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The European guidelines recommend low-density lipoprotein cholesterol (LDL-C) levels &lt;\u20091.8\u2009mmol\/L and early initiation of intensive lipid-lowering therapy (LLT) to reduce CV risk.<\/jats:p>\n<jats:p>In order to reduce the risk of further cardiac events, the study aimed to evaluate LDL-C goal attainment and LLT intensity in an incident ACS population.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A cohort study of patients with residency at Funen in Denmark at a first-ever ACS event registered within the period 2010\u20132015. Information on LLT use and LDL-C levels was extracted from national population registers and a Laboratory database at Odense University Hospital. Treatments and lipid patterns were evaluated during index hospitalization, at 6-month and 12-month follow-up.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 3040 patients with an LDL-C measurement during index hospitalization, 40.7 and 39.0% attained the recommended LDL-C target value (&lt;\u20091.8\u2009mmol\/L) within 6- and 12-month follow-up, respectively. During 6- and 12-month follow-up, a total of 89.2% (20.2%) and 88.4% (29.7%) used LLT (intensive LLT). Of the intensive LLT users, 43.4 and 47.7% reached the LDL-C target value at 6- and 12-month follow-up. The frequency of lipid monitoring was low: 69.5, 77.7 and 53.6% in patients with a first-ever ACS during index hospitalization, 6- and 12-month follow-up, respectively.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Using national health registers and laboratory data, a considerably gap was observed between treatment guidelines and clinical practice in the management of dyslipidemia leaving very high-risk patients without adequate lipid management strategy. Therefore, improved lipid management strategies aimed at reaching treatment targets are warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12872-020-01616-9","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T12:06:02Z","timestamp":1594641962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lipid-lowering therapy and low-density lipoprotein cholesterol goal attainment after acute coronary syndrome: a Danish population-based cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Marie Skov","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Nybo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone M\u00f8ller","family":"Hede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Handberg","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens Lytken","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-3387","authenticated-orcid":false,"given":"Annette Kj\u00e6r","family":"Ersb\u00f8ll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"1616_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.recesp.2015.06.016","volume":"69","author":"E Abu-Assi","year":"2016","unstructured":"Abu-Assi E, L\u00f3pez-L\u00f3pez A, Gonz\u00e1lez-Salvado V, et al. 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Before data collection, data management, and data analyses, approval was obtained from the relevant national data agencies required. The Act on Processing of Personal Data (Act No. 429 of 31 May 2000 with amendments) is the legal foundation for analyses of register-based data in Denmark [].","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors: MSK, MN, MLL and AKE declare that they have no competing interests.When this study was performed, KHM was an employee of Sanofi-Aventis Denmark A\/S. AG and SMH declare that they have received funding from Sanofi Aventis Denmark A\/S during the conduct of the study, and they declare no other relationships or activities that could appear to have influenced the submitted work. GG declare that he has received funding from Bristol Myers Squibb, Bayer, Boehringer Ingelheim and Pfizer outside the submitted work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"336"}}