{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:24:45Z","timestamp":1787955885819,"version":"build-2784847793"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cardiovasc Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ischemic cardiomyopathy (ICM) is one of the most usual causes of death worldwide. This study aimed to find the candidate gene for ICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied differentially expressed genes (DEGs) in ICM compared to healthy control. According to these DEGs, we carried out the functional annotation, protein-protein interaction (PPI) network and transcriptional regulatory network constructions. The expression of selected candidate genes were confirmed using a published dataset and Quantitative real time polymerase chain reaction (qRT-PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From three Gene Expression Omnibus (GEO) datasets, we acquired 1081 DEGs (578 up-regulated and 503 down-regulated genes) between ICM and healthy control. The functional annotation analysis revealed that cardiac muscle contraction, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy were significantly enriched pathways in ICM. SNRPB, BLM, RRS1, CDK2, BCL6, BCL2L1, FKBP5, IPO7, TUBB4B and ATP1A1 were considered the hub proteins. PALLD, THBS4, ATP1A1, NFASC, FKBP5, ECM2 and BCL2L1 were top six transcription factors (TFs) with the most downstream genes. The expression of 6 DEGs (MYH6, THBS4, BCL6, BLM, IPO7 and SERPINA3) were consistent with our integration analysis and GSE116250 validation results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The candidate DEGs and TFs may be related to the ICM process. This study provided novel perspective for understanding mechanism and exploiting new therapeutic means for ICM.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12872-020-01596-w","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T11:03:50Z","timestamp":1594033430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database"],"prefix":"10.1186","volume":"20","author":[{"given":"Haiming","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-963X","authenticated-orcid":false,"given":"Yong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"issue":"4","key":"1596_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jacc.2011.08.076","volume":"59","author":"A Schuster","year":"2012","unstructured":"Schuster A, Morton G, Chiribiri A, Perera D, Vanoverschelde JL, Nagel E. Imaging in the management of ischemic cardiomyopathy: special focus on magnetic resonance. J Am Coll Cardiol. 2012;59(4):359\u201370.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"1596_CR2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jchf.2018.01.024","volume":"6","author":"D Perera","year":"2018","unstructured":"Perera D, Clayton T, Petrie MC, Greenwood JP, O'Kane PD, Evans R, Sculpher M, McDonagh T, Gershlick A, de Belder M, et al. Percutaneous revascularization for ischemic ventricular dysfunction: rationale and design of the REVIVED-BCIS2 trial: percutaneous coronary intervention for ischemic cardiomyopathy. JACC Heart Fail. 2018;6(6):517\u201326.","journal-title":"JACC Heart Fail"},{"issue":"8","key":"1596_CR3","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1006\/jmcc.2002.2037","volume":"34","author":"G Hasenfuss","year":"2002","unstructured":"Hasenfuss G, Pieske B. Calcium cycling in congestive heart failure. J Mol Cell Cardiol. 2002;34(8):951\u201369.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"1596_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/jcp.10219","volume":"195","author":"S Cicconi","year":"2003","unstructured":"Cicconi S, Ventura N, Pastore D, Bonini P, Di NP, Lauro R, Marlier LN. Characterization of apoptosis signal transduction pathways in HL-5 cardiomyocytes exposed to ischemia\/reperfusion oxidative stress model. J Cell Physiol. 2003;195(1):27\u201337.","journal-title":"J Cell Physiol"},{"key":"1596_CR5","doi-asserted-by":"publisher","first-page":"e7722","DOI":"10.7717\/peerj.7722","volume":"7","author":"H Yang","year":"2019","unstructured":"Yang H, Li H. CD36 identified by weighted gene co-expression network analysis as a hub candidate gene in lupus nephritis. PeerJ. 