{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:40:55Z","timestamp":1782945655214,"version":"3.54.5"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Combined oral contraceptive pills are associated with an established risk for venous thrombosis; however, their risk for arterial thrombosis remains uncertain, especially with the development of low dose new generations of combined oral contraceptive. Arterial thrombosis is less likely to occur with the use of oral contraceptive pills in the absence of cardiovascular risk factors.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>We report a 35-year old female with no cardiovascular risk factors who presented with thrombotic anterior wall myocardial infarction 6 months after using a third generation low dose combined oral contraceptive pills (Marvelon; ethinylestradiol 30 mcg and desogestrel 150 mcg).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Third generation low dose combined oral contraceptives may lead to myocardial infarction in young women, even in the absence of other cardiovascular risk factors.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01462-9","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T14:02:33Z","timestamp":1587304953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low dose combined oral contraceptives induced thrombotic anterior wall myocardial infarction: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Alaa","family":"Rahhal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Khir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Aljundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Khalil","family":"Mohsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassim","family":"Al-Suwaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"issue":"1","key":"1462_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1055\/s-2003-38334","volume":"3","author":"BC Tanis","year":"2003","unstructured":"Tanis BC, Rosendaal FR. Venous and arterial thrombosis during Oral contraceptive use: risks and risk factors. Semin Vasc Med. 2003;3(1):69\u201384.","journal-title":"Semin Vasc Med"},{"key":"1462_CR2","unstructured":"Speroff L, Darney PH. A Clinical Guide for Contraception. 5th Edition. Wolters Kluwer, 2011."},{"issue":"20","key":"1462_CR3","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1056\/NEJM199011153232003","volume":"323","author":"IF Godsland","year":"1990","unstructured":"Godsland IF, Crook D, Simpson R, et al. The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med. 1990;323(20):1375\u201381.","journal-title":"N Engl J Med"},{"issue":"6 Pt 2","key":"1462_CR4","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1016\/0002-9378(92)91397-S","volume":"166","author":"J Bringer","year":"1992","unstructured":"Bringer J. Norgestimate: a clinical overview of a new progestin. Am J Obstet Gynecol. 1992;166(6 Pt 2):1969\u201377.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1462_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/humupd\/5.3.191","volume":"5","author":"L Badimon","year":"1999","unstructured":"Badimon L, Bay\u00e9s-Gen\u00eds A. Effects of progestogens on thrombosis and atherosclerosis. Hum Reprod Update. 1999;5(3):191\u20139.","journal-title":"Hum Reprod Update"},{"key":"1462_CR6","first-page":"CD011054","volume":"8","author":"RE Roach","year":"2015","unstructured":"Roach RE, Helmerhorst FM, Lijfering WM, Stijnen T, Algra A, Dekkers OM. Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke. Cochrane Database Syst Rev. 2015;8:CD011054.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"1462_CR7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1046\/j.1538-7836.2003.00079.x","volume":"1","author":"MA Van Den Bosch","year":"2003","unstructured":"Van Den Bosch MA, Kemmeren JM, Tanis BC, et al. The RATIO study: oral contraceptives and the risk of peripheral arterial disease in young women. J Thromb Haemost. 2003;1(3):439\u201344.","journal-title":"J Thromb Haemost"},{"issue":"4 Pt 2","key":"1462_CR8","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/0002-9378(90)91354-F","volume":"163","author":"IH Thorneycroft","year":"1990","unstructured":"Thorneycroft IH. Oral contraceptives and myocardial infarction. Am J Obstet Gynecol. 1990;163(4 Pt 2):1393\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"1462_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.thromres.2010.01.045","volume":"126","author":"SN Tchaikovski","year":"2010","unstructured":"Tchaikovski SN, Rosing J. Mechanisms of estrogen induced venous thromboembolism. Thromb Res. 2010;126(1):5\u201311.","journal-title":"Thromb Res"},{"key":"1462_CR10","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/j.jacc.2005.10.076","volume":"47","author":"P Ouyang","year":"2006","unstructured":"Ouyang P, Michos ED, Karas RH. Hormone replacement therapy and the cardiovascular system lessons learned and unan\u00acswered questions. J Am Coll Cardiol. 2006;47:1741\u201353.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"1462_CR11","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/13625187.2016.1225715","volume":"21","author":"AN Aslan","year":"2016","unstructured":"Aslan AN, S\u00fcyg\u00fcn H, Sivri S, Kele\u015f T. Low-dose oral contraceptive-induced acute myocardial infarction. Eur J Contracept Reprod Health Care. 2016;21(6):499\u2013501.","journal-title":"Eur J Contracept Reprod Health Care"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01462-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-020-01462-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01462-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T23:14:59Z","timestamp":1618787699000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-020-01462-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1462"],"URL":"https:\/\/doi.org\/10.1186\/s12872-020-01462-9","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"10 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by Hamad Medical Corporation Medical Research Centre and Institutional Review Board in Qatar on <i>Aug 18, 2019<\/i>, approval reference <i>MRC-04-19-232.<\/i>","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A written informed consent for publishing patient\u2019s information and images was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"182"}}