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Myocardial abnormalities, are present in early chronic kidney disease (CKD). To date there are no data defining prevalence, pattern and clinical implications of LGE-CMR in CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with pre-dialysis CKD (stage 2\u20135) attending specialist renal clinics at University Hospital Birmingham (UK) who underwent gadolinium enhanced CMR (1.5\u2009T) between 2005 and 2017 were included. The patterns and presence (LGEpos) \/ absence (LGEneg) of LGE were assessed by two blinded observers. Association between LGE and CV outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 159 patients received gadolinium (male 61%, mean age 55\u2009years, mean left ventricular ejection fraction 69%, left ventricular hypertrophy 5%) with a median follow up period of 3.8\u2009years [1.04\u201311.59]. LGEpos was present in 55 (34%) subjects; the patterns were: right ventricular insertion point\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928 (51%), mid wall\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918 (33%), sub-endocardial\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095 (9%) and sub-epicardial\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094 (7%). There were no differences in left ventricular structural or functional parameters with LGEpos. There were 12 adverse CV outcomes over follow up; 7 of 55 with LGEpos and 5 of 104 LGEneg. LGEpos was not predicted by age, gender, glomerular filtration rate or electrocardiographic abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a selected cohort of subjects with moderate CKD but low CV risk, LGE was present in approximately a third of patients. LGE was not associated with adverse CV outcomes. Further studies in high risk CKD cohorts are required to assess the role of LGE with multiplicative risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-019-1256-3","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T15:03:48Z","timestamp":1576508628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Myocardial characterization in pre-dialysis chronic kidney disease: a study of prevalence, patterns and outcomes"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-7688","authenticated-orcid":false,"given":"Anna M.","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvir K.","family":"Hayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Vijapurapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad A.","family":"Fyyaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Moody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Townend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Steeds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola C.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"issue":"22","key":"1256_CR1","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1161\/CIRCULATIONAHA.116.026910","volume":"135","author":"B Halliday","year":"2017","unstructured":"Halliday B, Gulati A, Ali A, Guha K, Newsome SJ, Arzanauskaite M, Vassiliou VS, Lota AS, Izgi C, Tayal U, et al. 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