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According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0\u20131 grade,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969) and the good CCC formation group (Rentrop2\u20133 grade,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients\u2019 blood vessel occlusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR\u2009=\u20091.190,95% CI (1.092\u20131.297),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001], while diabetes was negatively correlated with CCC formation [OR\u2009=\u20090.285,95% CI (0.094\u20130.864),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI,0.686\u20130.851, P&lt;0.001); the optimal cut-off value was 63.35 KU\/L, and the sensitivity was 71.2%,specificity is 71%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12872-020-01543-9","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T07:03:54Z","timestamp":1594191834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Correlation between ischemia-modified albumin level and coronary collateral circulation"],"prefix":"10.1186","volume":"20","author":[{"given":"Xin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-4471","authenticated-orcid":false,"given":"Zhiquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"1543_CR1","doi-asserted-by":"crossref","unstructured":"Galassi AR , Werner GS, Boukhris M, et al. 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All patients gave written informed consent to participate in this study. The study was conducted in accordance with 1964 Helsinki Declaration.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"326"}}