{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:46:42Z","timestamp":1784040402310,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Percutaneous closure (LAAC) of the left atrial appendage (LAA) is an efficacious preventive procedure for patients with non-valvular atrial fibrillation (NVAF) and considerable bleeding risk. We sought to systematically review the available LAAC data on the novel occluder device LAmbre\u2122.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>For this systematic review, a search of the literature was conducted by 3 independent reviewers, reporting the safety and therapeutic success of LAAC in patients being treated with a LAmbre\u2122. Publications reporting the safety and therapeutic success of LAAC using LAmbre\u2122 in <jats:italic>n<\/jats:italic>\u00a0<jats:underline>&gt;<\/jats:underline>\u00a05 patients were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The literature search retrieved <jats:italic>n<\/jats:italic>\u2009=\u200910 publications, encompassing <jats:italic>n<\/jats:italic>\u2009=\u2009403 NVAF patients treated with a LAmbre\u2122 LAAC, with relevant data regarding safety and therapeutic success of the procedure. The mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc Score was 4.0\u00a0<jats:underline>+<\/jats:underline>\u00a00.9, and the mean HAS-BLED score was 3.4\u00a0<jats:underline>+<\/jats:underline>\u00a00.5. The implantation success was 99.7%, with a mean procedure time of 45.4\u2009\u00b1\u200918.7\u2009min, and a fluoroscopy time of 9.6\u2009\u00b1\u20095.9\u2009min, and a contrast agent volume of 96.7\u2009\u00b1\u20090.7\u2009ml. The anticoagulation regimen was switched to DAPT post procedure in the majority of the patients (96.8%). Partial and full recapture were done in 45.5% and in 25.6%, respectively. Major complications were reported in 2.9%, with 0.3% mortality, 1.7% pericardial tamponade, 0.3% stroke, and 0.6% major bleeding complications; no device embolization was observed. During follow up at 6 or 12\u2009months, major adverse cardiovascular events were reported in 3.3%: Stroke or TIA in 1.7%, thrombus formation on the device in 0.7%, and residual flow &gt;\u20095\u2009mm in 1.0%. In some publications, the favorable implantion properties of the LAmbre\u2122 for difficult anatomies such as shallow or multilobular LAA anatomies were described.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This systematic review on the LAmbre\u2122 LAA-occluder including <jats:italic>n<\/jats:italic>\u2009=\u2009403 NVAF patients demonstrates an excellent implantion success rate, promising follow-up clinical data, and favorable properties for also challenging LAA anatomies,. While its design seems to be helpful in preventing device embolization, pericardial tamponade may not be substantially reduced by the LAmbre\u2122 as compared with other established LAAC devices. Further larger prospective multicenter registries and randomized trials are needed to scrutinize the value of the LAmbre\u2122 compared with established LAAC devices.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12872-020-01349-9","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T18:03:08Z","timestamp":1581530588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Systematic review on left atrial appendage closure with the LAmbre device in patients with non-valvular atrial fibrillation"],"prefix":"10.1186","volume":"20","author":[{"given":"Muhammad","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos G.","family":"Rigopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mammad","family":"Mammadov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Torky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Matiakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Abate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Bakogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios","family":"Tzikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Bigalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sedding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-5262","authenticated-orcid":false,"given":"Michel","family":"Noutsias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"issue":"38","key":"1349_CR1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","volume":"37","author":"P Kirchhof","year":"2016","unstructured":"Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Group ESCSD. 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS. 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MA and AGR gave received honoraria for presentations from AstraZeneca. MN has received honoraria for presentations and\/or participated in advisory boards from Abiomed, Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Boston, Fresenius, Miltenyi Biotech, Novartis, Pfizer and Zoll. All other authors declare no conflicts of interest. MN is Section Editor, and AGR is Associate Editor of BMC Cardiovascular Disorders.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}