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The differential diagnosis can include rheumatic mitral valve disease, pulmonary hypertension, endocarditis, myocarditis and vasculitis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>This case report involves a 49\u2009years old female with a 2.8\u2009cm\u2009\u00d7\u20093.4\u2009cm myxoma in the left atrium causing mitral valve obstruction. She presented with fatigue, fever of unknown origin, transient ischemic attack and shortness of breath. Prompt surgery is often recommended due to the risk of embolic complications or complete obstruction. Due to her symptoms, patient underwent successful cardiothoracic surgery to excise the myxoma within 2\u2009weeks of confirmation by cardiac echocardiography.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This case also emphasizes the diagnostic challenge as symptoms may be variable, ranging from fatigue, fever and shortness of breath to transient ischemic attack and at worst, sudden cardiac death. In conclusion, if a cardiac mass is suspected, echocardiography should be performed early. Surgical resection is curative and recurrence rate is very rare in sporadic isolated myxomas, however, recurrence can be higher in genetic diseases associated with increased frequency of myxomas such as Carney complex. This subpopulation of patients may present further research opportunity to learn more about the perioperative management of patients with myxomas such as determining the optimal time to surgical intervention and decision to anticoagulate.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01397-1","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T16:03:56Z","timestamp":1583424236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Case report: left atrial Myxoma causing elevated C-reactive protein, fatigue and fever, with literature review"],"prefix":"10.1186","volume":"20","author":[{"given":"Jake","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Quach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omeni","family":"Osian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"issue":"1","key":"1397_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2459\/JCM.0000000000000059","volume":"17","author":"A Cresti","year":"2016","unstructured":"Cresti A, Chiavarelli M, Glauber M, Tanganelli P, Scalese M, Cesareo F, et al. 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Need for ethics approval was waived by the C.A.R.R.I.E. (Centralized Algorithms for Research Rules on IRB Exemption) as part of the IRB of the University of Central Florida, College of Medicine, Orlando, FL and HCA Ocala Regional Medical Center.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report along with the accompanying images. Written informed consent was also obtained from the patient for the second surgical case for publication of this case report along with the accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.The Authors have no conflict of interest to declare, financial or otherwise.This paper is not under consideration elsewhere.None of the paper\u2019s contents have been previously published.Full disclosure of any relationship with industry: none to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}