2019;7:e7722.","journal-title":"PeerJ."},{"key":"1596_CR6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13000-015-0310-4","volume":"10","author":"Y Wang","year":"2015","unstructured":"Wang Y, Wu N, Liu J, Wu Z, Dong D. FusionCancer: a database of cancer fusion genes derived from RNA-seq data. Diagn Pathol. 2015;10:131.","journal-title":"Diagn Pathol"},{"issue":"24","key":"1596_CR7","doi-asserted-by":"publisher","first-page":"800","DOI":"10.21037\/atm.2019.12.59","volume":"7","author":"Y Sun","year":"2019","unstructured":"Sun Y, Lin J, Zhang L. The application of weighted gene co-expression network analysis in identifying key modules and hub genes associated with disease status in Alzheimer's disease. Ann Transl Med. 2019;7(24):800.","journal-title":"Ann Transl Med"},{"issue":"3\u20134","key":"1596_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","volume":"12","author":"M Rajabi","year":"2007","unstructured":"Rajabi M, Kassiotis C, Razeghi P, Taegtmeyer H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev. 2007;12(3\u20134):331\u201343.","journal-title":"Heart Fail Rev"},{"issue":"50","key":"1596_CR9","doi-asserted-by":"publisher","first-page":"82063","DOI":"10.18632\/oncotarget.13331","volume":"7","author":"W Li","year":"2016","unstructured":"Li W, Li L, Zhang S, Zhang C, Huang H, Li Y, Hu E, Deng G, Guo S, Wang Y, et al. Identification of potential genes for human ischemic cardiomyopathy based on RNA-Seq data. Oncotarget. 2016;7(50):82063\u201373.","journal-title":"Oncotarget."},{"key":"1596_CR10","doi-asserted-by":"publisher","first-page":"24060","DOI":"10.1038\/srep24060","volume":"6","author":"E Rosell\u00f3-Llet\u00ed","year":"2016","unstructured":"Rosell\u00f3-Llet\u00ed E, Carnicer R, Taraz\u00f3n E, Ortega A, Gil-Cayuela C, Lago F, Gonz\u00e1lez-Juanatey JR, Portol\u00e9s M, Rivera M. Human ischemic cardiomyopathy shows cardiac Nos1 translocation and its increased levels are related to left ventricular performance. Sci Rep. 2016;6:24060.","journal-title":"Sci Rep"},{"issue":"1","key":"1596_CR11","first-page":"14","volume":"8","author":"I Herrer","year":"2015","unstructured":"Herrer I, Rosell\u00f3-Llet\u00ed E, Ortega A, Taraz\u00f3n E, Molina-Navarro MM, Trivi\u00f1o JC, Mart\u00ednez-Dolz L, Almenar L, Lago F, S\u00e1nchez-L\u00e1zaro I. Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy. BMC Med Genet. 2015;8(1):14.","journal-title":"BMC Med Genet"},{"issue":"5","key":"1596_CR12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.prp.2016.12.017","volume":"213","author":"A Qiao","year":"2017","unstructured":"Qiao A, Zhao Z, Zhang H, Sun Z, Cui X. Gene expression profiling reveals genes and transcription factors associated with dilated and ischemic cardiomyopathies. Pathol Res Pract. 2017;213(5):548\u201357.","journal-title":"Pathol Res Pract"},{"issue":"11","key":"1596_CR13","first-page":"3553","volume":"22","author":"GM Li","year":"2018","unstructured":"Li GM, Zhang CL, Rui RP, Sun B, Guo W. Bioinformatics analysis of common differential genes of coronary artery disease and ischemic cardiomyopathy. Eur Rev Med Pharmacol Sci. 2018;22(11):3553\u201369.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"1596_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12031-018-1066-6","volume":"65","author":"J Wang","year":"2018","unstructured":"Wang J, Wang F, Zhu J, Song M, An J, Li W. Transcriptome profiling reveals PHLDA1 as a novel molecular marker for ischemic cardiomyopathy. J Mol Neurosci. 2018;65(1):102\u20139.","journal-title":"J Mol Neurosci"},{"issue":"2","key":"1596_CR15","doi-asserted-by":"publisher","first-page":"e30915","DOI":"10.1371\/journal.pone.0030915","volume":"7","author":"R Cort\u00e9s","year":"2012","unstructured":"Cort\u00e9s R, Rivera M, Rosell\u00f3-Llet\u00ed E, Mart\u00ednez-Dolz L, Almenar L, Azor\u00edn I, Lago F, Gonz\u00e1lez-Juanatey JR, Portol\u00e9s M. Differences in MEF2 and NFAT transcriptional pathways according to human heart failure Aetiology. PLoS One. 2012;7(2):e30915.","journal-title":"PLoS One"},{"issue":"3","key":"1596_CR16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0092-8674(04)00405-2","volume":"117","author":"M Pashmforoush","year":"2004","unstructured":"Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004;117(3):373\u201386.","journal-title":"Cell."