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Besides comparisons between BAV and TAV, BAV patients were also divided in subgroups according to baseline hemodynamics (i.e. maximal transaortic velocity, V<jats:sub>max<\/jats:sub>) and post-procedural reverse left ventricular (LV) remodeling (i.e. the change in LV mass index from baseline, \u2206LVMI) for further analysis. Metabolic differences between groups were identified by integrating univariate test, multivariate analysis and weighted correlation network analysis algorithm.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 57 patients were enrolled including 33 BAV patients. The BAV group showed lower arginine and proline metabolism both before and post TAVR than TAV represented by decreased expression of L-Glutamine. In BAV subgroup analysis, patients with baseline V<jats:sub>max<\/jats:sub>\u2009&gt;\u20095\u2009m\/s (<jats:italic>n<\/jats:italic>\u2009=\u200911) or the 4<jats:sup>th<\/jats:sup> quartile of change in \u2206LVMI at one-year follow-up (i.e. poorly-recovered LV, <jats:italic>n<\/jats:italic>\u2009=\u20098) showed elevated arachidonic acid metabolism compared with V<jats:sub>max<\/jats:sub>\u2009&lt;\u20094.5\u2009m\/s (<jats:italic>n<\/jats:italic>\u2009=\u200912) or the 1<jats:sup>st<\/jats:sup> quartile of \u2206LVMI (i.e. well-recovered LV, <jats:italic>n<\/jats:italic>\u2009=\u20098) respectively.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Difference in arginine and proline metabolism was identified between BAV and TAV in TAVR recipients. Elevated arachidonic acid metabolism may reflect more severe baseline hemodynamics and worse LV reserve remodeling after TAVR in BAV.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01491-4","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T15:05:37Z","timestamp":1589814337000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Differences in metabolic profiles between bicuspid and tricuspid aortic stenosis in the setting of transcatheter aortic valve replacement"],"prefix":"10.1186","volume":"20","author":[{"given":"Tian-Yuan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Biao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanweixiang","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"1491_CR1","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.3389\/fphys.2018.01921","volume":"9","author":"T Liu","year":"2018","unstructured":"Liu T, Xie M, Lv Q, Li Y, Fang L, Zhang L, et al. 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