{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:22:31Z","timestamp":1781493751715,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470491"],"award-info":[{"award-number":["81470491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Endothelial dysfunction may play a key role in non-obstructive coronary artery atherosclerosis. Our study aimed to evaluate the vascular endothelial function and its influencing factors in patients with non-obstructive coronary artery atherosclerosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 131 consecutive patients with non-obstructive coronary artery atherosclerosis were enrolled. Flow-mediated dilatation (FMD) was measured at baseline and 1-year follow-up. Endothelial progenitor cells (EPCs) were counted by staining the fasting venous blood with antibodies against CD34 and vascular endothelial growth factor receptor 2.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Systolic blood pressure, pulse pressure and the levels of HbA1c in participants with baseline FMD\u2009&lt;\u20096% (<jats:italic>n<\/jats:italic>\u2009=\u200965) were significantly higher than those with baseline FMD\u2009\u2265\u20096% (<jats:italic>n<\/jats:italic>\u2009=\u200966). Baseline FMD was negatively associated with EPC counts (r\u2009=\u2009\u2212\u20090.199, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and systolic blood pressure (r\u2009=\u2009\u2212\u20090.315, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The 1-year FMD was significantly increased compared to the baseline FMD [(9.31\u2009\u00b1\u20095.62) % vs (7.31\u2009\u00b1\u20095.26) %, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]. Independent predictors of FMD improvement included elevated EPC counts (OR\u2009=\u20091.104, 95% CI: 1.047\u20131.165, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and decreased levels of serum creatinine (OR\u2009=\u20090.915, 95% CI: 0.843\u20130.993, <jats:italic>P<\/jats:italic>\u2009=\u20090.034).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Family history of premature cardiovascular diseases, hypertension, elevated systolic pressure, and HbA1c\u2009&gt;\u20096.5% are independent risk factors for endothelial dysfunction in non-obstructive atherosclerotic patients. Elevated peripheral blood EPC counts and decreased levels of serum creatinine are independent predictors of endothelial function improvement.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01326-2","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T14:03:04Z","timestamp":1580392984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influencing factors of vascular endothelial function in patients with non-obstructive coronary atherosclerosis: a 1-year observational study"],"prefix":"10.1186","volume":"20","author":[{"given":"Yin-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Xing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Hua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Bing","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-3315","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"issue":"17","key":"1326_CR1","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1016\/j.jacc.2015.08.876","volume":"66","author":"CJ Pepine","year":"2015","unstructured":"Pepine CJ, Ferdinand KC, Shaw LJ, Light-McGroary KA, Shah RU, Gulati M, Duvernoy C, Walsh MN, Bairey Merz CN, ACC CVD in women committee. Emergence of nonobstructive coronary artery disease: a Woman's problem and need for change in definition on angiography. J Am Coll Cardiol. 2015;66(17):1918\u201333.","journal-title":"J Am Coll Cardiol"},{"key":"1326_CR2","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1093\/eurheartj\/ehr331","volume":"33","author":"L Jespersen","year":"2012","unstructured":"Jespersen L, Hvelplund A, Abildstr\u00f8m SZ, Pedersen F, Galatius S, Madsen JK, J\u00f8rgensen E, Kelb\u00e6k H, Prescott E. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. Eur Heart J. 2012;33:734\u201344. https:\/\/doi.org\/10.1093\/eurheartj\/ehr331.","journal-title":"Eur Heart J"},{"issue":"11","key":"1326_CR3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","volume":"135","author":"CN Bairey Merz","year":"2017","unstructured":"Bairey Merz CN, Pepine CJ, Walsh MN, Fleg JL. Ischemia and no obstructive coronary artery disease (INOCA): developing evidence-based therapies and research agenda for the next decade. Circ. 2017;135(11):1075\u201392.","journal-title":"Circ"},{"issue":"7347","key":"1326_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature10146","volume":"473","author":"P Libby","year":"2011","unstructured":"Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nat. 2011;473(7347):317\u201325.","journal-title":"Nat"},{"issue":"9","key":"1326_CR5","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","volume":"37","author":"S Godo","year":"2017","unstructured":"Godo S, Shimokawa H. Endothelial functions. Arterioscler Thromb Vasc Biol. 2017;37(9):e108\u201314.