},{"issue":"2","key":"1596_CR17","first-page":"543","volume":"276","author":"C Li","year":"1999","unstructured":"Li C, Browder W, Kao RL. Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol. 1999;276(2):543\u201352.","journal-title":"Am J Physiol"},{"issue":"1","key":"1596_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10741-010-9170-x","volume":"16","author":"A Haghikia","year":"2011","unstructured":"Haghikia A, Stapel B, Hoch M, Hilfikerkleiner D. STAT3 and cardiac remodeling. Heart Fail Rev. 2011;16(1):35\u201347.","journal-title":"Heart Fail Rev"},{"issue":"9","key":"1596_CR19","doi-asserted-by":"publisher","first-page":"e73294","DOI":"10.1371\/journal.pone.0073294","volume":"8","author":"W Renata","year":"2013","unstructured":"Renata W, Julius M, Allison F, Alexander A, Wagner EF, Thierry P, Grzegorz S, Romeo R. The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart. PLoS One. 2013;8(9):e73294.","journal-title":"PLoS One"},{"issue":"7","key":"1596_CR20","doi-asserted-by":"publisher","first-page":"e22843","DOI":"10.1371\/journal.pone.0022843","volume":"6","author":"KG Kugler","year":"2011","unstructured":"Kugler KG, Mueller LA, Graber A, Dehmer M. Integrative network biology: graph prototyping for co-expression cancer networks. PLoS One. 2011;6(7):e22843.","journal-title":"PLoS One"},{"issue":"3","key":"1596_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1049\/iet-syb.2010.0025","volume":"5","author":"F Emmertstreib","year":"2011","unstructured":"Emmertstreib F, Dehmer M. Networks for systems biology: conceptual connection of data and function. IET Syst Biol. 2011;5(3):185\u2013207.","journal-title":"IET Syst Biol"},{"issue":"9","key":"1596_CR22","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.113.003863","volume":"129","author":"KC Yang","year":"2014","unstructured":"Yang KC, Yamada KA, Patel AY, Topkara VK, George I, Cheema FH, Ewald GA, Mann DL, Nerbonne JM. Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation. 2014;129(9):1009\u201321.","journal-title":"Circulation."},{"issue":"30","key":"1596_CR23","doi-asserted-by":"publisher","first-page":"11151","DOI":"10.1073\/pnas.1401724111","volume":"111","author":"KM Akat","year":"2014","unstructured":"Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, Mihailovic A, Sauer M, Ji R, Ramarathnam A, et al. Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. Proc Natl Acad Sci U S A. 2014;111(30):11151\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"1596_CR24","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.106.632430","volume":"114","author":"S Hannenhalli","year":"2006","unstructured":"Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 2006;114(12):1269\u201376.","journal-title":"Circulation."},{"issue":"1","key":"1596_CR25","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1186\/s12864-018-5213-9","volume":"19","author":"ME Sweet","year":"2018","unstructured":"Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, et al. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018;19(1):812.","journal-title":"BMC Genomics"},{"issue":"2","key":"1596_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S0735-1097(01)01738-7","volume":"39","author":"GM Felker","year":"2002","unstructured":"Felker GM, Shaw LK, O'Connor CM. A standardized definition of ischemic cardiomyopathy for use in clinical research. J Am Coll Cardiol. 2002;39(2):210\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"1596_CR27","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.2147\/COPD.S163459","volume":"13","author":"X Liu","year":"2018","unstructured":"Liu X, Qu J, Xue W, He L, Wang J, Xi X, Yin Y, Qu Y. Bioinformatics-based identification of potential microRNA biomarkers in frequent and non-frequent exacerbators of COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:1217\u201328.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"10","key":"1596_CR28","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.euroneuro.2017.07.002","volume":"27","author":"M Manchia","year":"2017","unstructured":"Manchia M, Piras IS, Huentelman MJ, Pinna F, Zai CC, Kennedy JL, Carpiniello B. Pattern of gene expression in different stages of schizophrenia: Down-regulation of NPTX2 gene revealed by a meta-analysis of microarray datasets. Eur Neuropsychopharmacol. 