured":"O'Rourke MF, Mancia G. Arterial stiffness. J Hypertens. 1999;17(1):1\u20134.","journal-title":"J Hypertens"},{"issue":"4 Pt 2","key":"1235_CR38","first-page":"H747","volume":"249","author":"M Hori","year":"1985","unstructured":"Hori M, Inoue M, Kitakaze M, Tsujioka K, Ishida Y, Fukunami M, Nakajima S, Kitabatake A, Abe H. Loading sequence is a major determinant of afterload-dependent relaxation in intact canine heart. Am J Physiol. 1985;249(4 Pt 2):H747\u201354.","journal-title":"Am J Physiol"},{"issue":"5","key":"1235_CR39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0895-7061(97)00263-X","volume":"11","author":"F Veglio","year":"1998","unstructured":"Veglio F, Melchio R, Rabbia F, Molino P, Genova GC, Martini G, Schiavone D, Piga A, Chiandussi L. Blood pressure and heart rate in young thalassemia major patients. Am J Hypertens. 1998;11(5):539\u201347.","journal-title":"Am J Hypertens"},{"issue":"9","key":"1235_CR40","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/jch.12572","volume":"17","author":"M Pikilidou","year":"2015","unstructured":"Pikilidou M, Yavropoulou M, Antoniou M, Papakonstantinou E, Pantelidou D, Chalkia P, Nilsson P, Yovos J, Zebekakis P. Arterial stiffness and peripheral and central blood pressure in patients with sickle cell disease. J Clin Hypertens (Greenwich). 2015;17(9):726\u201331.","journal-title":"J Clin Hypertens (Greenwich)"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-019-1235-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12872-019-1235-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-019-1235-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:18:04Z","timestamp":1604535484000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-019-1235-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1235"],"URL":"https:\/\/doi.org\/10.1186\/s12872-019-1235-8","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,6]]},"assertion":[{"value":"31 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the Siriraj Institutional Review Board (SIRB), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Written informed consent was obtained from all included patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests relating to any aspect of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"245"}}