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Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, A general linear model adjusted for confounding factors (socio-demographic characteristics [age, educational levels, marital status, place of residence], health behaviors [cigarette smoking, alcohol drinking, eating habits, social and leisure activities, accidental injury, physical activities], medical history [history of cardiovascular diseases, hepatitis history, antidiabetic drugs, history of antilipidemic medication, anti-hypertensive therapy], metabolic measures [C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR), body mass index (BMI)]) was used to examine the synergistic effect of SUA and TG level on BP in middle-aged and elderly individuals in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age-adjusted partial Pearson\u2019s correlation coefficient showed that SUA and TG level positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both men and women. Multiple linear regression analysis showed the TG level was significantly and positively associated with SBP and DBP in both men (SBP: \u03b2 =0.068,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.001; DBP: \u03b2 =0.064,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.002) and women (SBP: \u03b2 =0.061,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.002; DBP: \u03b2 =0.084,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.000), but SUA were significantly and positively associated with SBP in both men (SBP: \u03b2 =0.047,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.013) and women (SBP: \u03b2 =0.040,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.028), regardless of other confounding factors. After adjusting for related potential confounders, evidence of interaction between SUA and TG level on SBP (men: \u03b2\u2009=\u2009\u2212\u20091.090,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.726; women: \u03b2\u2009=\u2009\u2212\u20090.692,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.861) and DBP (men: \u03b2\u2009=\u2009\u2212\u20091.026,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.572; women: \u03b2\u2009=\u2009\u2212\u20090.794,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u20090.842) was not observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The interaction effect of SUA and TG level on BP was not observed in our study. Moreover, high SUA level was significantly associated with SBP, while high TG level was strongly related to both DBP and SBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-020-01468-3","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T10:02:41Z","timestamp":1586944961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-long","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"issue":"1","key":"1468_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1161\/hy1201.097199","volume":"39","author":"RJ Glynn","year":"2002","unstructured":"Glynn RJ, L'Italien GJ, Sesso HD, Jackson EA, Buring JE. 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