2017;27(10):1054\u201363.","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"1596_CR29","first-page":"1338","volume":"39","author":"Y Huang","year":"2018","unstructured":"Huang Y, Zhu J, Li W, Zhang Z, Xiong P, Wang H, Zhang J. Serum microRNA panel excavated by machine learning as a potential biomarker for the detection of gastric cancer. Oncol Rep. 2018;39(3):1338\u201346.","journal-title":"Oncol Rep"},{"issue":"7","key":"1596_CR30","doi-asserted-by":"crossref","first-page":"e01319","DOI":"10.1002\/brb3.1319","volume":"9","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Chen W, Chen S, Li S, Wei D, He W. Identification of key genes and upstream regulators in ischemic stroke. Brain Behav. 2019;9(7):e01319.","journal-title":"Brain Behav"},{"issue":"1","key":"1596_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12886-017-0498-z","volume":"17","author":"B Zhao","year":"2017","unstructured":"Zhao B, Wang M, Xu J, Li M, Yu Y. Identification of pathogenic genes and upstream regulators in age-related macular degeneration. BMC Ophthalmol. 2017;17(1):102.","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"1596_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.104.507699","volume":"112","author":"E Carniel","year":"2005","unstructured":"Carniel E, Taylor MR, Sinagra G, Di Lenarda A, Ku L, Fain PR, Boucek MM, Cavanaugh J, Miocic S, Slavov D, et al. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation. 2005;112(1):54\u20139.","journal-title":"Circulation."},{"issue":"2","key":"1596_CR33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/CIRCGENETICS.109.912345","volume":"3","author":"RE Hershberger","year":"2010","unstructured":"Hershberger RE, Norton N, Morales A, Li D, Siegfried JD, Gonzalez-Quintana J. Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy. Circ Cardiovasc Genet. 2010;3(2):155\u201361.","journal-title":"Circ Cardiovasc Genet"},{"issue":"1","key":"1596_CR34","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12872-018-0867-4","volume":"18","author":"E Razmara","year":"2018","unstructured":"Razmara E, Garshasbi M. Whole-exome sequencing identifies R1279X of MYH6 gene to be associated with congenital heart disease. BMC Cardiovasc Disord. 2018;18(1):137.","journal-title":"BMC Cardiovasc Disord"},{"issue":"12","key":"1596_CR35","doi-asserted-by":"publisher","first-page":"e28872","DOI":"10.1371\/journal.pone.0028872","volume":"6","author":"MG Posch","year":"2011","unstructured":"Posch MG, Waldmuller S, Muller M, Scheffold T, Fournier D, Andrade-Navarro MA, De Geeter B, Guillaumont S, Dauphin C, Yousseff D, et al. Cardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defects. PLoS One. 2011;6(12):e28872.","journal-title":"PLoS One"},{"issue":"6154","key":"1596_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1126\/science.1236921","volume":"342","author":"J Jiang","year":"2013","unstructured":"Jiang J, Wakimoto H, Seidman JG, Seidman CE. Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy. Science (New York, NY). 2013;342(6154):111\u20134.","journal-title":"Science (New York, NY)"},{"key":"1596_CR37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jelectrocard.2019.01.002","volume":"53","author":"S Castellana","year":"2019","unstructured":"Castellana S, Mastroianno S, Palumbo P, Palumbo O, Biagini T, Leone MP, De Luca G, Potenza DR, Amico CM, Mazza T, et al. Sudden death in mild hypertrophic cardiomyopathy with compound DSG2\/DSC2\/MYH6 mutations: revisiting phenotype after genetic assessment in a master runner athlete. J Electrocardiol. 2019;53:95\u20139.","journal-title":"J Electrocardiol"},{"issue":"20","key":"1596_CR38","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1093\/hmg\/ddq315","volume":"19","author":"JT Granados-Riveron","year":"2010","unstructured":"Granados-Riveron JT, Ghosh TK, Pope M, Bu\u2019Lock F, Thornborough C, Eason J, Kirk EP, Fatkin D, Feneley MP, Harvey RP. Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects. Hum Mol Genet. 