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"27","key":"1326_CR6","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/eurheartj\/eht132","volume":"34","author":"BJ Choi","year":"2013","unstructured":"Choi BJ, Prasad A, Gulati R, Best PJ, Lennon RJ, Barsness GW, Lerman LO, Lerman A. Coronary endothelial dysfunction in patients with early coronary artery disease is associated with the increase in intravascular lipid core plaque. Eur Heart J. 2013;34(27):2047\u201354.","journal-title":"Eur Heart J"},{"issue":"7","key":"1326_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/01.mca.0000224420.67304.4d","volume":"17","author":"MI Mayranpaa","year":"2006","unstructured":"Mayranpaa MI, Heikkila HM, Lindstedt KA, Walls AF, Kovanen PT. Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion. Coron Artery Dis. 2006;17(7):611\u201321.","journal-title":"Coron Artery Dis"},{"issue":"25","key":"1326_CR8","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/CIRCULATIONAHA.111.078824","volume":"124","author":"JA Vita","year":"2011","unstructured":"Vita JA. Endothelial function. Circ. 2011;124(25):906\u201312.","journal-title":"Circ"},{"issue":"4","key":"1326_CR9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1748-1716.2010.02127.x","volume":"199","author":"JJ Whyte","year":"2010","unstructured":"Whyte JJ, Laughlin MH. The effects of acute and chronic exercise on the vasculature. Acta Physiologica (Oxford, England). 2010;199(4):441\u201350.","journal-title":"Acta Physiologica (Oxford, England)"},{"issue":"3","key":"1326_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.pharmthera.2014.06.003","volume":"144","author":"D Tousoulis","year":"2014","unstructured":"Tousoulis D, SimopoulouC PN, Oikonomou E, Hatzis G, Siasos G, Tsiamis E, Stefanadis C. endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches. Pharmacol Ther. 2014;144(3):253\u201367.","journal-title":"Pharmacol Ther"},{"key":"1326_CR11","first-page":"w13122","volume":"140","author":"AJ Flammer","year":"2010","unstructured":"Flammer AJ, L\u00fcscher TF. Three decades of endothelium research: from the detection of nitric oxide to the everyday implementation of endothelial function measurements in cardiovascular diseases. Swiss Med Wkly. 2010;140:w13122.","journal-title":"Swiss Med Wkly"},{"issue":"3","key":"1326_CR12","first-page":"H985","volume":"291","author":"M Feletou","year":"2006","unstructured":"Feletou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (the Wiggers award lecture). Am J Phys Heart Circ Phys. 2006;291(3):H985\u20131002.","journal-title":"Am J Phys Heart Circ Phys"},{"key":"1326_CR13","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-F","volume":"340","author":"SKE DS","year":"1992","unstructured":"DS SKE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111\u20135 [PubMed: 1359209].","journal-title":"Lancet"},{"key":"1326_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","volume":"39","author":"MC Corretti","year":"2002","unstructured":"Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endotheilal-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force. J Am Coll Cardiol. 2002;39:257\u201365.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1326_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1536\/ihj.14-385","volume":"56","author":"Y Higashi","year":"2015","unstructured":"Higashi Y. Assessment of endothelial function. History, methodological aspects, and clinical perspectives. Int Heart J. 2015;56(2):125\u201334.","journal-title":"Int Heart J"},{"key":"1326_CR16","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1253\/circj.68.1067","volume":"68","author":"T Takayama","year":"2004","unstructured":"Takayama T, Wada A, Tsutamoto T, Ohnishi M, Fujii M, Isono T, Horie M. Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor. Circ J. 2004;68:1067\u201375.","journal-title":"Circ J"},{"issue":"6","key":"1326_CR17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","volume":"126","author":"AJ Flammer","year":"2012","unstructured":"Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, Hamburg NM, L\u00fcscher TF, Shechter M, Taddei S, Vita JA, Lerman A. The assessment of endothelial function: from research into clinical practice. Circ. 2012;126(6):753\u201367.","journal-title":"Circ"},{"issue":"2","key":"1326_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115\u201326.","journal-title":"N Engl J Med"},{"issue":"5","key":"1326_CR19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/ajh\/hpt208","volume":"27","author":"R Suzuki","year":"2014","unstructured":"Suzuki R, Fukuda N, Katakawa M, Tsunemi A, Tahira Y, Matsumoto T, Ueno T, Soma M. Effects of an angiotensin II receptor blocker on the impaired function of endothelial progenitor cells in patients with essential hypertension. Am J Hypertens. 2014;27(5):695\u2013701.","journal-title":"Am J Hypertens"},{"key":"1326_CR20","doi-asserted-by":"publisher","first-page":"178","DOI":"10.5551\/jat.9.178","volume":"9","author":"S Morikawal","year":"2002","unstructured":"Morikawal S, Takabe W, Mataki C, Kanke T, Itoh T, Wada Y, Izumi A, Saito Y, Hamakubo T, Kodama T. The effect of statins on mRNA levels of genes related to inflammation, coagulation and vascular constriction in HUVEC. J Atheroscler Thromb. 2002;9:178\u201383.","journal-title":"J Atheroscler Thromb"},{"key":"1326_CR21","first-page":"772","volume":"231","author":"M Ohkita","year":"2006","unstructured":"Ohkita M, Sugii M, Ka Y, Mori T, Hayashi T, Takaoka M, Matsumura Y. Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells. Exp Biol Med. 2006;231:772\u20136.","journal-title":"Exp Biol Med"},{"key":"1326_CR22","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"The Seventh Report of the Joint Committee on Prevention","year":"2003","unstructured":"The Seventh Report of the Joint Committee on Prevention. Detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003 May 21;289:2560\u201372.","journal-title":"JAMA"},{"issue":"1","key":"1326_CR23","doi-asserted-by":"publisher","first-page":"H2","DOI":"10.1152\/ajpheart.00471.2010","volume":"300","author":"DH Thijssen","year":"2011","unstructured":"Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2011;300(1):H2\u2013H12.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"1326_CR24","first-page":"101","volume":"3","author":"DL Swift","year":"2007","unstructured":"Swift DL, Irving BA, Brock DW, Davis CK, Barrett EJ, Gaesser GA, Weltman A. Heart rate recovery does not predict endothelial function in obese women. Obes Metab. 2007 Sep 1;3(3):101\u20135.","journal-title":"Obes Metab"},{"issue":"2","key":"1326_CR25","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.atherosclerosis.2007.12.039","volume":"197","author":"GP Fadini","year":"2008","unstructured":"Fadini GP, Baesso I, Albiero M, Sartore S, Agostini C, Avogaro A. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis. 2008;197(2):496\u2013503.","journal-title":"Atherosclerosis"},{"issue":"4","key":"1326_CR26","doi-asserted-by":"publisher","first-page":"H455","DOI":"10.1152\/ajpheart.00726.2015","volume":"310","author":"L Hou","year":"2016","unstructured":"Hou L, Kim JJ, Woo YJ, Huang NF. Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease. Am J Physiol Heart Circ Physiol. 2016;310(4):H455\u201365.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"1326_CR27","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1007\/s10439-015-1400-x","volume":"43","author":"PA Williams","year":"2015","unstructured":"Williams PA, Silva EA. The role of synthetic extracellular matrices in endothelial progenitor cell homing for treatment of vascular disease. Ann Biomed Eng. 2015;43(10):2301\u201313.","journal-title":"Ann Biomed Eng"},{"issue":"2","key":"1326_CR28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/cvr\/cvq146","volume":"87","author":"JM Tarbell","year":"2010","unstructured":"Tarbell JM. Shear stress and the endothelial transport barrier. Cardiovasc Res. 2010;87(2):320\u201330.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"1326_CR29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s10439-005-2500-9","volume":"33","author":"JA LaMack","year":"2005","unstructured":"LaMack JA, Himburg HA, Li XM, Friedman MH. Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability. Ann Biomed Eng. 2005;33(4):457\u201364.","journal-title":"Ann Biomed Eng"},{"issue":"1","key":"1326_CR30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ahj.2006.02.001","volume":"152","author":"GA Kunz","year":"2006","unstructured":"Kunz GA, Ge L, Cuculi F, Gregg D, Vata KC, Shaw LK, Goldschmidt-Clermont PJ, Dong C, Taylor DA, Peterson ED. Circulating endothelial progenitor cells predict coronary artery disease severity. Am Heart J. 2006;152(1):190\u20135.","journal-title":"Am Heart J"},{"issue":"6","key":"1326_CR31","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s00395-008-0742-z","volume":"103","author":"S Keymel","year":"2008","unstructured":"Keymel S, Kalka C, Rassaf T, Yeghiazarians Y, Kelm M, Heiss C. Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening. Basic Res Cardiol. 2008;103(6):582\u20136.","journal-title":"Basic Res Cardiol"},{"issue":"7255","key":"1326_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1136\/bmj.321.7255.199","volume":"321","author":"J Danesh","year":"2000","unstructured":"Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Gallimore JR, Pepys MB. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. BMJ. 2000;321(7255):199\u2013204.","journal-title":"BMJ"},{"issue":"7","key":"1326_CR33","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1016\/S0735-1097(01)01657-6","volume":"38","author":"JT Kuvin","year":"2001","unstructured":"Kuvin JT, Patel AR, Sliney KA, Pandian NG, Rand WM, Udelson JE, Karas RH. Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease. J Am Coll Cardiol. 2001;38(7):1843\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"1326_CR34","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.nefro.2015.10.018","volume":"36","author":"D Mart\u00ednez-Urbistondo","year":"2016","unstructured":"Mart\u00ednez-Urbistondo D, Beltr\u00e1n A, Beloqui O, Huerta A. The neutrophil-to-lymphocyte ratio as a marker of systemic endothelial dysfunction in asymptomatic subjects. Nefrol. 2016;36(4):397\u2013403.","journal-title":"Nefrol"},{"issue":"1","key":"1326_CR35","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0002-8703(03)00094-2","volume":"146","author":"JT Kuvin","year":"2003","unstructured":"Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J. 2003;146(1):168\u201374.","journal-title":"Am Heart J"},{"issue":"4","key":"1326_CR36","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s10157-012-0728-x","volume":"17","author":"Y Solak","year":"2013","unstructured":"Solak Y, Yilmaz MI, Sonmez A, Saglam M, Cakir E, Unal HU, Gok M, Caglar K, Oguz Y, Yenicesu M, Karaman M, Ay SA, Gaipov A, Turk S, Vural A, Carrero JJ. Neutrophil to lymphocyte ratio independently predicts cardiovascular events in patients with chronic kidney disease. Clin Exp Nephrol. 2013 Aug;17(4):532\u201340.","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"1326_CR37","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.amjcard.2013.08.051","volume":"113","author":"M Shechter","year":"2014","unstructured":"Shechter M, Shechter A, Koren-Morag N, Feinberg MS, Hiersch L. Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease. Am J Cardiol. 2014;113(1):162\u20137.","journal-title":"Am J Cardiol"},{"issue":"7","key":"1326_CR38","doi-asserted-by":"publisher","first-page":"e0132047","DOI":"10.1371\/journal.pone.0132047","volume":"10","author":"J Chen","year":"2015","unstructured":"Chen J, Hamm LL, Mohler ER, Hudaihed A, Arora R, Chen C-S, Liu Y, Browne G, Mills KT, Kleinpeter MA, Simon EE, Rifai N, Klag MJ, He J. Interrelationship of multiple endothelial dysfunction biomarkers with chronic kidney disease. PLoS One. 2015;10(7):e0132047.","journal-title":"PLoS One"},{"issue":"5302","key":"1326_CR39","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.275.5302.964","volume":"275","author":"T Asahara","year":"1997","unstructured":"Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Sci. 1997;275(5302):964\u20137.","journal-title":"Sci"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01326-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12872-020-01326-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01326-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:19:02Z","timestamp":1611879542000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-020-01326-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1326"],"URL":"https:\/\/doi.org\/10.1186\/s12872-020-01326-2","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]},"assertion":[{"value":"8 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Our study was approved by the ethics committee of the Xuanwu Hospital of Capital Medical University. All participants have signed the informed consents.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no cmpeting interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40"}}