2010;19(20):4007\u201316.","journal-title":"Hum Mol Genet"},{"issue":"36","key":"1596_CR39","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1038\/onc.2017.140","volume":"36","author":"S Muppala","year":"2017","unstructured":"Muppala S, Xiao R, Krukovets I, Verbovetsky D, Yendamuri R, Habib N, Raman P, Plow E, Stenina-Adognravi O. Thrombospondin-4 mediates TGF-beta-induced angiogenesis. Oncogene. 2017;36(36):5189\u201398.","journal-title":"Oncogene."},{"key":"1596_CR40","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.matbio.2017.11.006","volume":"75-76","author":"O Stenina-Adognravi","year":"2019","unstructured":"Stenina-Adognravi O, Plow EF. Thrombospondin-4 in tissue remodeling. Matrix Biol. 2019;75-76:300\u201313.","journal-title":"Matrix Biol"},{"issue":"2","key":"1596_CR41","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3892\/mmr.2016.5443","volume":"14","author":"J Liu","year":"2016","unstructured":"Liu J, Cheng G, Yang H, Deng X, Qin C, Hua L, Yin C. Reciprocal regulation of long noncoding RNAs THBS4003 and THBS4 control migration and invasion in prostate cancer cell lines. Mol Med Rep. 2016;14(2):1451\u20138.","journal-title":"Mol Med Rep"},{"issue":"11","key":"1596_CR42","doi-asserted-by":"publisher","first-page":"e0224727","DOI":"10.1371\/journal.pone.0224727","volume":"14","author":"K Kuroda","year":"2019","unstructured":"Kuroda K, Yashiro M, Sera T, Yamamoto Y, Kushitani Y, Sugimoto A, Kushiyama S, Nishimura S, Togano S, Okuno T, et al. The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer. PLoS One. 2019;14(11):e0224727.","journal-title":"PLoS One"},{"key":"1596_CR43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.gene.2019.02.049","volume":"696","author":"H Wu","year":"2019","unstructured":"Wu H, Zhang G, Li Z, Ma J, Han X, Xiang T, Jiang X. Thrombospondin-4 expression as a prognostic marker in hepatocellular carcinoma. Gene. 2019;696:219\u201324.","journal-title":"Gene."},{"key":"1596_CR44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.yjmcc.2013.05.019","volume":"62","author":"T Tsoutsman","year":"2013","unstructured":"Tsoutsman T, Wang X, Garchow K, Riser B, Twigg S, Semsarian C. CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. J Mol Cell Cardiol. 2013;62:164\u201378.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"1596_CR45","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/path.2347","volume":"215","author":"JN Kloth","year":"2008","unstructured":"Kloth JN, Gorter A, Fleuren GJ, Oosting J, Uljee S, ter Haar N, Dreef EJ, Kenter GG, Jordanova ES. Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma. J Pathol. 2008;215(3):222\u201330.","journal-title":"J Pathol"},{"issue":"9","key":"1596_CR46","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1253\/circj.CJ-09-0465","volume":"73","author":"M Asakura","year":"2009","unstructured":"Asakura M, Kitakaze M. Global gene expression profiling in the failing myocardium. Circ J. 2009;73(9):1568\u201376.","journal-title":"Circ J"},{"key":"1596_CR47","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijcard.2020.01.067","volume":"306","author":"Z Liu","year":"2020","unstructured":"Liu Z, Hou L, Liu Y, Gong J. LncRNA GAS5 exacerbates myocardial ischemia-reperfusion injury through regulating serpina3 by targeting miR-137. Int J Cardiol. 2020;306:9.","journal-title":"Int J Cardiol"}],"container-title":["BMC Cardiovascular Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12872-020-01596-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12872-020-01596-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:03:11Z","timestamp":1696341791000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccardiovascdisord.biomedcentral.com\/articles\/10.1186\/s12872-020-01596-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1596"],"URL":"https:\/\/doi.org\/10.1186\/s12872-020-01596-w","relation":{},"ISSN":["1471-2261"],"issn-type":[{"value":"1471-2261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"26 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the ethical committee of the Capital medical university, Beijing Anzhen hospital. Written informed consent was obtained from all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The subjects gave written informed consent for the publication of any associated data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"320"}}